This presentation compares the effects of different animal proteins on cancer, diabetes, heart disease and stroke. Presentation covers fish, dairy, poultry, red meat, processed meat and eggs.
This slide deck summarizes the studies on edible fats and inflammation in humans. Saturated fat seems to mildly pro-inflammatory, omega-6 fats neutral among healthy individuals and omega-3 fats mildly anti-inflammatory. Margarine outperforms butter in terms of inflammation.
The recovery and re-evaluation of the old data on Sydney Diet Heart Study uncovers unexpected outcomes. However, interpret with care because things have changed since 1970s.
In this slide deck I demonstrate the effects of carbohydrate restriction on different lipoproteins such as HDL, LDL, non-HDL-cholesterol and apolipoprotein B (apoB). The effect of butter and saturated fat as such are compared to unsaturated fat and especially to canola oil. Meta-analysis by Mensink et al. 2003 is the primary reference for the analysis.
Predimed study is one of the few truly long term randomized trials with disease and mortality outcomes. It is unique in many ways and will have a strong and lasting impact
Dietary guidelines are accused to be the key reason for obesity and diabetes epidemic. This slide deck shows why they are not. Junk food diet is the key reason.
Fat intake US has remained rather stable during the past decades despite many claims. I present here the case based on USDA and NHANES data.
Claiming that fat intake has decreased in US is as silly as advising a dieter: “If you want to follow a low-fat diet just keep your fat intake at the current level and simply increase the consumption of carbs. Then you are on low-fat diet and you will reap all the benefits of the diet”
This slide deck summarizes the studies on edible fats and inflammation in humans. Saturated fat seems to mildly pro-inflammatory, omega-6 fats neutral among healthy individuals and omega-3 fats mildly anti-inflammatory. Margarine outperforms butter in terms of inflammation.
The recovery and re-evaluation of the old data on Sydney Diet Heart Study uncovers unexpected outcomes. However, interpret with care because things have changed since 1970s.
In this slide deck I demonstrate the effects of carbohydrate restriction on different lipoproteins such as HDL, LDL, non-HDL-cholesterol and apolipoprotein B (apoB). The effect of butter and saturated fat as such are compared to unsaturated fat and especially to canola oil. Meta-analysis by Mensink et al. 2003 is the primary reference for the analysis.
Predimed study is one of the few truly long term randomized trials with disease and mortality outcomes. It is unique in many ways and will have a strong and lasting impact
Dietary guidelines are accused to be the key reason for obesity and diabetes epidemic. This slide deck shows why they are not. Junk food diet is the key reason.
Fat intake US has remained rather stable during the past decades despite many claims. I present here the case based on USDA and NHANES data.
Claiming that fat intake has decreased in US is as silly as advising a dieter: “If you want to follow a low-fat diet just keep your fat intake at the current level and simply increase the consumption of carbs. Then you are on low-fat diet and you will reap all the benefits of the diet”
Lyon Diet Heart Study is still considered as the ultimate evidence for the health benefits of Mediterranean diet. Unfortunately its' results have never been re-produced since then. However, PREDIMED trial may change this situation.
In this slide deck, I describe the up-to-date evidence on Low Carbs and heart health. The evidence is based mainly on two recent meta-analyses (Hession et al. & Kodama et al.) and prospective cohort studies. Limited evidence on renal aspects is also demonstrated.
Targeting abdominal obesity in diabetology: What can we do about it?My Healthy Waist
By Luc Van Gaal, MD, PhD, Professor of Medicine, Antwerp University Hospital, Faculty of Medicine, Department of Diabetology, Metabolism & Clinical Nutrition, Antwerp, Belgium
Physical Activity in the Management of Abdominal ObesityMy Healthy Waist
By Robert Ross, PhD, Professor, School of Kinesiology and Health Studies, Department of Medicine, Division of Endocrinology and Metabolism, Queen's University, Kingston, ON, Canada
Abdominal obesity, intra-abdominal adiposity and related cardiometabolic risk...My Healthy Waist
By Jean-Pierre Després, PhD, FAHA, Scientific Director, International Chair on Cardiometabolic Risk, Professor, Division of Kinesiology, Université Laval, Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada.
