Salivary gland tumours are a relatively rare and morphologically diverse group of lesions. So here are slides containing information about salivary gland tumours with images.
This powerpoint describes the types of maxillectomy & operative steps for total maxillectomy. It also enumerates various flaps used for reconstruction of maxillectomy defect.
Salivary gland tumours are a relatively rare and morphologically diverse group of lesions. So here are slides containing information about salivary gland tumours with images.
This powerpoint describes the types of maxillectomy & operative steps for total maxillectomy. It also enumerates various flaps used for reconstruction of maxillectomy defect.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...
Salivary gland tumors
1.
2. Mid-17th century – Anatomy of the parotid
gland and the role of the main ducts.
Greeks called "para-auricular swellings" -
described findings associated with calculi and
inflammation.
1650-1750 , salivary gland surgery was limited to
the treatment of ranulas and oral calculi.
3. Bertrandi in 1802 - The concept of surgical
excision of a parotid tumor
Initial surgeries - serious disfiguration and disability
By1850, the focus shifted toward
dissection and the intimate relationship
between the FN and the parotid gland
4.
5. Codreanu (1892) - First total parotidectomy with
facial nerve preservation.
Early 1950s - Grafting of the facial nerve after
resection.
Beahrs and Adson (1958) - Surgical technique of
current parotid gland surgery.
*They stressed surgical landmarks for avoiding injury FN
*Advocated complete removal of the superficial portion for
benign lesions confined to that portion of the gland
6.
7.
8.
9. Largest salivary gland. (wt. 15gms)
Enclosed by investing layer of deep cervical
fascia.
FN divides the gland into the superficial (80 %)
and deep lobe (20%)
Parotid duct (Stensons) is 5 cm long and opens
opposite the upper second molar.
Lymphatic drainage – periparotid/intraparotid
Accessory parotid lobe – Present in 20% of
patients
10. Branches of the facial nerve
Terminal branch of the external carotid
artery that divides into the maxillary
artery and the superficial temporal artery
Retromandibular vein
Intraparotid lymph nodes
11. Parotid glands
Superficial lobe – 80% of the glandular mass
80% of all salivary tumors occur in the parotid
gland.
80% arise in the superficial lobe.
80% are benign
80% are pleomorphic adenomas.
12. Paired salivary glands -
lie below the mandible
Larger superficial and a
smaller deep lobe -
around the posterior
border of the mylohyoid
The deep part lies on
the hyoglossus muscle
13. Deep cervical fascia
which splits to enclose
it.
Wharton’s duct(5 cm)
emerges from deep
surface
It drains into the
anterior floor of the
mouth at the
sublingual papilla
14.
15. Paired set of salivary glands
Anterior part of the floor of mouth between
the mucous membrane, the mylohyoid
muscle and the body of the mandible
close to the mental symphysis
Numerous excretory ducts - open either
directly into the oral cavity or indirectly via
ducts that drain into the submandibular
duct
16.
17.
18. pleomorphic adenomas
originate from the
intercalated duct cells
and myoepithelial cells
oncocytic tumors
originate from the
striated duct cells
acinous cell tumors
originate from the acinar
cells
Mucoepidermoid
tumors and squamous
cell carcinomas develop
in the excretory duct
cells.
19.
20.
21.
22. Mixed tumour
(Pleos – many : morphus – form)
Commonest benign salivary tumour in
adult
Common in parotid (80%)
Common in females
Pseudocapsule, Pseudopodal extensions
31. Surgery is the TOC
Superficial parotidectomy- if only
superficial lobe is involved
Total conservative parotidectomy- if
both lobes are involved.
32. Adenolymphoma (misnomer)
Second most common tumor in the salivary glands.
Warthin in 1929
Slow growing , painless cystic neoplasm –
exclusively in the parotid gland.
Typically- lower pole
Proliferation of lymphoid tissues of intra/peri parotid LN
Predisposing factor – smoking, radiation exp and EBV
33. Round to oval Swelling , well
circumscribed encapsulated
masses
Multicentric or multifocal disease
Soft ,fluctuant
Fifth to seventh decades of life
Male : female :: 10:1
Elderly males , smokers
Bilateral 10%
No Malignant potential
34. Investigations
FNAC
Tc99 scan – hot spot
(due to high mitochondrial content)
Treatment
Superficial parotidectmy with preservation
of facial nerve
Enucleation
Observation
35. <1% of salivary tmrs
More common in females
Exclusively in parotid
Composed of oncocytes ,arranged in
chords or sheets
Descrete well encapsulated
Hot spot on Tc 99 scan
36. Rare
Females > males
Composed of columnar cells arranged in
double layer
Slow growing ,well circumscribed firm
nodule with cystic spaces
37. MC parotid tmr in children
Present at birth
Soft, compressible, fluctuant with typical
bluish hue
Usually spontaneous resolution (5-6 yrs)
Oral prednisolone
Surgery only in complicated cases
38.
