This patient presented with shortness of breath, palpitations, and pre-syncopal episodes. She was found to have right ventricular dilatation on echocardiogram and was admitted to rule out pulmonary embolism. CT angiogram results confirmed pulmonary embolism. She was treated with heparin and later discharged on oral anticoagulant Pradaxa to prevent further clots. Her other conditions included hypertension and obesity.
Massive pulmonary embolism case presentationSMSRAZA
A 35-year-old woman presented with sudden collapse and was found to have signs of pulmonary embolism including decreased oxygen levels and an enlarged right ventricle on echocardiogram. She received thrombolysis with alteplase and showed immediate improvement. Echocardiography is useful for evaluating suspected pulmonary embolism cases with hemodynamic instability or where other imaging is not available by showing signs like right ventricle enlargement or strain, though the findings are not specific. Thrombolysis has been shown to be more effective than other treatments for massive pulmonary embolism cases.
- Pulmonary embolism affects approximately 500,000 individuals per year in the US, with around 50,000 deaths annually.
- Deep vein thrombosis accounts for over 95% of pulmonary emboli. Risk factors for DVT and thus PE include surgery, trauma, cancer, prolonged immobility, and genetic or acquired hypercoagulable states.
- Diagnosis is suggested by symptoms like dyspnea and chest pain but requires imaging tests like CT pulmonary angiogram, ventilation-perfusion scanning, or echocardiogram to confirm the presence of emboli. Treatment involves anticoagulation with heparin or warfarin.
CVP Pulmonary artery wedge pressure monitoring: PhysiologySaneesh P J
This document discusses CVP and PCWP monitoring. It begins by outlining the cardiac cycle and then defines CVP as the pressure in the thoracic vena cava near the right atrium. Factors that can increase or decrease CVP are described. CVP monitoring involves inserting a catheter into a vein to measure pressure in the right atrium. The document then discusses PCWP monitoring, which involves advancing a catheter into the pulmonary artery to measure pressure. Normal ranges for various hemodynamic parameters are provided. Contraindications for PA catheter use are also outlined.
Patent ductus arteriosus A long case presentationNizam Uddin
The document discusses the history, diagnosis, and management of patent ductus arteriosus (PDA), including the timeline of surgical and transcatheter closure techniques. PDA is a persistent opening between the aorta and pulmonary artery that normally closes shortly after birth; if it remains open, closure may be recommended depending on the size of the shunt. Transcatheter closure has largely replaced surgery as the treatment of choice, with high success rates using devices designed to occlude the opening in the PDA.
This document discusses rescue therapies for refractory hypoxemia in acute respiratory distress syndrome (ARDS). It reviews evidence on inhaled nitric oxide (iNO), prone positioning, recruitment maneuvers and positive end-expiratory pressure (PEEP) titration, high frequency oscillatory ventilation (HFOV), and extracorporeal membrane oxygenation (ECMO). Prone positioning and iNO are first-line therapies that improve oxygenation but iNO does not reduce mortality. Recruitment maneuvers combined with PEEP titration may provide a survival benefit in severe ARDS. HFOV and ECMO are second-line therapies that can facilitate lung-protective ventilation but their effects on outcomes are unclear.
Pulmonary artery banding (PAB) is a palliative surgical technique used to reduce pulmonary blood flow in infants with congenital heart defects. It involves placing a band around the pulmonary artery to create stenosis and decrease blood flow to the lungs. PAB is used as an initial intervention for defects causing pulmonary overcirculation to prevent congestive heart failure and pulmonary hypertension before a definitive repair. It is also used to prepare the left ventricle in some patients with transposition of the great arteries prior to later procedures. The goal of PAB is to reduce pulmonary pressures and improve systemic circulation. It remains an important technique for staged surgical treatment of certain congenital heart conditions.
1) A study compared the yield of CT pulmonary angiograms (CTPAs) for patients with pulmonary embolism (PE) when clinicians overrode clinical decision support (CDS) guidelines versus adhering to them.
2) The override group had a lower yield of PE detection (4.2% vs 11.2%) and 51.3% lower odds of acute PE compared to the adherent group.
3) Guidelines for PE management include anticoagulation, thrombolysis, catheter-directed thrombolysis, surgical embolectomy, and consideration of inferior vena cava filters depending on the risk level and characteristics of the patient's PE.
Massive pulmonary embolism case presentationSMSRAZA
A 35-year-old woman presented with sudden collapse and was found to have signs of pulmonary embolism including decreased oxygen levels and an enlarged right ventricle on echocardiogram. She received thrombolysis with alteplase and showed immediate improvement. Echocardiography is useful for evaluating suspected pulmonary embolism cases with hemodynamic instability or where other imaging is not available by showing signs like right ventricle enlargement or strain, though the findings are not specific. Thrombolysis has been shown to be more effective than other treatments for massive pulmonary embolism cases.
- Pulmonary embolism affects approximately 500,000 individuals per year in the US, with around 50,000 deaths annually.
- Deep vein thrombosis accounts for over 95% of pulmonary emboli. Risk factors for DVT and thus PE include surgery, trauma, cancer, prolonged immobility, and genetic or acquired hypercoagulable states.
- Diagnosis is suggested by symptoms like dyspnea and chest pain but requires imaging tests like CT pulmonary angiogram, ventilation-perfusion scanning, or echocardiogram to confirm the presence of emboli. Treatment involves anticoagulation with heparin or warfarin.
CVP Pulmonary artery wedge pressure monitoring: PhysiologySaneesh P J
This document discusses CVP and PCWP monitoring. It begins by outlining the cardiac cycle and then defines CVP as the pressure in the thoracic vena cava near the right atrium. Factors that can increase or decrease CVP are described. CVP monitoring involves inserting a catheter into a vein to measure pressure in the right atrium. The document then discusses PCWP monitoring, which involves advancing a catheter into the pulmonary artery to measure pressure. Normal ranges for various hemodynamic parameters are provided. Contraindications for PA catheter use are also outlined.
Patent ductus arteriosus A long case presentationNizam Uddin
The document discusses the history, diagnosis, and management of patent ductus arteriosus (PDA), including the timeline of surgical and transcatheter closure techniques. PDA is a persistent opening between the aorta and pulmonary artery that normally closes shortly after birth; if it remains open, closure may be recommended depending on the size of the shunt. Transcatheter closure has largely replaced surgery as the treatment of choice, with high success rates using devices designed to occlude the opening in the PDA.
This document discusses rescue therapies for refractory hypoxemia in acute respiratory distress syndrome (ARDS). It reviews evidence on inhaled nitric oxide (iNO), prone positioning, recruitment maneuvers and positive end-expiratory pressure (PEEP) titration, high frequency oscillatory ventilation (HFOV), and extracorporeal membrane oxygenation (ECMO). Prone positioning and iNO are first-line therapies that improve oxygenation but iNO does not reduce mortality. Recruitment maneuvers combined with PEEP titration may provide a survival benefit in severe ARDS. HFOV and ECMO are second-line therapies that can facilitate lung-protective ventilation but their effects on outcomes are unclear.
