The document summarizes modeling and computation of expanding and shrinking interface problems. It discusses how interface problems arise in physical/biological sciences involving moving boundaries. It presents the classical Hele-Shaw problem as an example of an expanding interface problem and describes its governing equations. It also discusses a modified Hele-Shaw problem with a lifting plate as an example of a shrinking interface problem. It proposes an adaptive scaling technique to speed up simulations of slowly expanding interfaces and slow down rapidly shrinking interfaces.
MODELING OF REDISTRIBUTION OF INFUSED DOPANT IN A MULTILAYER STRUCTURE DOPANT...mathsjournal
In this paper we used an analytical approach to model nonlinear diffusion of dopant in a multilayer structure with account nonstationary annealing of the dopant. The approach do without crosslinking solutions at
the interface between layers of the multilayer structure. In this paper we analyzed influence of pressure of
vapor of infusing dopant during doping of multilayer structure on values of optimal parameters of technological process to manufacture p-n-junctions. It has been shown, that doping of multilayer structures by
diffusion and optimization of annealing of dopant gives us possibility to increase sharpness of p-n-junctions
(single p-n-junctions and p-n-junctions within transistors) and to increase homogeneity of dopant distribution in doped area.
International Journal of Computational Engineering Research(IJCER) is an intentional online Journal in English monthly publishing journal. This Journal publish original research work that contributes significantly to further the scientific knowledge in engineering and Technology.
The Queue Length of a GI M 1 Queue with Set Up Period and Bernoulli Working V...YogeshIJTSRD
Consider a GI M 1 queue with set up period and working vacations. During the working vacation period, customers can be served at a lower rate, if there are customers at a service completion instant, the vacation can be interrupted and the server will come back to a set up period with probability or continue the working vacation with probability , and when the set up period ends, the server will switch to the normal working level. Using the matrix analytic method, we obtain the steady state distributions for the queue length at arrival epochs. Li Tao "The Queue Length of a GI/M/1 Queue with Set-Up Period and Bernoulli Working Vacation Interruption" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43743.pdf Paper URL: https://www.ijtsrd.com/mathemetics/other/43743/the-queue-length-of-a-gim1-queue-with-setup-period-and-bernoulli-working-vacation-interruption/li-tao
SUCCESSIVE LINEARIZATION SOLUTION OF A BOUNDARY LAYER CONVECTIVE HEAT TRANSFE...ijcsa
The purpose of this paper is to discuss the flow of forced convection over a flat plate. The governing partial
differential equations are transformed into ordinary differential equations using suitable transformations.
The resulting equations were solved using a recent semi-numerical scheme known as the successive
linearization method (SLM). A comparison between the obtained results with homotopy perturbation method and numerical method (NM) has been included to test the accuracy and convergence of the method.
MODELING OF REDISTRIBUTION OF INFUSED DOPANT IN A MULTILAYER STRUCTURE DOPANT...mathsjournal
In this paper we used an analytical approach to model nonlinear diffusion of dopant in a multilayer structure with account nonstationary annealing of the dopant. The approach do without crosslinking solutions at
the interface between layers of the multilayer structure. In this paper we analyzed influence of pressure of
vapor of infusing dopant during doping of multilayer structure on values of optimal parameters of technological process to manufacture p-n-junctions. It has been shown, that doping of multilayer structures by
diffusion and optimization of annealing of dopant gives us possibility to increase sharpness of p-n-junctions
(single p-n-junctions and p-n-junctions within transistors) and to increase homogeneity of dopant distribution in doped area.
International Journal of Computational Engineering Research(IJCER) is an intentional online Journal in English monthly publishing journal. This Journal publish original research work that contributes significantly to further the scientific knowledge in engineering and Technology.
