CASE CONFERENCEEXTERN AKECHANOK WATCHARAPUNJAMART
RESPIRATORY FAILURE
IN PEDIATRICSEXTERN AKECHANOK WATCHARAPUNJAMART
DEFINITION
ā€œWhen oxygenation and ventilation are
insufficient to meet the metabolic
demands of the bodyā€
Reference:
Traditionally defined as respiratory
dysfunction resulting in PaO2 <60 mmHg
(room air) PaCO2 > 50 mmHg (acidosis)
Why does
RESPIRATORY FAILURE
tend to occur more in
Children than Adult?
Pediatric Airway Anatomy
1. Obligate nose breather
2. Small airway
3.Disproportionally bigger tongues
Pediatric Airway Anatomy
4. Long, floppy epiglottis, Larynx is higher in neck
Pediatric Airway Anatomy
Tracheal Position
Pediatric Airway Anatomy
5. Cone shaped, Cricoid ring is the narrowest
point of the pediatric airway
Pediatric Airway Anatomy
6.Children have large tonsils and adenoids
Pediatric Airway Anatomy
7.The process of alveolization continues beyond the infant age
20-50 million alveoli at birth in a term infant
300 million by the age of 8 years
Pediatric Airway Anatomy
8.Collateral ventilation through the
pores of Kohn and Lambert’s canal
are not well developed in the early
years
Pediatric Airway Anatomy
9.
Pediatric Airway Anatomy
10.Ossification of the rib cage,
calcification of the costal
cartilage, and development of
muscular mass develops
progressively until adulthood
Pediatric Airway Anatomy
11.development of Respiratory center
Apnea
Irregular
Respiration
What Causes
Respiratory Failure?
Causes of
Respiratory Failure?
1. Upper & Lower airway
obstruction
2.Alveolar-Interstitial lung
disease
3. Ventilatory pump failure
Reference:
Reference:
Acute respiratory failure in childhoood
Preterm infant
Hyaline membrane disease
= infant RDS
Lung immaturity
Congenital pneumonia
acquired lung diseases:
nosocomial pneumonia
bronchiolitis
sepsis
Newborn (at term)
Congenital pneumonia
Meconium aspiration
Malformations:
Lung hypoplasia, CDH
acquired lung diseases:
nosocomial pneumonia
bronchiolitis
sepsis
Acute respiratory failure in childhoood
Infant (1- 12 months)
sepsis-syndrome
infectious pneumonia
(RSV-bronchiolitis)
non infectious pneumonia
- inhalational injury
circulatory arrest
Preschool age
sepsis-syndrome
infectious pneumonia
(RSV-bronchiolitis)
non infectious pneumonia
- foreign body aspiration
- inhalational injury
- drowning
trauma
circulatory arrest
How do we know
if the patient has
RESPIRATORY
FAILURE?
Signs & Symptoms of
Respiratory Failure
Reference : http://depts.washington.edu/uwgenped/outpatient-clinical-guidelines (26/11/2015)
ā€œRCAā€ ( 2-R,2-C,1-A)
ąø„ąø³ąø¢ą¹ˆąø­ ąø„ąø³ąø­ąø˜ąø“ąøšąø³ąø¢
R Respiratory Rate (ąø«ąø³ąø¢ą¹ƒąøˆą¹€ąø£ą¹‡ąø§ąø‚ąø¶ą¹‰ąø™)
R Retraction (Work of Breathing)
(ą¹ƒąøŠą¹‰ą¹ąø£ąø‡ąø”ąø³ąøąø‚ąø¶ą¹‰ąø™ąøąø³ąø£ąø«ąø³ąø¢ą¹ƒąøˆ หอบ ąø«ąø™ą¹‰ąø³ąø­ąøąøšąøøą¹‹ąø”)
C Color (Cyanosis) (ดีอำกำรเขียว)
C Conscious Change (ąø£ąø°ąø”ąø±ąøšąøąø³ąø£ąø£ąø¹ą¹‰ąøŖąø•ąø“ą¹€ąø›ąø„ąøµą¹ˆąø¢ąø™ą¹ąø›ąø„ąø‡)
A Air Entry (เสียงคดเข้ำปอดคดคง)
Impending
respiratory failure
: Reference
How Is
Respiratory Failure
Diagnosed?
