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 Mid-17th century – Anatomy of the parotid
gland and the role of the main ducts.
 Greeks called "para-auricular swellings" -
described findings associated with calculi and
inflammation.
 1650-1750 , salivary gland surgery was limited to
the treatment of ranulas and oral calculi.
 Bertrandi in 1802 - The concept of surgical
excision of a parotid tumor
 Initial surgeries - serious disfiguration and disability
 By1850, the focus shifted toward
dissection and the intimate relationship
between the FN and the parotid gland
 Codreanu (1892) - First total parotidectomy with
facial nerve preservation.
 Early 1950s - Grafting of the facial nerve after
resection.
 Beahrs and Adson (1958) - Surgical technique of
current parotid gland surgery.
*They stressed surgical landmarks for avoiding injury FN
*Advocated complete removal of the superficial portion for
benign lesions confined to that portion of the gland
 Largest salivary gland. (wt. 15gms)
 Enclosed by investing layer of deep cervical
fascia.
 FN divides the gland into the superficial (80 %)
and deep lobe (20%)
 Parotid duct (Stensons) is 5 cm long and opens
opposite the upper second molar.
 Lymphatic drainage – periparotid/intraparotid
 Accessory parotid lobe – Present in 20% of
patients
 Branches of the facial nerve
 Terminal branch of the external carotid
artery that divides into the maxillary
artery and the superficial temporal artery
 Retromandibular vein
 Intraparotid lymph nodes
Parotid glands
 Superficial lobe – 80% of the glandular mass
 80% of all salivary tumors occur in the parotid
gland.
 80% arise in the superficial lobe.
 80% are benign
 80% are pleomorphic adenomas.
 Paired salivary glands -
lie below the mandible
 Larger superficial and a
smaller deep lobe -
around the posterior
border of the mylohyoid
 The deep part lies on
the hyoglossus muscle
 Deep cervical fascia
which splits to enclose
it.
 Wharton’s duct(5 cm)
emerges from deep
surface
 It drains into the
anterior floor of the
mouth at the
sublingual papilla
 Paired set of salivary glands
 Anterior part of the floor of mouth between
the mucous membrane, the mylohyoid
muscle and the body of the mandible
close to the mental symphysis
 Numerous excretory ducts - open either
directly into the oral cavity or indirectly via
ducts that drain into the submandibular
duct
 pleomorphic adenomas
originate from the
intercalated duct cells
and myoepithelial cells
 oncocytic tumors
originate from the
striated duct cells
 acinous cell tumors
originate from the acinar
cells
 Mucoepidermoid
tumors and squamous
cell carcinomas develop
in the excretory duct
cells.
 Mixed tumour
(Pleos – many : morphus – form)
 Commonest benign salivary tumour in
adult
 Common in parotid (80%)
 Common in females
 Pseudocapsule, Pseudopodal extensions
 Epithelial ,mesenchymal and
myoepithelial components,
 Abundant matrix mucoid,myxoid or
chondroid supporting tissue
 Contains cartilages, cystic spaces, solid
tissues.
 Dumb bell tumor –
if deep lobe is
involved
 Lobulated , painless swelling, Long duration
 Neither adherent to skin/ masseter muscle
 Generally firm / variable consistency
 Raised ear lobule
 Curtain sign – swelling cannot be moved
above zygomatic bone
Curtain sign deflected ear lobule
 FNAC
 CT Scan
 MRI Scan
 Incisional biopsy is contraindicated !!!!
 Surgery is the TOC
 Superficial parotidectomy- if only
superficial lobe is involved
 Total conservative parotidectomy- if
both lobes are involved.
Adenolymphoma (misnomer)
Second most common tumor in the salivary glands.
Warthin in 1929
Slow growing , painless cystic neoplasm –
exclusively in the parotid gland.
Typically- lower pole
Proliferation of lymphoid tissues of intra/peri parotid LN
Predisposing factor – smoking, radiation exp and EBV
 Round to oval Swelling , well
circumscribed encapsulated
masses
 Multicentric or multifocal disease
 Soft ,fluctuant
 Fifth to seventh decades of life
 Male : female :: 10:1
 Elderly males , smokers
 Bilateral 10%
 No Malignant potential
Investigations
 FNAC
 Tc99 scan – hot spot
(due to high mitochondrial content)
Treatment
 Superficial parotidectmy with preservation
of facial nerve
 Enucleation
 Observation
 <1% of salivary tmrs
 More common in females
 Exclusively in parotid
 Composed of oncocytes ,arranged in
chords or sheets
 Descrete well encapsulated
 Hot spot on Tc 99 scan
 Rare
 Females > males
 Composed of columnar cells arranged in
double layer
 Slow growing ,well circumscribed firm
nodule with cystic spaces
 MC parotid tmr in children
 Present at birth
 Soft, compressible, fluctuant with typical
bluish hue
 Usually spontaneous resolution (5-6 yrs)
 Oral prednisolone
 Surgery only in complicated cases
 MC malignant tumor of salivary gland
 MC malignant tumor to occur in parotid
 F > M
 Slow growing
 Pain , facial palsy
 Arises from excretory ducts of glands
 Presence of mucin prosucing cells,
squamous cells of ducts or acini.
