This document provides information on the anatomy, physiology and pathologies of the sclera. It begins with a description of the layers and structures of the sclera. It then discusses specific conditions like episcleritis, scleritis and staphyloma. Episcleritis is a benign inflammation of the outer layer of the sclera. Scleritis is a potentially serious inflammation of the inner layers that can be associated with autoimmune diseases. Staphyloma is a bulging of a weakened sclera that allows underlying tissues to protrude out. Causes like osteogenesis imperfecta are also mentioned.
you will get information about the layers of sclera and its diseases such as episcleritis and scleritis.
types of scleritis and episcleritis are also eplained in these slides. such as diffuse and nodular types of episclera, necrotizing and non-necrotizing types of anterior scleritis, posterior sleritis.
there etiologies. complications, investigations and treatment are also explained in detail.
Episcleritis is a benign inflammation of the outer layer of the eyeball (episclera) that causes redness and mild discomfort. It typically affects young adults and has no known cause, though it can be associated with conditions like gout. Scleritis is a more serious inflammation of the white part of the eyeball (sclera) that can cause vision loss if untreated. It usually occurs in older patients and has been linked to autoimmune disorders and infections. Scleritis is classified based on location and severity, with necrotizing forms requiring strong steroids or immunosuppressants to prevent complications like scleral thinning. Blue sclera is an asymptomatic condition where the sclera
This document discusses episcleritis and scleritis. Episcleritis involves inflammation of the episclera and is typically benign and self-limiting. Scleritis involves inflammation of the sclera and can be more serious, potentially causing vision loss if untreated. Scleritis is classified as anterior (non-necrotizing or necrotizing) or posterior. Treatment involves topical steroids and NSAIDs for mild cases and systemic steroids and immunosuppressants for more severe or necrotizing forms. Both conditions require treatment of any underlying systemic diseases.
Episcleritis and scleritis (ophthalmology)vishalbarun1
This document discusses episcleritis and scleritis. It begins with an introduction to the anatomy of the sclera and its blood supply, innervation and functions. It then discusses episcleritis, describing it as a common, self-limiting condition characterized by redness and mild discomfort. Scleritis is defined as inflammation of the sclera proper and can be classified as anterior or posterior. Anterior scleritis is further classified as non-necrotizing or necrotizing. Signs, symptoms, investigations, and treatments are provided for both conditions. Complications are also mentioned. The document concludes by briefly discussing blue sclera caused by thinning of the scleral collagen.
Connective tissue diseases can involve the eyes and cause various inflammatory conditions. Rheumatoid arthritis is a common cause of scleritis and episcleritis, occurring in 4-10% of patients. Keratoconjunctivitis sicca (dry eyes) is the most common ocular manifestation of rheumatoid arthritis, affecting 10-35% of patients, mostly women. Scleritis may occur and can cause vision loss if not treated adequately with immunosuppressants. Keratitis can also occur from corneal thinning or ulceration. Systemic lupus erythematosus can also cause ocular inflammation and is more common in women.
Scleritis and episcleritis affect the layers of the sclera and surrounding tissues. Episcleritis is usually benign and recurrent, occurring as either simple or nodular types. Scleritis can be anterior and non-necrotizing, nodular, or necrotizing. Complications of scleritis include keratitis, uveitis, glaucoma, hypotony, and perforation. Treatment involves topical steroids, NSAIDs, immunosuppressants, or antibiotics depending on the type and cause.
Sclera is the opaque outer fibrous tunic of the eyeball. Diseases of the sclera include episcleritis, which involves inflammation of the outer episcleral layer, and scleritis, which is a deeper inflammation of the sclera proper. Scleritis can be non-necrotizing or necrotizing, and is often associated with autoimmune disorders. Other scleral conditions include blue sclera seen in certain genetic disorders, and staphylomas which are localized bulgings of a weakened sclera lined by inner ocular layers.
you will get information about the layers of sclera and its diseases such as episcleritis and scleritis.
types of scleritis and episcleritis are also eplained in these slides. such as diffuse and nodular types of episclera, necrotizing and non-necrotizing types of anterior scleritis, posterior sleritis.
there etiologies. complications, investigations and treatment are also explained in detail.
Episcleritis is a benign inflammation of the outer layer of the eyeball (episclera) that causes redness and mild discomfort. It typically affects young adults and has no known cause, though it can be associated with conditions like gout. Scleritis is a more serious inflammation of the white part of the eyeball (sclera) that can cause vision loss if untreated. It usually occurs in older patients and has been linked to autoimmune disorders and infections. Scleritis is classified based on location and severity, with necrotizing forms requiring strong steroids or immunosuppressants to prevent complications like scleral thinning. Blue sclera is an asymptomatic condition where the sclera
This document discusses episcleritis and scleritis. Episcleritis involves inflammation of the episclera and is typically benign and self-limiting. Scleritis involves inflammation of the sclera and can be more serious, potentially causing vision loss if untreated. Scleritis is classified as anterior (non-necrotizing or necrotizing) or posterior. Treatment involves topical steroids and NSAIDs for mild cases and systemic steroids and immunosuppressants for more severe or necrotizing forms. Both conditions require treatment of any underlying systemic diseases.