Blood Gas Abnormalities
in Respiratory Failure
oTraditionally defined as
respiratory dysfunction resulting
in PaO2 <60 mmHg (room air)
PaCO2 > 50 mmHg (acidosis)
and Arterial Oxygen saturation,
SaO2 < 90%
o The patient’s general state, respiratory effort,
and potential for impending exhaustion are
more important indicators than blood gas
values.
• PaO2 Low ,PaCO2 Normal
• PaO2 Low ,PaCO2 High
Blood Gas Abnormalities
in Respiratory Failure
ā€œNon ventilatory or Normocapnic
or Type I Respiratory Failureā€
ā€œVentilatory or Hypercapnic or
Type II Respiratory Failureā€
: Reference
Pathophysiology
Most Common!!
Reference : Kevin E J Gunning, Pathophysiology of Respiratory
Failure and Indications for Respiratory Support ,page 6
Range of V/Q Relationships
Intrapulmonary Shunt
The effects of alveolar–capillary leak and
positive end-expiratory pressure (PEEP)
on pulmonary gas exchange.
Pathophysiology
Reference : Kevin E J Gunning, Pathophysiology of Respiratory
Failure and Indications for Respiratory Support ,page 6
How Is
Respiratory Failure
Management?
How Is
Respiratory Failure
Management?
Treat Underlying cause and
pathophysiology
Adequate Oxygenation
: Reference
Adequate Oxygenation
Oxygen delivery,DO2ąø‚ąø¶ą¹‰ąø™ąøąø±ąøš
cardiac output (Q),
hemoglobin (Hb) ,
oxygen saturation ą¹ƒąø™ą¹€ąø„ąø·ąø­ąø”ą¹ąø”ąø‡(SaO2)
ą¹ąø„ąø°ąø„ą¹ˆąø³ PaO2
Oxygen Administration
• Least invasive and most easily tolerated therapy
for hypoxic respiratory failure
• Oxygen nasal cannula 2-4 L/min
• Simple face mask 5-10 L/min, FiO2 0.35-0.65
• Partial rebreathing mask
• Non-rebreathing mask
Chronic CO2 retension
Positive-Pressure
Respiratory support
• High-flow nasal cannula (4-16 L/min)
