DNA STRUCTURE
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Importancia de la estructura del ADN, patologías relacionadas con su alteración y métodos para repararlo
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GENETIC MAPPING
This document summarizes two genetic studies on cancer. The first study mapped genetic mutations in cutaneous melanoma and identified four subtypes. It also found a protein related to immune response that is overexpressed in melanoma cells. The second study linked a genetic variation in the FOPNL gene to poorer survival rates in multiple myeloma patients, but the mechanism is still unknown. Both studies help locate genes of interest and their variations in diseases, which can inform targeted cancer therapies and improve patient outcomes.
Cancer breakthrough Sydney scientists record near complete elimination in mal...
Sydney scientists have achieved stunning survival rates in dogs with late stage brain tumors using a "trojan horse" therapy involving bacterially derived nanocells that target and kill tumor cells. The therapy has also shown near complete elimination of cancer in a male mesothelioma patient. Results to be published this week show the reversal of adverse brain tumor symptoms in dogs, with tumors disappearing in four dogs. The biotech company's therapy can destroy drug-resistant tumor cells, boosting patients' immune systems and allowing some patients to survive two years or longer compared to a normal expectancy of four months.
Diapositivas plegable biomol
The document summarizes two studies about proteins that cause mutations. One study found that APOBEC proteins, which are involved in immune activities, cause over 70% of mutations in cancers like cervical, bladder, and lung tumors. The mutations may be influenced by environmental factors. The second study was the first to perform full genome sequencing on people with autism and found genetic risk factors for autism that could lead to improved treatments and allow for earlier diagnosis through genetic screening.
Diapositivas plegable carolina cardona tobon
This document summarizes genetic mapping techniques and their medical utility. It discusses a new technique that maps phosphohistidine markers on proteins using antibodies, allowing visualization of this previously difficult to see bond. It also describes research finding a genetic marker, Lgr5, that is expressed after damage to supporting cells in the inner ear, causing proliferation and replacement of lost hair cells. Genome mapping is important for medical applications as it allows localization of genes associated with diseases to better understand illness processes and develop improved treatments, helping to advance precision medicine and improve quality of life.
Crisper
Two teams led by Jennifer Doudna and Emmanuelle Charpentier showed in 2012 how CRISPR, a bacterial immune system, could be used as a tool for editing genes. CRISPR provides a simple yet powerful way to edit genes with high efficiency through a guide RNA and Cas9 protein, allowing optimization of plant breeding and applications both in vivo and in vitro such as fixing genetic defects or creating long-shelf life tomatoes through gene mutation.
Plegable Biomol Mateo Torres
This document summarizes and comments on two scientific articles about recent research into noncoding RNA and developing vaccines for viruses. The first article discusses the discovery of a long noncoding RNA that regulates innate immunity and inflammation. The second describes work using a "genetic poison pill" to minimize mutations in a virus's RNA polymerase and reduce its ability to replicate when developing vaccines. The student observes that both studies could provide insights into treating inflammatory diseases and developing protections against lethal viruses.
Medical genetics
Medical genetics is a branch of human genetics confined to studying structure and function of the genetic material in health and disease states of human beings.
Gene therapy
Gene therapy is an experimental treatment that involves inserting genetic material into cells to give them a new or restored function, as damaged or missing genes can cause cancer. It works by using viral or non-viral vectors to deliver new genetic material into cells through various methods like electroporation, injection, or ultrasound. The goals are to modify tumor cells, add missing tumor suppressor genes, make cells more sensitive to treatment, inhibit angiogenesis, or enhance the immune response against cancer.
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GENETIC MAPPING
This document summarizes two genetic studies on cancer. The first study mapped genetic mutations in cutaneous melanoma and identified four subtypes. It also found a protein related to immune response that is overexpressed in melanoma cells. The second study linked a genetic variation in the FOPNL gene to poorer survival rates in multiple myeloma patients, but the mechanism is still unknown. Both studies help locate genes of interest and their variations in diseases, which can inform targeted cancer therapies and improve patient outcomes.
Cancer breakthrough Sydney scientists record near complete elimination in mal...
Sydney scientists have achieved stunning survival rates in dogs with late stage brain tumors using a "trojan horse" therapy involving bacterially derived nanocells that target and kill tumor cells. The therapy has also shown near complete elimination of cancer in a male mesothelioma patient. Results to be published this week show the reversal of adverse brain tumor symptoms in dogs, with tumors disappearing in four dogs. The biotech company's therapy can destroy drug-resistant tumor cells, boosting patients' immune systems and allowing some patients to survive two years or longer compared to a normal expectancy of four months.