Episcleritis and scleritis (ophthalmology)vishalbarun1
This document discusses episcleritis and scleritis. It begins with an introduction to the anatomy of the sclera and its blood supply, innervation and functions. It then discusses episcleritis, describing it as a common, self-limiting condition characterized by redness and mild discomfort. Scleritis is defined as inflammation of the sclera proper and can be classified as anterior or posterior. Anterior scleritis is further classified as non-necrotizing or necrotizing. Signs, symptoms, investigations, and treatments are provided for both conditions. Complications are also mentioned. The document concludes by briefly discussing blue sclera caused by thinning of the scleral collagen.
Connective tissue diseases can involve the eyes and cause various inflammatory conditions. Rheumatoid arthritis is a common cause of scleritis and episcleritis, occurring in 4-10% of patients. Keratoconjunctivitis sicca (dry eyes) is the most common ocular manifestation of rheumatoid arthritis, affecting 10-35% of patients, mostly women. Scleritis may occur and can cause vision loss if not treated adequately with immunosuppressants. Keratitis can also occur from corneal thinning or ulceration. Systemic lupus erythematosus can also cause ocular inflammation and is more common in women.
Scleritis and episcleritis affect the layers of the sclera and surrounding tissues. Episcleritis is usually benign and recurrent, occurring as either simple or nodular types. Scleritis can be anterior and non-necrotizing, nodular, or necrotizing. Complications of scleritis include keratitis, uveitis, glaucoma, hypotony, and perforation. Treatment involves topical steroids, NSAIDs, immunosuppressants, or antibiotics depending on the type and cause.
Sclera is the opaque outer fibrous tunic of the eyeball. Diseases of the sclera include episcleritis, which involves inflammation of the outer episcleral layer, and scleritis, which is a deeper inflammation of the sclera proper. Scleritis can be non-necrotizing or necrotizing, and is often associated with autoimmune disorders. Other scleral conditions include blue sclera seen in certain genetic disorders, and staphylomas which are localized bulgings of a weakened sclera lined by inner ocular layers.
Interstitial keratitis, also known as stromal keratitis, is a non-suppurative inflammation of the corneal stroma that can be caused by both infectious and non-infectious diseases. It is characterized by cellular infiltration and vascularization of the corneal stroma with minimal involvement of the corneal epithelium or endothelium. Congenital syphilis is a classic cause of interstitial keratitis. Stromal keratitis associated with congenital syphilis typically begins between ages 5-15, presents bilaterally, and can lead to diffuse corneal inflammation, edema, and neovascularization if left untreated. Acquired syphilis less commonly causes unilateral stromal keratitis, which
This document discusses ophthalmology topics including symblepharon, herpes zoster (shingles), and their causes and treatments. Symblepharon is defined as an adhesion between the eyelid and eyeball that can be caused by conjunctival infections leading to scarring. Herpes zoster is caused by reactivation of the varicella-zoster virus and presents as a painful skin rash. Management of symblepharon may involve lysis procedures while herpes zoster typically clears up within a few weeks.
This document provides information about ophthalmology topics including symblepharon, herpes zoster (shingles), and the lacrimal apparatus. Symblepharon is defined as an adhesion between the eyelid and eyeball. It can be caused by infections or injuries that lead to conjunctival scarring. Herpes zoster is caused by reactivation of the varicella zoster virus and presents as a painful skin rash. It poses contagion risks and treatment involves antivirals and pain management. The lacrimal apparatus includes the lacrimal gland, canaliculi, sac, and duct responsible for tear production and drainage.
Episcleritis and scleritis involve inflammation of the outer layers of the eye. Episcleritis affects just the episclera, while scleritis penetrates deeper into the sclera. Scleritis is more severe and can cause vision loss. It is often associated with autoimmune diseases. Treatment involves anti-inflammatory drugs like NSAIDs or corticosteroids. Necrotizing scleritis is the most severe form and requires prompt high-dose immunosuppressive therapy to prevent complications like scleral thinning and perforation that can cause permanent vision loss.
Viral Keratitis: Diagnosis, Management and Latest GuidelinesSahil Thakur
This document summarizes viral keratitis, with a focus on herpes simplex virus (HSV) keratitis. It discusses the epidemiology, pathophysiology, clinical manifestations, and types of HSV keratitis infections including congenital, neonatal, primary ocular, and recurrent ocular infections. It describes the characteristic presentations of HSV epithelial keratitis including dendritic ulcers, as well as various forms of stromal keratitis such as necrotizing, non-necrotizing, disciform, diffuse, and linear keratitis. Complications such as iridocyclitis, trabeculitis, and endotheliitis are also summarized.
Diseases of sclera
2. anatomy • Sclera posterior 5/6th opaque part of the external fibrous tunic of the eyeball.
3. • outer surface }covered by Tenon's capsule. • anterior part } covered by bulbar conjunctiva.
