The document discusses the 5 basic human senses and related sensory organs. It describes the sensory receptors for smell (olfactory cells), hearing and balance (hair cells in the inner ear), sight (rods and cones in the retina), taste (taste buds on the tongue and palate) and touch (mechanoreceptors in the skin). For each sense, it outlines the key structures involved and how sensory stimuli are transmitted to the brain for perception.
special sense organs (anatomy and physiology) - a brief discussion Pallab Nath
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brief discussion on special senses, Basic level class for technicians. topics discussed include eyes and vision, nose and sense of smell, tongue and sense of taste and ears and hearing
special sense organs (anatomy and physiology) - a brief discussion Pallab Nath
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brief discussion on special senses, Basic level class for technicians. topics discussed include eyes and vision, nose and sense of smell, tongue and sense of taste and ears and hearing
Olfaction, or the sense of smell, is an ancient sensory system that together with taste enables an organism to detect chemicals in the external environment. Olfaction is one of the five major human senses (vision, hearing, olfaction, taste, and touch) that occurs when odorants bind to specific sites in olfactory receptors.Olfaction is present in most species such as insects, worms, fish, amphibians, birds, and mammals. It is essential for survival by permitting the location of food, mates, and predators, although in humans, olfaction is often viewed as an esthetic sense capable of triggering emotion and memory.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Olfaction, or the sense of smell, is an ancient sensory system that together with taste enables an organism to detect chemicals in the external environment. Olfaction is one of the five major human senses (vision, hearing, olfaction, taste, and touch) that occurs when odorants bind to specific sites in olfactory receptors.Olfaction is present in most species such as insects, worms, fish, amphibians, birds, and mammals. It is essential for survival by permitting the location of food, mates, and predators, although in humans, olfaction is often viewed as an esthetic sense capable of triggering emotion and memory.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana LuĂsa Pinho
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Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
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Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other  chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released. Â
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules -Â a chemical called pyruvate. A small amount of ATP is formed during this process.Â
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to âburnâ the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP.  Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.Â
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.Â
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 â 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : Â cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's aventures in two entangled wonderlandsRichard Gill
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Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called âsmallâ because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.SĂŠrgio Sacani
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The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
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As consumer awareness of health and wellness rises, the nutraceutical marketâwhich includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutritionâis growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
3. 1. SENSE OF SMELL
⢠Receptor cells of smell are OLFACTORY CELLS
⢠Olfactory cells are located within olfactory epithelium high in the roof of
the nasal cavity
5. PERSEPTION OF SMELL
⢠The gas molecules in the air dissolves in the mucus of the
nasal cavity.
⢠It stimulates the microvilli of olfactory cells.
⢠This cause an impulse to be send from olfactory cell through
the sensory nerve fibres, to the olfactory bulb in the temporal
lobe of the cerebrum.
⢠Smell is integrated and perceived
6. SENSE OF HEARING AND BALANCE
⢠The ear has two sensory functions: Hearing and Balance.
⢠The sensory receptors for both of these is located in the inner ear, and each consist of
hair cells and cillia which are sensitive to mechanical stimulation. They are called
machanoreceptors.
7. STRUCTURE AND FUNCTION OF
HUMAN EAR
⢠Pinna â Concentrate sound waves in the direction of the external
auditory canal.
⢠External Auditory canal
⢠â Transport sound waves from the pinna to the tympanic membrane.
⢠- Contain fine hairs and cerumin glands that secrete cerumin (earwax) to
help guard the ear against foreign material and insects. (smell)
⢠Tympanic membrane
⢠â A thin membrane that covers the opening between the inner- and
middle ear.
⢠- Converts soundwaves into vibrations. (starts to vibrate)
8. HUMAN EAR
⢠3 Bony ossicles e.g.: (start to vibrate):
⢠- Malleus â transmit vibration to incus
⢠- Incus â transmit vibrations to stapes
⢠- Stapes â transmit vibrations to window (fenestra ovalis)
⢠Oval window â start to vibrate and cause waves in liquid (perilymph) in cochlea.
⢠Eustachian tube â Equalize the pressure between the atmosphere and the inside of the
ear. (Connected with the pharynx)
9. INNER EARCochlea:
- Snail shaped canal.
- Divided in 3 canals
- separated by membranes
1. Vestibular canal (scale vestibuli) â top canal, filled with perilymph. Receives vibration from oval window,
form waves in perilymph, causes Reissner membrane to form waves.
⢠Cochlear canal (Scala media) â middle canal, filled with endolymph.
⢠Form waves in endolymph, that causes Basilar membrane to wave up and down.
⢠Contains the receptor cells for hearing: Organ of Corti - which pushes the stereocilia against the
tectorial membrane, causes an impulse which is send through the cochlear nerves to the
temporal lobe of the brain for integration
⢠Tympanic canal (Scala tympani)â bottom canal, filled with perilymph. Form waves which are
carried to the round window (fenestra rotunda).