The Queue Length of a GI M 1 Queue with Set Up Period and Bernoulli Working V...YogeshIJTSRD
Consider a GI M 1 queue with set up period and working vacations. During the working vacation period, customers can be served at a lower rate, if there are customers at a service completion instant, the vacation can be interrupted and the server will come back to a set up period with probability or continue the working vacation with probability , and when the set up period ends, the server will switch to the normal working level. Using the matrix analytic method, we obtain the steady state distributions for the queue length at arrival epochs. Li Tao "The Queue Length of a GI/M/1 Queue with Set-Up Period and Bernoulli Working Vacation Interruption" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43743.pdf Paper URL: https://www.ijtsrd.com/mathemetics/other/43743/the-queue-length-of-a-gim1-queue-with-setup-period-and-bernoulli-working-vacation-interruption/li-tao
SUCCESSIVE LINEARIZATION SOLUTION OF A BOUNDARY LAYER CONVECTIVE HEAT TRANSFE...ijcsa
The purpose of this paper is to discuss the flow of forced convection over a flat plate. The governing partial
differential equations are transformed into ordinary differential equations using suitable transformations.
The resulting equations were solved using a recent semi-numerical scheme known as the successive
linearization method (SLM). A comparison between the obtained results with homotopy perturbation method and numerical method (NM) has been included to test the accuracy and convergence of the method.
Shear reversal simulations of a dense glass -forming supercooled colloidal melt: Rheology, microstructure and puzzles. Using non-equilibrium MD technique in nano to micro meter lengthscale and microsecond timescale, we show how "Bauschinger effect" can be realized in dense colloids.
In this paper, we show that the number of edges for any odd harmonious Eulerian graph is congruent to 0 or 2 (mod 4), and we found a counter example for the inverse of this statement is not true. We also proved that, the graphs which are constructed by two copies of even cycle Cn sharing a common edge are odd harmonious. In addition, we obtained an odd harmonious labeling for the graphs which are constructed by two copies of cycle Cn sharing a common vertex when n is congruent to 0 (mod 4). Moreover, we show that, the Cartesian product of cycle graph Cm and path Pn for each n ≥ 2, m ≡ 0 (mod 4) are odd harmonious graphs. Finally many new families of odd harmonious graphs are introduced.
On prognozisys of manufacturing doublebaseijaceeejournal
In this paper we introduce a modification of recently introduced analytical approach to model mass- and
heat transport. The approach gives us possibility to model the transport in multilayer structures with account
nonlinearity of the process and time-varing coefficients and without matching the solutions at the
interfaces of the multilayer structures. As an example of using of the approach we consider technological
process to manufacture more compact double base heterobipolar transistor. The technological approach
based on manufacturing a heterostructure with required configuration, doping of required areas of this
heterostructure by diffusion or ion implantation and optimal annealing of dopant and/or radiation defects.
The approach gives us possibility to manufacture p-n- junctions with higher sharpness framework the transistor.
In this situation we have a possibility to obtain smaller switching time of p-n- junctions and higher
compactness of the considered bipolar transistor.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
On prognozisys of manufacturing double basemsejjournal
In this paper we introduce a modification of recently introduced analytical approach to model mass- and
heat transport. The approach gives us possibility to model the transport in multilayer structures with account
nonlinearity of the process and time-varing coefficients and without matching the solutions at the
interfaces of the multilayer structures. As an example of using of the approach we consider technological
process to manufacture more compact double base heterobipolar transistor. The technological approach
based on manufacturing a heterostructure with required configuration, doping of required areas of this heterostructure
by diffusion or ion implantation and optimal annealing of dopant and/or radiation defects. The
approach gives us possibility to manufacture p-n- junctions with higher sharpness framework the transistor.
In this situation we have a possibility to obtain smaller switching time of p-n- junctions and higher compactness
of the considered bipolar transistor.
Positive and negative solutions of a boundary value problem for a fractional ...journal ijrtem
: In this work, we study a boundary value problem for a fractional
q, -difference equation. By
using the monotone iterative technique and lower-upper solution method, we get the existence of positive or
negative solutions under the nonlinear term is local continuity and local monotonicity. The results show that we
can construct two iterative sequences for approximating the solutions
Special Products and Factoring , Rational Algebraic Expressions Concept MapRocyl Anne Javagat
These concept maps consist of the major topics in Math 8 First Quarter (Special Products, Factoring, Rational Algebraic Expressions (simplifying, adding, subtracting (same and unlike denominators), multiplying, dividing.)))