Plant-based Eating: Enhancing Health Benefits, Minimizing Nutritional RisksRobin Allen
Learning Objectives
At the end of the session, the participants will be able to:
1. Know there is no single definition of a plant-based diet.
2. Discuss health aspects of vegetarian and vegan diets and quality of evidence supporting health claims.
3. Assess nutritional adequacy/status of vegetarians and/or vegans throughout the life cycle and provide strategies for meeting dietary recommendations for vitamin B12, DHA calcium, and zinc.
Prevalence of obesity.Body composition & body shape (body fat distribution ) and CVD risk .Mechanisms linking obesity with cardiovascular disease.Fat-but-Fit Paradigm and CVD,The Relationship of Metabolic Risk Factors and Cardiorespiratory Fitness. Metabolically Healthy but Obese ( MHO ) Phenotype and CVD.Obesity Paradox in Patients With CVD
Learn the basics of Diabetes Prevention, reversal and Management. The Science is clear, follow the five key behavior changes to live a diabetes-free life.
Join Doc Andrew to see the research that supports plant based diet recommendations. Address common misconceptions. Ask questions @DenverWWAD or join current discussions at #PlantBased, #PlantBasedRx, or #CulinaryRx.
Also, enjoy bonus learning with these topic-related, 2-minute podcasts by Dr. Andrew:
"The Plant Based Diet and How to Get Started"
https://soundcloud.com/denverwwad/healthcast-23
"Eat Your Way to the Finish Line"
https://soundcloud.com/denverwwad/healthcast-4
Andrew Freeman, MD, FACC, FACP is a cardiologist and Assistant Professor of Medicine at National Jewish Health, Denver, Colorado. He is part of the leadership of both the local and national American College of Cardiology.
Dr. Freeman founded the Denver chapter of the Walk with a Doc program and is the leader of Walk with a Doc-Colorado.
Walk with a Doc-Denver is a free health improvement and community empowerment initiative. Local doctors and a team of healthcare professionals--all volunteers--host Saturday walks that include expert talks, health screenings, refreshments, and motivational giveaways. For more info visit: Denver.WalkWithADoc.org
The root cause of chronic diseases, cancer and aging was recently understood. It includes 1- A state of chronic low grade inflammation secondary to hyperglycemia and obesity leading to insulin - leptin resistance. 2- Mitochondrial dysfunction. Diet, Intermittent fasting or its alternative the Metabolic Bariatric Surgery and Exercise play a significant rule in the salvage of these problems. Exercise is any bodily activity that enhances or maintain physical fitness and overall health, Exercise with its Countless Benefits is the logical salvage for a group of diseases related to inactivity . In view of the prevalence, global reach and health effect of these physical inactivity related diseases, the issue should be appropriately described as pandemic, with far-reaching health, economic, social and Environmental consequences.These diseases include, Obesity, Coronary artery disease, Diabetes, Hypertension, Cancer, Depression and anxiety, Arthritis, Osteoporosis, Etc, etc, etc… I think we have no option except doing regular exercises if we seriously search for a salvage to escape the bad and serious consequences of these new life style diseases.
The root cause of chronic diseases, cancer and aging is recently understood. It includes 1- A state of chronic low grade inflammation secondary to hyperglycemia and obesity leading to insulin resistance. 2- Mitochondrial dysfunction. Exercise play a significant rule in the salvage of these problems. Exercise is any bodily activity that enhances or maintain physical fitness and overall health, Exercise with its Countless Benefits is the logical salvage for a group of diseases related to inactivity . In view of the prevalence, global reach and health effect of these physical inactivity related diseases, the issue should be appropriately described as pandemic, with far-reaching health, economic, social and Environmental consequences.These diseases include, Obesity, Coronary artery disease, Diabetes, Hypertension, Cancer, Depression and anxiety, Arthritis, Osteoporosis, Etc, etc, etc… I think we have no option except doing regular exercises if we seriously searching for a salvage to escape the bad and serious consequences of these new life style diseases.