Pulmonary artery banding (PAB) is a palliative surgical technique used to reduce pulmonary blood flow in infants with congenital heart defects. It involves placing a band around the pulmonary artery to create stenosis and decrease blood flow to the lungs. PAB is used as an initial intervention for defects causing pulmonary overcirculation to prevent congestive heart failure and pulmonary hypertension before a definitive repair. It is also used to prepare the left ventricle in some patients with transposition of the great arteries prior to later procedures. The goal of PAB is to reduce pulmonary pressures and improve systemic circulation. It remains an important technique for staged surgical treatment of certain congenital heart conditions.
1) A study compared the yield of CT pulmonary angiograms (CTPAs) for patients with pulmonary embolism (PE) when clinicians overrode clinical decision support (CDS) guidelines versus adhering to them.
2) The override group had a lower yield of PE detection (4.2% vs 11.2%) and 51.3% lower odds of acute PE compared to the adherent group.
3) Guidelines for PE management include anticoagulation, thrombolysis, catheter-directed thrombolysis, surgical embolectomy, and consideration of inferior vena cava filters depending on the risk level and characteristics of the patient's PE.
1. A 30-year-old male with fever and altered mental status was found to have a potassium level disturbance based on his ECG.
2. ECG changes due to electrolyte imbalances can vary between individuals and depend on other electrolyte levels as well.
3. However, certain consistent ECG features often indicate increased or decreased potassium, making ECG useful for identifying electrolyte issues if prior tracings are available for comparison.
comprehensive presentation on 2D echo use in ICu set up. helpful in finding causes of shock and also in monitoring of fluid status in critically ill patients.
This document provides guidelines for managing supraventricular tachycardia (SVT) in adult patients. SVT is defined as a tachycardia with atrial and/or ventricular rates over 100 bpm involving tissue above the His bundle. Common types of SVT include atrioventricular nodal reentrant tachycardia (AVNRT), atrioventricular reentrant tachycardia (AVRT), atrial tachycardia (AT), multifocal atrial tachycardia (MAT), sinus node reentry tachycardia, and junctional tachycardia. The document reviews the clinical presentation, differential diagnosis, evaluation and treatment of these arrhythmias. It
The document discusses the case of a 27-year-old postpartum woman presenting with worsening dyspnea and hypoxia. It then reviews the key considerations and management strategies for acute respiratory distress syndrome (ARDS), including low tidal volume ventilation, open lung strategies using recruitment maneuvers and high positive end-expiratory pressure, unconventional approaches like airway pressure release ventilation and high frequency oscillatory ventilation, and adjunctive therapies such as prone positioning. The optimal ventilator mode, settings, and adjunctive strategies depend on the individual patient's severity of lung injury and response to different interventions.
The document provides an overview of mechanical ventilation, including its history and various modes. It begins with the origins of negative-pressure ventilators like iron lungs and the later development of positive-pressure ventilators. The main goals of ventilation are to facilitate carbon dioxide release and oxygen delivery. Various modes are described that can be used for invasive or non-invasive ventilation. Settings like PEEP, respiratory rate, tidal volume, and FiO2 are outlined that can be adjusted to optimize oxygenation and ventilation. Indications for intubation and criteria for safely extubating patients are also reviewed.
The document discusses hypercapnia (excess carbon dioxide in the body) and its effects on different body systems. It classifies hypercapnia as moderate (PCO2 40-100 mmHg) or severe (PCO2 over 100 mmHg). Hypercapnia affects the central nervous system by impacting cerebral blood flow, intracellular pH, and having an inert gas narcotic effect. It can also stimulate the sympathetic nervous system, impacting the cardiovascular system by increasing heart rate and cardiac output while decreasing systemic vascular resistance. The document examines the effects of hypercapnia under different anesthetic agents as well.
ventricular premature complexes and idioventricular rhythm identification is important in the ICU ..they may run into arryhthmias..look over my seminar...
any queries...
This document discusses ARDS (acute respiratory distress syndrome), including its history, definitions, pathophysiology, and evidence-based treatment strategies. ARDS is characterized by diffuse pulmonary inflammation and reduced lung compliance. Traditional ventilator strategies have been shown to cause ventilator-induced lung injury, so current recommendations focus on lung-protective ventilation with low tidal volumes and high PEEP. Additional rescue therapies for refractory hypoxemia include recruitment maneuvers, proning, and ECMO. Proper diagnosis requires consideration of alternative conditions and use of diagnostic tools like echocardiogram, bronchoscopy, and chest CT scan.
Pulmonary Hypertension: Clinical diagnosis, hemodynamics and approach - Dr. A...akifab93
This document discusses pulmonary hypertension (PH), including its definition, pathophysiology, causes, signs and symptoms, diagnostic evaluation, and radiographic findings. PH is defined as a mean pulmonary arterial pressure over 25 mmHg at rest as assessed by right heart catheterization. The pathophysiology involves pulmonary vasoconstriction, endothelial dysfunction, vascular remodeling, and an imbalance of various mediators. PH can be caused by left heart disease, lung diseases, chronic thromboembolic disease, or other rare diseases. Common signs include dyspnea, fatigue, edema, and right heart failure. Diagnostic tests include echocardiogram, CT, ventilation/perfusion scan, right heart catheterization. Chest x-ray may show
1) Acute coronary syndrome includes unstable angina and myocardial infarction, characterized by chest pain and elevated cardiac biomarkers.
2) Clinical features include severe, prolonged chest pain that may radiate to other areas, as well as syncope, vomiting, and arrhythmias.
3) Complications include heart failure, arrhythmias like ventricular fibrillation, cardiac rupture, and remodelling. Diagnosis involves ECG, cardiac enzymes, and angiography. Management focuses on reperfusion therapy, anticoagulation, and risk factor reduction.
The heart during systole, becoming smaller, generally withdraws from the chest wall except for the apex for the reasons explained above. The effect of this withdrawal on the chest wall can be observed as an inward movement of the chest wall during systole called "retraction." Although the heart is basically comprised of two separate pumps (right and left ventricles), these two pumps operate normally at two vastly different pressures. Left ventricular systolic pressures being approximately five times higher than that of the right ventricle, its wall tension is much higher, resulting in the increased wall thickness of the left ventricular chamber. The effect of the increased muscle mass on the left side leads to dominance of the left-sided hydrodynamic forces described above. This results in the left ventricular apex as the only area of normal contact during systole. The rest of the heart essentially retracts from the chest wall. In a normal heart, this retraction of the chest wall can be observed to be located medial to the apical impulse and involving part of the left anterior chest wall (20). Even the right ventricle, which is anatomically an anterior structure, is normally pulled away from the chest wall because of its own contraction (becoming smaller) and, more importantly, the septal contraction also pulling the right ventricle posteriorly. This retraction observed in normal patients is located medial to the apical impulse (23,24). It can be best appreciated with patients in the left lateral decu-bitus position with a palpating finger only on the apical impulse with clear view of the rest of the precordium for proper observation of the inward movement of the retraction (opposite in direction to the outward movement of the apical impulse). This "medial retraction" identifies and indicates that the left ventricle forms the apical impulse. The extent of the area of medial retraction may be variable depending on both cardiac and extracardiac factors such as the compliance of the chest wall. It may sometimes be noted only over a small area very close to the apex beat.
