The document discusses receptor serine/threonine kinases and their ligands. It defines receptors and ligands, explaining that ligands bind to receptors to cause a cellular response. It describes that serine/threonine kinases regulate phosphate transfer and are also known as TGF beta receptors, which bind the TGF beta ligand. Key proteins in the TGF beta signaling pathway include SMAD proteins and nuclear localization signals. The document also discusses how serine/threonine kinase receptors can phosphorylate other proteins and regulate processes like cell proliferation and differentiation after ligand binding. Dysfunctions in these receptors are implicated in diseases like cancer and Alzheimer's.

1. DNase
Group-08

2. Receptor
serine/threonine
kinase

3. Saima Mubashshira
Roll-013
3

4. Contents:
Receptor-ligand basic concept
Receptor-ligand binding

5. Receptor
A receptor is a protein molecule that
receives chemical signals from outside
a cell & when such chemical signals
bind to a receptor they cause some
form of cellular/tissue response.
5

6. Ligand
• A ligand is a substance that forms a complex
with receptor to serve a biological purpose.
• A ligand can be small molecule/ion/protein.
• Ligand includes substrates,inhibitors,activators
or neurotransmitters.
6

7. Ligand-Receptor Binding:
7

8. General functions of receptors:
8

9. Md. Fahim Saklain
Roll-025
9

10. Contents
▪ Kinase activity
▪ Introduction & Types of Ser/Thr Kinase
▪ Initiation of TGF Beta signaling pathway

11. Kinase
A protein that regulates the
transfer of phosphate groups
from high-energy phosphate-
donating molecules to specific
substrates like amino acid
residues.11

12. Is there any other name of Serine
Thrionine Kinase receptor?
The other name of Serine Thrionine Kinase is TGF
beta receptor as Transforming growth factor beta
(TGF-β) binds to it.
12

13. 13
Ser/Thr kinase receptor
Or
TGF Beta receptor
Type-I Type-II

14. Important proteins in Ser/Thr kinase
receptor or TGF Beta signaling
pathway
SMAD-Smads (or SMADs) comprise a family of structurally
similar proteins that are the main signal transducers for
receptors of the transforming growth factor beta (TGF-B)
superfamily, which are critically important for regulating cell
development and growth.
NLS-
A nuclear localization signal or sequence (NLS) is an amino
acid sequence that 'tags' a protein for import into the cell
nucleus by nuclear transport.
14

15. Afsana Rupa
15

16. TGF Beta(TGF-β)
Signaling pathway

17. 17

18. Bidhan Sarker
18

19. Contents
Serine Thrionine Kinase activity
Cell proliferation
Cell differentiation
19

20. Receptor Ser/Thr Kinase phosphorylates
other intracellular proteins
Ser-Thr Kinase receptor acts as a local mediator to
regulate wide range of biological function
20

21. Main two expressions of Ser/Thr
Kinase Receptor after binding ligand
▪ Cell Proliferation
▪ Cell Differentiation
21

22. Cell Proliferation
▪ Cell proliferation is the process that results in an increase of the
number of cells, and is defined by the balance between cell
divisions and cell loss through cell death or differentiation
22

23. Cell Differentiation
▪ Cellular
differentiation is
the process by
which a less
specialized cell
becomes a more
specialized cell
type.
23

24. Faria Rahman
Roll-044
24

25. Contents
▪ Importance of Ser/Thr Kinase receptor
▪ Dysfunctionality of Ser/Thr Kinase Receptor
25

26. Importance of Ser/Thr Kinase
Receptor
During Development
▪ Embryonic Development,
▪ Cell specification,
▪ Extracellular matrix production
In Adult
▪ Tissue Repair
▪ Immune Regulation
▪ Cell Plasticity & Migration
▪ Programmed Cell Death
26

27. Dysfunctionality of Ser/Thr
Kinase receptor
▪ Tumor promotion
▪ Causing Alzheimer’s disease
▪ Dysfunction in vascular biology
27

28. Inhibitory Smad7: emerging roles
in health and disease.
• Smad7 is an inhibitory Smad protein that blocks
Transforming Growth Factor-beta (TGF-β) signaling
through a negative feedback loop, also capable of
mediating the crosstalk between TGF-β and other
signaling pathways.
• Smad7 plays a key role in the control of various
physiological events, and even in some pathological
processes including fibrosis and cancer.
• Smad7 emerging roles in the development of several
human diseases that identify this protein as a potential
therapeutic target.28