E-Cordial Labeling of Some Mirror GraphsWaqas Tariq
Let G be a bipartite graph with a partite sets V1 and V2 and G\' be the copy of G with corresponding partite sets V1\' and V2\' . The mirror graph M(G) of G is obtained from G and G\' by joining each vertex of V2 to its corresponding vertex in V2\' by an edge. Here we investigate E-cordial labeling of some mirror graphs. We prove that the mirror graphs of even cycle Cn, even path Pn and hypercube Qk are E-cordial graphs.
Exact Solutions for MHD Flow of a Viscoelastic Fluid with the Fractional Bur...IJMER
This paper presents an analytical study for the magnetohydrodynamic (MHD) flow of a
generalized Burgers’ fluid in an annular pipe. Closed from solutions for velocity is obtained by using finite
Hankel transform and discrete Laplace transform of the sequential fractional derivatives. Finally, the
figures are plotted to show the effects of different parameters on the velocity profile.
In [1] Abdel-Aal has introduced the notions of m-shadow graphs and n-splitting graphs, for all m, n ³ 1.
In this paper, we prove that, the m-shadow graphs for paths and complete bipartite graphs are odd
harmonious graphs for allm³ 1. Also, we prove the n-splitting graphs for paths, stars and symmetric
product between paths and null graphs are odd harmonious graphs for all n³ 1. In addition, we present
some examples to illustrate the proposed theories. Moreover, we show that some families of graphs admit
odd harmonious libeling.
Using blurred images to assess damage in bridge structures?Alessandro Palmeri
Faster trains and augmented traffic have significantly increased the number and amplitude of loading cycles experienced on a daily basis by composite steel-concrete bridges. This higher demand accelerates the occurrence of damage in the shear connectors between the two materials, which in turn can severely affect performance and reliability of these structures. The aim of this talk is to present the preliminary results of theoretical and experimental investigations undertaken to assess the feasibility of using the envelope of deflections and rotations induced by moving loads as a practical and cost-effective alternative to traditional methods of health monitoring for composite bridges. Both analytical and numerical formulations for this dynamic problem are presented and the results of a parametric study are discussed. A novel photogrammetric approach is also introduced, which allows identifying vibration patterns in civil engineering structures by analysing blurred targets in long-exposure digital images. The initial experimental validation of this approach is presented and further challenges are highlighted.
optimal solution method of integro-differential equaitions under laplace tran...INFOGAIN PUBLICATION
In this paper, Laplace Transform method is developed to solve partial Integro-differential equations. Partial Integro-differential equations (PIDE) occur naturally in various fields of science. Engineering and Social Science. We propose a max general form of linear PIDE with a convolution Kernal. We convert the proposed PIDE to an ordinary differential equation (ODE) using the LT method. We applying inverse LT as exact solution of the problems obtained. It is observed that the LT is a simple and reliable technique for solving such equations. The proposed model illustrated by numerical examples.
Shear reversal simulations of a dense glass -forming supercooled colloidal melt: Rheology, microstructure and puzzles. Using non-equilibrium MD technique in nano to micro meter lengthscale and microsecond timescale, we show how "Bauschinger effect" can be realized in dense colloids.
In this paper, we show that the number of edges for any odd harmonious Eulerian graph is congruent to 0 or 2 (mod 4), and we found a counter example for the inverse of this statement is not true. We also proved that, the graphs which are constructed by two copies of even cycle Cn sharing a common edge are odd harmonious. In addition, we obtained an odd harmonious labeling for the graphs which are constructed by two copies of cycle Cn sharing a common vertex when n is congruent to 0 (mod 4). Moreover, we show that, the Cartesian product of cycle graph Cm and path Pn for each n ≥ 2, m ≡ 0 (mod 4) are odd harmonious graphs. Finally many new families of odd harmonious graphs are introduced.