4. Its inner surface lies in contact with choroid with a potential suprachoroidal space in between
5. Thickness of sclera. • thinner }children and in females Sclera • thickest} posteriorly (1mm) • gradually becomes thin when traced anteriorly. • thinnest } insertion of extraocular muscles (0.3 mm). • Lamina cribrosa is a sieve-like sclera from which fibres of optic nerve pass.
6. Apertures of sclera • Anterior • Anterior ciliary vessels • Middle • four vortex veins (vena verticosae) • Posterior • Optic nerve • Long & short ciliary nerves
7. Layers of sclera sclera episclera Sclera proper Lamina fusca thin, dense vascularised layer of connective tissue fibroblasts, macrophages and lymphocytes avascular structure dense bundles of collagen fibres. innermost blends with suprachoroidal and supraciliary laminae of the uveal tract. brownish in colour presence of pigmented cells.
The sclera is the dense outer layer of the eyeball. It can develop two types of inflammation - episcleritis and scleritis. Episcleritis is more common and self-limiting, often affecting young adults, while scleritis is more severe and can be associated with underlying systemic diseases. Scleritis presents with redness and swelling of the sclera and is classified as anterior or posterior depending on location. Imaging like ultrasound and CT are useful for diagnosing posterior scleritis. Treatment involves topical or oral steroids, with immunosuppressants used for severe or resistant cases. Complications can include scleral thinning and staphylomas if left untreated.
The cornea has five layers - epithelium, Bowman's membrane, stroma, Descemet's membrane, and endothelium. It is avascular and innervated by the trigeminal nerve. The cornea serves an optical function as the most powerful refractive surface of the eye and a protective function. Corneal inflammation can be ulcerative or non-ulcerative. Common causes of ulcerative keratitis include infection, trauma, exposure, neurotrophic changes, and vitamin A deficiency. Bacterial ulcers present with pain, photophobia, and hypopyon may occur. Herpes simplex virus causes recurrent dendritic ulcers. Treatment involves antibiotics, antivirals, patching, and sometimes surgery
Layers of skin of the Eye Lids, Eye Lashes, Eye Lid Pathology, Anatomy of Con...Nina Ko
This document describes the anatomy and common pathologies of the eyelids. It discusses the layers of the eyelid including the epidermis, dermis and subcutaneous layer. It describes the meibomian glands, glands of Zeis and glands of Moll. Common infections like hordeolum, chalazion and blepharitis are summarized. Anatomical deformities including entropion, ectropion, trichiasis and distichiasis are covered. Finally, the document outlines common benign and malignant tumors of the eyelids such as papillomas, xanthelasma, hemangiomas and basal cell carcinoma.
This document contains information about various eye conditions organized under headings for different structures of the eye including eyelid, orbit, cornea, complications of surgery, and miscellaneous conditions. Some specific conditions mentioned include molluscum contagiosum, blepharitis, ptosis, staphyloma, corneal opacity, disciform keratitis, nummular keratitis, diffuse lamellar keratitis, and keratoconus. Treatment options are provided for some conditions and include medications like steroids, surgical procedures like corneal transplantation, and nonsurgical approaches like rigid contact lenses. Differential diagnoses and distinguishing features between similar conditions are also outlined.
DISCUSS THE COMPLICATIONS OF SCLERITIS.pptxinfogapbricon
Scleritis can range from self-limiting to vision-threatening. It is classified as anterior or posterior, and as necrotizing or non-necrotizing. Anterior non-necrotizing scleritis presents with pain, redness, and blurred vision, and may appear diffuse or nodular on exam. Anterior necrotizing scleritis causes severe pain and can lead to scleral necrosis if untreated. Posterior scleritis is associated with proptosis, eye pain on movement, and fundus abnormalities. Investigations include imaging, angiography and lab tests to identify underlying systemic associations like rheumatoid arthritis.
Uveitis refers to inflammation of the uveal tract of the eye. It can be caused by infections, autoimmune disorders, trauma, medications, or rarely malignancies. It is a leading cause of blindness worldwide. Symptoms and signs depend on the location and severity of inflammation in the eye. Examination findings provide clues to the etiology and classification of uveitis. A thorough history and comprehensive ocular examination are important for diagnosis and management.
The document provides information about the sclera, including its structure, thickness, apertures, nerve supply, inflammation conditions like episcleritis and scleritis, and other related topics. The sclera forms the posterior five-sixths of the outer fibrous tunic of the eyeball. It varies in thickness from 1mm posteriorly to 0.3mm at the muscle insertions. It contains three layers and is pierced by blood vessels and nerves. Inflammation of the sclera can cause episcleritis or scleritis, with the latter being a more serious condition sometimes associated with underlying systemic diseases.
The document discusses corneal ulcer (ulcerative keratitis), which is characterized by discontinuation of the normal corneal epithelial surface associated with necrosis of surrounding corneal tissue. Bacterial corneal ulcers present as purulent corneal ulcers without or with hypopyon. Signs include a yellowish-white oval or irregular ulcer surrounded by clear cornea. Treatment involves topical and systemic antibiotics, along with cycloplegic drops to reduce pain. The goal is to identify and eliminate the causative bacteria through microbiological testing and targeted antibiotic therapy.
