This document discusses recognizing features of gait due to bone and joint impairments. It provides information on measuring and visualizing bone deformities such as femoral anteversion and tibial torsion. Examples of gait graphs are presented to analyze impairments like persistent femoral anteversion and abductor weakness that cause increased internal hip rotation throughout the gait cycle. The effects of bone deformities on lever arms and gait compensation strategies are also examined.
Physiotherapeutic Scoliosis Specific Exercises (PSSE): Recent evidence for th...Nikos Karavidas
The recent high methodological quality studies (RCT's) have proved the effectiveness of the PSSE for the scoliosis treatment (Level of Evidence I). The international scientific societies SRS, SOSORT, AAP, AAOS, POSNA recognize that the PSSE can halt the progression of scoliosis and must be the first step of treatment in curves below 25 degrees
A 100% free course for passionated cyclists, trainers, coaches, bikefitters that want to apply a scientific know-how on bike fittings and pedalling style evaluation to enhance performance and comfort
1) Various types of neurodynamic examination and mobilization techniques.
2) The proposed mechanisms behind the neurodynamic examination and mobilization techniques
3) Apply knowledge of the various neurodynamic mobilization techniques in the planning of a comprehensive rehabilitation program
What/Where is the true source of PFP?
What theories do we use for diagnosing PFP and how does literature support the theories?
How can we better treat “PFPS” patients through a more thorough evaluation and the developing classifications of PF disorders?
biomechanics of foot and ankle discusses the bony components of foot and ankle and discusses the architectural organization of the foot, and discusses the importance of ligamentous and muscular structures of foot and ankle that supports the joint and helps in locomotion.
Physiotherapeutic Scoliosis Specific Exercises (PSSE): Recent evidence for th...Nikos Karavidas
The recent high methodological quality studies (RCT's) have proved the effectiveness of the PSSE for the scoliosis treatment (Level of Evidence I). The international scientific societies SRS, SOSORT, AAP, AAOS, POSNA recognize that the PSSE can halt the progression of scoliosis and must be the first step of treatment in curves below 25 degrees
A 100% free course for passionated cyclists, trainers, coaches, bikefitters that want to apply a scientific know-how on bike fittings and pedalling style evaluation to enhance performance and comfort
1) Various types of neurodynamic examination and mobilization techniques.
2) The proposed mechanisms behind the neurodynamic examination and mobilization techniques
3) Apply knowledge of the various neurodynamic mobilization techniques in the planning of a comprehensive rehabilitation program
What/Where is the true source of PFP?
What theories do we use for diagnosing PFP and how does literature support the theories?
How can we better treat “PFPS” patients through a more thorough evaluation and the developing classifications of PF disorders?
biomechanics of foot and ankle discusses the bony components of foot and ankle and discusses the architectural organization of the foot, and discusses the importance of ligamentous and muscular structures of foot and ankle that supports the joint and helps in locomotion.
Differences between the lengths of the upper and/or lower arms and the upper and/or lower legs.
Except in extreme cases, arm length differences cause little
or no problem in how the arms function.
Pamper yourself with massages that would rejuvenate you while helping you detox and move lymphatics. At AWAREmed Health and Wellness Resource center Dr. Dalal Akoury Help designing healing therapeutic massages for you.
While working with the Latika Roy Foundation, I had been training rehabilitation professionals, on various aspects of disability rehabilitation. This course was an attempt to capacity building of rehabilitation professionals in Dehradun. I am a physiotherapist with Post Graduate Diploma in Developmental Therapy and a Public Health professional. I like training and developing professionals in disability and public health. I can be reached at physionalin1@indiatimes.com
Specialized Transfemoral External Prosthetic Support PowerPoint PresentationGarret Senti
The Specialized Transfemoral External Prosthetic Support team's presentation on the progress made over a year of exploring the possibilities of a mechanical external support for a transfemoral prosthetic. The presentation describes the effort put into concepts and prototypes that would be utilized with a prosthesis which includes background information, initial prototype, final prototype, tests performed, results obtained, and the overall outcome of the project.
Note: Download if you want to view all animations and videos to enhance the knowledge about the team's prosthetic support.
28,000 ankle sprains occur daily in the US (Kaminski 2013)
Ankle is the 2nd most commonly injured body site. (Ferran 2006)
Ankle sprains are the most common type of ankle injury. (Ferran 2006)
A sprained ankle can happen to athletes and non-athletes,
children and adults.
Inversion injury most common mechanism (Ferran 2006)
Only risk factor is previous ankle sprain (Ferran 2006)
Sex , generalized joint laxity or anatomical foot types are
not risk factors. (Beynnon et al. 2002 )
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
5. Bone Impairments
Deformations of whole bones:
• Persistent femoral anteversion
• Increased tibial torsion
• Bowing of long bones
Most often treated by osteotomies.