Diapositivas plegable biomol
The document summarizes two studies about proteins that cause mutations. One study found that APOBEC proteins, which are involved in immune activities, cause over 70% of mutations in cancers like cervical, bladder, and lung tumors. The mutations may be influenced by environmental factors. The second study was the first to perform full genome sequencing on people with autism and found genetic risk factors for autism that could lead to improved treatments and allow for earlier diagnosis through genetic screening.
Diapositivas plegable carolina cardona tobon
This document summarizes genetic mapping techniques and their medical utility. It discusses a new technique that maps phosphohistidine markers on proteins using antibodies, allowing visualization of this previously difficult to see bond. It also describes research finding a genetic marker, Lgr5, that is expressed after damage to supporting cells in the inner ear, causing proliferation and replacement of lost hair cells. Genome mapping is important for medical applications as it allows localization of genes associated with diseases to better understand illness processes and develop improved treatments, helping to advance precision medicine and improve quality of life.
Crisper
Two teams led by Jennifer Doudna and Emmanuelle Charpentier showed in 2012 how CRISPR, a bacterial immune system, could be used as a tool for editing genes. CRISPR provides a simple yet powerful way to edit genes with high efficiency through a guide RNA and Cas9 protein, allowing optimization of plant breeding and applications both in vivo and in vitro such as fixing genetic defects or creating long-shelf life tomatoes through gene mutation.
Plegable Biomol Mateo Torres
This document summarizes and comments on two scientific articles about recent research into noncoding RNA and developing vaccines for viruses. The first article discusses the discovery of a long noncoding RNA that regulates innate immunity and inflammation. The second describes work using a "genetic poison pill" to minimize mutations in a virus's RNA polymerase and reduce its ability to replicate when developing vaccines. The student observes that both studies could provide insights into treating inflammatory diseases and developing protections against lethal viruses.
Medical genetics
Medical genetics is a branch of human genetics confined to studying structure and function of the genetic material in health and disease states of human beings.
Gene therapy
Gene therapy is an experimental treatment that involves inserting genetic material into cells to give them a new or restored function, as damaged or missing genes can cause cancer. It works by using viral or non-viral vectors to deliver new genetic material into cells through various methods like electroporation, injection, or ultrasound. The goals are to modify tumor cells, add missing tumor suppressor genes, make cells more sensitive to treatment, inhibit angiogenesis, or enhance the immune response against cancer.
Technology will save our minds and bodies
The document discusses three emerging medical technologies: cancer immunotherapy, magnetic nanoparticles, and robots. Cancer immunotherapy works by undermining a cancer cell's defenses to allow the immune system to attack. Magnetic nanoparticles can be precisely delivered to areas needing bone regeneration. Robots are being used for surgical procedures and nanorobots may one day deliver drugs through the bloodstream. While these technologies show promise, their effectiveness varies and costs need to remain reasonable.
the cell
This document contains multiple passages about scientific research related to cells and viruses. The first passage provides background on common features of prokaryotic and eukaryotic cells. The second passage describes the role of the nucleus and DNA replication in eukaryotic cells. Subsequent passages summarize recent scientific findings on proteins that allow flu viruses to replicate, techniques to track chemotherapy using fluorescent nanoparticles, and the potential medical applications of manipulating cells and genetic material.
La celula plegable
This document discusses several scientific findings related to cells and viruses:
1. Scientists identified a protein called ANP32A that allows avian flu viruses to replicate in cells. When this protein was removed, viral infection stopped.
2. Researchers developed a technique to tag chemotherapy drugs with fluorescent nanoparticles in order to track how drugs move through cells in real time. This could help understand varying patient responses to treatments.
3. The document discusses how genetic material in cells can be manipulated for therapeutic use, and cells like stem cells may help treat conditions like Alzheimer's and Parkinson's. The cell is an important target for various medical therapies.
FOLDING. SARA SANCHEZ RESTREPO
The document discusses several studies related to lung cancer and DNA. It summarizes that mouse models show similarities to human lung cancer, allowing scientists to study disease progression. Researchers identified a gene called NF-Iβ associated with lung cancer. A separate study found specific DNA breakage characteristics in cancer cells. This molecular-level analysis improves understanding of cancer development and susceptibility.
Folding. SARA SANCHEZ RPO.
The document discusses several studies related to lung cancer and DNA. It summarizes that mouse models show similarities to human lung cancer, allowing scientists to study disease progression. Researchers identified a gene called NF-Iβ associated with lung cancer. A separate study found specific DNA breakage characteristics in cancer cells. This molecular-level analysis improves understanding of cancer development and susceptibility.
