A sprain is a stretch or tear of a ligament connecting bones at a joint, while a strain is an injury to a muscle or tendon. Sprains commonly occur in the ankle after a twist or fall, while strains often affect the back or hamstrings from overuse. Symptoms include pain, swelling, bruising and loss of movement. Treatment focuses on RICE (rest, ice, compression, elevation) followed by rehabilitation exercises to regain strength and flexibility.