A pulmonary embolism occurs when a blood clot forms in the deep veins of the legs or pelvis and travels through the bloodstream, lodging in the pulmonary arteries of the lungs. It can be difficult to diagnose and is a potentially life-threatening condition. Diagnostic tests may include a d-dimer blood test, CT scan, ventilation-perfusion scan, echocardiogram, and angiogram. Treatment involves anticoagulation medications to prevent further clotting and thrombolysis in some severe cases. Prevention by minimizing risk factors for deep vein thrombosis is important.
Ventilator Management In Different Disease EntitiesDang Thanh Tuan
The document discusses ventilator management in different disease entities. It covers indications for mechanical ventilation in conditions like respiratory failure, ARDS, COPD, chest trauma, and head injury. For ARDS specifically, it summarizes the key findings of the NIH ARDS Network trial which demonstrated that a lower tidal volume strategy of 6 ml/kg predicted body weight reduced mortality compared to the traditional higher tidal volume approach.
This document discusses supraventricular tachycardias (SVT). It defines different types of SVT including paroxysmal SVT, which is common in emergency rooms. Quality of life is often poor for those with paroxysmal SVT. The document discusses mechanisms of SVT including reentry circuits, enhanced automaticity, and triggered activity. It provides details on differentiating AV nodal reentrant tachycardia from AV reentrant tachycardia using electrocardiogram findings. Treatment options discussed include carotid sinus massage, adenosine, and catheter ablation.
1. Mitral stenosis is most commonly caused by rheumatic fever and results in thickening and calcification of the mitral valve, reducing the valve orifice area and obstructing blood flow from the left atrium to ventricle.
2. The pathophysiology involves elevated left atrial pressure, pulmonary hypertension, and reduced cardiac output. Symptoms range from easy fatigability to pulmonary edema.
3. Physical exam findings include an opening snap, rumbling diastolic murmur, and signs of right heart failure in severe cases. Severity is graded based on orifice area, pulmonary artery pressure, and NYHA functional
Dr. Jakeer Hussain discusses pneumothorax, beginning with an introduction and definition. He then covers the classification of pneumothorax as either spontaneous, traumatic, or iatrogenic. Spontaneous pneumothorax is further classified as primary or secondary. The document discusses signs, symptoms, investigations including x-ray and CT scan findings, differential diagnosis, quantification methods, and various treatment options including observation, oxygen supplementation, needle aspiration, tube thoracostomy, medical or VATS pleurodesis, and open thoracotomy.
1) The proposal presents a pre-hospital thrombolytic therapy (PHT) pilot project in Temerloh, Pahang to reduce door-to-needle times for STEMI patients by administering thrombolytics in the field before transporting patients to hospitals.
2) The project would involve two Klinik Kesihatan as pilot sites for PHT. Paramedics and doctors would be trained to recognize STEMI, perform ECGs in the field, and administer thrombolytics.
3) Initial results of the pilot project showed a first PHT was administered on May 13, 2018, meeting the goals of early recognition, treatment and transport of STEMI patients. Ongoing
A 2-day-old infant presented with shock and was found to have severe coarctation of the aorta. After discharge from the hospital following delivery, the infant collapsed at home. Examination showed poor perfusion and enlarged liver. Echocardiogram revealed severe coarctation, and the infant went into shock once the ductus arteriosus closed, obstructing left heart outflow. Management involved prostaglandin infusion to keep the ductus patent and stabilize the infant until surgery.
Pulmonary embolism (PE) is a common and potentially fatal cardiovascular condition caused by blood clots in the lungs. The document discusses the classification, pathophysiology, risk factors, clinical features, diagnostic testing and management of PE. Key points include that PE has a 15% fatality rate if untreated, but mortality decreases to around 10% with anticoagulation therapy. Rapid risk stratification and treatment of high-risk PE cases with thrombolysis, surgery or other interventions is important for reducing mortality.
1. A 30-year-old male with fever and altered mental status was found to have a potassium level disturbance based on his ECG.
2. ECG changes due to electrolyte imbalances can vary between individuals and depend on other electrolyte levels as well.
3. However, certain consistent ECG features often indicate increased or decreased potassium, making ECG useful for identifying electrolyte issues if prior tracings are available for comparison.
comprehensive presentation on 2D echo use in ICu set up. helpful in finding causes of shock and also in monitoring of fluid status in critically ill patients.
This document provides guidelines for managing supraventricular tachycardia (SVT) in adult patients. SVT is defined as a tachycardia with atrial and/or ventricular rates over 100 bpm involving tissue above the His bundle. Common types of SVT include atrioventricular nodal reentrant tachycardia (AVNRT), atrioventricular reentrant tachycardia (AVRT), atrial tachycardia (AT), multifocal atrial tachycardia (MAT), sinus node reentry tachycardia, and junctional tachycardia. The document reviews the clinical presentation, differential diagnosis, evaluation and treatment of these arrhythmias. It
The document discusses the case of a 27-year-old postpartum woman presenting with worsening dyspnea and hypoxia. It then reviews the key considerations and management strategies for acute respiratory distress syndrome (ARDS), including low tidal volume ventilation, open lung strategies using recruitment maneuvers and high positive end-expiratory pressure, unconventional approaches like airway pressure release ventilation and high frequency oscillatory ventilation, and adjunctive therapies such as prone positioning. The optimal ventilator mode, settings, and adjunctive strategies depend on the individual patient's severity of lung injury and response to different interventions.
The document provides an overview of mechanical ventilation, including its history and various modes. It begins with the origins of negative-pressure ventilators like iron lungs and the later development of positive-pressure ventilators. The main goals of ventilation are to facilitate carbon dioxide release and oxygen delivery. Various modes are described that can be used for invasive or non-invasive ventilation. Settings like PEEP, respiratory rate, tidal volume, and FiO2 are outlined that can be adjusted to optimize oxygenation and ventilation. Indications for intubation and criteria for safely extubating patients are also reviewed.
The document discusses hypercapnia (excess carbon dioxide in the body) and its effects on different body systems. It classifies hypercapnia as moderate (PCO2 40-100 mmHg) or severe (PCO2 over 100 mmHg). Hypercapnia affects the central nervous system by impacting cerebral blood flow, intracellular pH, and having an inert gas narcotic effect. It can also stimulate the sympathetic nervous system, impacting the cardiovascular system by increasing heart rate and cardiac output while decreasing systemic vascular resistance. The document examines the effects of hypercapnia under different anesthetic agents as well.
ventricular premature complexes and idioventricular rhythm identification is important in the ICU ..they may run into arryhthmias..look over my seminar...
any queries...