Folding sara sanchez r
The document discusses several studies related to lung cancer and DNA. It summarizes that mouse models show similarities to human lung cancer, allowing scientists to study disease progression. Researchers identified a gene called NF-Iβ associated with lung cancer. A separate study found specific DNA breakage characteristics in cancer cells. This molecular-level analysis improves understanding of cancer development and susceptibility.
Networks of proteins and diseases
The document discusses Lars Juhl Jensen's research using networks of proteins and diseases. His lab uses text mining of biomedical literature, curated databases, and experimental data to build protein-protein interaction networks. These networks are then used to study relationships between proteins, diseases, tissues, and cellular compartments. Jensen's lab has created web interfaces and databases to disseminate the results of their computational predictions and analyses of disease networks. They also use medical data like electronic health records to study relationships between diseases and adverse drug reactions.
Transforming pharmaceutical developments through big data. Amy Levál, JANSSEN.
Transforming pharmaceutical developments through big data. Amy Levál, JANSSEN. Upgraded - Health Startup Association of Finland
Presented in Upgraded Life Festival 31.5.2016 by Amy Levál, JANSSEN. http://www.upgradedlifefestival.com/ Folding: NEWS Principles of Medical Genetics
News.
Principles of Medical Genetics.
Folding: Molecular Biology.
Universidad Pontificia Bolivariana.
Juan Lab Summary 2
This document contains summaries of three laboratory assignments from a biomedical techniques course at the University of Puerto Rico - Cayey. The first summary describes learning about nanotechnology and observing nano fibers using an electron microscope. The second discusses using nanoparticles and affinity chromatography to isolate specific proteins, then using SDS-Page gel electrophoresis to measure the results. The third summary explains how computer programs help researchers visualize proteins and compare them to databases to understand protein-protein interactions and design new drugs.
Genetic mapping
Recombination sequences in DNA may help determine the order of genes on chromosomes. This allows estimation of relative distances between genes and localization of genes. A study genotyped nearly 700,000 markers in the genomes of about 9,000 individuals to identify genes associated with polycystic ovary syndrome (PCOS). The study did not find genes regulating testosterone production in the ovaries, which was previously thought to be a major factor in PCOS. Another study mapped gene activity in the first few days of human embryo development from fertilization to provide insight into the "ignition key" that switches on human development.
Plegable biologia molecular
The document discusses two recent scientific discoveries:
1) Researchers at the University of Edinburgh discovered a protein complex called Ska that helps stabilize cell division and the distribution of genetic material between daughter cells. Disruptions to this process could lead to cancer, offering new insights into cancer development.
2) A team at the University of California, Davis found that new genes can arise from ancestral non-coding DNA sequences, which is occurring at a high rate across animals and plants. Random mutations can cause non-coding DNA to be transcribed, forming new genes over time through selection. Understanding how genomes change could inform future therapies.
Disease Powerpoint
Scientists at Harvard have developed a new cancer vaccine in pill form containing polymer disks saturated with tumor-specific antigens. In mouse studies, the magnetic nanodisc vaccines induced cancer cells to undergo apoptosis when implanted in the skin near tumors, leading to remission and longer survival for many mice. However, similar human trials of the vaccine failed to show effectiveness against cancer.
DNA– REPAIRING PROTEIN MAY BE KEY TO PREVENTING RECURRENCE OF SOME CANCER ...
The document discusses two scientific articles about discoveries related to cancer recurrence and stem cells. The first article describes a DNA-repairing protein that may help prevent cancer recurrence by allowing cancer cells to repair DNA damage from chemotherapy. The second article finds that a retrovirus present in the human genome is active in pluripotent stem cells and could help develop new gene therapy treatments.
Cancer cells use our nerves to spread from one part of our body to another.
Cancer cells use nerves to spread to other parts of the body, and recent studies have uncovered that tumors form a partnership with nerves to promote their growth. Research in 2013 and 2019 revealed that nerve fibers near tumors supply them with neurons to enhance growth, and neural precursor cells in the brain migrate to prostate tumors in mice. Researchers are now attempting to target this relationship between tumors and nerves to stop cancer progression and develop new therapies.
DNA replication
The document discusses two studies related to DNA replication and cancer. The first study found that certain enzymes in the APOBEC family can cause mutations during DNA replication by deaminating cytosines, potentially leading to cancer. The second study identified a protein pathway that some cancer cells use to replicate their DNA and which could be a target for new cancer therapies. Understanding the processes of DNA replication and how they can be disrupted provides insights into cancer development and new opportunities for diagnosis and treatment.