This document summarizes different types of keratitis (inflammation of the cornea). It describes various infectious and non-infectious causes of keratitis including bacteria, viruses, fungi, parasites, exposure, neurotrophic disorders, and hypersensitivity reactions. For each type of keratitis, it outlines the etiology, clinical features such as symptoms and signs, and recommended treatment approaches. The document provides an overview of key information on managing various forms of keratitis for eye care professionals.
The document discusses diseases of the sclera, including episcleritis and scleritis. Episcleritis is a benign inflammation of the outer layer of the eyeball that comes in two forms - simple and nodular. Scleritis is a deeper inflammation that involves the entire thickness of the sclera. Scleritis can be immune-mediated, infectious, or necrotizing. Treatment depends on the type but may include topical steroids, NSAIDs, or systemic steroids and immunosuppressive drugs.
Ocular manifestations of tuberculosis infectionShahid Manzoor
Ocular manifestations of TB can affect any part of the eye. Secondary ocular TB results from hematogenous spread from a distant site. Presentations include adnexal lesions like lupus vulgaris and eyelid granulomas. Anterior segment involvement includes conjunctivitis, granulomas, keratitis and iridocyclitis. Posterior segment manifestations are choroidal tubercles, tuberculomas, serpiginous-like choroiditis and subretinal abscesses. Neuro-ophthalmic signs consist of optic nerve tubercles or neuritis. Complications include cataracts, glaucoma, cystoid macular edema and retinal detachment. Treatment involves antitubercular drugs
This document discusses endogenous fungal infections of the eye, specifically Candida and Aspergillus infections. It outlines the typical causative organisms, symptoms of redness and vision loss, and signs seen on examination. Common findings on OCT for different types of Candida lesions are described. Aspergillus causes more fulminant infections involving the anterior chamber with hypopyon and risk of systemic involvement. Treatment involves antifungal medications like amphotericin B or voriconazole administered intravitreally or systemically depending on the organism, along with possible vitrectomy.
Systemic sclerosis is an autoimmune connective tissue disease that affects the skin, blood vessels, and internal organs. There are two major subtypes: limited, characterized by skin changes limited to the hands, face, and CREST syndrome features; and diffuse, with generalized skin thickening. Systemic sclerosis causes fibrosis of skin and internal organs due to vascular dysfunction, immune dysregulation, and excessive collagen deposition. It commonly involves the lungs, gastrointestinal tract, kidneys, heart, and musculoskeletal system. Prognosis depends on the degree of internal organ involvement.
Systemic sclerosis is an autoimmune connective tissue disease that affects the skin, blood vessels, and internal organs. There are two major subtypes: limited, characterized by skin changes limited to the hands, face, and CREST syndrome features; and diffuse, with generalized skin thickening that spreads from the hands and arms. Systemic involvement can include pulmonary fibrosis/hypertension, gastrointestinal dysmotility, renal crisis, cardiac and musculoskeletal issues. The pathogenesis involves vascular dysfunction, immune dysregulation, and excessive fibrosis. Diagnosis is based on characteristic skin changes and internal organ involvement. Prognosis depends on the specific organ systems affected.
Interstitial keratitis, also known as stromal keratitis, is a non-suppurative inflammation of the corneal stroma that can be caused by both infectious and non-infectious diseases. It is characterized by cellular infiltration and vascularization of the corneal stroma with minimal involvement of the corneal epithelium or endothelium. Congenital syphilis is a classic cause of interstitial keratitis. Stromal keratitis associated with congenital syphilis typically begins between ages 5-15, presents bilaterally, and can lead to diffuse corneal inflammation, edema, and neovascularization if left untreated. Acquired syphilis less commonly causes unilateral stromal keratitis, which
This document discusses ophthalmology topics including symblepharon, herpes zoster (shingles), and their causes and treatments. Symblepharon is defined as an adhesion between the eyelid and eyeball that can be caused by conjunctival infections leading to scarring. Herpes zoster is caused by reactivation of the varicella-zoster virus and presents as a painful skin rash. Management of symblepharon may involve lysis procedures while herpes zoster typically clears up within a few weeks.
This document provides information about ophthalmology topics including symblepharon, herpes zoster (shingles), and the lacrimal apparatus. Symblepharon is defined as an adhesion between the eyelid and eyeball. It can be caused by infections or injuries that lead to conjunctival scarring. Herpes zoster is caused by reactivation of the varicella zoster virus and presents as a painful skin rash. It poses contagion risks and treatment involves antivirals and pain management. The lacrimal apparatus includes the lacrimal gland, canaliculi, sac, and duct responsible for tear production and drainage.
Episcleritis and scleritis involve inflammation of the outer layers of the eye. Episcleritis affects just the episclera, while scleritis penetrates deeper into the sclera. Scleritis is more severe and can cause vision loss. It is often associated with autoimmune diseases. Treatment involves anti-inflammatory drugs like NSAIDs or corticosteroids. Necrotizing scleritis is the most severe form and requires prompt high-dose immunosuppressive therapy to prevent complications like scleral thinning and perforation that can cause permanent vision loss.