This document discusses ARDS (acute respiratory distress syndrome), including its history, definitions, pathophysiology, and evidence-based treatment strategies. ARDS is characterized by diffuse pulmonary inflammation and reduced lung compliance. Traditional ventilator strategies have been shown to cause ventilator-induced lung injury, so current recommendations focus on lung-protective ventilation with low tidal volumes and high PEEP. Additional rescue therapies for refractory hypoxemia include recruitment maneuvers, proning, and ECMO. Proper diagnosis requires consideration of alternative conditions and use of diagnostic tools like echocardiogram, bronchoscopy, and chest CT scan.
Pulmonary Hypertension: Clinical diagnosis, hemodynamics and approach - Dr. A...akifab93
This document discusses pulmonary hypertension (PH), including its definition, pathophysiology, causes, signs and symptoms, diagnostic evaluation, and radiographic findings. PH is defined as a mean pulmonary arterial pressure over 25 mmHg at rest as assessed by right heart catheterization. The pathophysiology involves pulmonary vasoconstriction, endothelial dysfunction, vascular remodeling, and an imbalance of various mediators. PH can be caused by left heart disease, lung diseases, chronic thromboembolic disease, or other rare diseases. Common signs include dyspnea, fatigue, edema, and right heart failure. Diagnostic tests include echocardiogram, CT, ventilation/perfusion scan, right heart catheterization. Chest x-ray may show
1) Acute coronary syndrome includes unstable angina and myocardial infarction, characterized by chest pain and elevated cardiac biomarkers.
2) Clinical features include severe, prolonged chest pain that may radiate to other areas, as well as syncope, vomiting, and arrhythmias.
3) Complications include heart failure, arrhythmias like ventricular fibrillation, cardiac rupture, and remodelling. Diagnosis involves ECG, cardiac enzymes, and angiography. Management focuses on reperfusion therapy, anticoagulation, and risk factor reduction.
The heart during systole, becoming smaller, generally withdraws from the chest wall except for the apex for the reasons explained above. The effect of this withdrawal on the chest wall can be observed as an inward movement of the chest wall during systole called "retraction." Although the heart is basically comprised of two separate pumps (right and left ventricles), these two pumps operate normally at two vastly different pressures. Left ventricular systolic pressures being approximately five times higher than that of the right ventricle, its wall tension is much higher, resulting in the increased wall thickness of the left ventricular chamber. The effect of the increased muscle mass on the left side leads to dominance of the left-sided hydrodynamic forces described above. This results in the left ventricular apex as the only area of normal contact during systole. The rest of the heart essentially retracts from the chest wall. In a normal heart, this retraction of the chest wall can be observed to be located medial to the apical impulse and involving part of the left anterior chest wall (20). Even the right ventricle, which is anatomically an anterior structure, is normally pulled away from the chest wall because of its own contraction (becoming smaller) and, more importantly, the septal contraction also pulling the right ventricle posteriorly. This retraction observed in normal patients is located medial to the apical impulse (23,24). It can be best appreciated with patients in the left lateral decu-bitus position with a palpating finger only on the apical impulse with clear view of the rest of the precordium for proper observation of the inward movement of the retraction (opposite in direction to the outward movement of the apical impulse). This "medial retraction" identifies and indicates that the left ventricle forms the apical impulse. The extent of the area of medial retraction may be variable depending on both cardiac and extracardiac factors such as the compliance of the chest wall. It may sometimes be noted only over a small area very close to the apex beat.
A pulmonary embolism occurs when a blood clot forms in the deep veins of the legs or pelvis and travels through the bloodstream, lodging in the pulmonary arteries of the lungs. It can be difficult to diagnose and is a potentially life-threatening condition. Diagnostic tests may include a d-dimer blood test, CT scan, ventilation-perfusion scan, echocardiogram, and angiogram. Treatment involves anticoagulation medications to prevent further clotting and thrombolysis in some severe cases. Prevention by minimizing risk factors for deep vein thrombosis is important.
Ventilator Management In Different Disease EntitiesDang Thanh Tuan
The document discusses ventilator management in different disease entities. It covers indications for mechanical ventilation in conditions like respiratory failure, ARDS, COPD, chest trauma, and head injury. For ARDS specifically, it summarizes the key findings of the NIH ARDS Network trial which demonstrated that a lower tidal volume strategy of 6 ml/kg predicted body weight reduced mortality compared to the traditional higher tidal volume approach.
This document discusses supraventricular tachycardias (SVT). It defines different types of SVT including paroxysmal SVT, which is common in emergency rooms. Quality of life is often poor for those with paroxysmal SVT. The document discusses mechanisms of SVT including reentry circuits, enhanced automaticity, and triggered activity. It provides details on differentiating AV nodal reentrant tachycardia from AV reentrant tachycardia using electrocardiogram findings. Treatment options discussed include carotid sinus massage, adenosine, and catheter ablation.
1. Mitral stenosis is most commonly caused by rheumatic fever and results in thickening and calcification of the mitral valve, reducing the valve orifice area and obstructing blood flow from the left atrium to ventricle.
2. The pathophysiology involves elevated left atrial pressure, pulmonary hypertension, and reduced cardiac output. Symptoms range from easy fatigability to pulmonary edema.
3. Physical exam findings include an opening snap, rumbling diastolic murmur, and signs of right heart failure in severe cases. Severity is graded based on orifice area, pulmonary artery pressure, and NYHA functional
Dr. Jakeer Hussain discusses pneumothorax, beginning with an introduction and definition. He then covers the classification of pneumothorax as either spontaneous, traumatic, or iatrogenic. Spontaneous pneumothorax is further classified as primary or secondary. The document discusses signs, symptoms, investigations including x-ray and CT scan findings, differential diagnosis, quantification methods, and various treatment options including observation, oxygen supplementation, needle aspiration, tube thoracostomy, medical or VATS pleurodesis, and open thoracotomy.
1) The proposal presents a pre-hospital thrombolytic therapy (PHT) pilot project in Temerloh, Pahang to reduce door-to-needle times for STEMI patients by administering thrombolytics in the field before transporting patients to hospitals.
2) The project would involve two Klinik Kesihatan as pilot sites for PHT. Paramedics and doctors would be trained to recognize STEMI, perform ECGs in the field, and administer thrombolytics.
3) Initial results of the pilot project showed a first PHT was administered on May 13, 2018, meeting the goals of early recognition, treatment and transport of STEMI patients. Ongoing
A 2-day-old infant presented with shock and was found to have severe coarctation of the aorta. After discharge from the hospital following delivery, the infant collapsed at home. Examination showed poor perfusion and enlarged liver. Echocardiogram revealed severe coarctation, and the infant went into shock once the ductus arteriosus closed, obstructing left heart outflow. Management involved prostaglandin infusion to keep the ductus patent and stabilize the infant until surgery.
Pulmonary embolism (PE) is a common and potentially fatal cardiovascular condition caused by blood clots in the lungs. The document discusses the classification, pathophysiology, risk factors, clinical features, diagnostic testing and management of PE. Key points include that PE has a 15% fatality rate if untreated, but mortality decreases to around 10% with anticoagulation therapy. Rapid risk stratification and treatment of high-risk PE cases with thrombolysis, surgery or other interventions is important for reducing mortality.
