This document presents a seminar on microneedles given by Mr. Ghanvat Mitesh D. It introduces microneedles as a new drug delivery system that can administer drugs transdermally without the drawbacks of injections. It describes the different types of microneedles including solid, hollow, silicon, metal and polymer varieties. It also discusses fabrication techniques, coating methods, penetration ability, evaluation methods, and advantages and disadvantages of microneedles. Microneedles are presented as a promising new drug delivery system that can penetrate the skin with low force and be fabricated with high yields.
Microneedles are a type of micromachined structure that promotes the transport of substance through an interface or media, via enhanced permeability or microchannels. In most cases, microneedles are similar in shape to hypodermic needle but are much smaller in size, enabling localized and painless delivery of drugs into cells or tissues. It have its own use,advantages and disadvantages.
Microneedles are made of solid or hollow cannula for the delivery of drugs. it helps to eliminate the pain caused by injections. They are painless drug delivery systems. In future they can be used for mass vaccination and immunization programs. .
Microneedles in Transdermal Drug Delivery SystemChandni Verma
This presentation includes the recent fivE year patentS as well as research articles mainly on dissolving needles and further description on typesof mns,mechanism of drug release,etc
Microneedle a smart approch for transdermal drug delivery systemHarshal Kathane
Microneedle is a smart approach in the field of transdermal drug delivery, Why we called it smart over other formulations what's its significance, advantages, and applications are given In this presentation. In this presentation, I also included one case study on the cost-effectiveness of microneedle over the hypodermic needle, in measles vaccination.
Microneedles are a type of micromachined structure that promotes the transport of substance through an interface or media, via enhanced permeability or microchannels. In most cases, microneedles are similar in shape to hypodermic needle but are much smaller in size, enabling localized and painless delivery of drugs into cells or tissues. It have its own use,advantages and disadvantages.
Microneedles are made of solid or hollow cannula for the delivery of drugs. it helps to eliminate the pain caused by injections. They are painless drug delivery systems. In future they can be used for mass vaccination and immunization programs. .
Microneedles in Transdermal Drug Delivery SystemChandni Verma
This presentation includes the recent fivE year patentS as well as research articles mainly on dissolving needles and further description on typesof mns,mechanism of drug release,etc
Microneedle a smart approch for transdermal drug delivery systemHarshal Kathane
Microneedle is a smart approach in the field of transdermal drug delivery, Why we called it smart over other formulations what's its significance, advantages, and applications are given In this presentation. In this presentation, I also included one case study on the cost-effectiveness of microneedle over the hypodermic needle, in measles vaccination.
M.pharm (Pharmaceutics) Molecular Pharmaceutics (NTDS) unit 1 part 1 Targeted Drug Delivery Systems: Concepts, Events and biological process involved in drug targeting.
M.pharm (Pharmaceutics) Molecular Pharmaceutics (NTDS) unit 1 part 1 Targeted Drug Delivery Systems: Concepts, Events and biological process involved in drug targeting.
A Novel Approach Towards Transdermal Drug Delivery system: Microneedlesrxashutosh04
Demand for a painless method of delivering macromolecular compounds
is on the rise. However, large-molecule drugs typically cannot be administered
in the oral tablet form patients and doctors prefer. In addition to the
molecular weight being too high to enter the bloodstream from tablet ingestion,
the bodys digestion process would dilute the drug potency to a
level of inefficacy. Microneedles are long and robust enough to penetrate
across the barrier, but short enough to prevent nerve stimulation which
projections of solid silicon or hollow drug-filled metal needle which are
fabricated in several shapes and sizes
AdminMed is developing an
innovative line of novel
microneedle-based transdermal
drug delivery devices. The current pipeline
comprises an advanced microneedle array based
pen-injector device (the AdminPen TM)
that painlessly and conveniently injects
therapeutic levels of standard liquid
pharmaceutical drugs or cosmetic actives
through the skin. This breakthrough
technology revolutionizes the way in which
medicines can be administered, increasing
efficacy, safety, and compliance.
Microneedling, A brief review by Dr. Mohammad Baghaei Mohammad Baghaei
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Review on microneedles
1. A
SEMINAR ON
A REVIEW ON MICRONEEDLES
DEPARTMENT OF PHARMACEUTICS
Guided by. Presented by.