DNA replication
The document discusses two recent scientific findings related to cancer research. First, scientists discovered that the APOBEC protein, which normally fights viruses by modifying single-stranded DNA, can cause mutations in human DNA when the DNA replication process goes wrong. Abnormalities that leave parts of DNA single-stranded allow APOBEC to act as a mutagen. Second, the FDA approved the drug Halaven to treat liposarcoma, a rare soft tissue cancer. Halaven blocks cell division and has been shown to be effective against tumors, though it can lower white blood cell count. The findings contribute to understanding cancer causes at the molecular level and to developing new targeted treatments.
Emerging collaboration models for academic medical centers _ our place in the...
- The document discusses emerging collaboration models between academic medical centers and other organizations in the genomics and precision medicine field, as genomic sequencing capabilities advance and more clinical cases are needed to power artificial intelligence platforms. It explores new partnership approaches around data sharing, patient engagement, infrastructure needs, and how academic medical centers can position themselves in this evolving ecosystem.
BE Retreat 2015 Poster
This document discusses using machine learning models to predict pathogen phenotypes like drug resistance and virulence from genomic data. It presents results from models trained to predict HIV drug resistance from protease sequences with good performance. The models captured the temporal emergence of resistance after new drug approvals. The approach aims to establish genomic surveillance pipelines for pathogens by computing a "risk factor" from sequence data to help monitor zoonotic pathogens. Challenges include mapping genotypes to phenotypes given epistasis and lack of data. The vision is to assay pathogen populations to build genotype-phenotype datasets to train models that can quantify risk profiles and inform interventions.
ELISA TEST
The document discusses several ways that ELISA tests can be used to detect proteins and antibodies in blood samples. It describes a study that found high levels of the DEK gene in plasma are correlated with better outcomes for head and neck cancer patients. The document also summarizes the development of a new type of simple test strip that can detect blood proteins with high precision and may have applications for disease diagnosis, food/drug testing, and environmental monitoring.
DNA, the great mistery
This document discusses two scientific articles about cellular processes and potential applications to cancer treatment. The first article describes how a newly identified protease, Wss1, can chop down the protein components of DNA-protein crosslinks, allowing cells to replicate their genome. The second article discusses how DNA origami was used to test the effects of ephrin placement on the EphA2 receptor in cancer cells, finding it reduced invasiveness. The document concludes that further research using specialized techniques can improve understanding of disease pathophysiology and lead to potential cures in the future.
Plegable biologia molecular
The document discusses several topics related to DNA replication and repair:
1) A study found that faulty proteins involved in DNA repair may be linked to ovarian cancer recurrence and response to PARP inhibitor drugs.
2) PARP inhibitors are being tested for ovarian cancer patients with BRCA1/BRCA2 mutations or other damaged DNA repair proteins.
3) Research is exploring an earlier genetic molecule called TNA that may have preceded DNA and RNA due to its simpler structure and ability to self-replicate, providing insights into the origins of life.
4) Understanding DNA repair mechanisms and how they relate to disease could help develop new treatments, such as genomic therapies that insert missing genes.
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Technology will save our minds and bodies
The document discusses three emerging medical technologies: cancer immunotherapy, magnetic nanoparticles, and robots. Cancer immunotherapy works by undermining a cancer cell's defenses to allow the immune system to attack. Magnetic nanoparticles can be precisely delivered to areas needing bone regeneration. Robots are being used for surgical procedures and nanorobots may one day deliver drugs through the bloodstream. While these technologies show promise, their effectiveness varies and costs need to remain reasonable.
the cell
This document contains multiple passages about scientific research related to cells and viruses. The first passage provides background on common features of prokaryotic and eukaryotic cells. The second passage describes the role of the nucleus and DNA replication in eukaryotic cells. Subsequent passages summarize recent scientific findings on proteins that allow flu viruses to replicate, techniques to track chemotherapy using fluorescent nanoparticles, and the potential medical applications of manipulating cells and genetic material.
La celula plegable
This document discusses several scientific findings related to cells and viruses:
1. Scientists identified a protein called ANP32A that allows avian flu viruses to replicate in cells. When this protein was removed, viral infection stopped.
2. Researchers developed a technique to tag chemotherapy drugs with fluorescent nanoparticles in order to track how drugs move through cells in real time. This could help understand varying patient responses to treatments.
3. The document discusses how genetic material in cells can be manipulated for therapeutic use, and cells like stem cells may help treat conditions like Alzheimer's and Parkinson's. The cell is an important target for various medical therapies.