This document provides guidance on evaluating and managing chest pain. It lists common cardiac, pulmonary, aortic, chest wall, and esophageal causes of chest pain. It describes typical versus atypical chest pain characteristics and provides the Modified Wells Criteria for evaluating pulmonary embolism risk. Evaluation steps are outlined including EKG, labs, and imaging. Specific cases are presented and addressed, including acute coronary syndrome, pulmonary embolism, aortic dissection, and pericarditis.
This document provides guidance on evaluating and managing chest pain. It lists common cardiac, pulmonary, aortic, chest wall, and esophageal causes of chest pain. It describes typical versus atypical chest pain characteristics and provides the Modified Wells Criteria for evaluating pulmonary embolism risk. Evaluation involves history, physical exam, EKG, and lab tests. The document reviews two case studies of patients presenting with chest pain and outlines diagnostic and treatment approaches.
Pulmonary Embolism, Case Report of b/l PE & Literature ReviewBadarJamal4
A 50-year-old male presented with palpitations, chest discomfort and dyspnea for 3 days following hip replacement surgery 15 days prior. Investigations revealed elevated D-dimer, signs of right heart strain on echocardiogram, and CT pulmonary angiogram showed bilateral saddle pulmonary embolism. He was treated with oxygen, low molecular weight heparin and rivaroxaban. Symptoms resolved and follow up echo showed improvement. He was discharged on long term anticoagulation for pulmonary embolism.
1. A 35-year-old man presented with acute onset of breathlessness and was found to have pulmonary thromboembolism and deficiencies in protein C and protein S without evidence of deep vein thrombosis.
2. He was treated with supportive measures, heparin, acenocoumarol, and supplements but developed massive hemoptysis and succumbed to his illness despite intensive care.
3. The case report discusses evaluation, treatment, and long-term management of venous thromboembolism and highlights complications that can arise.
The document discusses acute pulmonary embolism (PE). PE is common but difficult to diagnose, with nonspecific symptoms. It describes a case of a 48-year-old woman presenting with sudden dyspnea, tachycardia, and leg swelling who may have PE. Risk factors for PE include recent surgery or trauma, prolonged immobilization, and inherited or acquired hypercoagulable states. Diagnosis involves clinical scoring, D-dimer, imaging like CTPA, and treatment includes anticoagulation with heparin or warfarin.
Pulmonary hypertension is defined as a mean pulmonary arterial pressure of at least 25 mm Hg. It can be caused by various conditions and is classified accordingly. Idiopathic pulmonary hypertension has no known cause. It presents with dyspnea and right heart failure. Diagnosis involves right heart catheterization showing elevated pulmonary pressures. Treatment includes diuretics, vasodilators like calcium channel blockers, endothelin receptor antagonists, phosphodiesterase inhibitors, prostanoids, and sometimes atrial septostomy or lung transplantation for severe cases refractory to medical therapy. Prognosis depends on factors like functional status, hemodynamics, and response to treatment.
This document provides information on acute pulmonary embolism (PE), including its definition, risk factors, pathophysiology, clinical features, diagnostic tests, treatment with anticoagulation therapy, and classifications. It describes PE as obstruction of the pulmonary artery or its branches by material originating elsewhere. Risk factors include older age, surgery, trauma, cancers, and prolonged immobilization. Diagnostic tests include D-dimer, CT pulmonary angiogram, ventilation-perfusion scan, echocardiogram, and angiogram. Treatment involves anticoagulation therapy such as low molecular weight heparin, fondaparinux, warfarin, or direct oral anticoagulants. Duration of therapy depends on whether the PE was
The document discusses venous thromboembolism (VTE), specifically deep vein thrombosis (DVT). It describes the causes, risk factors, clinical presentation, and diagnostic evaluation of VTE. It then presents a case study of a patient with systemic lupus erythematosus who presented with right upper extremity DVT and swelling. The document outlines her medical history and examination findings. It analyzes her multiple acute conditions, including VTE, lupus flare, acute kidney injury, anemia, and suspected UTI. Finally, it discusses recommended treatment and management options for VTE, antiphospholipid antibody syndrome, and her other conditions based on clinical practice guidelines.
Pulmonary thromboembolism is caused by obstruction of pulmonary vessels, usually by blood clots. Clots can form in the lungs (primary) or originate elsewhere and travel to the lungs (secondary). Symptoms range from none (silent) to chest pain, dyspnea, tachycardia, and hemodynamic instability. Diagnosis involves evaluating likelihood based on risk factors and symptoms, d-dimer testing, imaging like CT, lung scan, or echocardiogram. Treatment is anticoagulation with heparin or warfarin long term. For some high risk cases thrombolysis or embolectomy may be considered.
Esc guideline for atrial fibrillation 2020 [dr pranab]PranabanandaPal1
This document discusses atrial fibrillation (AF) and its management. It defines AF and describes its prevalence, complications, and patterns. It outlines how to confirm, characterize, and screen for AF. Investigations for AF are discussed. The integrated ABC pathway for managing AF is described, including assessing stroke risk and bleeding risk, and options for anticoagulation. Methods for rate control and rhythm control of AF are provided.
Cases in cardiology --LMB-- part one -- PART TWO-- MAGDI SASI 2016cardilogy
This patient presented with progressive dyspnea, fatigue on exertion, and recent palpitations. On examination, she had an irregular pulse, low blood pressure, and a malar flush. ECG showed atrial fibrillation with rapid ventricular response and echo revealed severe mitral stenosis.
The incorrect statement is that she needs valve replacement. Current guidelines indicate valve replacement is indicated for symptomatic patients with mitral valve area <1.5cm2 who are unsuitable for percutaneous mitral balloon valvuloplasty. This patient should first undergo repeat echo and consideration of cardioversion and rate control medications before deciding on invasive treatment.
This document summarizes the evaluation and treatment of a 59-year-old man presenting with right leg swelling and edema. It notes his medical history including diabetes, hypertension, pulmonary hypertension, sleep apnea, chronic kidney disease, and congestive heart failure. It discusses diagnostic testing performed, including a positive D-dimer and imaging, and treatment options for deep vein thrombosis including anticoagulant medications like warfarin, heparin, and fondaparinux as well as interventional procedures like IVC filters and thrombolytic therapy in certain situations.
Colin Farquharson - what becomes of the broken hearted?Colin Farquharson
1. Takotsubo cardiomyopathy is a syndrome of transient left ventricular dysfunction resulting in apical ballooning that mimics ST-elevation myocardial infarction.
2. It is typically triggered by severe emotional or physical stress and is more common in post-menopausal women.
3. While symptoms and test results can appear similar to a heart attack, coronary angiography shows no significant arterial narrowing, and left ventricular function typically recovers within weeks.
