Livestock sector is an important sector in indian economy. To boost the productive performance of existing livestock population in india, biotechnolgy plays a key role to fullfill this.
Genetic material of plants which is of value as a resource for present and future generations of people is referred to as plant genetic resources.
The whole library of different alleles of a species or sum total of genes in a species is known as gene pool, also called germplasm, genetic stock and genetic resources.
The term gene pool was coined by Dobzhansky in 1951.
The term germplasm was first used by Weismann in 1883.
Livestock sector is an important sector in indian economy. To boost the productive performance of existing livestock population in india, biotechnolgy plays a key role to fullfill this.
Genetic material of plants which is of value as a resource for present and future generations of people is referred to as plant genetic resources.
The whole library of different alleles of a species or sum total of genes in a species is known as gene pool, also called germplasm, genetic stock and genetic resources.
The term gene pool was coined by Dobzhansky in 1951.
The term germplasm was first used by Weismann in 1883.
The presentation gives overview of production of secondary metabolites using callus culture as well as tissue culture techniques. Various batch and continuous culturing process are described on the basis of secondary metabolite to be synthesised.
A gene knockout is a genetic technique in which one of an organism's genes is made inoperative ("knocked out" of the organism). However, gene knockout can also refer to the gene that is knocked out or the organism that carries the gene knockout. Knockout organisms or simply knockouts are used to study gene function, usually by investigating the effect of gene loss. Researchers draw inferences from the difference between the knockout organism and normal individuals.
Ethical issues related to animal biotechnologyKAUSHAL SAHU
Introduction
Why are genetically modified animals produced?
Examples of transgenic animals
Why are animals used instead of genetically modified microbes or plants?
Ethical issues
Religious concerns
Responsibility of Scientists
Need for Guidelines
Conclusion
References
The presentation gives overview of production of secondary metabolites using callus culture as well as tissue culture techniques. Various batch and continuous culturing process are described on the basis of secondary metabolite to be synthesised.
A gene knockout is a genetic technique in which one of an organism's genes is made inoperative ("knocked out" of the organism). However, gene knockout can also refer to the gene that is knocked out or the organism that carries the gene knockout. Knockout organisms or simply knockouts are used to study gene function, usually by investigating the effect of gene loss. Researchers draw inferences from the difference between the knockout organism and normal individuals.
Ethical issues related to animal biotechnologyKAUSHAL SAHU
Introduction
Why are genetically modified animals produced?
Examples of transgenic animals
Why are animals used instead of genetically modified microbes or plants?
Ethical issues
Religious concerns
Responsibility of Scientists
Need for Guidelines
Conclusion
References
Spermatotoxic impact of bonny light crude oil (BLCO) ingestion on adult male ...lukeman Joseph Ade shittu
Increasing concern has been expressed about the possible declining trend in the sperm quality and sperm count of man as a result of exposure to environmental estrogenic agents in the past few years now. There is a general paucity of knowledge of BLCO ingestion on the reproductive effect. Hence, we aim to evaluate the impact of sub-lethal dose of BLCO ingestion on semen parameters of adult male mice. Initial acute toxicity study was carried out to determine the lethal dose of BLCO, which was calculated to be 37.4 mg/Kg body wt. A sub-lethal dose of 20 mg/Kg bwt /day of BLCO were then given to 8 male mice in the experimental group. While, the control group of 7 animals received equal volume of 0.9% normal saline via oral garvage for 2 weeks. Data were analysed using SPSS 12 statistical software with P < 0.05 considered statistically significant. There was a significant (P < 0.05) weight gain in the treated group with a significant (P < 0.05) reduction in sperm motility in the treated compared with control. The sperm density of treated and control were 14.5 x 106 /ml and 20.5 x 106 /ml respectively. However, there were also no significant difference in the relative testicular weight and sperm density of treated from that of the control respectively. Thus, it was concluded that BLCO ingestion is spermatotoxic in the adult male Swiss mice
The use of genetic engineering technology in animals has been associated with ethical issues, some of which relate to animal welfare. Discuss examples of genetically engineered animals and evaluate the ethical concerns of genetic engineering.