Suomalaisten energiaravintoaineiden ja ruokien kulutusReijo Laatikainen
Tämä diasarjaa kertoo miten suomalaisten ruuan käyttö on muuttunut. Luvut perustuvat FAO:n tilastoihin, jotka puolestaan perustuvat suomalaisiin Ravintotaseisiin.
Lyon Diet Heart Study is still considered as the ultimate evidence for the health benefits of Mediterranean diet. Unfortunately its' results have never been re-produced since then. However, PREDIMED trial may change this situation.
In this slide deck, I describe the up-to-date evidence on Low Carbs and heart health. The evidence is based mainly on two recent meta-analyses (Hession et al. & Kodama et al.) and prospective cohort studies. Limited evidence on renal aspects is also demonstrated.
Targeting abdominal obesity in diabetology: What can we do about it?My Healthy Waist
By Luc Van Gaal, MD, PhD, Professor of Medicine, Antwerp University Hospital, Faculty of Medicine, Department of Diabetology, Metabolism & Clinical Nutrition, Antwerp, Belgium
Physical Activity in the Management of Abdominal ObesityMy Healthy Waist
By Robert Ross, PhD, Professor, School of Kinesiology and Health Studies, Department of Medicine, Division of Endocrinology and Metabolism, Queen's University, Kingston, ON, Canada
Abdominal obesity, intra-abdominal adiposity and related cardiometabolic risk...My Healthy Waist
By Jean-Pierre Després, PhD, FAHA, Scientific Director, International Chair on Cardiometabolic Risk, Professor, Division of Kinesiology, Université Laval, Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada.
Plant-based Eating: Enhancing Health Benefits, Minimizing Nutritional RisksRobin Allen
Learning Objectives
At the end of the session, the participants will be able to:
1. Know there is no single definition of a plant-based diet.
2. Discuss health aspects of vegetarian and vegan diets and quality of evidence supporting health claims.
3. Assess nutritional adequacy/status of vegetarians and/or vegans throughout the life cycle and provide strategies for meeting dietary recommendations for vitamin B12, DHA calcium, and zinc.
Prevalence of obesity.Body composition & body shape (body fat distribution ) and CVD risk .Mechanisms linking obesity with cardiovascular disease.Fat-but-Fit Paradigm and CVD,The Relationship of Metabolic Risk Factors and Cardiorespiratory Fitness. Metabolically Healthy but Obese ( MHO ) Phenotype and CVD.Obesity Paradox in Patients With CVD
Learn the basics of Diabetes Prevention, reversal and Management. The Science is clear, follow the five key behavior changes to live a diabetes-free life.
Join Doc Andrew to see the research that supports plant based diet recommendations. Address common misconceptions. Ask questions @DenverWWAD or join current discussions at #PlantBased, #PlantBasedRx, or #CulinaryRx.
Also, enjoy bonus learning with these topic-related, 2-minute podcasts by Dr. Andrew:
"The Plant Based Diet and How to Get Started"
https://soundcloud.com/denverwwad/healthcast-23
"Eat Your Way to the Finish Line"
https://soundcloud.com/denverwwad/healthcast-4
Andrew Freeman, MD, FACC, FACP is a cardiologist and Assistant Professor of Medicine at National Jewish Health, Denver, Colorado. He is part of the leadership of both the local and national American College of Cardiology.
Dr. Freeman founded the Denver chapter of the Walk with a Doc program and is the leader of Walk with a Doc-Colorado.