This document discusses the anaesthetic management of closed mitral valvotomy. It begins with the anatomy and pathophysiology of mitral stenosis. It then discusses the indications for closed mitral valvotomy and the pre-anaesthetic assessment. The key aspects of anaesthetic management are maintaining haemodynamic stability, avoiding tachycardia and hypotension, and careful fluid management. Etomidate is recommended for induction due to hemodynamic stability. Post-operatively, risks of pulmonary edema and right heart failure must be assessed and managed.
preoperative evaluation for residents of anesthesia part 2mansoor masjedi
This document summarizes key points from a presentation on preoperative evaluation and management of patients with pulmonary and other medical conditions. Some important topics discussed include: evaluating asthma severity and control; differentiating causes of wheezing; COPD diagnosis and management; restrictive lung diseases; dyspnea workup; pulmonary hypertension; smokers and second-hand smoke exposure; diabetes; renal and liver diseases; coagulation disorders; neurologic issues; upper respiratory infections; obesity; allergies; fasting guidelines; postoperative pain management; and components of a thorough preoperative consultation.
Atrial fibrillation is the most common arrhythmia and increases mortality risk. It is classified as paroxysmal, persistent, or permanent based on duration. The CHA2DS2-VASc score is used to assess stroke risk and determine need for anticoagulation. Treatment focuses on rate control with medications like calcium channel blockers or cardioversion for hemodynamic instability. Anticoagulation is recommended for CHA2DS2-VASc score over 2 to prevent stroke.
A 37-year-old female presented with acute onset weakness of all four limbs for 5 hours. On examination, she had flaccid quadriparesis with decreased tone and power in both upper and lower limbs. Investigations revealed hypokalemia, metabolic alkalosis, hypertension, and renal potassium wasting. CT angiogram showed bilateral thinning and stenosis of the subclavian arteries and diffuse aortic wall thickening. This is consistent with Takayasu's arteritis, a large vessel vasculitis most commonly affecting the aorta and its major branches in young females.
anesthesia in patient a patient with IHD posted for lap cholecystectomy. pres...Swastika Swaro
1) The document discusses anaesthetic management for laparoscopic cholecystectomy in patients with coronary artery disease (CAD), outlining how to provide safe anaesthesia for non-cardiac surgery in these high-risk patients.
2) Patients with CAD have increased perioperative cardiac risk due to exaggerated hemodynamic responses to stimuli. Careful preoperative risk stratification is important to identify risk factors and determine if preoperative intervention is needed.
3) Intraoperatively, the goals are to maintain a normal heart rate and blood pressure, adequate oxygen delivery, and minimize hemodynamic stress responses through careful use of anesthetic agents and techniques. Close monitoring is important to detect and treat any cardiac complications promptly.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
2. CASE HISTORY
PL
Age 41
Female
PC- SOB
Known to have Hypertension but have been off meds for quite a while.
Had a sudden episode of palpitations then sat down and felt severe SOB
associated with pre-syncopal episode, diaphoresis and dizziness.
No history of orthopnea, PND or leg swelling
3. She denies any cough, wheeze but admits a low grade chest pain worsened
by inspiration.
She had travelled abroad 1-2 weeks ago
No history of trauma, personal history of malignancy, recent surgery or any
prior history of DVT
She presented to her private practitioner who then referred her to this
intuition.
Past Medical History: nil prior medical admissions
4. Past Surgical History: LSCS Feb 2015 (pre-eclampsia)
Drug History: nil, no h/o hormonal contraceptive usage Nil known drug
allergies
Family History: breast ca (aunt)
Nil known family history of thrombophilia
Social History: Does not smoke nor drink alcohol
5. EXAMINATION
O/E Middle aged morbidly obese female in mild respiratory distress
MM= pink + moist, anicteric, afebrile, acyanotic
Vitals BP 170/104 P 110 RR 28 T 96.3 F SpO2 90%
RS : Trachea central , air entry equal bilaterally, nil creps, nil rhonchi
appreciated.
CVS- Pulses synchronous and regular. JVP not appreciated
Heart sounds 1 & 2 heard, nil other sounds, nil murmurs
Mild pitting oedema bilaterally
6. Abd: Obese soft, non-tender nil organomegally
CNS: unremarkable, oriented in time, place and person. Nil gross deficits
MSK: nil calf tenderness, nil warmth or erythema
19. DAY 4
S- nil complaints
O/E
RS- chest clinically clear
CVS- S1 S2 nil Murmurs
Abd – unremarkable
CNS- unremarkable
A- Stable
Plan – For (Rx) Pradaxa 150mg PO bd
Continue Management
VITALS
BP 130/80
HR 95
RR 20
Temp 98
Pulmonary Embolism
Hypertension
Morbid Obesity
20. DAY 5
S- nil complaints
O/E
RS- chest clinically clear
CVS- S1 S2 nil Murmurs
Abd – unremarkable
CNS- unremarkable
A- Stable
Plan – For HOME
Pradaxa 150mg PO bd
MOPD X 1/12
VITALS
BP 133/97
HR 98
RR 20
Temp 97.7
Pulmonary Embolism
Hypertension
Morbid Obesity
21. PRADAXA (DABIGATRAN)
Dabigitran is an oral direct thrombin inhibitor
It can be easily started following at least 5 days of heparin (LMWH) in
the case of a DVT/PE.
It has its own reversal drug , Praxbind that can be used in a life-
threatening bleed
Patients with mild to moderate renal impairment can be treated with
Pradaxa however, it is contraindicated in those with severe renal
impairment (CrCL <30mL/min).
22. PRADAXA
It does not need routine clinical monitoring, when used for either
short- or long-term treatment.
Currently approved for:
Treatment of DVT/PE
Prevention of recurrent DVT/PE
Stroke prevention in non valvular Atrial Fibrillation
VTE post surgery
25. Pulmonary embolism is not a disease of itself, but is a complication of venous
thrombosis.
Pulmonary emboli usually arise from thrombi that originate in the deep venous
system of the lower extremities.
Pulmonary embolism is potentially lethal and most patients succumb to the event
within the first few hours of the event.
28. SIGNS AND SYMPTOMS
TYPICAL
Shortness of Breath
Chest pain (pleuritic)
Coughing
Palpitations/Tachycardia
Hypoxia
Tachypnea
ATYPICAL
Seizures
Syncope
Abdominal pain
Fever
Wheezing
Decreasing level of consciousness
New onset of atrial fibrillation
Hemoptysis
Flank pain
Delirium (in elderly patients)
29. INVESTIGATIONS
D-Dimer
ECG - classic S1Q3T3 pattern, most common finding sinus tachycardia,
RBBB, atrial fibrillation, non specificT-wave changes and non specific ST
segment changes
CXR – non specific generally may show pleural effusion, atelectasis and
consolidation
ABG- might show significant hypoxia, however it can be normal
Cardiac Biomarkers (Troponins and Brain Natriuretic Peptide)
30. Echocardiography – might show RV dilatation ,TR, septal flattening, left diastolic
ventricular impairment due to septal displacement, pulmonary artery
hypertension etc
CT-PA -The standard imaging modality
Ventilation-Perfusion Scanning – 2nd line less costly, helpful in patients with
renal insufficiency, contrast allergy, obesity or in pregnancy.