On prognozisys of manufacturing doublebaseijaceeejournal
In this paper we introduce a modification of recently introduced analytical approach to model mass- and
heat transport. The approach gives us possibility to model the transport in multilayer structures with account
nonlinearity of the process and time-varing coefficients and without matching the solutions at the
interfaces of the multilayer structures. As an example of using of the approach we consider technological
process to manufacture more compact double base heterobipolar transistor. The technological approach
based on manufacturing a heterostructure with required configuration, doping of required areas of this
heterostructure by diffusion or ion implantation and optimal annealing of dopant and/or radiation defects.
The approach gives us possibility to manufacture p-n- junctions with higher sharpness framework the transistor.
In this situation we have a possibility to obtain smaller switching time of p-n- junctions and higher
compactness of the considered bipolar transistor.
IJERA (International journal of Engineering Research and Applications) is International online, ... peer reviewed journal. For more detail or submit your article, please visit www.ijera.com
On prognozisys of manufacturing double basemsejjournal
In this paper we introduce a modification of recently introduced analytical approach to model mass- and
heat transport. The approach gives us possibility to model the transport in multilayer structures with account
nonlinearity of the process and time-varing coefficients and without matching the solutions at the
interfaces of the multilayer structures. As an example of using of the approach we consider technological
process to manufacture more compact double base heterobipolar transistor. The technological approach
based on manufacturing a heterostructure with required configuration, doping of required areas of this heterostructure
by diffusion or ion implantation and optimal annealing of dopant and/or radiation defects. The
approach gives us possibility to manufacture p-n- junctions with higher sharpness framework the transistor.
In this situation we have a possibility to obtain smaller switching time of p-n- junctions and higher compactness
of the considered bipolar transistor.
Positive and negative solutions of a boundary value problem for a fractional ...journal ijrtem
: In this work, we study a boundary value problem for a fractional
q, -difference equation. By
using the monotone iterative technique and lower-upper solution method, we get the existence of positive or
negative solutions under the nonlinear term is local continuity and local monotonicity. The results show that we
can construct two iterative sequences for approximating the solutions
Special Products and Factoring , Rational Algebraic Expressions Concept MapRocyl Anne Javagat
These concept maps consist of the major topics in Math 8 First Quarter (Special Products, Factoring, Rational Algebraic Expressions (simplifying, adding, subtracting (same and unlike denominators), multiplying, dividing.)))
E-Cordial Labeling of Some Mirror GraphsWaqas Tariq
Let G be a bipartite graph with a partite sets V1 and V2 and G\' be the copy of G with corresponding partite sets V1\' and V2\' . The mirror graph M(G) of G is obtained from G and G\' by joining each vertex of V2 to its corresponding vertex in V2\' by an edge. Here we investigate E-cordial labeling of some mirror graphs. We prove that the mirror graphs of even cycle Cn, even path Pn and hypercube Qk are E-cordial graphs.
Exact Solutions for MHD Flow of a Viscoelastic Fluid with the Fractional Bur...IJMER
This paper presents an analytical study for the magnetohydrodynamic (MHD) flow of a
generalized Burgers’ fluid in an annular pipe. Closed from solutions for velocity is obtained by using finite
Hankel transform and discrete Laplace transform of the sequential fractional derivatives. Finally, the
figures are plotted to show the effects of different parameters on the velocity profile.
In [1] Abdel-Aal has introduced the notions of m-shadow graphs and n-splitting graphs, for all m, n ³ 1.
In this paper, we prove that, the m-shadow graphs for paths and complete bipartite graphs are odd
harmonious graphs for allm³ 1. Also, we prove the n-splitting graphs for paths, stars and symmetric
product between paths and null graphs are odd harmonious graphs for all n³ 1. In addition, we present
some examples to illustrate the proposed theories. Moreover, we show that some families of graphs admit
odd harmonious libeling.