39.
40.
41. MC malignant tumor of salivary gland
MC malignant tumor to occur in parotid
F > M
Slow growing
Pain , facial palsy
Arises from excretory ducts of glands
Presence of mucin prosucing cells,
squamous cells of ducts or acini.
43. Low grade can be managed similar to that
of pleomorphic adenoma
Positive margin- post op RT
Intermediate grade- total conservative
parotidectomy
High grade- more aggressive treatment
Total parotidectomy with resection of
involved facial N br. And nerve grafting
Neck dissection,full course of post op RT
44. 2nd MC malignant tmr of parotid
MC malignant tmr of SM & SL gland
Cystic or Cribriform arrange ment- “Swiss
Cheese pattern”
Perineural invasion
Tubular , cribriform, solid
(prgnosis best to worst)
45. Treatment – Aggressive resection of the
gland
Any nerve in the path of tmr should be
resected.
Recurrences – skull base ,cranial nerves as
the tmr spreds into CNS
Resistant to RT, recurrence cannot be
cured with RT
46. Malignant tmr of acinic cells
Slow growing, almost always in parotid
Finger like extension into adjacent tissues
LN involvement is common.
Trtmnt – aggressive resection with TP ,
resection of FN, nerve grafts, complete ND
if nodes are palpable.
47. Hard infiltrating mass often associated with
FN involvement
Cervical node mets
Systemic organ mets
Treamment – surgery f/b post op RT
Poor prognosis
48. Parotid is common site
High grade tmr
M> F
High propensity for regional nodal
spread
Poor prognosis
49. Almost always in parotid (only SG which
contain LN or lymphatic tissue)
Primary (NHL) or secondary
Local manifestation of syst disease
Often found in pts with AIDS
50. MC involved SG – parotid (rich lymphoid
tissue)
Arise from malignant neoplasm of head
and neck area
Melanoma > Sq cell ca >others
Hematogenous spread– parotid is MC
site– MC from Ca of thyroid
54. ‘Lazy S’ pre auricular mastoid-cervical
incision
55. Development of skin
flap
Mobilisation of gland
Development of
avascular plane
56. Identification of facial
nerve
* 1cm deep and
inferior to Conley’s
pointer
* Immediately superior
to upper border of
post belly of digastric
muscle
57. Dissection of the
gland off the FN (in
the perineural plane
with scissors)
64. 1) Tmr with peri neural invasion
Adenoid cystic Ca
2) MC SG tmr in adults
Pleomorphic adenoma
3) MC parotid tmr in children
Hemangioma
4) Male smoker with Tc 99 hot spot
warthins
65. 5) MC malignant tmr of parotid
Mucoepidermoid Ca
6) MC malignant tmr of SM/SL
Adenoid cystic Ca
7)MC parotid tmr
Pleomorphic adenoma
8)Mets MC from
Head and neck tmr (MC- Ca Thyroid)
66. Adenolymphoma of parotid gland is
primarily NHL
False
Adenoid cystic ca recurrence can be
easily treated by post operative RT
false
67. 3) TOC for hemangioma of parotid is
superficial parotidectomy
False
4) Salivary gland lymphoma almost always
involves parotid as it is the only SG that
contain lymphoid tissue
True
68. The most common parotid tumor is
› A. Pleomorphic adenoma
› B. Mucoepidermoid carcinoma
› C. Adenoid cystic carcinoma
› D. Detroit tigers
69. Most parotid tumors are ___________
› A. Benign 60%
› B. Benign 80%
› C. Malignant 60%
› D. Malignant 80%
70. All of the following are true regarding
adenoid cystic carcinoma except?
› A. It rarely spreads to Lymph nodes
› B. It is a common minor salivary tumor
› C. It typically does not involve nerves
› D. 40% develop pulmonary metastasis
71. What is the most common tumor of
minor salivary glands
› A. Pleiomorphic Adenoma
› B. Adenoid cystic carcinoma
› C. Mucoepidermoid carcinoma
› D. Squamous cell carcinoma
72. What seperates the superficial parotid
from the deep lobe?
› Facial Nerve