Walk with a Doc-Denver is a free health improvement and community empowerment initiative. Local doctors and a team of healthcare professionals--all volunteers--host Saturday walks that include expert talks, health screenings, refreshments, and motivational giveaways. For more info visit: Denver.WalkWithADoc.org
The root cause of chronic diseases, cancer and aging was recently understood. It includes 1- A state of chronic low grade inflammation secondary to hyperglycemia and obesity leading to insulin - leptin resistance. 2- Mitochondrial dysfunction. Diet, Intermittent fasting or its alternative the Metabolic Bariatric Surgery and Exercise play a significant rule in the salvage of these problems. Exercise is any bodily activity that enhances or maintain physical fitness and overall health, Exercise with its Countless Benefits is the logical salvage for a group of diseases related to inactivity . In view of the prevalence, global reach and health effect of these physical inactivity related diseases, the issue should be appropriately described as pandemic, with far-reaching health, economic, social and Environmental consequences.These diseases include, Obesity, Coronary artery disease, Diabetes, Hypertension, Cancer, Depression and anxiety, Arthritis, Osteoporosis, Etc, etc, etc… I think we have no option except doing regular exercises if we seriously search for a salvage to escape the bad and serious consequences of these new life style diseases.
The root cause of chronic diseases, cancer and aging is recently understood. It includes 1- A state of chronic low grade inflammation secondary to hyperglycemia and obesity leading to insulin resistance. 2- Mitochondrial dysfunction. Exercise play a significant rule in the salvage of these problems. Exercise is any bodily activity that enhances or maintain physical fitness and overall health, Exercise with its Countless Benefits is the logical salvage for a group of diseases related to inactivity . In view of the prevalence, global reach and health effect of these physical inactivity related diseases, the issue should be appropriately described as pandemic, with far-reaching health, economic, social and Environmental consequences.These diseases include, Obesity, Coronary artery disease, Diabetes, Hypertension, Cancer, Depression and anxiety, Arthritis, Osteoporosis, Etc, etc, etc… I think we have no option except doing regular exercises if we seriously searching for a salvage to escape the bad and serious consequences of these new life style diseases.
Suomalaisten energiaravintoaineiden ja ruokien kulutusReijo Laatikainen
Tämä diasarjaa kertoo miten suomalaisten ruuan käyttö on muuttunut. Luvut perustuvat FAO:n tilastoihin, jotka puolestaan perustuvat suomalaisiin Ravintotaseisiin.
Ruokavalio ja sydän- ja verisuonisairaudet SuomessaReijo Laatikainen
Tässä diasarjassa esittelen sydänsairauksien ja ravinnon välisiä yhteyksiä erityisesti suomalaisten perspektiivistä. Esittelen pääasiassa meta-analyysien ja systemoitujen katsauksien tuloksia koska ne ovat luotettavampia kuin yksittäiset tutkimukset.
Hullua menoa ravintotutkimuksessa ja -keskustelussaReijo Laatikainen
Tässä diasarjassa kerron näkemyksiäni siitä miksi ravintotutkimukset tuntuvat välillä niin hulluilta ja miksi keskustelu on välillä niin vaikeaa ja miksi solvaaminen on yleistä.
Miten ruoka, laihdutus ja ravintolisät, kuten kurkuma, inkivääri ja omega-3 rasvahapot (kalaöljy) vaikuttavat tavallisten nivelsairauksien riskiin ja miten ne toimivat vaivojen hoidossa? Tutkimustietoon perustuvat diasarja.
Tässä kuvasarjassa kerron karppaukseen liittyvästä kliinisestä tutkimuksesta ja esitän oman näkemykseni karppauksen asemasta ja siitä miten se tulisi toteuttaa.
Paleo ja terveys, onko maidosta ja viljoista haittaa vai hyötyäReijo Laatikainen
Tässä diasarjassa kuvataan maidon välttämisen ja viljan välttämisen mahdollisia hyötyjä ja toisaalta mahdollisia välttämisen mukanaan tuomia joitakin riskejä.
Epidemiological evidence linking food, nutrition, physical activity and prostate cancer risk: results from the Continuous Update Project
By Michael Leitzmann, Dept. of Epidemiology and Preventive Medicine, University of Regensburg, Continuous Update Project Panel member
World Cancer Congress, Saturday 6 December 2014
Professor Michael Leitzmann presentation on The Continuous Update Project: Recent Findings on Diet, Nutrition, Physical Activity and Cancer at FENS European Nutrition Conference, 20-23 October 2015 Berlin (Germany).
Clinical Question: Does meat consumption affect mortality?
Evidence: All-cause mortality is higher for increased daily consumption of red meat, especially processed meat. However, the compiled evidence does not link other meat products to all-cause mortality.