5
6. Joint Impairments
Deformations of joints from local
deformation of bones and/or cartilage and or
pathology in ligamentous constraints.
• Knee flexion contracture
Tend to be treated by osteotomies or guided
growth (eight plates or stapling)
6
9. “Lever-arm disease”
All bones act mechanically as levers.
“Lever-arm disease” or “dysfunction” really just means
bony abnormality and is not sufficiently specific to be
useful.
Often used to refer to torsional malalignment but the way
that this affects lever mechanisms is particularly poorly
understood.
“Lever-arm disease” is a phrase which is best avoided!
9
16. Normal femur development
16
Von Lanz T (1953). Z Anat 117:317-45.
Shands A, Steele M (1958). Journal of Bone and Joint Surgery 40-A:803.
Crane L (1959).Journal of Bone and Joint Surgery 41-A:421.
Fabry G, MacEwen GD, Shands AR (1973). Journal of Bone and Joint Surgery 55-A:1726-1738.
0
10
20
30
40
50
0 2 4 6 8 10 12 14 16 18
Anteversion(degrees)
Age( years)
Lanz
Shands
Crane
Fabry
17. Femoral anteversion
The reduction in femoral anteversion is
almost certainly a consequence of bone
remodelling of the whole femur and not just
the femoral neck.
17
27. 27
-30°
-20°
-10°
0°
10°
20°
30°
0° 20° 40° 60° 80° 100°
Hiprotation
% gait cycleHip abductor strength 3(2) 3(2)
Hip adductor tone (Ashworth) 1 1
Hip internal rotation range 57°int 61°int
External rotation range 8°ext 5°ext
Femoral anteversion 21°int 24°int
28. 28
a
Features: Comments:
a. too much int. hip rotation through cycle bilaterally
Supplementary data: left right Comments:
Hip internal rotation range 57° 61°
Hip external rotation range 8° 5°
Femoral anteversion 21° 24°
Hip abductor strength 3 3
Impairment: Bilateral persistent femoral anteversion Evidence: clear Effect on walking: major
Impairment: Bilateral hip abductor weakness Evidence: clear Effect on walking: major
29. Hemiplegia
29
-30°
-20°
-10°
0°
10°
20°
30°
0° 20° 40° 60° 80° 100°
Pelvicrotation
% gait cycle
-30°
-20°
-10°
0°
10°
20°
30°
0° 20° 40° 60° 80° 100°
Hiprotation
% gait cycle
-30°
-20°
-10°
0°
10°
20°
30°
0° 20° 40° 60° 80° 100°
Footprogression
% gait cycle
Hip abductor strength 3(1) 5(2)
Hip adductor tone (Ashworth) 1 0
Hip internal rotation range 56°int 44°int
External rotation range 1°ext 33°ext
Femoral anteversion 31°int 15°int
Features: Comments:
Supplementary data: left right Comments:
Impairment: Evidence: Effect on walking:
Impairment: Evidence: Effect on walking:
a. Increased left hip. rot. throughout
a
c. Increased left ext. pel. rot. throughout Compensation for internal hip rot
c
d
d. Inc. bilat. int. foot prog. throughout On left consequence of int. hip rot
On right consequence of int. pel. rot.
b b. Right hip within normal limits
Internal hip rot. range 56 44
External hip rot. range 1 33
Femoral anteversion 31 15
Hip abductor strength 3 5
Left femoral anteversion
Left hip abductor weakness
clear
clear
marked
marked
34. Normal tibia development
34
Can be increased or decreased in CP suggesting different mechanism to anteversion
Staheli, L.T., et al., J Bone Joint Surg Am, 1985. 67(1):39-47.
35. Knee forward foot out
Is it in the tibia or in the foot?
35
-30°
-20°
-10°
0°
10°
20°
30°
0° 20° 40° 60° 80° 100°
Footprogression
% gait cycle
-30°
-20°
-10°
0°
10°
20°
30°
0° 20° 40° 60° 80° 100°
Anklerotation
% gait cycle
-30°
-20°
-10°
0°
10°
20°
30°
0° 20° 40° 60° 80° 100°
Footprogression
% gait cycle
-30°
-20°
-10°
0°
10°
20°
30°
0° 20° 40° 60° 80° 100°
Anklerotation
% gait cycle
Ankle rotation
normal so
deformity must
be in tibia
Ankle rotation
sufficiently
external to
explain foot
progression
51. “True” joint contractures
• Consequence of focal impairment of
bone, cartilage andor ligaments
• Distinguish from limited joint range as a
consequence of short muscles
51
52. 52
Knee flexion is probably the impairment limiting knee flexion
Measured
knee flexion
contracture