This document summarizes research on how environmental stressors and changes impact the expression of genes in oysters. The summary is: [1] The research program examines how environmental stressors such as pathogens, carbon dioxide, mechanical stress, and anthropogenic activities affect the oyster stress response at the transcriptome, proteome, and epigenome levels. [2] Studies found that multiple environmental stressors can interact to reduce an oyster's ability to respond to stress, and that characterizing gene expression in natural oyster populations exposed to different human impacts provided insight into their biology and adaptation. [3] DNA methylation is an important mechanism in oysters for transcriptional control that can be impacted