SEMINARIO BIOLOGIA MOLECULAR-MARIA MANUELA HERNANDEZ ALVAREZ
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Esta presentación trata acerca de la interacción de la proteina p37 del Mycoplasma Hyorhinis y el Carcinoma Hepatocelular.
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13. Hyperplastic Polyposis Syndrome
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Cancer Res-2015-Bonastre-1287-97
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IMMUNOHISTOCHEMICAL ALTERATIONS IN HEPATOCELLULAR CARCINOMA PATIENTS TREATED ...
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Dr. Carlos García Echeverría - Simposio Internacional 'Terapias oncológicas a...
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This document discusses the importance of personalized medicine in drug discovery and development. It describes how understanding a disease's pathogenesis and targeting specific genetic dependencies can lead to more rational drug design compared to empirical approaches. Successful examples are given of targeting drivers of cancer like BCR-Abl in CML and HDM2 amplification in liposarcoma. Combination strategies and imaging companions are discussed to address intratumoral heterogeneity and safely identify patients most likely to benefit from targeted therapies.Ana Ramírez de Molina-El impacto de las ciencias ómicas en la medicina, la nu...
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1. Cancer therapies are becoming more precise and personalized by taking into account a patient's unique genetic profile and molecular alterations in their tumor.
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This document summarizes a study on CD93, a transmembrane glycoprotein that regulates phagocytosis of apoptotic cells and promotes angiogenesis. The study blocked CD93 in pleural mesothelial cells, which fueled anti-lung tumor immune responses. Methods included using western blot, flow cytometry, PCR, and immunohistochemistry to analyze tumor extracellular vesicles and test antibodies. Results found that blocking CD93 increased levels of CCL21a, promoting an anti-tumor response. The discussion notes that extracellular vesicles play roles in tumorigenesis and immunotherapy. Blocking PD-L1 on vesicles inhibited antitumor immunity. The conclusion emphasizes the importance of further researching CD93 and extracellular vesicles to help cancer patients.
CARCINOMA STOMACH
Gastric carcinoma is the major cause of mortality worldwide. It is more common in males than females and incidence peaks between 50-70 years of age. Risk factors include H. pylori infection, smoking, low socioeconomic status, and family history. Histologically, adenocarcinoma accounts for 90% of cases. Early detection is key to improving outcomes, as resection surgery can potentially cure localized disease, but prognosis is generally poor.
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SEMINARIO BIOLOGIA MOLECULAR-MARIA MANUELA HERNANDEZ ALVAREZ
- 1. María Manuela Hernández Álvarez Semestre III Facultad de Medicina, UPB
- 2. INTRODUCTION Swine pathogen and is one of the common contaminants Prevalent in many cancer tissues Encoded membrane protein p37 MYCOPLASMA HYORHINIS Expressions predicts poor survival of gastric cancerpatients Associates with metastasis ofgastric cancercells P37 Animal and human cells cultures Gastric Lung Renal Proliferation Metastases Annexin A2 Epithermal growth factor receptor
- 3. INTRODUCTION Tumor usually hypervascularized Is currently the third leading cause of cancer death worldwide Risk factors HEPATOCELLULAR CARCINOMA (HCC) Hepatic artery Viral Hepatitis Hemochromatosis Alcoholic Cirrhosis
- 4. GENERAL OBJECTIVE "We demonstrated that p37 expression associates with higher histologic stages and vascular invasion and predicts poor disease-free survival of HCC patients" P37
- 5. MATERIALES Y MÉTODOS 1 INMUNOHISTOQUIMICA Anticuerpo visiblemente marcado Célula se colorea para demostrar Presencia Localización molecular Molecula de interés
- 6. 2 CITOMETRÍA DE FLUJO • Tamaño celular • Medidas de densidad epitopes • Mecanismos de fluidos de membrana Analiza población celular proporcionando parámetros Obtención muestreo estadistico de parametros Células individuales Expresado en formatos multidimensionales Detecta población celular en una muestra Con predominio de otras celulas mayoritarias
- 7. 3 WESTERN BLOT Tamaño Técnica SDS-PAGE Reacción proteina de interés Identificación proteina Dirigida a anticuerpo
- 8. 4 MICROARREGLOS Generar información en muy poco espacio Déposito de cadenas de DNA en vidrio Sonda específica Mólecula diana Análisis de imagen indica expresión gen
- 9. RESULTADOS
- 13. DISCUSSION AUTHOR WHAT HE SAID YES OR NOT H.S Choi (2014)/ M.K. Kim (2016) "We accidently found the presence of mycoplasma-infected CTCs in the peripheral blood of HCC patients by using MAb CA27 recognizing the p37 protein". T. Yamashita (2009)/ B. Terris (2010) "EpCAM- positive HCC cells are also identified as cancer-initiating cells". K. Schuize (2013)/ Y.F.Sun (2013) "Furthermore, EpCAM-positive CTCs display EMT phenotype, cancer stem cell biomarkers, high tumorigenic potential, and low apoptotic propensity, and lead to decreased overall survival in HCC patients".
- 14. CONCLUSIONS The techniques used in Molecular Biology are constantly evolving, helping to improve processes in multiple sciences such as medicine. They are tools to give a better diagnosis, management plan and adequate prevention in the diseases of today´s world. The Mycoplasma infection drives Hepatocelullar Carcinoma progression by promoting the vascular invasion of tumoral cells and the interaction between the mycoplasmal p37 and EpCAM is involved in AKT/mTOR pathway in HCC cells, causing survival in patients to decrease.