Randomized Controlled Trials ppt.pptx
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Randomized controlled trials (RCTs) are considered the gold standard for evaluating health care technologies. RCTs involve randomly assigning participants into experimental and control groups to receive different interventions. This randomization helps reduce bias. The key steps of RCTs include developing a protocol, selecting and randomizing study populations, implementing the intervention/manipulation, following up with participants, and assessing outcomes. RCTs can be single, double, or triple blinded depending on who is unaware of group assignments. Types of RCTs include clinical trials, preventive trials, and risk factor trials. RCTs use randomization as the central feature to obtain comparable groups and draw valid conclusions about interventions.
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RCT.pptx
Steps in conducting a RCT
1. Drawing up a protocol
2. Selecting Reference & Experimental population
3. Randomization
4. Manipulation or Intervention
5. Follow up
6. Assessment of outcome
1. Drawing up a protocol
Aims and objectives of the study
Questions to be answered
Criteria for the selection of study and control groups
Size of the sample & allocation of subjects in both groups
Treatment to be applied - when, where, how
Standardization of working procedures and
Schedules as well as responsibilities of persons involved in the trial up to the stage of evaluation of outcome of the study.
2. Selecting Reference and Experimental Populations
Reference or target population - Population to which the findings of the trial, if found successful, are expected to be applicable (Eg: drugs, vaccines, etc.)
Experimental or Study population
Derived from the Reference population
Has same characteristics as the Reference population
Actual population that participates in the experimental study
Must give informed consent - Should be qualified or eligible for the trial
3. Randomization
Heart of the control trial
Procedure:
Participants are allocated into study and control groups
Eliminates bias and allows comparability
By random allocation every individual gets an equal chance for being allocated in to either groups.
4. Manipulation/ Intervention
Having formed the study and control group, the next step is to intervene or manipulate the study (experimental) group by deliberate application or withdrawal or reduction of a suspected causal factor
Eg: Drug, Vaccine, Dietary component, a habit
5. Follow up
Implies examination of the experimental and control group subjects at defined intervals of time in a standard manner, with equal intensity, under the same given circumstances in the same time frame till final assessment of outcome.
Attrition:
Inevitable losses to follow up (death, migration, loss of interest)
6. Assessment
a. Positive results:
Reduced incidence or severity of disease
Reduced cost to health service
Appropriate outcome in the study
b. Negative results:
Increased severity or frequency of side effects
Complications
Deaths
BIAS:
Any systematic error in the determination of association and outcome.
Bias may arise from errors of assessment of outcome due to human element
Subjective bias
Observer bias
Evaluation bias
1. Subjective Bias:
Participants, subjectively feel better or report improvement if they knew they were receiving a new form of treatment. This is known as “Subject variation”.
2. Observer Bias:
Investigator measuring the outcome of a therapeutic trial may be influenced if he knows beforehand the particular procedure or therapy to which the patient has been subjected.
3. Evaluation Bias:
Investigator may subconsciously give a favorable report of the outcome of the trial.
Blinding:
1. Single Blind Trial: Participant
2. Double Blind: Partcipant + Investigator
3. Triple Blind: Participant + Investigator + Data Analyzer
Clinical trials
From History to Application Procedure OF CLINICAL TRIALS IN INDIA. PHASES 0,1,2,3,4 & 5.IMPORTANCE, advantages, guidelines global and India. Types, Design & blinding technique.
Research methodology
This document discusses research methodology and how it can be applied to homeopathy. It defines different types of study designs including observational studies, treatment studies, randomized controlled trials, and meta-analyses. It explains how to apply these research methodologies to homeopathy through drug provings, clinical research studies, and disease-related studies while respecting homeopathic principles. Randomized controlled trials and meta-analyses are important for providing evidence but must be designed carefully to fit within homeopathic individualization and philosophy.
Research methodology
This document discusses research methodology and how it can be applied to homeopathy. It defines different types of study designs including observational studies, treatment studies, randomized controlled trials, and meta-analyses. It explains how to apply research methodologies like randomized controlled trials and meta-analyses to homeopathic drug provings and clinical research while respecting homeopathic principles. Clinical research in homeopathy should involve screening and confirming diagnoses, individualized case taking and prescribing for all patients regardless of group allocation in a blinded manner.
True experimental research design
True experimental research designs aim to establish causal relationships. They have four key elements: manipulation of the independent variable, use of control groups, random assignment of subjects to conditions, and random selection of subjects. Randomized controlled trials are a type of true experiment that are considered the gold standard for determining cause and effect. Common true experimental designs include pre-test post-test control group designs, post-test only control group designs, and Solomon four-group designs.