Viral Keratitis: Diagnosis, Management and Latest GuidelinesSahil Thakur
This document summarizes viral keratitis, with a focus on herpes simplex virus (HSV) keratitis. It discusses the epidemiology, pathophysiology, clinical manifestations, and types of HSV keratitis infections including congenital, neonatal, primary ocular, and recurrent ocular infections. It describes the characteristic presentations of HSV epithelial keratitis including dendritic ulcers, as well as various forms of stromal keratitis such as necrotizing, non-necrotizing, disciform, diffuse, and linear keratitis. Complications such as iridocyclitis, trabeculitis, and endotheliitis are also summarized.
Diseases of sclera
2. anatomy • Sclera posterior 5/6th opaque part of the external fibrous tunic of the eyeball.
3. • outer surface }covered by Tenon's capsule. • anterior part } covered by bulbar conjunctiva.
4. Its inner surface lies in contact with choroid with a potential suprachoroidal space in between
5. Thickness of sclera. • thinner }children and in females Sclera • thickest} posteriorly (1mm) • gradually becomes thin when traced anteriorly. • thinnest } insertion of extraocular muscles (0.3 mm). • Lamina cribrosa is a sieve-like sclera from which fibres of optic nerve pass.
6. Apertures of sclera • Anterior • Anterior ciliary vessels • Middle • four vortex veins (vena verticosae) • Posterior • Optic nerve • Long & short ciliary nerves
7. Layers of sclera sclera episclera Sclera proper Lamina fusca thin, dense vascularised layer of connective tissue fibroblasts, macrophages and lymphocytes avascular structure dense bundles of collagen fibres. innermost blends with suprachoroidal and supraciliary laminae of the uveal tract. brownish in colour presence of pigmented cells.
The sclera is the dense outer layer of the eyeball. It can develop two types of inflammation - episcleritis and scleritis. Episcleritis is more common and self-limiting, often affecting young adults, while scleritis is more severe and can be associated with underlying systemic diseases. Scleritis presents with redness and swelling of the sclera and is classified as anterior or posterior depending on location. Imaging like ultrasound and CT are useful for diagnosing posterior scleritis. Treatment involves topical or oral steroids, with immunosuppressants used for severe or resistant cases. Complications can include scleral thinning and staphylomas if left untreated.
The cornea has five layers - epithelium, Bowman's membrane, stroma, Descemet's membrane, and endothelium. It is avascular and innervated by the trigeminal nerve. The cornea serves an optical function as the most powerful refractive surface of the eye and a protective function. Corneal inflammation can be ulcerative or non-ulcerative. Common causes of ulcerative keratitis include infection, trauma, exposure, neurotrophic changes, and vitamin A deficiency. Bacterial ulcers present with pain, photophobia, and hypopyon may occur. Herpes simplex virus causes recurrent dendritic ulcers. Treatment involves antibiotics, antivirals, patching, and sometimes surgery
Layers of skin of the Eye Lids, Eye Lashes, Eye Lid Pathology, Anatomy of Con...Nina Ko
This document describes the anatomy and common pathologies of the eyelids. It discusses the layers of the eyelid including the epidermis, dermis and subcutaneous layer. It describes the meibomian glands, glands of Zeis and glands of Moll. Common infections like hordeolum, chalazion and blepharitis are summarized. Anatomical deformities including entropion, ectropion, trichiasis and distichiasis are covered. Finally, the document outlines common benign and malignant tumors of the eyelids such as papillomas, xanthelasma, hemangiomas and basal cell carcinoma.
This document contains information about various eye conditions organized under headings for different structures of the eye including eyelid, orbit, cornea, complications of surgery, and miscellaneous conditions. Some specific conditions mentioned include molluscum contagiosum, blepharitis, ptosis, staphyloma, corneal opacity, disciform keratitis, nummular keratitis, diffuse lamellar keratitis, and keratoconus. Treatment options are provided for some conditions and include medications like steroids, surgical procedures like corneal transplantation, and nonsurgical approaches like rigid contact lenses. Differential diagnoses and distinguishing features between similar conditions are also outlined.
DISCUSS THE COMPLICATIONS OF SCLERITIS.pptxinfogapbricon
Scleritis can range from self-limiting to vision-threatening. It is classified as anterior or posterior, and as necrotizing or non-necrotizing. Anterior non-necrotizing scleritis presents with pain, redness, and blurred vision, and may appear diffuse or nodular on exam. Anterior necrotizing scleritis causes severe pain and can lead to scleral necrosis if untreated. Posterior scleritis is associated with proptosis, eye pain on movement, and fundus abnormalities. Investigations include imaging, angiography and lab tests to identify underlying systemic associations like rheumatoid arthritis.