Characteristics of Anatomical Parameters of Rat Testes in Normal Conditions a...YogeshIJTSRD
The aim is to study the anatomical parameters of the testes of rats in normal conditions and under irradiation in postnatal ontogenesis.Materials and methods. The study used 124 white outbred rats in newborns, 3, 6, 9, 12 months of age. The animals were divided into 2 groups control and experimental. The rats of the experimental group were irradiated for 20 days with a total dose of 4 Gy of ionizing radiation.Results. The morphometry of the testes showed that their weight, length, and thickness in postnatal ontogeny vary unevenly. Comparison of the rate of increase in body weight and length with the weight and volume of the testes shows that with an increase in their volume, body weight increases more than length.Conclusions. It was found that in the experimental group, the parameters of physical development lag behind intact animals. The lag is more pronounced in the 6 month period. Teshayev Shukhrat Jumayevich | Baymuradov Ravshan Radjabovich "Characteristics of Anatomical Parameters of Rat Testes in Normal Conditions and Under Irradiation in the Age Aspect" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | International Research Development and Scientific Excellence in Academic Life , March 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38744.pdf Paper Url: https://www.ijtsrd.com/medicine/other/38744/characteristics-of-anatomical-parameters-of-rat-testes-in-normal-conditions-and-under-irradiation-in-the-age-aspect/teshayev-shukhrat-jumayevich
Bioethics associated with transgenic animals.pptxKaurKawaljeet
There are many ethical issues that are needed to be considered while scientifically handling and creating transgenic animals. This presentation the bioethics which are related to the transgenic animals.
Similar to Recent Advances in animal biotechnology: Welfare and Ethical Implications (20)
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...
Recent Advances in animal biotechnology: Welfare and Ethical Implications
1. DEPARTMENT OF ANIMAL SCIENCE
UNIVERSITY OF IBADAN
THE RECENT ADVANCES IN ANIMAL
BIOTECHNOLOGY: WELFARE AND ETHICAL
IMPLICATIONS
BY
OBIASOGU VALENTINE ODINAKACHUKWU
MATRICULATION NUMBER: 155490
OCTOBER, 2015
2. DEFINITION OF TERMS
• Animal biotechnology is any technological
application that utilizes animals to make or modify
products (Schook et al., 2014)
• Socrates defined ethics as “Knowing the difference
between good and evil and choosing to do good”
• Animal welfare is the science that deals with the
mental, physical health and well-being of animals
and thus, our moral obligations towards them
(Pascalev, 2006) 2
3. THE RECENT ADVANCES IN ANIMAL
BIOTECHNOLOGY
• Artificial Insemination (A.I)
• Embryo Transfer (E.T)
• Semen and Embryo Cryopreservation (S&EC)
• In-vitro oocyte maturation and fertilization (IVM/IVF)
• Sperm Sexing Technology (SST)
• Cloning
• Transgenesis
3
4. THE RECENT ADVANCES IN ANIMAL
BIOTECHNOLOGY
• A.I is the introduction of semen and viable sperm
into the female reproductive tract via artificial
means (Schook et al., 2014)
• E.T is the transfer of a cultured, 7 days old embryo
into a recipient female animal of the same specie
• S&EC is a method of preservation of semen or
embryo by freezing to ensure viability and conserve
endangered species 4
5. THE RECENT ADVANCES IN ANIMAL
BIOTECHNOLOGY
• IVM/IVF is the fertilization of an ovum by a
spermatozoon outside the body
• SST involves sorting the spermatozoa according to its
DNA content using a standard flow cytometry
equipment
• Cloning is the creation of an organism that is an exact
genetic copy of another organism
• Transgenesis is a process whereby an isolated DNA
fragment is introduced into an animal so that the
resulting animal will express a desired trait 5
6. 6FIG. 1. ARTIFICIAL INSEMINATION
Source: images.google.com
FIG. 2. PROCESS OF TRANSGENESIS
Source: images.google.com
7. BENEFITS OF ANIMAL BIOTECHNOLOGY
TECHNIQUES
• Cost saving and effectiveness (Van Eenennaam, 2006)
• Convenience and safety (Abdullah et al., 2011)
• Tremendous shortening of generation interval
• Maintenance of superior females
• Prevention from extinction and environmental
sustainability (Seamark, 1993)