Pulmonary Angiography - infrequently used now since the advent of CT-PA,
invasive and costly
Magnetic Resonance Angiography- an alternative for patients with contrast
allergy and renal impairment
32. TREATMENT
Immediate full anticoagulation is mandatory for all patients suspected of having a
pulmonary embolism.
In the acute setting, parenteral anticoagulation is recommended :
Anticoagulation medications include:
Unfractionated Heparin [UFH] IV / SC
Low-molecular weight heparin [LMWH] (eg.enoxaparin [clexane] IV/SC
Fondaparinux SC
The American College of Chest Physicans (ACCP) recommends LMWH or
Fondaparinux over IV UFH and over SC UFH
However LMWH or Fondaparinux are retained in patients with renal impairment and have impaired
absorption in obese patients.
36. TREATMENT
Thrombolytic therapy is indicated in patients who have hypotension (systolic BP
<90mm Hg) who do not have a high bleeding risk.
Thrombolytic agents include:
Alteplase
Reteplase
Urokinase
Streptokinase
Surgical Methods
Placement of vena cava filters
Catheter embolectomy
37. ADDITIONAL ACCP GUIDELINES
Patients with PE provoked by surgery, anticoagulation is recommended for
3months
Patients with PE by a non surgical factor, anticoagulation is recommended for at
least three months. After three months, they should be evaluated for further
therapy.
Extended therapy is recommended for patients with recurrent PE and active
cancer.
For patients with PE and no cancer who are not treated with dabigatran,
rivaroxaban, apixaban, or edoxaban, we suggestVKA therapy over low-molecular
weight heparin (LMWH).
38. SUMMARY
Pulmonary embolism is as a result of venous thrombosis.
Treatment is initiated on suspicion before confirmation as it has lethal
consequences.
Anticoagulation is the mainstay of management
39. REFERENCES
Bartholomew, J. R., MD. (2012, December).VenousThromboembolism (Deep
VenousThrombosis & Pulmonary Embolism). Retrieved May 31, 2016, from
http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/car
diology/venous-thromboembolism/
Antithrombotic Therapy ForVte Disease: Chest Guideline And Expert Panel
Report Kearon C, Akl EA, Ornelas J, et al.Chest. 2016;149(2):315-
352.doi:10.1016/j.chest.2015.11.026.http://journal.publications.chestnet.org/articl
e.aspx?articleid=2479255
Updated Guidelines on Outpatient Anticoagulation. (2013, April 15). Retrieved
June 08, 2016, from http://www.aafp.org/afp/2013/0415/p556.html#sec-3
Ouellette, D. R., MD. (2015, October 9). Pulmonary Embolism. Retrieved June 05,
2016, from http://emedicine.medscape.com/article/300901-overview
Relatively well until the morning of presentation while walking from her bedroom she had a sudden onset episode of palpitation. She sat down then had SOB , this being described as so severe that she felt like she was going to pass out , had diaphoresis
The Wells score or Wells criteria can refer to one of two clinical prediction rules in clinical medicine
DVT probability scoring for diagnosing deep vein thrombosis
Pulmonary embolism probability scoring for diagnosing pulmonary embolism
Two doses
150mg BD & 110mg BD ( patients at risk for bleeding,patients >80, on verapamil,
How do I switch my patients to Pradaxa from warfarin?
To switch to Pradaxa from warfarin, or any other vitamin K antagonist (VKA), treatment with the VKA and start the patient on Pradaxa once their INR falls to <2.0.1
For your DVT/PE patients, Pradaxa can be easily started following at least 5 days of heparin (LMWH).1 Give Pradaxa 0–2 hours prior to the time at which the dose of LMWH would have been due.1
How do I switch my patients from Pradaxa to a parenteral anticoagulant?
For patients being treated for primary prevention of venous thromboembolism (pVTEp), it is recommended to wait 24 hours after the last dose of Pradaxa before switching to a parenteral anticoagulant.1
For patients with non-valvular atrial fibrillation (NVAF) being treated for stroke prevention, it is recommended to wait 12 hours after the last dose of Pradaxa before switching to a parenteral anticoagulant.1
How do I switch my patients to Pradaxa from a parental anticoagulant?
When switching a patient to Pradaxa from an injectable anticoagulant, give Pradaxa 0–2 hours prior to the time the next dose of injectable anticoagulant would have been due.1
For your DVT/PE patients, Pradaxa can be easily started following at least 5 days of heparin (LMWH).1 Give Pradaxa 0–2 hours prior to the time at which the dose of LMWH would have been due.1
D-Dimer Testing for PE
Patients with a low pretest probability score for PE and negative D-dimer have a high negative predictive value similar to that observed in patients with DVT. However, the patient who has an intermediate to high pretest probability score with a negative D-dimer requires further diagnostic testing to exclude PE.28
Electrocardiography
The major utility of electrocardiography (ECG) in the diagnosis of PE is to rule out other major diagnoses, such as acute myocardial infarction (MI). The most specific finding on ECG is the classic S1Q3T3 pattern, but the most common findings consist of nonspecific ST-segment and T-wave changes. Other commonly reported but nonspecific findings include sinus tachycardia, atrial fibrillation, and right bundle-branch block.29
Chest Radiography
Chest radiography may also be more helpful in establishing other diagnoses. The most common findings are nonspecific and include pleural effusion, atelectasis, and consolidation.
Arterial Blood Gas Determination
Pulmonary embolism can result in significant hypoxia, and in the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) study, only 26% of patients with angiographically proven PE had a PaO2 greater than 80 mmHg.30 Therefore, a normal PaO2 cannot rule out PE; however, hypoxia in the absence of cardiopulmonary disease should raise suspicion for this diagnosis. In patients with cardiopulmonary collapse, a normal PaO2 suggests an alternative diagnosis. Similarly, an elevated alveolar-arterial gradient is suggestive but not specific for the diagnosis of an acute PE. Therefore if the alveolar-arterial gradient is normal, an acute PE cannot be excluded.31
Biomarkers (Troponins and Brain Natriuretic peptide)
Elevated levels of cardiac troponins correlate with echocardiographic findings of RV pressure overload in patients with acute PE and overall mortality. In-hospital complications are more frequent in these patients compared to patients with normal levels.38 Brain natriuretic peptide (BNP) elevation in the absence of renal dysfunction is also a marker of RV dysfunction in patients with PE and has been shown to predict adverse outcome in patients with acute PE.39
Causes of troponin elevation other than MI include the following:
Myocarditis
Pericarditis
Cardiac contusion/trauma
Aortic dissection
Endocarditis
Cardiac surgery
Pulmonary embolism
Stroke (ischemic or hemorrhagic)
Cardiopulmonary resuscitation (CPR)
Defibrillation
Chronic severe heart failure
Cardiac arrhythmias (tachyarrhythmias, bradyarrhythmias, heart blocks)
Sepsis
Echocardiography (Transthoracic and Transesophageal)
More than 50% of hemodynamically stable patients with PE do not have evidence of RV dysfunction on transthoracic echocardiography (TTE).40 Patients with hemodynamic collapse, however, generally suffer severe RV dysfunction, and TTE or transesophageal echocardiography (TEE) can provide rapid bedside assessment in these critically ill patients who are at increased risk for death. Echocardiography findings include RV dilatation, RV hypokinesis, tricuspid regurgitation, septal flattening, paradoxical septal motion, diastolic left ventricular impairment resulting from septal displacement, pulmonary artery hypertension, lack of inspiratory collapse of the inferior vena cava, and occasionally direct visualization of the thrombus. In patients with large PE, it has been observed that despite moderate or severe RV free-wall hypokinesis there is relative sparing of the apex. This finding is referred to as McConnell's sign and has a specificity of 94% and a positive predictive value of 71% for acute PE.41 McConnell's sign may be useful in discriminating RV dysfunction resulting from PE from that of other causes.