⢠Round Window: absorb excess sound waves to prevent echoing in the ear
10. SENSE OF SIGHT
Three main parts of the eye
1. Outer layer (Cornea, Sclera)
2. Middle layer (Choroid, ciliary body, iris)
3. Inner layer (Retina â rods, cones, fovea)
11. THE HUMAN EYE
Most important part of the human eye
⢠Lens (Attach to suspensory ligaments)
⢠Humors (Aqueous humor and vitreous humor â Transmit light rays and
support eyeball)
⢠Optic nerves â Transmits impulses to the brain
The outer part and functions
⢠The sclera: white outer layer, protects and supports eyeball
⢠Cornea: Front transparent part of eye. Refracts light rays
⢠Conjunctiva: Transparent membrane (front). Moistens eye surface
12. THE MIDDLE PART OF HUMAN EYE
⢠Pupil: Hole in middle of eye. Black. Admits light into
eye.
⢠The choroid: Pigmented 2nd layer. Absorb stray light.
Contain blood vessels for nutrition and oxygen.
⢠The iris: Coloured part of the eye that regulates the
size of the pupil and therefore light entrance
⢠The lens: Transparent biconvex structure that refract
and focuses light on the retina
13. THE INNER PART OF HUMAN EYE
⢠The retina: contains photoreceptors (cones and rods)
- Rods: Make black and white vision possible/ overview
sight
- Cones: Make colour vision possible
- Fovea centralis: Best image possible
- Blind spot: place where nerves and blood vessels
enter and leave the eyeball. No image can be seen if
light is focused on this point.
14. HUMAN EYE
⢠The eye is divided into two cavities separated by the lens and cilliary body:
⢠The anterior cavity is filled with watery aqueous humor.
⢠The posterior cavity is filled with jellylike vitreous humor.
⢠The cilliary body produces the aqueous humor
⢠ACCOMODATION
⢠The ability of the lens to change shape to enable the eye to focus on near and far
objects.= accommodation
16. FUNCTIONS OF TASTE BUDS
⢠Chemical molecules in food, dissolve in the saliva.
⢠The molecules bind to the receptor proteins in the
microvilli of the taste buds.
⢠This stimulates the taste cells to send an impulse through
the sensory nerve fibers.
⢠Impulse move to the parietal lobe of cerebrum.
⢠Taste is interpreted
18. SENSE OF TASTE
⢠Taste receptors = TASTE BUDS
⢠Taste buds are located on tongue(mainly), hard palate,
pharynx and epiglottis.
⢠The tongue very rough, due to numerous papillae.
⢠3 Types of papillae:
- Fungiform- found on front and sides of tongue.
- Foliate found on front 2/3 of tongue
- Curcumvallate- found on the back of the tongue.
⢠The taste buds are located on the papillae.
19. SENSE ORGAN SKIN
⢠Mechanoreceptors sense physical deformation caused by stimuli such as pressure,
stretch, motion, and sound
⢠The sense of touch in mammals relies on mechanoreceptors
⢠Thermoreceptors, which respond to heat or cold, help regulate body temperature by
signalling both surface and body core temperature
⢠Pain receptors, or nociceptors, respond to excess heat, pressure, or chemicals released
from damaged or inflamed tissues.
⢠The sensory cutaneous mechanoreceptors in the skin are:
⢠Ruffini's end organ (sustained pressure and heat â all over body)
⢠Meissner's corpuscle (changes in texture, slow vibrations â light touch â lips, finger
tips)
⢠Pacinian corpuscle (deep pressure, fast vibrations â visceral organs)
⢠Merkel's disc (sustained touch and pressure)
⢠Free nerve endings (pain â all over body)
⢠End bulbs of Krause â cold â all over body
22. REFERENCES
Haq, N. (2017) human sense organ. Available from slideshare at:
https://www.slideshare.net/NOORULHAQ20/human-sense-organs-
78479516?qid=49705910-c7b8-44c3-b6fc-93807e174b63&v=&b=&from_search=1 [
Assessed 13 September 2017]
Yudianto, A. (2013) The human nervous system and sense organ. Available from
slideshare at: https://www.slideshare.net/anikyudianto/the-human-nervous-system-and-
sense-organ?qid=ca82cb87-a5af-4885-a9bb-9f3befa9f9f3&v=&b=&from_search=13 [
Assessed 13 September 2017]
Kennedy, S. (2007) Introduction to nervous system. Available from slideshare at:
https://www.slideshare.net/mrskennedy/introduction-to-nervous-system [ Assessed 14
September 2017]
Ternio, E. (2016) Sense organs of the human body. Available from slideshare at:
https://www.slideshare.net/katnisshetan/sense-organs-of-the-human-
body?qid=ca82cb87-a5af-4885-a9bb-9f3befa9f9f3&v=&b=&from_search=15 [ Assessed
13 September 2017]
23. REFERENCES
CASTEJON, T. (2015) My sense of taste mix. Available from slideshare at:
https://www.slideshare.net/Teachersteam/my-sense-of-taste-mix [ Assessed 14
September 2017]
Khan, B. (2013) 56514243 physiology-of-hearing-balance. Available from slideshare at:
https://www.slideshare.net/sweetburhan/56514243-
physiologyofhearingbalance?qid=9308c66d-96c5-4ae6-998a-
0d053ebd1d59&v=&b=&from_search=2 [Assessed15 September 2017]
Lizz, A. (2011) The ears, hearing, and balance presentation . Available from slideshare at:
https://www.slideshare.net/Angie_Lizz/the-ears-hearing-and-balance-presentation-
presentation?qid=a406d09d-e7b0-4519-a8bc-75c258e65544&v=&b=&from_search=4
[Assessed15 September 2017]