Using blurred images to assess damage in bridge structures?Alessandro Palmeri
Faster trains and augmented traffic have significantly increased the number and amplitude of loading cycles experienced on a daily basis by composite steel-concrete bridges. This higher demand accelerates the occurrence of damage in the shear connectors between the two materials, which in turn can severely affect performance and reliability of these structures. The aim of this talk is to present the preliminary results of theoretical and experimental investigations undertaken to assess the feasibility of using the envelope of deflections and rotations induced by moving loads as a practical and cost-effective alternative to traditional methods of health monitoring for composite bridges. Both analytical and numerical formulations for this dynamic problem are presented and the results of a parametric study are discussed. A novel photogrammetric approach is also introduced, which allows identifying vibration patterns in civil engineering structures by analysing blurred targets in long-exposure digital images. The initial experimental validation of this approach is presented and further challenges are highlighted.
optimal solution method of integro-differential equaitions under laplace tran...INFOGAIN PUBLICATION
In this paper, Laplace Transform method is developed to solve partial Integro-differential equations. Partial Integro-differential equations (PIDE) occur naturally in various fields of science. Engineering and Social Science. We propose a max general form of linear PIDE with a convolution Kernal. We convert the proposed PIDE to an ordinary differential equation (ODE) using the LT method. We applying inverse LT as exact solution of the problems obtained. It is observed that the LT is a simple and reliable technique for solving such equations. The proposed model illustrated by numerical examples.
On Approach to Increase Integration Rate of Elements of a Switched-capacitor ...BRNSS Publication Hub
In this paper, we introduce an approach to increase integration rate of elements of a switched-
capacitor step-down DC–DC converter. Framework the approach, we consider a heterostructure with
special configuration. Several specific areas of the heterostructure should be doped by diffusion or ion
implantation. Annealing of dopant and/or radiation defects should be optimized.
GDQ SIMULATION FOR FLOW AND HEAT TRANSFER OF A NANOFLUID OVER A NONLINEARLY S...AEIJjournal2
This paper presents the generalized differential quadrature (GDQ) simulation for analysis of a nanofluid
over a nonlinearly stretching sheet. The obtained governing equations of flow and heat transfer are
discretized by GDQ method and then are solved by Newton-Raphson method. The effects of stretching
parameter, Brownian motion number (Nb), Thermophoresis number (Nt) and Lewis number (Le), on the
concentration distribution and temperature distribution are evaluated. The obtained results exhibit that
The purpose of this work is to formulate and investigate a boundary integral method for the solution of the internal waves/Rayleigh-Taylor problem. This problem describes the evolution of the interface between two immiscible, inviscid, incompressible, irrotational fluids of different density in three dimensions. The motion of the interface and fluids is driven by the action of a gravity force, surface tension at the interface, elastic bending and/or a prescribed far-field pressure gradient. The interface is a generalized vortex sheet, and dipole density is interpreted as the (unnormalized) vortex sheet strength. Presence of the surface tension or elastic bending effects introduces high order derivatives into the evolution equations. This makes the considered problem stiff and the application of the standard explicit time-integration methods suffers strong time-step stability constraints.
The proposed numerical method employs a special interface parameterization that enables the use of an efficient implicit time-integration method via a small-scale decomposition. This approach allows one to capture the nonlinear growth of normal modes for the case of Rayleigh-Taylor instability with the heavier fluid on top.
Validation of the results is done by comparison of numeric solution to the analytic solution of the linearized problem for a short time. We check the energy and the interface mean height preservation. The developed model and numerical method can be efficiently applied to study the motion of internal waves for doubly periodic interfacial flows with surface tension and elastic bending stress at the interface.
Within the framework of the theory of plane steady filtration of an incompressible fluid according to Darcy’s law, two limiting schemes modeling the filtration flows under the Joukowski tongue through a soil massive spread over an impermeable foundation or strongly permeable confined water bearing horizon are considered.