• Preservation of desirable traits(Abdullah et al., 2011)
• Production of desirable sex
• Increment of the rate of genetic gain (Pascalev, 2006)
• Generation of high quality low cost embryo 7
8. DIFFERENCES BETWEEN ANIMAL WELFARE
AND ANIMAL RIGHTS
ANIMAL WELFARE ANIMAL RIGHTS
Using animals is morally right Using animals is morally wrong
We can use animals to benefit
ourselves
We should not use animals to benefit
ourselves
Our interests are always more
important than the interests of
animals
We should not invariably overrule the
interests of animals with human
interests
We should not inflict “unnecessary”
pain or death on animals
We should not inflict pain or death on
animals
We should treat animals as humanely
as convenient to us
We should always treat animals
humanely and eliminate the human
made causes of animal suffering
8Source: images.google.com
9. WELFARE AND ETHICAL IMPLICATIONS
• Loss of credibility in scientists amongst the public
(Hodges, 2003)
• Disappearance of the boundary between humans and animals
morally and biologically (Ohl and Van der Staay, 2011)
• Health, physiological complications and its long term effects
• Pain and suffering of animals (Seamark, 1993)
• Economic, environmental and social effects
(Schook et al., 2014)
• Food safety concerns (Cowan et al., 2009)
9
10. RECOMMENDATION
It is true that animal biotechnology poses some ethical
and welfare problems. However, the suggestions
animal welfare scientist’s make must comply with the
moral values of the society in other to generate
sustainable approaches to animal welfare management
(Ohl and Van der Staay, 2011)
10
11. CONCLUSION
Animal Scientist’s need to embrace a new vision
beyond the single-minded existing pursuit of
biological efficiency and move from an “Era of
Intensification” to a “Quality of Life Agricultural Era”
11
12. QUOTE
“The creatures outside looked from pig to man, and
from man to pig, and from pig to man again; but
already it was impossible to say which was which.”
George Orwell, Animal Farm
12
FIG.3. AN ILLUSRATION OF GEORGE ORWELL’S QUOTE
Source: images.google.com
13. REFERENCES
Abdullah, B. R., Wan Embong, W. K., Soh, H. H. (2011). Biotechnology in animal
production in developing countries : 2nd international conference on
agricultural and animal science, IPCBEE volume .22 IACSIT Press,
Singapore.
AgBiotechNet. (2010, October 22). Cloning hopes for extinct species. Agricultural
Biotechnology website: http:www.agbiotechnet.com.
Bazer, F., Einsiedel, E., Gaskell, G. Murray, J., Riley, M. (2010). Ethical
implications of animal biotechnology: Considerations for animal welfare
decision making Animal Agriculture’s Future through Biotechnology,
Part 9, Number 46. USA: Council for Agricultural Science and
Technology.
Cowan, T. (2011). Agricultural Biotechnology: Background and Recent Issues.
Washington, DC: Congressional Research Service On Biotechnology, the
Media and Public Policy, June 12, 2003.
Fiester, A. (2005). Ethical Issues in Animal cloning. Centre for Bioethics Papers.
Hodges, J. (2003). Livestock, ethics and quality of life. European Association for
Animal Production, Mittersill, Austria. Journal of Animal Science
2003.81:2887-2894. 13
14. REFERENCES
Krishna, S. V. (2007). Bioethics and biosafety in Biotechnology. New Age
International Limited
Lassen, J., Gjerris, M., Sandoe, P. (2006). After Dolly- Ethical limits to the use of
biotechnology on farm animals. Theriogenology
Ohl, F., Van der Staay, F. J. (2011). Animal Welfare : At The interface between
Science and Society . Journal of Livestock Science 103 (2006) 208–220
Pascalev, A. K. (2006). We and They : Animal Welfare in the era of advanced
agricultural biotechnology. The Veterinary Journal
Seamark, R. F. (1993). Recent advances in animal biotechnology : welfare and
ethical implications. Livestock production Science, 36, 5-15
Schook, L. B., Rund, L. A., Hu, W., Darfour-Oduro, K. A., Knapp, L. A.,
Rodrigues, F. M., Schachtscheider, K. M. (2014). Advances in
Animal Biotechnology. Elsevier Inc.
Straughan, R. (2006). Ethics, Morality and Animal Biotechnology. Biotechnology
and biological science research council
Van Eenennaam, L. A. (2006). What is the future of animal biotechnology.
California Agriculture Volume 60
14