 High grade(predominantly squamous
cells)
 Intermediate grade,
 low grade (predominantly mucous cells)
 Low grade can be managed similar to that
of pleomorphic adenoma
 Positive margin- post op RT
 Intermediate grade- total conservative
parotidectomy
 High grade- more aggressive treatment
 Total parotidectomy with resection of
involved facial N br. And nerve grafting
 Neck dissection,full course of post op RT
 2nd MC malignant tmr of parotid
 MC malignant tmr of SM & SL gland
 Cystic or Cribriform arrange ment- “Swiss
Cheese pattern”
 Perineural invasion
 Tubular , cribriform, solid
(prgnosis best to worst)
 Treatment – Aggressive resection of the
gland
 Any nerve in the path of tmr should be
resected.
 Recurrences – skull base ,cranial nerves as
the tmr spreds into CNS
 Resistant to RT, recurrence cannot be
cured with RT
 Malignant tmr of acinic cells
 Slow growing, almost always in parotid
 Finger like extension into adjacent tissues
 LN involvement is common.
 Trtmnt – aggressive resection with TP ,
resection of FN, nerve grafts, complete ND
if nodes are palpable.
Hard infiltrating mass often associated with
 FN involvement
 Cervical node mets
 Systemic organ mets
 Treamment – surgery f/b post op RT
 Poor prognosis
 Parotid is common site
 High grade tmr
 M> F
 High propensity for regional nodal
spread
 Poor prognosis
 Almost always in parotid (only SG which
contain LN or lymphatic tissue)
 Primary (NHL) or secondary
 Local manifestation of syst disease
 Often found in pts with AIDS
 MC involved SG – parotid (rich lymphoid
tissue)
 Arise from malignant neoplasm of head
and neck area
 Melanoma > Sq cell ca >others
 Hematogenous spread– parotid is MC
site– MC from Ca of thyroid
 Superficial Parotidectomy
 Total parotidectomy with or with out FN
conservation
 ‘Lazy S’ pre auricular mastoid-cervical
incision
 Development of skin
flap
 Mobilisation of gland
 Development of
avascular plane
 Identification of facial
nerve
* 1cm deep and
inferior to Conley’s
pointer
* Immediately superior
to upper border of
post belly of digastric
muscle
 Dissection of the
gland off the FN (in
the perineural plane
with scissors)
 Closure with a suction drain
1) Tmr with peri neural invasion
 Adenoid cystic Ca
2) MC SG tmr in adults
 Pleomorphic adenoma
3) MC parotid tmr in children
 Hemangioma
4) Male smoker with Tc 99 hot spot
 warthins
5) MC malignant tmr of parotid
 Mucoepidermoid Ca
6) MC malignant tmr of SM/SL
 Adenoid cystic Ca
7)MC parotid tmr
 Pleomorphic adenoma
8)Mets MC from
 Head and neck tmr (MC- Ca Thyroid)
 Adenolymphoma of parotid gland is
primarily NHL
 False
 Adenoid cystic ca recurrence can be
easily treated by post operative RT
 false
3) TOC for hemangioma of parotid is
superficial parotidectomy
 False
4) Salivary gland lymphoma almost always
involves parotid as it is the only SG that
contain lymphoid tissue
 True
 The most common parotid tumor is
› A. Pleomorphic adenoma
› B. Mucoepidermoid carcinoma
› C. Adenoid cystic carcinoma
› D. Detroit tigers
 Most parotid tumors are ___________
› A. Benign 60%
› B. Benign 80%
› C. Malignant 60%
› D. Malignant 80%
 All of the following are true regarding
adenoid cystic carcinoma except?
› A. It rarely spreads to Lymph nodes
› B. It is a common minor salivary tumor
› C. It typically does not involve nerves
› D. 40% develop pulmonary metastasis
 What is the most common tumor of
minor salivary glands
› A. Pleiomorphic Adenoma
› B. Adenoid cystic carcinoma
› C. Mucoepidermoid carcinoma
› D. Squamous cell carcinoma
 What seperates the superficial parotid
from the deep lobe?
› Facial Nerve
Salivary gland tumors

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Salivary gland tumors

  • 1.
