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GKM
Ahmed
RNA processing5' cap, 3' poly A tail
GKM
DNA mRNA Protein
Transcription TranslationReplication
RNA processing
5' cap, 3' poly A tail
RNA processing
GKM
RNA processing
5' cap, 3' poly A tail
RNA processing
(1)5’ Cap
(2)3’ Poly A Tail
(3)Splicing
GKM
RNA processing
5' cap, 3' poly A tail
5’ Cap
Capping of the pre-mRNA involves the addition of 7-
methylguanosine (m7G) to the 5' end.
Pre-mRNANN
PPPP
5’
Phosphatase
P
G
P P
guanosyl
transferase
7
CH3
GKM
RNA processing
5' cap, 3' poly A tail
3’ Poly A Tail
Pre-mRNA AAUAAA
Signal
CPSF
CSTF
GKM
RNA processing
5' cap, 3' poly A tail
Pre-mRNA AAUAAA
CSTF
CPSF
3’ Poly A Tail
GKM
RNA processing
5' cap, 3' poly A tail
3’ Poly A Tail
Pre-mRNA AAUAAACPSF A A A A A A A A A A A A A A A A A
Poly A
Polymerase
Poly Adenine Binding Protein
PAB
A A A A A A A A A ANN
PPPP
G

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Rna processing