This document provides an overview of respiratory physiology topics including lung mechanics, ventilation-perfusion relationships, gas transport, and regulation of respiration. Key points discussed include:
- Compliance and flow-volume loops measure lung elasticity and airflow.
- Ventilation is preferentially distributed to central, gravity-dependent lung regions while perfusion follows pulmonary blood flow.
- The ventilation-perfusion ratio balances ventilation and perfusion; a low ratio decreases oxygen and increases carbon dioxide in the alveoli and blood.
- Oxygen is transported in blood dissolved and reversibly bound to hemoglobin; carbon dioxide is transported as bicarbonate, dissolved, and bound to hemoglobin.
- Respiration is regulated by chemore
One of the academic presentations reflecting the Academic activity at Grande International Hospital, Dhapasi, Kathmandu; an initiative of our HOD of ED, Dr. Ajay Singh Thapa.
One of the academic presentations reflecting the Academic activity at Grande International Hospital, Dhapasi, Kathmandu; an initiative of our HOD of ED, Dr. Ajay Singh Thapa.
Ventilation and Perfusion in different zones of lungs.Gyaltsen Gurung
This powerpoint presentation will make you explore about the Perfusion and Ventilation in different zones of lungs with its co-relation with pulmonary tuberculosis.
Ventilation and Perfusion in different zones of lungs.Gyaltsen Gurung
This powerpoint presentation will make you explore about the Perfusion and Ventilation in different zones of lungs with its co-relation with pulmonary tuberculosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
10. Ventilation Distribution
• Ventilation distribution within the lung depends on the compliance of alveoli and the relative
distending pressure.
• Theoretically, the pressure within all the alveoli in the lung is constant, but the pressure outside the
alveoli is heterogenous throughout the lung, resulting in different- sized alveoli.
• Ventilation distribution is also affected by anatomy and flow rates.
• Central regions of the lung are preferentially ventilated, but as flow rates are increased, this
ventilatory difference is minimized.
• Simply stated, during spontaneous ventilation, more gas is distributed to gravity- dependent areas.
17. The V/Q ratio is the balance between the ventilation (bringing oxygen in to /removing 𝐂𝐎 𝟐 from the
alveoli) and the perfusion (removing 𝐎 𝟐 from the alveoli and adding 𝐂𝐎 𝟐). The V/Q ratio is important
because the ratio between the ventilation and the perfusion is one of the major factors affecting the
alveolar (and therefore arterial) levels of oxygen and carbon dioxide.
Variable Normal Value
PAO2 ~ 100 mm Hg
PACO2 40 mm Hg
PaO2 95 - 100 mm Hg
PaCO2 40 mm Hg
18. • Decrease the V/Q ratio : A decrease in the V/Q ratio is produced by either decreasing ventilation or
increasing blood flow (without altering the other variable). These will both have the same effect - the
alveolar (and therefore arterial) levels of oxygen will decrease and the 𝐂𝐎 𝟐 will increase.
• When you consider a decrease in the V/Q ratio, all you need to remember is:
• Ventilation is not keeping pace with perfusion.
• The alveolar oxygen levels will decrease, which will lead to a decrease in arterial oxygen levels
(Pa𝐎 𝟐)
• The alveolar 𝐂𝐎 𝟐 levels will increase (we're not getting rid of it as fast), also leading to an
increase in arterial 𝐂𝐎 𝟐 .
• To increase the ventilation-perfusion ratio.
• Increase in the V/Q ratio means that ventilation is in excess of the metabolic needs being met by
perfusion, so we blow off 𝐂𝐎 𝟐 (lower PA𝐂𝐎 𝟐 ) and increase our P𝐀𝐎 𝟐 (and Pa𝐎 𝟐).
20. Changing the V/Q Ratio Pathologically
• Increasing the V/Q ratio to infinity. Pulmonary embolism
• This blood will be very well oxygenated (lots of ventilation, little perfusion) and have a very low
𝐂𝐎 𝟐.
• Not much blood gets through to these alveoli, so the volume of blood in this condition is very
low. However, 5 liters of blood is still coming to the lungs every minute - the blood that can't get
to the area of lung affected by the embolism gets shunted to other parts of the lung (leading to
a low V/Q ratio in those parts of the lung).