  • 2.  Mid-17th century – Anatomy of the parotid gland and the role of the main ducts.  Greeks called "para-auricular swellings" - described findings associated with calculi and inflammation.  1650-1750 , salivary gland surgery was limited to the treatment of ranulas and oral calculi.
  • 3.  Bertrandi in 1802 - The concept of surgical excision of a parotid tumor  Initial surgeries - serious disfiguration and disability  By1850, the focus shifted toward dissection and the intimate relationship between the FN and the parotid gland
  • 4.
  • 5.  Codreanu (1892) - First total parotidectomy with facial nerve preservation.  Early 1950s - Grafting of the facial nerve after resection.  Beahrs and Adson (1958) - Surgical technique of current parotid gland surgery. *They stressed surgical landmarks for avoiding injury FN *Advocated complete removal of the superficial portion for benign lesions confined to that portion of the gland
  • 6.
  • 7.
  • 8.
  • 9.  Largest salivary gland. (wt. 15gms)  Enclosed by investing layer of deep cervical fascia.  FN divides the gland into the superficial (80 %) and deep lobe (20%)  Parotid duct (Stensons) is 5 cm long and opens opposite the upper second molar.  Lymphatic drainage – periparotid/intraparotid  Accessory parotid lobe – Present in 20% of patients
  • 10.  Branches of the facial nerve  Terminal branch of the external carotid artery that divides into the maxillary artery and the superficial temporal artery  Retromandibular vein  Intraparotid lymph nodes
  • 11. Parotid glands  Superficial lobe – 80% of the glandular mass  80% of all salivary tumors occur in the parotid gland.  80% arise in the superficial lobe.  80% are benign  80% are pleomorphic adenomas.
  • 12.  Paired salivary glands - lie below the mandible  Larger superficial and a smaller deep lobe - around the posterior border of the mylohyoid  The deep part lies on the hyoglossus muscle
  • 13.  Deep cervical fascia which splits to enclose it.  Wharton’s duct(5 cm) emerges from deep surface  It drains into the anterior floor of the mouth at the sublingual papilla
  • 14.
  • 15.  Paired set of salivary glands  Anterior part of the floor of mouth between the mucous membrane, the mylohyoid muscle and the body of the mandible close to the mental symphysis  Numerous excretory ducts - open either directly into the oral cavity or indirectly via ducts that drain into the submandibular duct
  • 16.
  • 17.
  • 18.  pleomorphic adenomas originate from the intercalated duct cells and myoepithelial cells  oncocytic tumors originate from the striated duct cells  acinous cell tumors originate from the acinar cells  Mucoepidermoid tumors and squamous cell carcinomas develop in the excretory duct cells.
  • 19.
  • 20.
  • 21.
  • 22.  Mixed tumour (Pleos – many : morphus – form)  Commonest benign salivary tumour in adult  Common in parotid (80%)  Common in females  Pseudocapsule, Pseudopodal extensions
  • 23.  Epithelial ,mesenchymal and myoepithelial components,  Abundant matrix mucoid,myxoid or chondroid supporting tissue  Contains cartilages, cystic spaces, solid tissues.
  • 24.
  • 25.  Dumb bell tumor – if deep lobe is involved
  • 26.  Lobulated , painless swelling, Long duration  Neither adherent to skin/ masseter muscle  Generally firm / variable consistency  Raised ear lobule  Curtain sign – swelling cannot be moved above zygomatic bone
  • 28.
  • 29.
  • 30.  FNAC  CT Scan  MRI Scan  Incisional biopsy is contraindicated !!!!
  • 31.  Surgery is the TOC  Superficial parotidectomy- if only superficial lobe is involved  Total conservative parotidectomy- if both lobes are involved.
  • 32. Adenolymphoma (misnomer) Second most common tumor in the salivary glands. Warthin in 1929 Slow growing , painless cystic neoplasm – exclusively in the parotid gland. Typically- lower pole Proliferation of lymphoid tissues of intra/peri parotid LN Predisposing factor – smoking, radiation exp and EBV
  • 33.  Round to oval Swelling , well circumscribed encapsulated masses  Multicentric or multifocal disease  Soft ,fluctuant  Fifth to seventh decades of life  Male : female :: 10:1  Elderly males , smokers  Bilateral 10%  No Malignant potential
  • 34. Investigations  FNAC  Tc99 scan – hot spot (due to high mitochondrial content) Treatment  Superficial parotidectmy with preservation of facial nerve  Enucleation  Observation
  • 35.  <1% of salivary tmrs  More common in females  Exclusively in parotid  Composed of oncocytes ,arranged in chords or sheets  Descrete well encapsulated  Hot spot on Tc 99 scan
  • 36.  Rare  Females > males  Composed of columnar cells arranged in double layer  Slow growing ,well circumscribed firm nodule with cystic spaces
  • 37.  MC parotid tmr in children  Present at birth  Soft, compressible, fluctuant with typical bluish hue  Usually spontaneous resolution (5-6 yrs)  Oral prednisolone  Surgery only in complicated cases
  • 38.