Similar to Shuwang Li Moving Interface Modeling and Computation (20)
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Shuwang Li Moving Interface Modeling and Computation
1. Interface problems Expanding interface problem Shrinking interface problem
Modeling and Computation of Moving Interface
Problems
Shuwang Li 1
1
Applied Math Dept., Illinois Institute of Technology, Chicago
CISC Lunchtime Matchmaking Seminar
October 18, 2017
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
2. Interface problems Expanding interface problem Shrinking interface problem
1 Interface problems
2 Expanding interface problem
Classical Hele-Shaw problem
Numerical Methods
Numerical Results
3 Shrinking interface problem
Modified Hele-Shaw problem with lifting plate
Numerical Results
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
3. Interface problems Expanding interface problem Shrinking interface problem
Interface problems in physical/biological sciences
Moving boundary/interface problems: boundary value problems defined
in a domain whose boundary is a priori unknown and evolving with time;
interface separating different domains.
Examples: multiphase flow in fluids; phase transformations in materials
including crystal growth (solid/liquid), epitaxial thin film growth
(solid/vapor), and elastic precipitate growth/shrink (solid/solid); tumor
growth, bio-membrane, and pattern formation via diffusion in
bio-systems; fluid-structure interactions;
Central question: dynamical stability of the interface
What I can help: modeling and computation (numerics); understand
dynamics and instabilities...
What you can help: new problems; experimental verifications;
interpretations...
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
4. Interface problems Expanding interface problem Shrinking interface problem
Computational challenges due to expanding/shrinking
Key questions besides solving PDEs: identify the interface and evolve
the interface (front tracking/level set/phase field). Consider a simple
interface: a sphere or a circle driven by an injection flux (growth) or
extraction flux (shrinkage)
Evolving Velocity
3D:
d(volume : 4πR3
(t)/3)
dt
= J, i.e. interface velocity:
dR(t)
dt
=
J
πR2(t)
2D:
d(area : πR2
(t))
dt
= J, i.e. interface velocity:
dR(t)
dt
=
J
πR(t)
Challenges for expanding and shrinking interfaces (open
non-equilibrium system):
slow dynamics for the growth problem (R increase); need to
increase resolution;
fast dynamics for the shrinking problem (R decrease); need to
reduce resolution.
From a computational point of view, we want to: speed up the slow
dynamics for expanding interface or slow down the fast dynamics for
shrinking interface without changing the real physics.
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
5. Interface problems Expanding interface problem Shrinking interface problem
Example: Hele-Shaw and expanding viscous fingering
Hele-Shaw problem is a classical example for studying the interface
dynamics. Application: oil recovery in petroleum engineering, natural
gas storage.
Saffman-Taylor instability (fingering pattern) occurs when less viscous
fluid is injected into existing viscous fluid.
blue: air
white: oil
Pressure jump at the interface is given by the Laplace-Young condition.
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
6. Interface problems Expanding interface problem Shrinking interface problem
Governing Equations (air-oil system)
Differential equations (exterior problem):
2
P = 0, x ∈ ΩL
V = − P · n, x ∈ Σ(t)
Pin − Pout = τκ, x ∈ Σ(t)
Σ
∂P
∂n
ds = J(t)
Interface evolution:
dx
dt
· n = V(x), x ∈ Σ(t).
Linear Stability (Mullins-Sekerka, 1963; Saffman-Taylor, 1958).
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
7. Interface problems Expanding interface problem Shrinking interface problem
Rescaling
The Idea
isolate morphological change from overall growth by mapping onto a new
time and space: (x, t) → (¯x,¯t), i.e. scale out the growth: R(t(¯t)) = ¯R(¯t).
x(α, t) = ¯R(¯t)¯x(α,¯t), ¯t =
t
0
1
ρ(t )
dt .
Integrable ¯ρ(¯t) = ρ(t(¯t)) > 0
speed up or slow down
adaptive
The normal velocity in the rescaled frame ¯V,
¯V(¯t) =
¯ρ
¯R
V(t(¯t)) −
¯x · n
¯R
d ¯R
d¯t
Set
d ¯A
d¯t
= 0,
¯Σ(¯t)
¯Vd¯s = 0 →
d ¯R
d¯t
=
π¯ρ¯J
¯A(0)¯R
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
8. Interface problems Expanding interface problem Shrinking interface problem
Rescaling contd.