Randomized Controlled Trials (RCTs)
This document discusses randomized controlled trials (RCTs). It defines RCTs as experiments that randomly allocate subjects to a study group that receives treatment or a control group. RCTs are considered the gold standard for determining causality because randomization creates comparable groups free from bias. The document outlines the steps in conducting an RCT, including developing a protocol, randomizing subjects, intervening, following up, analyzing outcomes, and publishing results. It also discusses types of randomization, blinding, trial monitoring, and important ethical considerations like informed consent.
Experimental epidemiology
Experimental epidemiology involves controlled studies in which researchers introduce an intervention and observe its effects. Randomized controlled trials are considered the gold standard, as they randomly assign subjects to study and control groups to limit bias. This allows investigators to determine cause-and-effect relationships. Key features of randomized controlled trials include developing a study protocol, selecting and randomizing a population, implementing an intervention for the study group, following up with both groups, and assessing outcomes to compare results. Well-designed randomized controlled trials provide the strongest evidence for evaluating health interventions and establishing epidemiological relationships.
experimental research ppt
This document outlines an experimental research methods assignment for a group of students at Addis Ababa University College of Veterinary Medicine and Agriculture. It discusses key aspects of experimental design including objectives, variables, validity, types of designs, and potential sources of invalidity. The group's assignment is to design an experiment and address factors such as controls, randomization, measurements, and data analysis. Attention to these elements in the planning stage can help produce reliable and valid experimental results.
Study design of Prof Zak
How to scientifically conduct a clinical professional research trial? In the current era of Collaborate or parish, we need to keep this design in our mind.
Enjoy
@copyLeft
Lecture 10 Experimental study-1.pdf
The document discusses experimental study designs and randomized clinical trials. It provides information on the different phases of clinical trials including objectives, demographics, and goals. Phase I trials test safety and dosing in small groups. Phase II explores biological effects and estimates response rates. Phase III confirms efficacy in larger and more diverse populations to provide evidence for marketing approval. Randomization, blinding, and placebos are used to reduce bias. Experimental studies directly manipulate variables under controlled conditions to measure outcomes compared to control groups.
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Writing the research protocol part 2- Methodology-Dr. Yasser Mohammed Hassana...
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四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
学历顾问：微信：176555708
快速办理(新加坡SMU毕业证书)新加坡管理大学毕业证文凭证书一模一样
学校原件一模一样【微信：741003700 】《(新加坡SMU毕业证书)新加坡管理大学毕业证文凭证书》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
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一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
不能毕业如何获得(USYD毕业证)悉尼大学毕业证成绩单一比一原版制作
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一.毕业证、成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
国外毕业证、学位证、成绩单办理流程：
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2、开始安排制作毕业证、成绩单电子图；
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4、毕业证、成绩单电子版您确认信息无误之后安排制作成品；
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6、快递给客户（国内顺丰，国外DHL、UPS等快读邮寄）。
专业服务，请勿犹豫联系我！本公司是留学创业和海归创业者们的桥梁。一次办理，终生受用，一步到位，高效服务。详情请在线咨询办理,欢迎有诚意办理的客户咨询!洽谈。
◆招聘代理：本公司诚聘英国、加拿大、澳洲、新西兰、加拿大、法国、德国、新加坡各地代理人员，如果你有业余时间，有兴趣就请联系我们咨询【微信176555708】
没文凭怎么找工作。让您回国发展信心十足！
