The document discusses two discoveries related to repair mechanisms in the body. The first is a discovery using polymer nano-shells that deliver molecules to damaged bone to stimulate the body's own bone cells to repair itself, reducing risks from foreign cells. The second is a Nobel Prize-winning discovery of a DNA repair mechanism failure link to cancer susceptibility, which could help identify high-risk patients and fuel cancer immunotherapy research working with drug companies. Both discoveries are seen as important progress for diseases like cancer and bone injuries that could improve patients' quality of life worldwide.

1. REPAIR MECHANISMS OF
GENETIC MATERIAL
Luisa Gómez Palacio
Med. Student
2016

4. INTRODUCTION
Repair mechanism consists in
detecting damages in the
DNA as a result of radioactivity
or chemical agents

5. NANO-SHELLS DELIVER
MOLECULES THAT TELL BONE TO
REPARIR ITSELF
UNIVERSITY OF MICHIGAN
JANUARY 14, 2016

6. NANO-SHELLS DELIVER MOLECULES
THAT TELL BONE TO REPARIR ITSELF
Polymer sphere delivers
molecule to bone wounds to
repair the damaged

7. NANO-SHELLS DELIVER MOLECULES THAT
TELL BONE TO REPARIR ITSELF
The polymer sphere
introduces MicroDNA into
the bone cells elevating
their healing activity

8. NANO-SHELLS DELIVER MOLECULES THAT
TELL BONE TO REPARIR ITSELF
Foreign cells won’t be
necessary so the risk of
rejection or tumors would
be much less because the
body will be working with
their own bone cells.

9. NANO-SHELLS DELIVER MOLECULES THAT
TELL BONE TO REPARIR ITSELF
STUDENT OBSERVATION
I believe that if this investigation can make it in
the future as a bone repair therapy, the
outcomes will be very positive for everyone,
especially patients with osteoporosis, bone
cancer, Paget’s disease and imperfect
osteogenesis. Besides being able to heal them,
the therapy would give these patients a better
quality of life.
Also, if it does work, scientists could improve
Nano shells so they can work almost the same
but in other body parts.

10. NOBEL DISCOVERIES ON DNA REPAIR
MECHANISM FUELLING CANCER DRUG
RESEARCH
SINGAPORE-BASED BIOTECH AND
HEALTHCARE NEWS WEBSITE
JANUARY 09, 2016

11. NOBEL DISCOVERIES ON DNA REPAIR
MECHANISM FUELLING CANCER DRUG
RESEARCH
If the repair mechanism
fails, the body is more
susceptible to present
diseases like Cancer

12. NOBEL DISCOVERIES ON DNA REPAIR
MECHANISM FUELLING CANCER DRUG
RESEARCH
This discovery involving
mismatching defects can
be used to identify these
patients and help them
with Cancer
immunotherapy,
eliminating tumors with
mutations.

13. NOBEL DISCOVERIES ON DNA REPAIR
MECHANISM FUELLING CANCER DRUG
RESEARCH
Researchers are planning
on working hand to hand
with drug companies in
order for them to recreate
our immune system so the
drugs can recognize
Cancer.

14. NOBEL DISCOVERIES ON DNA REPAIR
MECHANISM FUELLING CANCER DRUG
RESEARCH
STUDENT OBSERVATION
I think that this discovery will
improve modern medicine to a
whole new level because we
are living in a time were Cancer
is quickly growing so having the
medicine to work identifying in
which body part the cancer is
growing, it could provide a very
useful therapy for patients
worldwide

15. MEDICAL
UTILITY

16. MEDICAL
UTILITY
Both of the discoveries are
working on highly important
diseases, especially Cancer
which is a strong progress in
finding the cure and creating a
strong ground for other
investigations and researchers.

17. MEDICAL
UTILITY
Besides working against the
disease, these discoveries will
improve the quality of life of
every patient around the
world

18. MEDICAL
UTILITY
Finally, these investigations
could work without using
chemotherapy or strong
therapies for patients with
bone wounds which could
lead to more affordable
drugs for patients with low
resources.

19. BIBLIOGRAPHY
Bioteching.asia (2016, Januray 09). Nobel discoveries on
DNA repair mechanism fuelling cancer drug research.
Retrived January 22, 2016 from
http://biotechin.asia/2016/01/09/nobel-discoveries-on-
dna-repair-mechanism-fuelling-cancer-drug-research/
University of Michigan (2016, January 14). Nano- shells
deliver molecules that tell bone to repair itself. Natural
Communications. Retrived January 22, 2016 from
http://phys.org/news/2016-01-nano-shells-molecules-
bone.html
MARTINEZ, SÁNCHEZ, Lina María. Biología Molecular. 8va
ed. Medellín: UPB. Fac de Medicina, 2015. 109 p