FOLDING. SARA SANCHEZ RESTREPO
The document discusses several studies related to lung cancer and DNA. It summarizes that mouse models show similarities to human lung cancer, allowing scientists to study disease progression. Researchers identified a gene called NF-Iβ associated with lung cancer. A separate study found specific DNA breakage characteristics in cancer cells. This molecular-level analysis improves understanding of cancer development and susceptibility.
Folding. SARA SANCHEZ RPO.
The document discusses several studies related to lung cancer and DNA. It summarizes that mouse models show similarities to human lung cancer, allowing scientists to study disease progression. Researchers identified a gene called NF-Iβ associated with lung cancer. A separate study found specific DNA breakage characteristics in cancer cells. This molecular-level analysis improves understanding of cancer development and susceptibility.
Folding sara sanchez r
The document discusses several studies related to lung cancer and DNA. It summarizes that mouse models show similarities to human lung cancer, allowing scientists to study disease progression. Researchers identified a gene called NF-Iβ associated with lung cancer. A separate study found specific DNA breakage characteristics in cancer cells. This molecular-level analysis improves understanding of cancer development and susceptibility.
Networks of proteins and diseases
The document discusses Lars Juhl Jensen's research using networks of proteins and diseases. His lab uses text mining of biomedical literature, curated databases, and experimental data to build protein-protein interaction networks. These networks are then used to study relationships between proteins, diseases, tissues, and cellular compartments. Jensen's lab has created web interfaces and databases to disseminate the results of their computational predictions and analyses of disease networks. They also use medical data like electronic health records to study relationships between diseases and adverse drug reactions.
Transforming pharmaceutical developments through big data. Amy Levál, JANSSEN.
Transforming pharmaceutical developments through big data. Amy Levál, JANSSEN. Upgraded - Health Startup Association of Finland
Presented in Upgraded Life Festival 31.5.2016 by Amy Levál, JANSSEN. http://www.upgradedlifefestival.com/ Folding: NEWS Principles of Medical Genetics
News.
Principles of Medical Genetics.
Folding: Molecular Biology.
Universidad Pontificia Bolivariana.
Juan Lab Summary 2
This document contains summaries of three laboratory assignments from a biomedical techniques course at the University of Puerto Rico - Cayey. The first summary describes learning about nanotechnology and observing nano fibers using an electron microscope. The second discusses using nanoparticles and affinity chromatography to isolate specific proteins, then using SDS-Page gel electrophoresis to measure the results. The third summary explains how computer programs help researchers visualize proteins and compare them to databases to understand protein-protein interactions and design new drugs.
Genetic mapping
Recombination sequences in DNA may help determine the order of genes on chromosomes. This allows estimation of relative distances between genes and localization of genes. A study genotyped nearly 700,000 markers in the genomes of about 9,000 individuals to identify genes associated with polycystic ovary syndrome (PCOS). The study did not find genes regulating testosterone production in the ovaries, which was previously thought to be a major factor in PCOS. Another study mapped gene activity in the first few days of human embryo development from fertilization to provide insight into the "ignition key" that switches on human development.
Plegable biologia molecular
The document discusses two recent scientific discoveries:
1) Researchers at the University of Edinburgh discovered a protein complex called Ska that helps stabilize cell division and the distribution of genetic material between daughter cells. Disruptions to this process could lead to cancer, offering new insights into cancer development.
2) A team at the University of California, Davis found that new genes can arise from ancestral non-coding DNA sequences, which is occurring at a high rate across animals and plants. Random mutations can cause non-coding DNA to be transcribed, forming new genes over time through selection. Understanding how genomes change could inform future therapies.
Disease Powerpoint
Scientists at Harvard have developed a new cancer vaccine in pill form containing polymer disks saturated with tumor-specific antigens. In mouse studies, the magnetic nanodisc vaccines induced cancer cells to undergo apoptosis when implanted in the skin near tumors, leading to remission and longer survival for many mice. However, similar human trials of the vaccine failed to show effectiveness against cancer.
DNA– REPAIRING PROTEIN MAY BE KEY TO PREVENTING RECURRENCE OF SOME CANCER ...
The document discusses two scientific articles about discoveries related to cancer recurrence and stem cells. The first article describes a DNA-repairing protein that may help prevent cancer recurrence by allowing cancer cells to repair DNA damage from chemotherapy. The second article finds that a retrovirus present in the human genome is active in pluripotent stem cells and could help develop new gene therapy treatments.
Cancer cells use our nerves to spread from one part of our body to another.