Uveitis refers to inflammation of the uveal tract of the eye. It can be caused by infections, autoimmune disorders, trauma, medications, or rarely malignancies. It is a leading cause of blindness worldwide. Symptoms and signs depend on the location and severity of inflammation in the eye. Examination findings provide clues to the etiology and classification of uveitis. A thorough history and comprehensive ocular examination are important for diagnosis and management.
The document provides information about the sclera, including its structure, thickness, apertures, nerve supply, inflammation conditions like episcleritis and scleritis, and other related topics. The sclera forms the posterior five-sixths of the outer fibrous tunic of the eyeball. It varies in thickness from 1mm posteriorly to 0.3mm at the muscle insertions. It contains three layers and is pierced by blood vessels and nerves. Inflammation of the sclera can cause episcleritis or scleritis, with the latter being a more serious condition sometimes associated with underlying systemic diseases.
The document discusses corneal ulcer (ulcerative keratitis), which is characterized by discontinuation of the normal corneal epithelial surface associated with necrosis of surrounding corneal tissue. Bacterial corneal ulcers present as purulent corneal ulcers without or with hypopyon. Signs include a yellowish-white oval or irregular ulcer surrounded by clear cornea. Treatment involves topical and systemic antibiotics, along with cycloplegic drops to reduce pain. The goal is to identify and eliminate the causative bacteria through microbiological testing and targeted antibiotic therapy.
This document summarizes different types of keratitis (inflammation of the cornea). It describes various infectious and non-infectious causes of keratitis including bacteria, viruses, fungi, parasites, exposure, neurotrophic disorders, and hypersensitivity reactions. For each type of keratitis, it outlines the etiology, clinical features such as symptoms and signs, and recommended treatment approaches. The document provides an overview of key information on managing various forms of keratitis for eye care professionals.
The document discusses diseases of the sclera, including episcleritis and scleritis. Episcleritis is a benign inflammation of the outer layer of the eyeball that comes in two forms - simple and nodular. Scleritis is a deeper inflammation that involves the entire thickness of the sclera. Scleritis can be immune-mediated, infectious, or necrotizing. Treatment depends on the type but may include topical steroids, NSAIDs, or systemic steroids and immunosuppressive drugs.
Ocular manifestations of tuberculosis infectionShahid Manzoor
Ocular manifestations of TB can affect any part of the eye. Secondary ocular TB results from hematogenous spread from a distant site. Presentations include adnexal lesions like lupus vulgaris and eyelid granulomas. Anterior segment involvement includes conjunctivitis, granulomas, keratitis and iridocyclitis. Posterior segment manifestations are choroidal tubercles, tuberculomas, serpiginous-like choroiditis and subretinal abscesses. Neuro-ophthalmic signs consist of optic nerve tubercles or neuritis. Complications include cataracts, glaucoma, cystoid macular edema and retinal detachment. Treatment involves antitubercular drugs
This document discusses endogenous fungal infections of the eye, specifically Candida and Aspergillus infections. It outlines the typical causative organisms, symptoms of redness and vision loss, and signs seen on examination. Common findings on OCT for different types of Candida lesions are described. Aspergillus causes more fulminant infections involving the anterior chamber with hypopyon and risk of systemic involvement. Treatment involves antifungal medications like amphotericin B or voriconazole administered intravitreally or systemically depending on the organism, along with possible vitrectomy.
Systemic sclerosis is an autoimmune connective tissue disease that affects the skin, blood vessels, and internal organs. There are two major subtypes: limited, characterized by skin changes limited to the hands, face, and CREST syndrome features; and diffuse, with generalized skin thickening. Systemic sclerosis causes fibrosis of skin and internal organs due to vascular dysfunction, immune dysregulation, and excessive collagen deposition. It commonly involves the lungs, gastrointestinal tract, kidneys, heart, and musculoskeletal system. Prognosis depends on the degree of internal organ involvement.
Systemic sclerosis is an autoimmune connective tissue disease that affects the skin, blood vessels, and internal organs. There are two major subtypes: limited, characterized by skin changes limited to the hands, face, and CREST syndrome features; and diffuse, with generalized skin thickening that spreads from the hands and arms. Systemic involvement can include pulmonary fibrosis/hypertension, gastrointestinal dysmotility, renal crisis, cardiac and musculoskeletal issues. The pathogenesis involves vascular dysfunction, immune dysregulation, and excessive fibrosis. Diagnosis is based on characteristic skin changes and internal organ involvement. Prognosis depends on the specific organ systems affected.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
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Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
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Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...AyushGadhvi1
learning occurs when a stimulus (unconditioned stimulus) eliciting a response (unconditioned response) • is paired with another stimulus (conditioned stimulus)
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
2. ANATOMY
Sclera forms the posterior five-sixth opaque
part of the external fibrous tunic of the
eyeball.
Its whole outer surface is covered by Tenon’s
capsule. In the anterior part it is also covered
by bulbar conjunctiva.
Its inner surface lies in contact with choroid
with a potential suprachoroidal space in
between.
.
3. ANATOMY
• Sclera is thickest posteriorly (1 mm)
and gradually becomes thin when
traced anteriorly. It is thinnest at the
insertion of extraocular muscles (0.3
mm).
