4. GKM
RNA processing
5' cap, 3' poly A tail
5’ Cap
Capping of the pre-mRNA involves the addition of 7-
methylguanosine (m7G) to the 5' end.
Pre-mRNANN
PPPP
5’
Phosphatase
P
G
P P
guanosyl
transferase
7
CH3
7. GKM
RNA processing
5' cap, 3' poly A tail
3’ Poly A Tail
Pre-mRNA AAUAAACPSF A A A A A A A A A A A A A A A A A
Poly A
Polymerase
Poly Adenine Binding Protein
PAB
A A A A A A A A A ANN
PPPP
G