• We wasted energy by bringing ventilation to this area - in fact, this is alveolar dead space.
21. Changing the V/Q Ratio Pathologically
• Decreasing the V/Q ratio to zero:
• In this case, we wasted cardiac effort to send the blood to the lungs even though nothing
happened to it as far as oxygen and carbon dioxide go. We call this a physiological shunt -
although the blood travelled to the lungs, it didn't get any oxygen.
• In contrast, an anatomical shunt occurs when the blood physically doesn't enter the lungs (e.g. a
right-to-left shunt - the blood jumps straight from the right ventricle to the left ventricle without
going to the lungs). The end result is- some of the arterial blood has very low oxygen and high
𝐂𝐎 𝟐.
25. A-a gradient
• P𝐀𝐎 𝟐 – Pa𝐎 𝟐
• A normal A–a gradient for a young adult non-smoker breathing air, is between 5–10 mm Hg.
• It gives an idea about the cause of hypoxemia.
• However, the A–a gradient increases with age.
31. 𝐎 𝟐 and 𝐂𝐎 𝟐 Transport in Lungs
• 2 modes: Convection and Diffusion
• The pulmonary diffusion capacity/ability of 𝐂𝐎 𝟐 to pass between the alveoli to blood is 20 times more
than Oxygen which allows it to diffuse across the alveolar membrane with greater efficiency.
• Diffusion allows for 𝐎 𝟐 and 𝐂𝐎 𝟐 to be exchanged at the alveoli-pulmonary capillary interface along a
concentration gradient.
32. 𝐎 𝟐Transport in Blood
• 𝐎 𝟐 is carried in blood in 2 forms:
1. Dissolved in plasma (2%)
2. Reversibly bound to Haemoglobin (98 %)
• The Hb molecule consists of four intertwined subunits, each of which consists of a:
• Polypeptide globin chain (alpha or beta)
• Haem group (porphyrin ring containing a Fe2+ ion)
• 𝐎 𝟐 binds reversibly to the Fe2+ ion in the haem group, each Hb molecule holding up to four 𝐎 𝟐
(one to each Fe2+)
34. Oxygen Haemoglobin Saturation Curve
• The P50 is the P𝐎 𝟐 at which the Hb-𝐎 𝟐 saturation is 50%, normally around 3.5 kPa. It is a reference point that
describes the position of the curve and changes as the curve moves under different conditions.
35. Factors that Influence Oxygen Binding
1. Temperature
2. pH : A decrease in pH by addition of carbon dioxide or other acids causes a Bohr Shift.nA Bohr shift is
characterized by causing more oxygen to be given up as oxygen pressure increases.
3. 2,3-Diphosphoglycerate (DPG) : It is the main primary organic phosphate. DPG binds to haemoglobin
which rearranges the haemoglobin into the T-state, thus decreasing the affinity of oxygen for
haemoglobin
36. 𝐂𝐎 𝟐 Transport in Blood
• 𝐂𝐎 𝟐 is transported in the blood in 3 different forms :-
• Either dissolved in blood (5 %) or
• transported as bicarbonate (90 %) or
• as a carbo-amino (5%) compound.
42. Chemosensitive Area
• This area located in the Medulla is highly sensitive to PaCO2 or H+ which in turn excites the
other portions of the Respiratory Center.
• The sensory neurons are specifically excited by H+ ions. However, they do not cross the BBB.
But BBB is permeable to dissolved CO2.
• Increase in PaCO2 à Increase in CSF [H+] à Activates Chemoreceptors à Secondary
Stimulation to Medullary Centers à Increase Alveolar Ventilation à Reduce PaCO2 to
normal.
46. Respiratory Reflexes
• Hering- Breuer Inflation reflex : Overinflated lungs à stretch receptors + à feedback response à
switches off the inspiratory ramp and stops further inspiration.
• Hering-Breuer Deflation Reflex : Marked lung deflation causes a decrease in Expiration time.
• Pulmonary irritant receptors : Stimulated by some types of irritants that enter the tracheobronchial
tree which causes coughing and sneezing.
• J Receptors : Stimulated especially when the pulmonary capillaries become engorged with blood or
fluids which can in turn lead to dyspnea.