Cancer cells use nerves to spread to other parts of the body, and recent studies have uncovered that tumors form a partnership with nerves to promote their growth. Research in 2013 and 2019 revealed that nerve fibers near tumors supply them with neurons to enhance growth, and neural precursor cells in the brain migrate to prostate tumors in mice. Researchers are now attempting to target this relationship between tumors and nerves to stop cancer progression and develop new therapies.
DNA replication
The document discusses two studies related to DNA replication and cancer. The first study found that certain enzymes in the APOBEC family can cause mutations during DNA replication by deaminating cytosines, potentially leading to cancer. The second study identified a protein pathway that some cancer cells use to replicate their DNA and which could be a target for new cancer therapies. Understanding the processes of DNA replication and how they can be disrupted provides insights into cancer development and new opportunities for diagnosis and treatment.
DNA replication
The document discusses two recent scientific findings related to cancer research. First, scientists discovered that the APOBEC protein, which normally fights viruses by modifying single-stranded DNA, can cause mutations in human DNA when the DNA replication process goes wrong. Abnormalities that leave parts of DNA single-stranded allow APOBEC to act as a mutagen. Second, the FDA approved the drug Halaven to treat liposarcoma, a rare soft tissue cancer. Halaven blocks cell division and has been shown to be effective against tumors, though it can lower white blood cell count. The findings contribute to understanding cancer causes at the molecular level and to developing new targeted treatments.
Emerging collaboration models for academic medical centers _ our place in the...
- The document discusses emerging collaboration models between academic medical centers and other organizations in the genomics and precision medicine field, as genomic sequencing capabilities advance and more clinical cases are needed to power artificial intelligence platforms. It explores new partnership approaches around data sharing, patient engagement, infrastructure needs, and how academic medical centers can position themselves in this evolving ecosystem.
BE Retreat 2015 Poster
This document discusses using machine learning models to predict pathogen phenotypes like drug resistance and virulence from genomic data. It presents results from models trained to predict HIV drug resistance from protease sequences with good performance. The models captured the temporal emergence of resistance after new drug approvals. The approach aims to establish genomic surveillance pipelines for pathogens by computing a "risk factor" from sequence data to help monitor zoonotic pathogens. Challenges include mapping genotypes to phenotypes given epistasis and lack of data. The vision is to assay pathogen populations to build genotype-phenotype datasets to train models that can quantify risk profiles and inform interventions.
ELISA TEST
The document discusses several ways that ELISA tests can be used to detect proteins and antibodies in blood samples. It describes a study that found high levels of the DEK gene in plasma are correlated with better outcomes for head and neck cancer patients. The document also summarizes the development of a new type of simple test strip that can detect blood proteins with high precision and may have applications for disease diagnosis, food/drug testing, and environmental monitoring.
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Transforming pharmaceutical developments through big data. Amy Levál, JANSSEN.
Transforming pharmaceutical developments through big data. Amy Levál, JANSSEN.
DNA– REPAIRING PROTEIN MAY BE KEY TO PREVENTING RECURRENCE OF SOME CANCER ...
DNA– REPAIRING PROTEIN MAY BE KEY TO PREVENTING RECURRENCE OF SOME CANCER ...
Cancer cells use our nerves to spread from one part of our body to another.
Cancer cells use our nerves to spread from one part of our body to another.
Emerging collaboration models for academic medical centers _ our place in the...
Emerging collaboration models for academic medical centers _ our place in the...
Similar to DNA STRUCTURE
DNA, the great mistery
This document discusses two scientific articles about cellular processes and potential applications to cancer treatment. The first article describes how a newly identified protease, Wss1, can chop down the protein components of DNA-protein crosslinks, allowing cells to replicate their genome. The second article discusses how DNA origami was used to test the effects of ephrin placement on the EphA2 receptor in cancer cells, finding it reduced invasiveness. The document concludes that further research using specialized techniques can improve understanding of disease pathophysiology and lead to potential cures in the future.
Plegable biologia molecular
The document discusses several topics related to DNA replication and repair:
1) A study found that faulty proteins involved in DNA repair may be linked to ovarian cancer recurrence and response to PARP inhibitor drugs.
2) PARP inhibitors are being tested for ovarian cancer patients with BRCA1/BRCA2 mutations or other damaged DNA repair proteins.
3) Research is exploring an earlier genetic molecule called TNA that may have preceded DNA and RNA due to its simpler structure and ability to self-replicate, providing insights into the origins of life.
4) Understanding DNA repair mechanisms and how they relate to disease could help develop new treatments, such as genomic therapies that insert missing genes.
