This document provides information on assessing the chest and lungs, including the functions of the respiratory system, anatomical structures and landmarks, examination techniques, normal and abnormal findings, and developmental variations. It describes ventilation, diffusion, gas exchange, and breathing control. Topics covered include inspection, palpation, percussion, auscultation, breath sounds, and examining infants, children, pregnant patients and older adults. Videos are referenced for demonstrations of examination.
Respiratory obstruction / Airway Obstruction Aby Thankachan
Precise guide for DGNM, B.Sc Nursing & M.Sc Nursing Students .. regarding Respiratory obstruction / Airway Obstruction, and its management. Highly recommended for II B.Sc Nursing Students.
Emphysema is a type of COPD involving damage to the air sacs (alveoli) in the lungs. As a result, your body does not get the oxygen it needs. Emphysema makes it hard to catch your breath. You may also have a chronic cough and have trouble breathing during exercise. The most common cause is cigarette smoking
Respiratory obstruction / Airway Obstruction Aby Thankachan
Precise guide for DGNM, B.Sc Nursing & M.Sc Nursing Students .. regarding Respiratory obstruction / Airway Obstruction, and its management. Highly recommended for II B.Sc Nursing Students.
Emphysema is a type of COPD involving damage to the air sacs (alveoli) in the lungs. As a result, your body does not get the oxygen it needs. Emphysema makes it hard to catch your breath. You may also have a chronic cough and have trouble breathing during exercise. The most common cause is cigarette smoking
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
2. Functions of the Respiratory
System
Ventilation
Diffusion and Perfusion
Control of Breathing
3. Functions
Ventilation
Movement of air into and out of the lungs
Inspiratory phase
Expiratory phase
4. Functions
Hypoventilation
Slow, shallow breathing
Causes CO2 to build up in the blood
Acidosis
Hyperventilation
Rapid, deep breathing
Causes CO2 to be blown off
Alkalosis
5. Functions
Diffusion and Perfusion
Gas exchange across the alveolar-pulmonary
capillary membranes
Control of breathing
Influenced by neural and chemical factors
Pons, medulla, chemoreceptors in the carotid
body
Stimulus for breathing
Increased carbon dioxide - PRIMARY
6. Anatomical Structures
Reference points for pinpointing findings from
the physical examination
Topographical Landmarks
Reference Lines
7. Topographical Landmarks
Nipples
Manubriosternal junction (Angle of Louis)
Point at which the 2nd rib articulates with the sternum
Suprasternal notch
Costal Angle
Usually no more than 90 degrees
Ribs insert at approximately 45 degree angles
Clavicles
14. Anatomy Points to Remember
Lungs are symmetric
Lungs are divided into lobes
Right lung = 3 lobes
Left lung = 2 lobes
Primary muscles of respiration
Diaphragm – divides chest from abdomen
External intercostal muscles
Accessory muscles
15. Anatomy Points to Remember
Upper Airway
Nose, pharynx, larynx, intrathoracic trachea
Functions in respiration
Conduct air to lower airway
Filter to protect lower airway
Warm and humidify inspired air
16. Anatomy Points to Remember
Lower Airway
Trachea, bronchi, bronchioles
Functions in respiration
Conduct air to alveoli
Clear mucociliary structures
Alveoli
Functional unit
Gas exchange
Production of surfactant
17. Anatomy Points to Remember
Lower Airway
Trachea splits into left and right mainstem
bronchi which are further subdivided into
bronchioles
Right bronchus is shorted, wider and more
upright than the left
Functions in respiration
Conduct air to alveoli
Clear mucociliary structures
18.
19.
20.
21.
22. Chest Anatomy
Web Anatomy:
http://www.gen.umn.edu/faculty_staff/jensen
/1135/webanatomy/
24. Cough
Onset – sudden, gradual
Duration
Nature – dry, moist, hacking, barking
Sputum – amount, color, odor
Severity – disrupts activities
Associated symptoms – sneezing, dyspnea, fever, chills,
congestion, gagging
What brings it on? – anxiety, talking, activity
What makes it better?
What has been tried? – medications, treatments
Anything similar in the past?
