Siobahn Morse of the National Institute for Holistic Addiction Studies discusses Roxanol (morphine sulfate) addiction and abuse. Roxanol is an opioid pain reliever used to treat moderate to severe pain. Abusing Roxanol can lead to overdose due to high doses released too quickly if crushed. Roxanol addiction is possible due to its abuse liability and schedule II controlled substance status. Withdrawal from Roxanol includes severe flu-like symptoms and increased heart rate and breathing.