Computed Tomographic Pulmonary Angiography
Because of its wide availability and ability to visualize thrombus directly, computed tomographic pulmonary angiography (CTPA) imaging has become the standard imaging technique for diagnosing PE. Although initially considered useful only for evaluating central PE and not thought to be the equal to ventilation perfusion (V/Q) scanning, the sensitivity and specificity of newer CTPA scans with multiple slices has increased greatly for diagnosing smaller peripheral or subsegmental PEs. In a study by Anderson and colleagues, patients were randomly assigned to undergo either PTCA or V/Q scanning.
The results suggested that CTPA was more sensitive than V/Q scans.32
CTPA also allows direct imaging of the inferior vena cava and the pelvic and leg veins, and can identify other pathologies that can mimic acute PE. The major disadvantages of CTPA are radiation exposure, higher cost, and the possibility of contrast-induced nephrotoxicity. In a meta-analysis of 23 studies involving 4,657 patients with suspected PE who had a normal CTPA, only 1.4% developed VTE and 0.51% developed fatal PE by 3 months.33 These rates are similar to those seen in studies of patients with suspected PE who had normal pulmonary angiograms.34 CTPA can also identify right ventricle enlargement (defined as a ratio of right ventricle diameter to left ventricle diameter >0.9), which has been shown to predict adverse clinical events. This procedure may be an alternative to echocardiography for diagnosing RV enlargement.35
Ventilation-Perfusion Scanning
Ventilation-perfusion scanning is now considered a second-line imaging method for the diagnosis of PE. It is helpful in patients who have normal chest radiography or who are unable to undergo CTPA (patients with renal insufficiency, contrast allergy, obesity, or pregnancy). A normal perfusion scan rules out the diagnosis of PE, whereas a high-probability scan along with a high degree of clinical suspicion is diagnostic. Unfortunately, nondiagnostic lung scans (intermediate or low probability) are the most common, and in the PIOPED study they occurred in 72% of patients, thereby limiting the usefulness of this modality.36 It must also be noted that in PIOPED, patients with a high or intermediate clinical suspicion for PE but a low-probability scan had a 40% and 16% rate of PE diagnosed by pulmonary angiography, respectively.36 Hence, it is currently advised that patients with a high or intermediate clinical suspicion for PE but a low-probability V/Q scan have additional tests to confirm or exclude the diagnosis. More recently, PIOPED II, using a different classification system (present or absent) reported that 21% of studies were nondiagnostic leading the authors to suggest that the lung scan may be making a revival.37
Pulmonary Angiography
Pulmonary angiography remains the reference standard diagnostic test for PE, but it has been used infrequently since the advent of CTPA. It is invasive, costly, and associated with nephrotoxicity due to contrast exposure; however, in experienced centers, associated morbidity and mortality are low. An intraluminal filling defect or an abrupt cutoff of a pulmonary artery is considered diagnostic.
Magnetic Resonance Angiography
Magnetic resonance angiography (MRA) may be an alternative to CTPA for the diagnosis of PE in patients who have contrast allergy or for whom avoidance of radiation exposure is desired. Reports of sensitivity and specificity are varied but compared to CTPA, MRA has been reported to be both less sensitive and less specific and limited by interobserver variability
http://www.aafp.org/afp/2013/0415/p556.html
Natural anticoagulants
Antithrombin III
Protein C & S
Tissue factor Plasminogen Inhibitor
Thrombomodulin
UFH binds to the enzyme inhibitor antithrombin III (AT), activated AT then inactivates thrombin and other proteases involved in blood clotting
LMWH binds to anti-thrombin, creates a conformational change. This change accelerates its inhibition of activated factor X in conversion of prothrombin to thrombin.
LMWH VS UFH
Less frequent subcutaneous dosing than for heparin for postoperative prophylaxis of venous thromboembolism.
Once or twice daily subcutaneous injection for treatment of venous thromboembolism and in unstable angina instead of intravenous infusion of high dose heparin.
No need for monitoring of the APTT coagulation parameter as required for high dose heparin.[15]
Possibly a smaller risk of bleeding.
Smaller risk of osteoporosis in long-term use.
Smaller risk of heparin-induced thrombocytopenia, a potential side effect of heparin.
LMWH--- once daily administration is preferred than twice daily
Fondaparinux–Factor 10a inhibitor. Unlike direct factor Xa inhibitors, it mediates its effects indirectly through antithrombin III, but unlike heparin, it is selective for factor Xa It also potentiates Anti-thrombin III (about 300 times) the innate neutralization of Factor Xa .
One potential advantage of fondaparinux over LMWH or unfractionated heparin is that the risk for heparin-induced thrombocytopenia (HIT) is substantially lower.
Local considerations such as cost, availability and familiarity dictate the choice
In patients where thrombolytic therapy is considered or planned, IV UFH is preferred
The oral anticoagulants available in the UK are warfarin, acenocoumarol, phenindione, dabigatran etexilate, rivaroxaban and apixaban.[1]
Warfarin continues to be the most widely used oral anticoagulant but the use of the newer oral anticoagulants (dabigatran etexilate, rivaroxaban and apixaban) is increasing.
Warfarin antagonises vitamin K (needed for the synthesis of clotting factors) and takes 2-3 days to exert its full effect.
In some situations heparin needs to be given for immediate anticoagulation, whilst waiting for the INR to get into the required range.
Dabigatran etexilate, rivaroxaban and apixaban are relatively newer oral anticoagulants. Dabigatran etexilate is a direct thrombin inhibitor, whilst rivaroxaban and apixaban inhibit activated factor Xa.
Dabigatran etexilate, rivaroxaban and apixaban do not require monitoring of the INR.
Contraindicated in pregnancy
As it is teratogenic
Studies have not yet been done on the use of the other agents
http://www.aafp.org/afp/2013/0415/p556.html#sec-3
Cathether embolectomy is :-required if they failed thrombolysis
-Contraindications to thrombolysis
-Patients in shock
http://journal.publications.chestnet.org/article.aspx?preview=true&articleid=2479255
More studies are being done to on the newer anticoagulants.