Recommendation: Physicians should encourage patients to limit animal products when possible, and substitute red meat and processed red meat with plant-based foods. Patients may supplement a plant-based diet with moderate amounts of fish, poultry, eggs, and dairy if desired.
Join Doc Andrew to see what's new in health research that supports plant based diet recommendations. Share your questions via @DenverWWAD or email FreemanA@njhealth.org
Andrew Freeman, MD, FACC, FACP is a cardiologist and Director of Clinical Cardiology and Operations at National Jewish Health in Denver, Colorado. He holds leadership roles in the American College of Cardiology at the local and national levels. Dr. Freeman founded Denver's chapter of the Walk with a Doc program and heads Walk with a Doc-Colorado.
Walk with a Doc-Denver is a cost-free empowerment initiative powered by people improving their health, local doctors, and other health professionals who prescribe exercise-as-medicine. The mission? To elevate community health--one walk at a time! The program's Saturday walks include expert talks, health screenings, refreshments, and motivational giveaways. For more info visit: http://walkwithadoc.org/our-locations/denver/
Nutrition in Cancer Prevention and TreatmentTim Crowe
This presentation will help you to understand the influence that dietary and lifestyle factors play in the prevention and causation of cancer. It outlines the important nutritional considerations for patients undergoing treatment for cancer and reviews procedures to improve patient safety by knowing the risks and benefits of antioxidant supplementation during cancer treatment
Recomendaciones para luchar contra el cambio climático mediante la alimentación
1. Comer poca carne
2. Reducir el sobre consumo de energía (disminuir las tasas de obesidad)
Food choices can help prevent cancer and, when cancer has been diagnosed, nutrition can improve survival. These links between diet and cancer are nothing short of dramatic. And now you can learn how certain dietary patterns help people diagnosed with cancer live longer, healthier lives.
Presentazione a cura del Dottor Riccardo Marmo - "HOT TOPICS IN GASTROENTEROLOGIA - I TUMORI DELL'APPARATO DIGERENTE: cosa è cambiato e cosa bisogna sapere" - Roma 10/11/2018
Professor Alan Jackson’s presentation, The Continuous Update Project: Recent Findings on Diet, Nutrition, Physical Activity and Cancer, at the African Organisation for Research & Training in Cancer (AORTIC) conference, 18-22 November 2015, Marrakech, Morocco.
Kaurajuomien, -jogurttien-, kermojen vertailua ravitsemuksellisen arvon suhteen. Fokus rasvan laadussa, proteiinissa, kuidussa ja suojaravintoaineissa, kuten D-vitamiinisssa, kalsiumissa, B12-vitamiinissa ja jodissa.
Teen tässä diasrajassa vertailua, miten suomalaisten syöminen muuttuisi ravintoaineiden saannin ja toisaalta ruuan käytön näkökulmasta, jos siirtyisimme planetaariseen ruokavalioon.
Tässä kuvasarjassa verrataan mineraalisuolaa, ruusu- eli vuorisuolaa ja tavallista ruokasuolaa. Merisuolan mineraalipitoisuudet ovat hyvin lähellä ruususuolaa.
Tässä diasarjassa esitellään ruokavalion ja yleensä ravitsemuksen merkitystä hedelmällisyydessä. Tieto perustuu ihmisillä tehtyihin kliinisiin ja väestötutkimuksiin.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
1. Effects of sources of animal
protein on major chronic diseases.
Meta-analyses of prospective
cohorts.
Registered dietitian, M.Sc, MBA
Reijo Laatikainen
Aava Medical Center
Docrates Cancer Center
www.pronutritionist.net
www.tervevatsa.fi
2. Introduction
• This slide deck bases on recent meta-analyses of prospective cohorts
which are considered at least as important as surrogate marker
randomized studies.
• Small box depicts actual outcome (meta-regression). Red =risk is
increased, blue=no statistically significant change in risk and
green=risk is reduced
• Vertical line depicts confidence interval in each meta-analysis.
