This document summarizes Sjogren's syndrome, an autoimmune disease affecting the salivary and lacrimal glands. It causes dryness of the eyes and mouth. The hallmark is infiltration of T4 lymphocytes into the exocrine glands, triggering B lymphocytes to form autoantibodies. Clinical features include dry eyes and mouth, occurring most often in women ages 40-60. Diagnosis involves labial gland biopsy showing lymphocyte infiltration and reduced tear and saliva production on tests. Treatment focuses on lubricating the eyes and mouth, and stimulating saliva production with drugs like pilocarpine.