Take ¯ρe =
¯A(0)¯R2
(¯t)
π¯J
, then ¯R(¯t) = exp(¯t), i.e. exponential growth.
Take ¯ρl = b
log(a)(a+b¯t)
¯A(0)
π¯J
¯R, then ¯R(¯t) = log(a+b¯t)
log(a)
, i.e. logarithmic growth.
If you want to use the boundary integral method, the rescaled integral
form for ¯ρe case
¯µ(¯x) −
1
π ¯Σ(¯t)
¯µ(¯x )[
∂ ln |¯x − ¯x |
∂n(¯x )
+ ¯R(¯t)]d¯s(¯x ) = 2τ ¯κ
+ 2¯R(¯t)¯J(ln(¯R(¯t)) + ln |¯x|).
The normal velocity in scaled frame ¯V is given by,
¯V(¯x) =
¯A
2π2¯J
(
1
¯R ¯Σ
¯µ¯s
(¯x − ¯x)⊥
· ¯n(¯s)
|¯x − ¯x|2
d¯s + 2π¯J
¯x · ¯n
|¯x|2
) − ¯x · ¯n,
where ¯x⊥
= (¯y, −¯x). We evolve the interface in the scaled frame
d ¯x(¯t, s)
d¯t
· ¯n = ¯V(¯t, s).
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
9. Interface problems Expanding interface problem Shrinking interface problem
Critics and Suggestions (exponential fast growth)
Good: ∆¯t is fixed, while equivalent ∆t in the original frame is increasing.
Bad: fast growth requires small time step for numerical stability (a waste
of CPU time at the early growth stage when the interface size is small.)
Ugly (Adaptive): Choose the time scale to be (1) a log function when R
is small; (2) an exponential function when R is large.
0 10 20 30 40 50 60
10
−4
10
−3
10
−2
10
−1
10
0
R
∆t
ρe
ρ
s
original
Figure: shows the corresponding time step in the original real frame.
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
10. Interface problems Expanding interface problem Shrinking interface problem
Adaptive scaling function
Logarithmic scaling at small R(t)
ρl =
b
log(a)(a + b¯t)
¯A(0)
π¯J
¯R,
¯R =
log(a + b¯t)
log(a)
t =
¯A(0)
2 log2
(a)π¯J
(log2
(a + b¯t)
− log2
(a)),
¯Vl =
b¯A(0)
log(a)(a + b¯t)π¯J ¯R
(
1
2π ¯R ¯Σ
¯µ¯s
(¯x − ¯x)⊥ · ¯n(¯x)
|¯x − ¯x|2
d¯s
+¯J
¯x · ¯n
|¯x|2
)
−
b
log(a)(a + b¯t)¯R
¯x · ¯n.
Switch back to exponential at large R(t)
Switch at ¯t = ¯t0 with ¯R = ¯R0
ρe = c ¯R2
,
¯R = ¯R0 exp(c(¯t − ¯t0)),
t =
R2
0
¯A(0)
2π¯J
(exp(2c(¯t − ¯t0)) − 1)
+
¯A(0)
2π¯J
(¯R2
0 − 1), ¯t ≥ ¯t0,
¯Ve = c(
1
2π ¯R ¯Σ
¯µ¯s
(¯x − ¯x)⊥ · ¯n(¯x)
|¯x − ¯x|2
d¯s
+¯J
¯x · ¯n
|¯x|2
) −
π¯Jc
¯A(0)
¯x · ¯n.
where c =
b¯A(0)
log(a)(a + b¯t0)πJ ¯R0
and
¯R0 =
log(a + b¯t0)
log(a)
is the space scaling factor at
¯t0.
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
11. Interface problems Expanding interface problem Shrinking interface problem
Adaptive scaling function contd.