DR. BANERGEE S. K. Mr. ghanvat mitesh d.
m. Pharm, Ph. d M.PHARM FIRST YEAR
VISHAL JUNNAR SEVA MANDAL,S
VISHAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH, ALE, PUNE
2. CONTENTS
INTRODUCTION
MICRONEEDLES
TYPES OF MICRONEEDLES
FABRICATION TECHNIQUE OF MICRONEEDLES
COATING OF MICRONEEDLES
PENITRATION OF MICRONEEDLES
EVALUATION OF MICRONEEDLES
ADVANTAGES OF MICRONEEDLES
DISADVANTAGES OF MICRONEEDLES
CONCLUSION
REFERENCES
3. I. INTRODUCTION
Patch-based transdermal drug delivery offers a
convenient way to administer drugs without the
drawbacks of standard hypodermic injections relating
to patient acceptability and injection safety.
• Types - Routes Of Administration
• New Drug Delivery System
• Transdermal Drug Delivery System
5. TYPES OF MICRONEEDLES
I. Solid microneedles
1. Silicon microprobes
2. Silicon microneedles
3. Metal microneedles
II. Hollow microneedles
1. Silicon hollow microneedles
2. Metal hollow microneedles
3. Glass hollow microneedles
6. I. Solid microneedles
1. Silicon microprobes
Figure 2: A single silicon microprobe fabricated by anisotropic silicon etching and
used to deliver genes to plant and mammalian cells.
7. 2. Silicon microneedles
Figure 3: Arrays of solid silicon microneedles used in transdermal drug delivery study
and demonstrated enhancement of dermal permeability.
8. 3. Metal microneedles
Figure 4: Solid stainless steel microneedle arrays Figure 5: Images of coated solid metal
used in an insulin delivery test using diabetic rats microneedles.
in vivo.
9. II. Hollow microneedles
1. Silicon hollow microneedles
Figure 6: Arrays of symmetric silicon hollow Figure 7: Arrays of hollow silicon microneedles
microneedles used in fluid injection used for transdermal liquid transport.
experiments.
10. 2. Metal hollow microneedles
Figure 8: An array of hollow, metallic microneedles used for skin insertion test.
11. 3. Glass hollow microneedles
Figure 9: A single, beveled-tip, hollow glass microneedle used in
micro-infusion within human cadaver skin.
12. Other type of microneedles
Figure 10: Solid biodegradable polymer microneedles with calcium encapsulated at the needle
tips used for in vitro transdermal insertion test.
13. FABRICATION OF MICRONEEDLES
1. Fabrication of solid microneedles
2. Fabrication of hollow microneedles
Figure 12: A schematic representation of fabrication process used in making the
hollow microneedle array.
14. COATING OF MICRONEEDLES
Coating solution:
• 1% (w/v) carboxymethyalcellulose sodium salt
• 0.5% lutrol F-68 NF
• drug model/ biopharmaceutical.
Drug model:
• 0.01% suforhodamine
• 0.01% calcium
• 3% vitamin B
• 1% bovine serum albumin
• 0.5% plasmid DNA
16. EVALUATION OF MICRONEEDLES
In vitro evaluation
In vitro evaluation is carried out to determine
optimization of microneedles, penetration force,
strength of microneedles, delivery efficacy etc.
In vivo evaluation
The in vivo preclinical evaluation of microneedles was
performed on animals like mice and guinea pig in order
to determine the delivery efficacy, penetration force,
bending force and to evaluate the skin toxicity testes
using vaccine delivery.
17. ADVANTAGES OF MICRONEEDLES
• Pain-free administration.
• Easy to use.
• Discreetness.
• Continuous release.
• Controlled release.
• Safer handling.
19. CONCLUSION
require a very low insertion force .
penetrate human skin.
fabricated with high process yield.
20. REFERENCES
Roxhed N; A fully integrated microneedle-based transdermal drug
delivery system; 2007; Royal institute of technology.
getDocument_urn_nbn_se_kth_diva-4484-2__fulltext.pdf
Lad J; Clinical evaluation of a novel microneedle patch, 2006-2007;
Cranfield University;
search_hl=en&q=drug+used+for+preparation+microneedles(pdf)&sta
rt20&sa=N.pdf
Satoskar RS, Bhandarkar SD and Ainapure SS. Text book of
pharmacology and pharmacotherapeutics. 2003, 18th Ed. 5-9.
Roxhed N; A fully integrated microneedle-based transdermal drug
delivery system; 2007; Royal institute of technology.
getDocument_urn_nbn_se_kth_diva-4484-2__fulltext.pdf