• Lamina cribrosa is a sieve-like
sclera from which fibres of optic
nerve pass
In its anterior most part near the
limbus there is a furrow
which encloses the canal of Schlemm
4. ANATOMY
• Apertures. Sclera is pierced by three sets of
apertures
1. Posterior apertures are situated around the optic
nerve and transmit long and short ciliary nerves
and vessels.
2. Middle apertures (four in number) are situated
slightly posterior to the equator; through these
pass the four vortex veins (vena verticosae).
3. Anterior apertures are situated 3 to 4 mm away
from the limbus. Anterior ciliary vessels and
branches from long ciliary nerves pass through
these apertures.
5. ANATOMY
Microscopic structure.
1. Episcleral tissue. It is a thin, dense
vascularised layer of connective tissue which
covers the sclera proper.
2. Sclera proper. It is an avascular structure
which
consists of dense bundles of collagen fibres. The
bands of collagen tissue cross each other in all
directions.
3. Lamina fusca. It is the innermost part of sclera
which blends with suprachoroidal and supraciliary
laminae of the uveal tract. It is brownish in colour
.
6. EPISCLERITIS
Episcleritis is benign recurrent inflammation of the
episclera, involving the overlying Tenon’s capsule but
not the underlying sclera.
It typically affects young adults,
Twice as common in women than men.
7. EPISCLERITIS
• Etiology
1. Idiopathic. Exact etiology is not known in many cases.
2. Systemic diseases associated with episcleritis, include gout, rosacea, psoriasis and connective
tissue diseases.
3. Hypersensitivity reaction to endogenous tubercular or streptococcal toxins is also reported.
4. Infectious episcleritis may be caused by herpes zoster virus, syphillis, Lyme disease and
tuberculosis.
8. EPISCLERITIS
Histologically, there occurs localised lymphocytic
infiltration of episcleral tissue associated with
oedema and congestion of overlying Tenon’s
capsule
and conjunctiva
9. EPISCLERITIS
Symptoms. Episcleritis redness, mild ocular
discomfort described as gritty, burning or foreign
body sensation/ mild photophobia and lacrimation/
Asymptomatic
• Simple episcleritis is characterised by sectorial
(occasionally diffuse) inflammation of episclera.
The engorged episcleral vessels are large and run
in radial direction beneath the conjunctiva
• Nodular episcleritis is characterised by a pink
or purple flat nodule surrounded by injection,
usually situated 2–3 mm away from the limbus.
The nodule is firm, tender, can be moved
separately from the sclera and the overlying
conjunctiva also moves freely.
10. EPISCLERITIS
Differential diagnosis
• Simple episcleritis- conjunctivitis.
• Nodular episcleritis –inflamed pinguecula,
swelling and congestion due to foreign body
lodged in bulbar conjunctiva and, very rarely
with scleritis.
Treatment
1. Topical NSAIDs, e.g., ketorolac 0.3% may be
useful.
2. Topical mild corticosteroid eyedrops e.g.,
fluorometholone or loteprednol instilled 2–3
hourly, render the eye more comfortable and
resolve the episcleritis within a few days.
3. Topical artificial tears e.g., 0.5% carboxy
methyl
11. EPISCLERITIS
Treatment
1. Topical NSAIDs, e.g., ketorolac 0.3% may be
useful.
2. Topical mild corticosteroid eyedrops e.g.,
fluorometholone or loteprednol
3. Topical artificial tears e.g., 0.5% carboxy methyl
cellulose have soothing effect.
4. Cold compresses applied to the closed lids may
offer symptomatic relief from ocular discomfort.
5. Systemic nonsteroidal anti-inflammatory drugs
(NSAIDs) such as flurbiprofen (300 mg OD),
indomethacin (25 mg three times a day)
12. SCLERITIS
Scleritis refers to a inflammation of the sclera proper.
It usually occurs in elderlypatients (40-70 years)
females more than the males
Scleritis can be classified as follows:
A. Non-infectious scleritis
I. Anterior scleritis (98%)
a. Non-necrotizing scleritis (85%)
1. Diffuse
2. Nodular
b. Necrotizing scleritis (13%)
1. with inflammation
2. without inflammation (scleromalacia perforans)
II. Posterior scleritis (2%)
B. Infectious scleritis
13. SCLERITIS-
• Overall about 50% cases of scleritis are associated with some systemic diseases, M/C CTD
1. Autoimmune collagen disorders, especially rheumatoid arthritis, is the most common association. About
0.5% of patients (1 in 200) suffering from seropositive rheumatoid arthritis develop scleritis. Other - Wegener’s
granulomatosis, polyarteritis nodosa (PAN), systemic lupus erythematosus (SLE) and ankylosing spondylitis.
