2. GKM
Promoter
Is a sequence of DNA to which proteins bind that
initiate transcription of a single mRNA from the DNA
Promoter
Promoter START
Response elements
GENE
In the cell nucleus, it seems that promoters are
distributed preferentially at the edge of the chromosomal
territories
3. GKM
Promoter
TATAAA START GENE
PROMOTER ELEMENTS
1. Core promoter
Transcription Start Site (TSS)
A binding site for RNA polymerase
General transcription factor binding sites
TATA box , B Recognition Element
2. Proximal promoter
BRE
Core promoterProximal promoter
-25-75
Eukaryotic
4. GKM
Promoter
TATAAT START GENE-10-35
prokaryotic
the promoter contains two short sequence elements approximately
10 (Pribnow Box) and 35 nucleotides upstream from the transcription
start site.
TTGACA
SIGMA
RNA
Polymerase