  • 39.
  • 40.
  • 41.  MC malignant tumor of salivary gland  MC malignant tumor to occur in parotid  F > M  Slow growing  Pain , facial palsy  Arises from excretory ducts of glands  Presence of mucin prosucing cells, squamous cells of ducts or acini.
  • 42.  High grade(predominantly squamous cells)  Intermediate grade,  low grade (predominantly mucous cells)
  • 43.  Low grade can be managed similar to that of pleomorphic adenoma  Positive margin- post op RT  Intermediate grade- total conservative parotidectomy  High grade- more aggressive treatment  Total parotidectomy with resection of involved facial N br. And nerve grafting  Neck dissection,full course of post op RT
  • 44.  2nd MC malignant tmr of parotid  MC malignant tmr of SM & SL gland  Cystic or Cribriform arrange ment- “Swiss Cheese pattern”  Perineural invasion  Tubular , cribriform, solid (prgnosis best to worst)
  • 45.  Treatment – Aggressive resection of the gland  Any nerve in the path of tmr should be resected.  Recurrences – skull base ,cranial nerves as the tmr spreds into CNS  Resistant to RT, recurrence cannot be cured with RT
  • 46.  Malignant tmr of acinic cells  Slow growing, almost always in parotid  Finger like extension into adjacent tissues  LN involvement is common.  Trtmnt – aggressive resection with TP , resection of FN, nerve grafts, complete ND if nodes are palpable.
  • 47. Hard infiltrating mass often associated with  FN involvement  Cervical node mets  Systemic organ mets  Treamment – surgery f/b post op RT  Poor prognosis
  • 48.  Parotid is common site  High grade tmr  M> F  High propensity for regional nodal spread  Poor prognosis
  • 49.  Almost always in parotid (only SG which contain LN or lymphatic tissue)  Primary (NHL) or secondary  Local manifestation of syst disease  Often found in pts with AIDS
  • 50.  MC involved SG – parotid (rich lymphoid tissue)  Arise from malignant neoplasm of head and neck area  Melanoma > Sq cell ca >others  Hematogenous spread– parotid is MC site– MC from Ca of thyroid
  • 51.
  • 52.
  • 53.  Superficial Parotidectomy  Total parotidectomy with or with out FN conservation
  • 54.  ‘Lazy S’ pre auricular mastoid-cervical incision
  • 55.  Development of skin flap  Mobilisation of gland  Development of avascular plane
  • 56.  Identification of facial nerve * 1cm deep and inferior to Conley’s pointer * Immediately superior to upper border of post belly of digastric muscle
  • 57.  Dissection of the gland off the FN (in the perineural plane with scissors)
  • 58.  Closure with a suction drain
  • 59.
  • 60.
  • 61.
  • 62.
  • 63.
  • 64. 1) Tmr with peri neural invasion  Adenoid cystic Ca 2) MC SG tmr in adults  Pleomorphic adenoma 3) MC parotid tmr in children  Hemangioma 4) Male smoker with Tc 99 hot spot  warthins
  • 65. 5) MC malignant tmr of parotid  Mucoepidermoid Ca 6) MC malignant tmr of SM/SL  Adenoid cystic Ca 7)MC parotid tmr  Pleomorphic adenoma 8)Mets MC from  Head and neck tmr (MC- Ca Thyroid)
  • 66.  Adenolymphoma of parotid gland is primarily NHL  False  Adenoid cystic ca recurrence can be easily treated by post operative RT  false
  • 67. 3) TOC for hemangioma of parotid is superficial parotidectomy  False 4) Salivary gland lymphoma almost always involves parotid as it is the only SG that contain lymphoid tissue  True
  • 68.  The most common parotid tumor is › A. Pleomorphic adenoma › B. Mucoepidermoid carcinoma › C. Adenoid cystic carcinoma › D. Detroit tigers
  • 69.  Most parotid tumors are ___________ › A. Benign 60% › B. Benign 80% › C. Malignant 60% › D. Malignant 80%
  • 70.  All of the following are true regarding adenoid cystic carcinoma except? › A. It rarely spreads to Lymph nodes › B. It is a common minor salivary tumor › C. It typically does not involve nerves › D. 40% develop pulmonary metastasis
  • 71.  What is the most common tumor of minor salivary glands › A. Pleiomorphic Adenoma › B. Adenoid cystic carcinoma › C. Mucoepidermoid carcinoma › D. Squamous cell carcinoma
  • 72.  What seperates the superficial parotid from the deep lobe? › Facial Nerve