This chapter discusses ethics in research involving human and animal subjects. It outlines the roles of Institutional Review Boards (IRBs) and APA guidelines in ensuring ethical research practices. IRBs evaluate proposed studies to protect participant safety and determine if any risks are outweighed by potential benefits. The chapter also discusses informed consent, avoiding plagiarism and fraud, and the views of animal rights activists regarding animal welfare in research. The overall goal of ethical research is to advance scientific understanding in ways that benefit humanity without harming individual participants.