Combined Scaling Function
ρs =
b
log(a)
¯A(0)
π¯J
¯R2
(
1
a¯R ¯R
logarithmic part
+
1
a¯R0 ¯R0
exponential part
)
¯Vs =
b¯A(0)
log(a)π¯J
(
1
a¯R ¯R
+
1
aR0 R0
)
(
1
2π ¯R ¯Σ
¯µ¯s
(¯x − ¯x)⊥
· ¯n(¯x)
|¯x − ¯x|2
d¯s
+¯J
¯x · ¯n
|¯x|2
−
π¯J
¯A(0)
¯x · ¯n)
= ¯Vl + ¯Ve.
0 10 20 30 40 50 60
10
0
10
1
10
2
10
3
10
4
R
ρ
ρ
l
ρ
e
ρ
s
R
0
=11
[a]
0 10 20 30 40 50 60
10
1
10
2
10
3
10
4
10
5
10
6
R
CPUtime
ρ
e
ρ
s
[b]
Figure: [a] Relation between the time
scaling function ρ and the radius R. [b]
shows the CPU time to different
scaling factor ρ.Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
12. Interface problems Expanding interface problem Shrinking interface problem
Efficiency of adaptive scaling function
0 50 100 150
10
−1
10
0
10
1
10
2
10
3
10
4
R
currenttimeT
−10 0 10
−10
0
10
1994, T=45, R=9.41
−50 0 50
−50
0
50
2006, T=500, R=31.62
−100 0 100
−100
0
100
2007, T=2300, R=65.52
−200 0 200
−200
0
200
2016, T=7514, R=122
(40 mins)
(7.9 hours)
(1.09 days)
1994 Hou et al.
50 days
2007 Li et al.
21 days 5.8 days
2016 Zhao et al.
2006 Fast et al.
50 days
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
13. Interface problems Expanding interface problem Shrinking interface problem
Example: Hele-Shaw and shrinking viscous fingering
Shrinking interface: (1) Hele-Shaw cell with suction has singularity at the
sink; (2) Hele-Shaw cell with time dependent gap has no singularity.
The interior region Ω is oil with viscosity µ.The exterior region is air. ∂Ω
represents the interface. The time dependent gap is b(t). The normal n
is pointing inward.
Air pushes oil from the exterior instead of from the interior for the
expanding fingering problem. This is an interior problem.
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
14. Interface problems Expanding interface problem Shrinking interface problem
Governing equations
Equations in the viscous fluid domain
u = −
b2
(t)
12µ
P in Ω, (1)
· u = −
˙b(t)
b(t)
in Ω, (2)
[P]t = σκ on ∂Ω, (3)
V = −
b2
(t)
12µ
∂P
∂n
on ∂Ω. (4)
Eq. (1) follows from the Darcy’s law, where u is the velocity, P is the
pressure, b(t) is the time dependent gap, and µ is the viscosity of oil.
Eq. (2) specifies the incompressible fluid with conserved volume. ˙b(t) is
the time derivative of b(t), which is the lifting speed.
Eq. (3) is the Laplace-Young condition given by the product of surface
tension σ and the curvature κ of the interface.
Eq. (4) expresses the normal velocity V and n is the unit inward normal.
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
15. Interface problems Expanding interface problem Shrinking interface problem
Comparison with experiment
Experiment: τ = 9.6 × 10−6
and b(t) = 1 + t from Nase et al. physical
of fluid (2011). Use random initial shape in simulations.
0 5 10 15
10
0
10
1
10
2
t
numberoffingers
experiment
simulation
ψ= −0.13
[a] [b]
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT
16. Interface problems Expanding interface problem Shrinking interface problem
Fission with exponential gap
(x2
+ y2
)2
= 20x2
3
+ 20y2
5
, b(t) = exp(t) ⇒ ¯b(¯t) = 1 + 0.5¯t; N = 16, 384,
∆¯t = 1E − 4 and τ = 2E − 5.
Show a movie...
Acknowledgement: NSF-DMS
Thank you for your attention...
Modeling and Computation of Moving Interface Problems Shuwang Li, IIT