★、真实教育部学历学位认证；（一对一专业服务，可全程监控跟踪进度）
★、真实使馆认证，可以通过大使馆查询确认；（即教育部留服认证，不成功不收费）
★、毕业证、成绩单等材料，从防伪到印刷、水印到钢印烫金，高精仿度都是跟学校原版100%相同的；（敬请放心使用）
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原版一模一样【微信：741003700 】【新西兰奥克兰大学毕业证学位证书】【微信：741003700 】学位证，留信认证（真实可查，永久存档）offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原海外各大学 Bachelor Diploma degree, Master Degree Diploma
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
留学挂科(UofM毕业证)明尼苏达大学毕业证成绩单复刻办理
精仿办理明尼苏达大学学历证书＜176555708微信＞【毕业证明信-推荐信做学费单＞【微信176555708】【制作UofM毕业证文凭认证明尼苏达大学毕业证成绩单购买】【UofM毕业证书】{明尼苏达大学文凭购买}】成绩单，录取通知书，Offer，在读证明，雅思托福成绩单，真实大使馆教育部认证，回国人员证明，＞【制作UofM毕业证文凭认证明尼苏达大学毕业证成绩单购买】【UofM毕业证书】{明尼苏达大学文凭购买}留信网认证。
明尼苏达大学学历证书＜微信176555708（一对一服务包括毕业院长签字,专业课程,学位类型,专业或教育领域,以及毕业日期.不要忽视这些细节.这两份文件同样重要!毕业证成绩单文凭留信网学历认证！）（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
◆◆◆◆◆ — — — — — — — — 【留学教育】留学归国服务中心 — — — — — -◆◆◆◆◆
【主营项目】
一.毕业证【微信：176555708】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【微信：176555708】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分→ 【关于价格问题（保证一手价格）
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
选择实体注册公司办理，更放心，更安全！我们的承诺：可来公司面谈，可签订合同，会陪同客户一起到教育部认证窗口递交认证材料，客户在教育部官方认证查询网站查询到认证通过结果后付款，不成功不收费！
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
学历顾问：微信：176555708
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一比一原版(USYD毕业证)悉尼大学毕业证如何办理
USYD硕士毕业证成绩单【微信95270640】《如何办理悉尼大学毕业证认证》【办证Q微信95270640】《悉尼大学文凭毕业证制作》《USYD学历学位证书哪里买》办理悉尼大学学位证书扫描件、办理悉尼大学雅思证书！
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如果您是以下情况，我们都能竭诚为您解决实际问题：【公司采用定金+余款的付款流程，以最大化保障您的利益，让您放心无忧】
1、在校期间，因各种原因未能顺利毕业，拿不到官方毕业证+微信95270640
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面向美国乔治城大学毕业留学生提供以下服务:
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我们从事工作十余年的有着丰富经验的业务顾问，熟悉海外各国大学的学制及教育体系，并且以挂科生解决毕业材料不全问题为基础，为客户量身定制1对1方案，未能毕业的回国留学生成功搭建回国顺利发展所需的桥梁。我们一直努力以高品质的教育为起点，以诚信、专业、高效、创新作为一切的行动宗旨，始终把“诚信为主、质量为本、客户第一”作为我们全部工作的出发点和归宿点。同时为海内外留学生提供大学毕业证购买、补办成绩单及各类分数修改等服务；归国认证方面，提供《留信网入库》申请、《国外学历学位认证》申请以及真实学籍办理等服务，帮助众多莘莘学子实现了一个又一个梦想。
专业服务，请勿犹豫联系我
如果您真实毕业回国，对于学历认证无从下手，请联系我，我们免费帮您递交
诚招代理：本公司诚聘当地代理人员，如果你有业余时间，或者你有同学朋友需要，有兴趣就请联系我
你赢我赢，共创双赢
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你做代理，可以改变自己，改变他人，给他人和自己一个机会过暑假的小学生快乐的日子总是过得飞快山娃尚未完全认清那几位小朋友时他们却一个接一个地回家了山娃这时才恍然发现二个月的暑假已转到了尽头他的城市生活也将划上一个不很圆满的句号了值得庆幸的是山娃早记下了他们的学校和联系方式说也奇怪在山娃离城的头一天父亲居然请假陪山娃耍了一天那一天父亲陪着山娃辗转长隆水上乐园疯了一整天水上漂流高空冲浪看大马戏大凡里面有的父亲都带着他去疯一把山娃算了算这一次足足花了老爸元很
存档可查的(USC毕业证)南加利福尼亚大学毕业证成绩单制做办理
精仿办理南加利福尼亚大学毕业证成绩单（【微信176555708】）毕业证学历认证OFFER专卖国外文凭学历学位证书办理澳洲文凭|澳洲毕业证,澳洲学历认证,澳洲成绩单【微信176555708】 澳洲offer,教育部学历认证及使馆认证永久可查 ,国外毕业证|国外学历认证,国外学历文凭证书 USC毕业证，USC毕业证，USC毕业证，USC毕业证，USC毕业证，USC毕业证【微信176555708】，USC毕业证，专业为留学生办理毕业证、成绩单、使馆留学回国人员证明、教育部学历学位认证、录取通知书、Offer、（留信学历认证永久存档查询）采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
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留信网认证的作用:
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5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
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我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
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怎么办理(umiami毕业证书)美国迈阿密大学毕业证文凭证书实拍图原版一模一样
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留信网认证的作用:
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3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
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我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
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本公司拥有海外各大学样板无数，能完美还原。
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【主营项目】
一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
HijackLoader Evolution: Interactive Process Hollowing
CrowdStrike researchers have identified a HijackLoader (aka IDAT Loader) sample that employs sophisticated evasion techniques to enhance the complexity of the threat. HijackLoader, an increasingly popular tool among adversaries for deploying additional payloads and tooling, continues to evolve as its developers experiment and enhance its capabilities.