2. Metabolic disorders like gout and thyrotoxicosis
3. Some infections, herpes zoster ophthalmicus, chronic staphylococcal and streptococcal
4. Granulomatous diseases like tuberculosis, syphilis, sarcoidosis, leprosy
5. Miscellaneous conditions like irradiation, chemical burns, Vogt-Koyanagi-Harada syndrome, Behcet’s,
rosacea
6. Surgically induced scleritis (SIS) is a rare complication of ocular surgery. It occurs within 6 months
7. Idiopathic.
14. SCLERITIS
Histopathological changes are that of a chronic
granulomatous disorder characterised by fibrinoid
necrosis, destruction of collagen together with
infiltration by polymorphonuclear cells,
lymphocytes,
plasma cells and macrophages. The granuloma
is
surrounded by multinucleated epithelioid giant
cells
and old and new vessels, some of which may
show
evidence of vasculitis.
15. SCLERITIS
■■Pain: Patients complain of moderate to severe pain
which is deep and boring in character and often
wakes the patient early in the morning. Ocular pain
radiates to the jaw and temple.
■■Redness may be localized or diffuse.
■■Photophobia and lacrimation may be mild to
moderate.
■■Diminution of vision may occur occasionally
16.
17. SCLERITIS
Non-necrotizing anterior diffuse
scleritis.
commonest variety, characterised by
widespread
inflammation involving a quadrant or more of
the
anterior sclera. The involved area is raised and
salmon pink to purple in colour
• Topical steroid eyedrops
• Systemic indomethacin 75 mg twice a day
until
inflammation resolves.
18. SCLERITIS
Non-necrotizing anterior nodular scleritis. It is
characterised by one or two hard, purplish elevated
immovable scleral nodules, usually situated near
the limbus (Fig. 7.4). Sometimes, the nodules are
arranged in a ring around the limbus (annular
scleritis).
19. SCLERITIS
Anterior necrotizing scleritis with
inflammation.
It is an acute severe form of scleritis characterised
by
intense localised inflammation associated with
areas
of infarction due to vasculitis. The affected
necrosed area is thinned out and sclera becomes
transparent and ectatic with uveal tissue shining
through it. It is usually associated with anterior
uveitis.
Topical steroids
• Oral steroids on heavy doses, tapered slowly.
• Immunosuppressive agents like methotrexate
or cyclophosphamide
• Subconjunctival steroids are contraindicated
• Surgical treatment, in the form of scleral patch graft
20. SCLERITIS
Anterior necrotizing scleritis without inflammation
(scleromalacia perforans). This specific entity typically
occurs in elderly females usually suffering from
longstanding
rheumatoid arthritis. It is characterised by
development of yellowish patch of melting sclera
(due to obliteration of arterial supply); which often
together with the overlying episclera and conjunctiva
completely separates from the surrounding normal
sclera. This sequestrum of sclera becomes dead white
in colour, which eventually absorbs leaving behind
it a large punched out area of thin sclera through
which the uveal tissue shines. Spontaneous
perforation is extremely rare.
21. SCLERITIS
• Posterior scleritis.
It is an inflammation involving the sclera behind
the
equator. The condition is frequently
misdiagnosed.
It is characterised by features of associated
inflammation of adjacent structures, which
include:
exudative retinal detachment, macular oedema,
proptosis and limitation of ocular movements.
22. SCLERITIS
• Infectious scleritis
• Infectious scleritis accounts for 5–10% of all
cases.
• In the early stage diagnosis becomes difficult as
presentation is similar to as non-infectious
scleritis.
• Scleritis with purulent exudates or
infiltrates should raise the suspicion of an
infectious etiology.
• Formation of fistulae, painful nodules,
conjunctival
and scleral ulcers are usually the signs of
infectious scleritis.
• Antimicrobial therapy, both with topical and oral
agents is required in an aggressive manner.
• Surgical debridement is found useful by debulking
the infected scleral tissue and also facilitating the
effect of antibiotics STEROIDS MAY WORSEN THE INFECTIVE SCLERITIS
23. SCLERITIS
COMPLICATIONS: are quite common with necrotizing
scleritis
and include sclerosing keratitis, keratolysis,
complicated cataract and secondary glaucoma.
24. SCLERITIS
SYSTEMIC INVESTIGATIONS
1. TLC, DLC and ESR.
2. Serum levels of complement (C3),
immune
complexes, rheumatoid factor, antinuclear
antibodies and L.E cells for an
immunological
survey.
3. FTA–ABS, VDRL for syphilis.
4. Serum uric acid for gout.
5. Urine analysis.
6. Mantoux test.
7. X-rays of chest, paranasal sinuses,
sacroiliac jointand orbit (to rule out foreign
body especially inpatients with nodular
scleritis).
25. STAPHYLOMA
Staphyloma refers to a localised bulging of weak
and
thin outer tunic of the eyeball (cornea or sclera),
lined by uveal tissue which shines through the
thinned out fibrous coat.
• Staphylomas (diagrammatic depiction) A,
Intercalary; B, Ciliary; C, Equatorial; D, Posterior
osteogenesis imperfecta. Its other causes are
Marfan’s syndrome, Ehlers-Danlos syndrome,
pseudoxanthoma elasticum, buphthalmos, high
myopia and healed scleritis.