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This document discusses new research that has developed a tool to analyze DNA and RNA strands much faster, in hours rather than months. Typically, specific DNA sequences were studied using melting curve analysis, but this method was found to be inaccurate. The new tool can more accurately measure thermodynamics at different temperatures and variables. It will make analysis available to more researchers. Faster DNA analysis could help further research on cell mutations and diseases, potentially leading to improved treatments by better understanding genetic and environmental factors involved in health conditions.
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DNA contains the genetic blueprint for human life. It can be used to diagnose diseases by comparing DNA sequences between past and present humans. DNA is transcribed into RNA, some of which encodes proteins and some that performs regulatory functions by determining gene expression. Scientists have discovered that up to 30% of human DNA is conserved at the RNA structure level through a process called transcription. Understanding how RNA is regulated through interactions with proteins and sequences is important for identifying patterns involved in diseases and their treatment.Reparación material genético
Scientists have developed new methods to study DNA structure and mutations. One study showed how smoking can chemically alter DNA building blocks, leading to mutations, and researchers created artificial counterparts to detect specific mutation sites. Another found that DNA replication leaves about 1.5% of "scaffold" sequences unremoved, in regulatory gene switches, causing diseases. Understanding these scaffolds may help find disease-causing mutations, aiding treatment.
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The document discusses two studies on the causes of cancer at the chromosomal and DNA level. The first study found that dramatic structural changes to chromosomes could not be explained by standard models of DNA damage and were a major cause of cancer proliferation. The second study discovered the overexpression of repetitive satellite DNA sequences in common tumor cells that are normally found in heterochromatin and centromeres. Understanding the molecular causes of diseases like cancer will enable early diagnosis, new therapeutic targets, and improved treatment strategies.
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pleable biologia molecular
The document discusses transcription and RNA processing. It summarizes two scientific articles about regulating DNA transcription in bacteria and accessing DNA in mitochondria to treat disease. The first article finds that a riboswitch can regulate transcription in bacteria and may be a target for new antibiotics. The second discovers compounds that can access mitochondrial DNA to silence genes associated with nerve and muscle diseases. The medical utility section argues that further research on transcription and RNA processing could provide new treatments for common neurological disorders and address the growing problem of antibiotic resistance.
DNA Repair
DNA Repair is a process that corrects a damage in the cell but not always it is good for her, sometimes this reparation is the real problem.
Biology m vanessa (2)
Scientists have discovered seven new DNA regions that are linked to an increased risk of prostate cancer. A study of prostate cancer patients found variants in these DNA regions that are associated with carcinogenesis. This discovery may help explain the 25% risk of familial prostate cancer. Identifying the specific genes influencing prostate cancer risk can lead to new prevention techniques.
Biology molecular vanessa
Scientists have discovered seven new DNA regions that are linked to an increased risk of prostate cancer. A study of prostate cancer patients found variants in these DNA regions that are associated with carcinogenesis. This discovery may help explain the 25% risk of familial prostate cancer. Identifying the specific genes and DNA regions involved in prostate cancer risk could allow for new prevention techniques.
Plegable biomol Ana Maria Parada Pérez.
The document discusses two scientific discoveries. The first is that an enzyme called UvrD was found to reverse stalled transcription machinery in E. coli, allowing RNA polymerase to backtrack and expose problems in the DNA strand to facilitate repair without terminating transcription. The second discovery found that a genetic mutation in the DNA repair gene POLB in mice unexpectedly caused lupus-like symptoms, identifying a potential genetic cause of the autoimmune disease lupus in humans. Finding the causes of diseases like lupus could help develop new and less toxic treatments. Both discoveries provide insights that could improve understanding of diseases and lead to better prevention and treatment options.
Plegable: Biología Molecular
Biología Molecular
Plegable
New discoveries of elements involved in genetic alteration and tools to find them
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Dna repair mechanisms
P53 protein can repair DNA damage before cell replication. Studies found higher rates of germline DNA repair mutations in men with metastatic prostate cancer, such as with the BRCA1, BRCA2, MHSH2, and HOXB13 genes. These mutations were independent of family history and age of diagnosis. A limitation is that the studies only focused on specific genes and not how multiple genes may interact to influence disease. The student notes that identifying DNA mutations could help various cancer types and that education is needed on tobacco and UV radiation risks.
