Recent advances in endodontics include improved methods for diagnosis using tools like pulse oximetry and laser Doppler flowmetry. Cone beam CT and newer apex locators provide more accurate determination of working length. Advances in instrumentation include nickel-titanium rotary files and self-adjusting files. New irrigants and devices improve cleaning and disinfection of the root canal. Regenerative endodontic procedures aim to regenerate damaged tissues through stem cell therapy and tissue engineering.