Tuberculosis persists as a global public health problem, with multi-drug resistant TB found in many countries including India. Studies have found MDR TB levels between 2-14% in some areas of India. The emergence of drug resistant TB can be prevented through adequate case finding, prompt diagnosis and effective treatment under DOTS programs. DOTS Plus programs were established to diagnose and treat MDR TB through quality assured drug susceptibility testing and the use of second line drugs administered properly under DOTS Plus guidelines. Contact management is also important to prevent the spread of MDR TB.