FOLDING
This document summarizes two recent discoveries: 1) A new "megapixel" DNA replication technique that can detect single nucleotide variations and rare mutations with greater sensitivity and precision than previous methods. 2) The identification of two new bases in DNA, 5-formylcytosine and 5 carboxylcytosine, that are involved in DNA methylation and demethylation and could advance stem cell and cancer research. The document discusses how these discoveries may enable earlier disease diagnosis and more precise biomedical research and diagnostics.
DNA repair mechanisms
This document discusses two recent studies on DNA repair mechanisms and their implications for cancer research and treatment. The first study found a higher incidence of germline mutations in DNA repair genes in men with metastatic prostate cancer compared to localized disease, which could enable more personalized cancer therapies. The second study was able to film the enzymes involved in DNA repair, providing insights into the repair process that may help counter cancer's resistance to chemotherapy and develop new treatments. Both studies increase understanding of cancer at the molecular level and open doors to improved early detection and more targeted therapies.
Plegable
Scientists have identified molecular bases for DNA breakage, a hallmark of cancer cells. Studying DNA replication in fragile sites could provide insights into cancer development. Understanding weak areas in the DNA that are prone to breakage may help advise new therapeutic interventions and allow modification of cancer progression. More accurate DNA testing techniques in laboratories could help physicians improve cancer diagnosis and treatment.
Mechanisms of genetic material repair.
The mechanisms of DNA repair help us maintain the body in a normal physiological state, despite of the constant inducing damage that we are exposed.
But if these repair mechanisms fail for some reason it could cause mutations, cell death and many diseases.
Therefore, a low mutation rate indicates the efficiency of repair mechanisms, but a failure of these will be the cause of several mutations.
Several studies point to the discovery of new mechanisms of repair, so try to create treatments for diseases.
DNA repair and replication - Biology
This document summarizes and reviews two medical news articles about recent research on DNA damage and repair. The first study found that cancer cells may simplify their genomes to proliferate more easily, making the cells more vulnerable to DNA-damaging drugs. The second mapped the specific locations in the genome where cigarette smoking causes DNA damage, providing insights to help prevent and treat smoking-related lung cancer. The student concludes that further investigating DNA repair and damage mechanisms could reveal new treatment strategies and advance the understanding and prevention of diseases like cancer.
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Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
How to choose the best dermatologists in Indore.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.The Nervous and Chemical Regulation of Respiration
These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
share - Lions, tigers, AI and health misinformation, oh my!.pptx
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• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
pathology MCQS introduction to pathology general pathology
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Ketone bodies and metabolism-biochemistry
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June 2024 Oncology Cartoons By Dr Kanhu Charan Patro
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The Nervous and Chemical Regulation of Respiration
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DNA STRUCTURE
- 4. Watson & Crick described the double stand DNA, this one is the base of the genetic studies because there are many pathologies that can be treated if there is information about their genetic reason.
- 5. There is a new way to identify the genes that may cause autism spectrum disorder
- 6. The researchers used a functional map of the brain to provide a prediction of some autism genes
- 7. Researchers created an interactive web portal where there is information to any biomedical researcher about autism genes
- 8. This method is cheaper and faster than others and this will help to many investigators
- 9. I think this investigation is so important because If we know what genes are implicated in different diseases, we could develop better treatments, plus this method is cheaper and faster and that's good for everyone .
- 10. The DNA can be damaged by external agents like UV radiation.
- 11. The RNA polymerase is responsible for stop the production of proteins if there is a damage in the DNA
- 12. Mfd, UvrA, UvrB and UvrC are proteins and they interacting with the RNA polymerase to repair the DNA
- 13. This can be a process implicated in the resistance of cancer cells against chemotherapy or radiation therapy.
- 14. I think this is very useful for the treatment of carcinogenic cells and resistant bacteria because it could be an alternative to control the cellular over-excited growth
- 15. Many syndromes have their cause in mutations of the DNA
- 16. Some bacteria could be destroyed if We could keep out the mechanism of the repair of the ADN
- 17. If we discover how to avoid tumor resistance to therapy in cancer cells We could find the cure against cancer
- 18. Many diseases need a gene therapy and if We know which are the implied genes the treatment might be better
- 19. • Princeton University. (2016, August 01). Autism genes identified using new approach. ScienceDaily. Retrieved August 06, 2016 from www.sciencedaily.comreleases/2016/08/160801113827.htm • CNRS (Délégation Paris Michel-Ange). (2016, August 3). The keys to a major process in DNA repair. ScienceDaily. Retrieved August 6, 2016 from www.sciencedaily.com/releases/2016/08/160803140242.htm • Martinez Sánchez, Lina Maria. Biología Molecular.8.ed. Medellin:UPB. Fac.Medicina.