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Rheumatic fever
Upasana Ghosh
etiology
• GAS- Grp A betahemolytic streptococcus
• 2/3rd of rheumatic fever have h/o antecedent upper resp tract
infection.
• Outbreaks in overcrowding
• Strains-M1,3,5,6,18,29-more freq associated.
• Acute rheumatic fever versus rheumatic heart disease??
Epidemiology
• 50/1,000 000 children
• Most common form of acquired heart disease
• Age grp-5-15 years
pathogenesis
• Components of streptococci and the structures with which antibodies
cross react:
• Call wall protein-myocardium
• Carbohydrate antigen-cardiac valve
• Hyaluronic acid-human synovial fluid
• Cytoplasmic membrane antigen- vascular intima
Clinical features
• Revised JONES CRITERIA 2015 by AHA
• Low risk—ARF incidence <2/1,00,000 school aged children(5-14yr) or
all age rheumatic heart disease incidence<1/1000 population.
• High risk area- other than low risk
There are 5 major and 4 minor criteria.
Major criteria
1.Migratory polyarthritis-
• Red ,swollen,tender
• Dramatic response to aspirin.
• It is never deforming.(ARF licks the joints,bites the heart)
2.CARDITIS
• 2015 AHA guideline has major change in the form of subclinical
carditis(no murmur but 2d echo evidence of vavulitis) taken as a
major criteria.
• Carditis contd.
• Endocarditis is universal,usually pancarditis.
• Mitral regurgitation in acute stage. Mitral+/- aotic stenosis seen as
sequel.
• Clinically,
-tachycardia,CCF, pulmonary edema
-s3gallop, muffled s1s2
-pericardial rub
- pansystolic murmur at the apex (MR)/AR murmur.
3.Chorea
• Emotional lability,uncontrolled movements, exacerbated in stress and
absence in sleep is characteristic
• Chorea-usually unilateral
• Latent period from GAS infection to chorea is usually long.
• Milkmaid’s grip
• Pronator sign
• Jack in the box tongue
• 4. erythema marginatum
• 5.s/c nodules- extensor surface
About the criteria-
• 3 conditions in which diagnosis of acute rheumatic fever can be made
without fulfilling criteria-
1.When Chorea as the only major criterion.
2.Indolent carditis is the only manifestation who come months after
the first attack of ARF.
3.Recurrences of rheumatic fever
Supporting evidence of GAS infection
• IT IS AN ABSOLUTE REQUIREMENT FOR ARF.
• ASO titre, anti- DNAase B, antihyaluronidase
• Throat culture
• Slide agglutination test(streptozyme test)
d/d-
treatment
• STRICT BEDREST
• O2 Support, ABC management
• Inotropes
SPECIFIC MANAGEMENT-
1. antibiotics-
-10days penicillin/amoxicillin/single i/m bnzathine penicillin to
eradicate GAS from throat.
2.anti-inflammatory drugs
• Mild carditis- questionable cardiomegaly
• Mod carditis-mild cardiomegaly
• Severe carditis-marked cardiomegaly or CCF
Total duration of aspirin- 12 weeks if severe carditis
3.Treatment of CCF-
-Propped up position
-furosemide
-Digoxin(half dose)
4. Chorea
-phenobarbitone
-haloperidol
-valparin/chlopromazine
Prevention
• Primary prevention-treat sore throat(GAS pharyngitis) adequately.
• Secondary prevention-
60lb=27kg
Prognosis
• 50-70% recover without residual disease.
• Patients with carditis during initial episode are likely to have recurrent
carditis.
• Those with carditis have chance of reinfection with GAS.
• 20% present with pure chorea,if not treated ,develop RHD in20 yrs..

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Rheumatic fever

  • 2. etiology • GAS- Grp A betahemolytic streptococcus • 2/3rd of rheumatic fever have h/o antecedent upper resp tract infection. • Outbreaks in overcrowding • Strains-M1,3,5,6,18,29-more freq associated.
  • 3. • Acute rheumatic fever versus rheumatic heart disease??
  • 4. Epidemiology • 50/1,000 000 children • Most common form of acquired heart disease • Age grp-5-15 years
  • 5. pathogenesis • Components of streptococci and the structures with which antibodies cross react: • Call wall protein-myocardium • Carbohydrate antigen-cardiac valve • Hyaluronic acid-human synovial fluid • Cytoplasmic membrane antigen- vascular intima
  • 6. Clinical features • Revised JONES CRITERIA 2015 by AHA • Low risk—ARF incidence <2/1,00,000 school aged children(5-14yr) or all age rheumatic heart disease incidence<1/1000 population. • High risk area- other than low risk
  • 7. There are 5 major and 4 minor criteria.
  • 8.
  • 9.
  • 10. Major criteria 1.Migratory polyarthritis- • Red ,swollen,tender • Dramatic response to aspirin. • It is never deforming.(ARF licks the joints,bites the heart) 2.CARDITIS • 2015 AHA guideline has major change in the form of subclinical carditis(no murmur but 2d echo evidence of vavulitis) taken as a major criteria.
  • 11. • Carditis contd. • Endocarditis is universal,usually pancarditis. • Mitral regurgitation in acute stage. Mitral+/- aotic stenosis seen as sequel. • Clinically, -tachycardia,CCF, pulmonary edema -s3gallop, muffled s1s2 -pericardial rub - pansystolic murmur at the apex (MR)/AR murmur.
  • 12. 3.Chorea • Emotional lability,uncontrolled movements, exacerbated in stress and absence in sleep is characteristic • Chorea-usually unilateral • Latent period from GAS infection to chorea is usually long. • Milkmaid’s grip • Pronator sign • Jack in the box tongue
  • 13. • 4. erythema marginatum • 5.s/c nodules- extensor surface
  • 14. About the criteria- • 3 conditions in which diagnosis of acute rheumatic fever can be made without fulfilling criteria- 1.When Chorea as the only major criterion. 2.Indolent carditis is the only manifestation who come months after the first attack of ARF. 3.Recurrences of rheumatic fever
  • 15.
  • 16. Supporting evidence of GAS infection • IT IS AN ABSOLUTE REQUIREMENT FOR ARF. • ASO titre, anti- DNAase B, antihyaluronidase • Throat culture • Slide agglutination test(streptozyme test)
  • 17. d/d-
  • 18. treatment • STRICT BEDREST • O2 Support, ABC management • Inotropes SPECIFIC MANAGEMENT- 1. antibiotics- -10days penicillin/amoxicillin/single i/m bnzathine penicillin to eradicate GAS from throat.
  • 19. 2.anti-inflammatory drugs • Mild carditis- questionable cardiomegaly • Mod carditis-mild cardiomegaly • Severe carditis-marked cardiomegaly or CCF Total duration of aspirin- 12 weeks if severe carditis
  • 20. 3.Treatment of CCF- -Propped up position -furosemide -Digoxin(half dose) 4. Chorea -phenobarbitone -haloperidol -valparin/chlopromazine
  • 21. Prevention • Primary prevention-treat sore throat(GAS pharyngitis) adequately. • Secondary prevention- 60lb=27kg
  • 22.
  • 23. Prognosis • 50-70% recover without residual disease. • Patients with carditis during initial episode are likely to have recurrent carditis. • Those with carditis have chance of reinfection with GAS. • 20% present with pure chorea,if not treated ,develop RHD in20 yrs..