• Risk comparisons are formed by comparing the highest vs lowest
category of consumption (ie. quintiles, tertiles, thirds or so). Exception:
Red and processed meat (per 100g/50 g) and cardiovascular diseases.
4. Red meat is associated with increased of
risk of diabetes, stroke and colorectal
cancer
Page 4
0.70
0.80
0.90
1.00
1.10
1.20
1.30
1.40
1.50
1.60
1.70
1.80
1.90
2.00 Relative RIsk
(Vertical line: 95% CI)
1.10
1.02 1.00
1.19
1.09 1.00
Colorectal cancer Breast cancer Prostate cancer Type 2 Diabetes Stroke Coronary Heart disease
Stroke and CHD: Per 100 g/day, because comparison between lowest vs highest categories not given
6. Processed meat is associated with
increased of diabetes, CHD, stroke and
colorectal cancer
0.70
0.80
0.90
1.00
1.10
1.20
1.30
1.40
1.50
1.60
1.70
1.80
1.90
2.00 Relative RIsk
(Vertical line: 95% CI)
Colorectal cancer Breast cancer Prostate cancer Type 2 Diabetes Stroke Coronary Heart disease
Colorectal cancer Breast cancer Prostate cancer Type 2 Diabetes Stroke Coronary Heart disease
Stroke and CHD: Per 50 g/day, because comparison between lowest vs. highest categories not given
1.17
1.00 1.05
1.51
1.15
1.42
12. Dairy is associated with decreased risk of
diabetes, CV diseases, breast and colorectal
cancer but also with increased risk of
prostate cancer
0.7
0.8
0.9
1
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
2 Relative RIsk
(Vertical line: 95% CI)
Colorectal cancer Breast cancer Prostate cancer Type 2 Diabetes Stroke Coronary Heart disease
0.81 0.85
1.13
0.89 0.87
0.94
14. There are no meta-analyses of
prospective cohorts available on white
meat.
0.5
0.6
0.7
0.8
0.9
1
1.1
1.2
1.3
1.4
1.5
However, individual cohorts most
often so neutrality of poultry. Also,
meta-analysis of colorectal adenomas
demonstrated neutrality of poultry
(Xu et al. 2014)
Colorectal cancer Breast cancer Prostate cancer Type 2 Diabetes Stroke Coronary Heart disease
15. Sources 1/2
Alexander DD, Morimoto LM, Mink PJ, Cushing CA. A review and meta-analysis of red and processed meat
consumption and breast cancer. Nutr Res Rev. 2010;23(2):349-65.
Alexander DD, Mink PJ, Cushing CA, Sceurman B.. A review and meta-analysis of prospective studies of red
and processed meat intake and prostate cancer. Nutr J. 2010;9:50.
Aune et al, Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort
studies, ,Ann Oncol. 2012;23(1):37-45.
Chan DSM, Lau R, Aune D, et al. Red and Processed Meat and Colorectal Cancer Incidence: Meta-Analysis
of Prospective Studies. PLoS ONE. 2011;6(6):e20456
Chen GC, Lv DB, Pang Z, Liu QF. Red and processed meat consumption and risk of stroke: a meta-analysis
of prospective cohort studies. Eur J Clin Nutr. 2013 Jan;67(1):91-5.
Dong J et al. Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies.
Breast Cancer Res Treat. 2011;127(1):23-31
Gao D, Ning N, Wang C, Wang Y, Li Q, Meng Z, Liu Y, Li Q.Dairy products consumption and risk of type 2
diabetes: systematic review and dose-response meta-analysis.PLoS One. 2013 Sep 27;8(9):e73965
Leung Yinko SS, Stark KD, Thanassoulis G, Pilote L.Fish consumption and acute coronary syndrome: a
meta-analysis. Am J Med. 2014 Sep;127(9):848-57.e2
Micha R, Mozaffarian D. Unprocessed Red and Processed Meats and Risk of Coronary Artery Disease and
Type 2 Diabetes - An Updated Review of the Evidence. Atheroscler Rep. 2012:14;515-52
Qin LQ, Milk consumption is a risk factor for prostate cancer in Western countries: evidence from cohort
studies. Asia Pac J Clin Nutr. 2007;16(3):467-76.
