Rheumatic fever is caused by a prior Group A streptococcal infection and causes inflammation in the heart, joints, brain, and skin. It most commonly affects children between 5-15 years old. The pathogenesis involves antibodies produced against streptococcal antigens cross-reacting with human tissues. Diagnosis is based on revised Jones criteria from 2015 including migratory arthritis, carditis, chorea, erythema marginatum, and subcutaneous nodules. Treatment involves bed rest, antibiotics to eradicate the streptococcal infection, aspirin or other anti-inflammatory drugs, and management of any heart failure. Prevention relies on promptly treating streptococcal infections and long-term antibiotics to prevent recurrences.