• Continuous positive airway
pressure (CPAP)
• Bilevel Positive Airway Pressure (BiPaP)
ąø‚ą¹‰ąø­ąøšą¹ˆąø‡ąøŠąøµą¹‰ą¹ƒąø™ąøąø³ąø£ą¹ƒąøŠą¹‰ NIPPV ą¹ƒąø™ąø—ąø³ąø‡ąø›ąøąø“ąøšąø±ąø•ąø“
• ąø­ąø±ąø•ąø£ąø³ąøąø³ąø£ąø«ąø³ąø¢ą¹ƒąøˆą¹€ąø£ą¹‡ąø§ąø«ąø£ąø·ąø­ąø«ąø³ąø¢ą¹ƒąøˆą¹€ąø£ą¹‡ąø§
ą¹€ąøžąø“ą¹ˆąø”ąø‚ąø¶ą¹‰ąø™
• ą¹ƒąøŠą¹‰ąøąø„ą¹‰ąø³ąø”ą¹€ąø™ąø·ą¹‰ąø­ Accessory ą¹ƒąø™ąøąø³ąø£
หำยใจ
• ดีกำรหำยใจแบบ Paradox
• PaCO2 >45 mm Hg, pH <7.35
ąø‚ą¹‰ąø­ąø«ą¹‰ąø³ąø”ą¹ƒąø™ąøąø³ąø£ą¹ƒąøŠą¹‰ NIPPV
1.ąøŖąø±ąøąøąø³ąø“ąøŠąøµąøžą¹„ąø”ą¹ˆąø„ąø‡ąø—ąøµą¹ˆ
2.ดีเสดหะปรณดำณดำก
3.ą¹„ąø”ą¹ˆąøŖąø³ąø”ąø³ąø£ąø–ąøŖąø±ąø‡ą¹€ąøąø•ąø­ąø³ąøąø³ąø£ąø‚ąø­ąø‡
Upper airway Obstruction ได้
ąø­ąø¢ą¹ˆąø³ąø‡ą¹ƒąøąø„ą¹‰ąøŠąø“ąø”
: Reference
ąø‚ą¹‰ąø­ąøšą¹ˆąø‡ąøŠąøµą¹‰ą¹ƒąø™ąøąø³ąø£ą¹ƒąøŠą¹‰ IPPV ą¹ƒąø™ą¹€ąø§ąøŠąø›ąøąø“ąøšąø±ąø•ąø“
1.ąø ąø³ąø§ąø°ąøąø³ąø£ąø«ąø³ąø¢ą¹ƒąøˆąø„ą¹‰ąø”ą¹€ąø«ąø„ąø§ (Impending Respiratory failure)
2.Circulatory Instability
3.Increase intracranial pressure,ICP
4.Pulmonary Hypertension
Reference
Other Management
• ąøąø³ąø£ą¹ƒąø«ą¹‰ą¹€ąø„ąø·ąø­ąø”
• ąøąø³ąø£ąø„ąø”ąø„ąø§ąø³ąø”ąø•ą¹‰ąø­ąø‡ąøąø³ąø£ąø‚ąø­ąø‡ąø­ąø­ąøąø‹ąø“ą¹€ąøˆąø™ ą¹€ąøŠą¹ˆąø™ ą¹ƒąø«ą¹‰ąø¢ąø³ąø„ąø”ą¹„ąø‚ą¹‰ ą¹€ąøŠą¹‡ąø”ąø•ąø±ąø§ąø„ąø”ą¹„ąø‚ą¹‰ ą¹ƒąø«ą¹‰ąø¢ąø³
ąø™ąø­ąø™ąø«ąø„ąø±ąøš ยำคคำยกค้ำดเนื้อ เป็นต้น
• ąøąø³ąø£ą¹€ąøžąø“ą¹ˆąø” cardiac output ą¹‚ąø”ąø¢ąøąø³ąø£ą¹ƒąø«ą¹‰ąøŖąø³ąø£ąø™ą¹‰ąø³ąø—ąø³ąø‡ąø«ąø„ąø­ąø”ą¹€ąø„ąø·ąø­ąø”ąø”ąø³ ą¹ƒąø«ą¹‰ąø¢ąø³
ąøąø£ąø°ąø•ąøøą¹‰ąø™ąøąø³ąø£ąø—ąø³ąø‡ąø³ąø™ąø‚ąø­ąø‡ąø«ąø±ąø§ą¹ƒąøˆ เป็นต้น
• ąøąø³ąø£ą¹€ąø›ąø„ąøµą¹ˆąø¢ąø™ąø—ąøµą¹ˆąø™ąø­ąø™
• ąøąø³ąø£ą¹ƒąø«ą¹‰ąø¢ąø³ąø‚ąø¢ąø³ąø¢ąø«ąø„ąø­ąø”ąø„ąø” ąø«ąø£ąø·ąø­ąø¢ąø³ąø•ą¹‰ąø³ąø™ąøˆąøøąø„ąøŠąøµąøžą¹€ąø”ąø·ą¹ˆąø­ąø”ąøµąø‚ą¹‰ąø­ąøšą¹ˆąø‡ąøŠąøµą¹‰
: Reference

Respiratory failure ped