In their analysis of a recent HijackLoader sample, CrowdStrike researchers discovered new techniques designed to increase the defense evasion capabilities of the loader. The malware developer used a standard process hollowing technique coupled with an additional trigger that was activated by the parent process writing to a pipe. This new approach, called "Interactive Process Hollowing", has the potential to make defense evasion stealthier.
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Randomized Controlled Trials ppt.pptx
- 1. UNIT-4 EPIDEMIOLOGY Randomized Controlled Trials Submitted To, Dr. ANJALATCHI M.Sc(N)MD(AM)MBA(HA) ERA COLLEGE OF NURSING SARFARAJ GANJ LUCKNOW Submitted By, Mrs. MARY TEENA M.Sc(N) I YEAR ERA COLLEGE OF NURSING SARFARAJ GANJ LUCKNOW
- 2. At the end of the topic the learner will be able to, o Discuss about experimental epidemiology. o Define Randomized Controlled Trials. o Explain Randomized Controlled Trials. o Design the Randomized Controlled Trial. o Enlist the basic steps in conducting Randomized Controlled Trial. o List down the types of Randomized Controlled Trial. Learning Objectives
- 3. Random = Governed by chance Randomization = Allocation of individuals to groups by chance (Each sampling unit has the same chance of selection Variables = It refers to a person, place, thing or phenomenon that you are trying to measure in some way. Terminology
- 4. Independent: It is the characteristic of a psychology experiment that is manipulated or changed by research. Dependent: It is the variable that is being measured or tested in an experiment. Field trial: It is a real life experiment which test directly whether proposed interventions actually works. Community trial: The studies with whole community on experimental units.
- 5. Epidemiological experiment: It is the study of the relationships of various factors, determining the frequency and distribution of disease in a community. Quantitative: It is research strategy that focuses on quantifying the collection and analysis of data. Comparative: It is the act of comparing two or more things. Controlled experiment: An independent variable (the cause) is systematically manipulated and the dependent variables (the effect) is measured. Protocol: It is the guide book for research study .
- 6. Manipulation : It refers to control over the independent variables. Intervention: Strategy and process designed to measure the change in a situation after a systematic modification. Bias: It occurs when systemic error is introduced into sampling or testing by selecting one outcome or answer over others. Attrition: The loss of follow up due to death or migration of an individual is called as attrition.
- 7. Blinding: It refers to a practice where study participants are prevented from knowing certain information that may somehow influence them.
- 9. Introduction: It is mainly in the last 35-40 years, determined efforts have been made to use scientific techniques to evaluate methods of treatment and prevention. It is really an epidemiologic experiment. It is widely regarded as gold standard for evaluating health care technologies as it allows us to be confident that a difference in outcome can be directly attributed to a difference in the treatments and not due to some other factor. Randomized Controlled Trials
- 10. Definition: Randomized Controlled Trials are quantitative, comparative, controlled experiments in which investigators study two or more receive them in random order. The RCT is one of the simplest and powerful tools in clinical research.
- 11. Drawing up a protocol Selecting reference and experimental population Randomization Manipulation and Intervention Follow-up Assessment of outcome Basic steps in conducting a RCT
- 12. Strict protocol Aims and objectives Questions to be answered Criteria of selection 1. DRAWING UP A PROTOCOL
- 13. Reference or target population - population to which the findings of the trial, if found successful, are expected to be applicable (eg. drugs, vaccines, etc.) Experimental or study population - actual population that participates in the experimental study 2.Selecting reference and experimental population
- 14. Procedure: Participants are allocated into study and control groups Eliminates bias and allows comparability Both groups should be alike with regards to certain variables that might affect the outcome of the experiment Best done by using table of random numbers 3.Randomization
- 15. Deliberate application or withdrawal or reduction of a suspected causal factor It creates an independent variable 4.Manipulation and intervention
- 16. Implies examination of the experimental and control group subjects -: at defined intervals of time, -: in a standard manner, with equal intensity, under the same given circumstances. 5.Follow up
- 17. Positive results Negative results Biases: subject variation, observer bias, evaluation bias Can be corrected by blinding 6.Assessment
- 18. • Single • (patient doesn’t know) • Double • (neither patient nor investigator knows) • Triple • (none of the patients, investigators or analysts know) Blinding masking
- 19. Randomization is a key feature And heart of RCT
- 20. The types of Randomized Controlled Trials: Clinical trials Preventive trials Risk factor trials Cessational experiment Trial of aetiological agents Evaluation of health services
- 21. Park’s text book of preventive and Social Medicine, Park. K, 23rd edition, Bhanot, Page no: 88-97. Nursing Research statistics, Suresh K Sharma, ELESEVIER, 3rd Edition Page No: 162. www.wikipedia.com REFERENCES
- 22. THANK YOU