Joe Ferguson discusses common web application vulnerabilities like cross-site scripting (XSS) and cross-site request forgery (CSRF). He explains different types of XSS exploits and how CSRF works. To prevent these issues, he recommends sanitizing user input, using cryptographic nonces, and leveraging security features in frameworks like Angular, Zend, Symfony, Laravel and others. He also provides examples of widespread exploits on sites like Twitter, Facebook and MySpace to demonstrate the importance of secure form processing.