16. Sources 2/2
Qin LQ, Xu JY, Han SF, Zhang ZL, Zhao YY, Szeto IM. Dairy consumption and risk of cardiovascular disease:
an updated meta-analysis of prospective cohort studies. Asia Pac J Clin Nutr. 2015;24(1):90-100
Shin JY, Xun P, Nakamura Y, He K. Egg consumption in relation to risk of cardiovascular disease and
diabetes: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98(1):146-59.
Si R, Qu K, Jiang Z, Yang X, Gao P. Egg consumption and breast cancer risk: a meta-analysis. Breast Cancer.
2014 May;21(3):251-61
Szymanski KM, Wheeler DC, Mucci LA. Fish consumption and prostate cancer risk: a review and meta-
analysis. Am J Clin Nutr. 2010;92(5):1223-33.
Xie B, He H. No association between egg intake and prostate cancer risk: a meta-analysis. Asian Pac J
Cancer Prev. 2012;13(9):4677-81.
Xun P, Qin B, Song Y. Fish consumption and risk of stroke and its subtypes: accumulative evidence from a
meta-analysis of prospective cohort studies. Eur J Clin Nutr. 2012;66(11):1199-207.
Wu S1, Feng B, Li K, Zhu X, Liang S, Liu X, Han S, Wang B, Wu K, Miao D, Liang J, Fan D.
Fish consumption and colorectal cancer risk in humans: a systematic review and meta-analysis. Am J Med.
2012 Jun;125(6):551-9.e5.
Zheng Ju-Sheng, Hu Xiao-Jie, Zhao Yi-Min, Yang Jing, Li Duo. Intake of fish and marine n-3 polyunsaturated
fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies
BMJ 2013; 346 :f3706
17. Discussion 1/2
• Results are very well in line with recommendations of
World Cancer Research Fund (WCRF/AIRC expert report
2007), and with most international dietary guidelines
• Results are rather well in line with results of randomized
trials regarding Mediterranean Diet (Predimed, Lyon, Oslo
Diet Heart)
• Results are very well in line with the analysis of systematic
reviews and meta-analyses published between 1950-2013
(Fardet & Boirie 2013)
18. Discussion 2/2
• These data are not the ”final word”. Prospective cohorts
cannot show causality and various confounders can affect
results. However, no better data exists on the long term
effects of protein sources on health.
• Magnitude of effects is relatively small
• These data do not tell much about extreme users. One is
classified as a high user of eggs if consumption exceeds 7
eggs per week. This may dilute the actual effects.
• More randomized trials are needed to clarify the effects of
different animal protein sources on health, but none of this
data shows we should increase the intake of red or
processed meat at the population level.
19. What might explain effects of red and
processed meat?
• Excessive intake of heme iron
• Advanced glycation end products, AGE:s ↑
• Polycyclic aromatic hydrocarbons, PAH:s ↑
• N-nitroso compounds (NOC) and N-nitrosation ↑
• IGF-1↑
• Amount of bifidobacteria ↓. Amount of various bad bacteria ↑
• Salt
• Phosphates and other additives
• Induction of TMAO production in the gut (from choline & carnitine)
• Saturated fat
• Arachidonic acid
• Endotoxins (LPS) in minced and processed meat and increased LPS
production in gut
• Neu5gc
• Meat substitutes healthier choices of protein such as fish or plant protein
(less n-3 fatty acids, iodine, taurine & vitamin D)
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20. Why dairy might be healthier than red
and processed meat?
• Fermented dairy has beneficial effects on gut bacteria
• Natural ACE-inhibitors of fermented dairy products
• Anti-inflammatory effects of whey protein
• Vitamin K2 of cheese and fermented dairy
• Production of TMAO in the gut decreases (studies on
cheese)
• Production of butyrate increases in the gut (studies on
cheese)
• Dairy substitutes unhealthier animal protein sources (less
heme iron, less NOCs, less PAH, less neu5gc, less
arachidonic acid etc.)
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