25. Shortness of Breath (SOB) /
Dyspnea
Onset – sudden, gradual
Duration
Severity – disrupts activities
Associated symptoms – night sweats, pain, chest
pressure, discomfort, ankle edema, diaphoresis, cyanosis
What brings it on? – position, time of day, exercise,
allergens, emotions
What makes it better?
What has been tried? – medications, inhalers, oxygen
Anything similar in the past?
26. History
Past Health History
Lung disease or breathing problems
Frequent severe colds, asthma, emphysema,
bronchitis, pneumonia, tuberculosis
Last PPD and/or chest x-ray
Allergies
Medication use
Family History
27. History
Personal and Social History
Tobacco
Alcohol
Drugs
Home environment
Occupational environment
Travel
Health Promotional Activities
34. Palpation
Thoracic Expansion (Excursion)
Place both thumbs at about 7th rib
posteriorly along the spinal process
Click on the pictures to view video
Extend the fingers of both hands
outward over the posterior chest wall
Have the person take a deep breath
and observe for bilateral outward
movement of thumbs
Normal: bilateral, symmetric
expansion
Abnormal: unilateral or unequal
35. Palpation
Vocal (Tactile) Fremitus
Use palmar or ulnar surfaces of hands
Systematically position hands over both sides of
posterior chest
Have person repeat “1 – 2 – 3” or “99” as you
move from the apices to the bases
Normal: bilaterally symmetrical vibrations
Decreased or absent: obstruction of transmission
0bronchitis, emphysema)
Increased: consolidation (compression) of lung
tissue (pneumonia)
36. Auscultation
Auscultate in a systematic manner
Compare one side to the other
Listen one full respiration at each spot
Displace breast tissue to listen directly over
chest wall
DO NOT listen through gowns, clothes, etc.
Place your stethoscope over bare skin
37. Auscultation
Evaluate posterior, lateral, and anterior chest
Instruct person to sit upright and breathe in
and out slowly through the mouth
This makes it easier to hear the air movement
Use the diaphragm of the stethoscope
Move from the apices to the bases
38. Auscultation
Evaluate for normal sounds
Sound Pitch Intensity Quality I:E Location
Bronchial High Loud Blowing/ I<E Trachea
hollow
Bronchovesicular Moderate Moderate Combination I=E Between scapulae,
1st & 2nd ICS lateral to
sternum
Vesicular Low Soft Gentle rustling/ I>E Peripheral lung
breezy
39. Auscultation
Evaluate for adventitious sounds
Sound Intensity/ Pitch I/E Quality Clear with Cough
Crackles/ Soft (fine)/ High I Discontinuous, Possibly
Rales Loud (coarse)/ Low nonmusical, brief
Wheeze High E Continuous musical Possibly
sounds
Ronchi Low E Continuous snoring Possibly
sounds
Pleural I&E Continuous or Never
Friction Rub discontinuous creaking or
brushing sounds
Stridor I Continuous, crowing Never
40. Auscultation
Copy this URL into your Web browser to hear normal and abnormal lung sounds :
http://medocs.ucdavis.edu/IMD/420C/sounds/lngsound.htm
41. Developmental Variations
Neonates
Measure the chest circumference
Usually 2-3 cm smaller than head circumference
Chest is round (i.e. AP diameter = transverse)
Obligate nose breathers
Periodic breathing is common
Sequence of vigorous breathing followed by apnea
for 10-15 seconds
Only concern if it is prolonged or baby becomes
cyanotic
42. Developmental Variations
Neonates
Breathing is diaphragmatic and abdominal
Signs of compromise
Stridor (“crowing”)
Grunting
Central cyanosis
Flaring nares
43. Developmental Variations
Infants and Young Children
Roundness of the chest persist for first 2 years
Chest walls are thinner than the adult’s
Breath sounds may sound louder, and more
bronchial than the adult
Bronchovesicular sounds may be heard
throughout the chest
44. Developmental Variations
Pregnancy
Costal angle increases to about 105 degrees in
the third trimester
Dyspnea and orthopnea are common
Breathes more deeply
45. Developmental Variations
Older Adult
Chest expansion is often decreased
Bony prominences are marked
AP diameter is increased with respect to
transverse (but not 1:1)
46. Videos of Thorax and Lung
Assessment
Copy these URLs into your Web browser
http://www.conntutorials.com/chapter5.html
OR
http://medinfo.ufl.edu/other/opeta/chest/CH_main