This document discusses principles of fracture management. It defines fractures as breaks in bone continuity and classifies them as closed or open. For open fractures, initial management involves antibiotic prophylaxis, wound and fracture debridement, and early wound cover or stabilization. Closed fracture management focuses on reduction, maintaining reduction through splinting, casting or fixation, and rehabilitation. Complications of different fixation methods like skeletal traction are also reviewed. The main goals of fracture treatment are outlined as reduction, maintaining reduction, and rehabilitation.
classification of soft tissue injuries. gustilo anderson classification, tscheren classification, hanover fracture scale and ao soft tissue grading system, types of wounds. orthopedic open fracture classification for management of soft tissue injuries
classification of soft tissue injuries. gustilo anderson classification, tscheren classification, hanover fracture scale and ao soft tissue grading system, types of wounds. orthopedic open fracture classification for management of soft tissue injuries
This slide includes general principles of fracture management. This is just a basic idea. I have tried to include figures as well as videos. But unfortunately videos wont play here.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
2. A fracture is a break in the structural continuity of
bone. It may be no more than a crack, a crushing
or a splintering of the cortex .
Fracture
Closed fracture:
the overlying skin remains intact.
Open fractures:
An open fracture is a fracture that communicates
with an overlying break in the skin. also known
as a compound fracture) AAOS 2009
4. A -Airwaywith cervical spine protection.
B -Breathing.
C -Circulationwith haemorrhage control.
D -Disabilityor neurological status.
E-Exposure and Environment.
ABCDE
5. OPEN vs. CLOSED
• Reduction
• Maintain reduction
• Rehabilitation.
Three main objectives
6. IIIC
There is an arterial injury which needs to be repaired,
regardless of the amount of other soft-tissue damage.
Openfractures
7.
8. Initial management
A. Antibiotic prophylaxis
B. Urgent wound and fracture
debridement
C. Early definitive wound cover
D. Stabilization of the fracture
Openfractures
10. B. Urgent wound and fracture debridement
• Wound excision& extension
• Examinationof the fracture
surfaces
• Removal of devitalized tissue
• Nerves and tendons
“As a general rule it is best to
leave cut nerves and tendons
alone”
11. Earlydefinitivewoundcover
Wound closure
A small, uncontaminated wound
in a type I or II fracture may be
sutured (after debridement),
second look at surgery….
definite fracture covering should
be done ideally within 48–72
hours, and not later than 5–7
days
12. The method of fixation selected depends on
• The degree of contamination,
• Time from injury to operation and
• Amount of soft-tissue damage.
Stabilizationof the fracture
open fractures of all types can be treated as for a closed injury?
If there is no obvious contamination and definitive
wound cover can be achieved at the time of
debridement
13. The External fixator vs. Internal fixation
(1) the delay towound coveris less than 7 days;
(2) wound contamination is not visible; and
(3) internal fixation can control the fracture as well as the
external fixator
When to change external
fixation to internal fixation ?
19. • Function
• Mobility
• Union
• Neurovascular compromise
• Cosmesis
Reduction is important if
20. Situations in which reduction is unnecessary:
(1)when thereis little or nodisplacement;
(2) Whendisplacement does not initially matter (e.g. in some fracturesofthe
clavicle); and
(3) when reductionis unlikely to succeed(e.g. with compression fracturesof
the vertebrae).
Could reduction be unnecessary ?
21. Open Vs. Closed
Reduction
Closed manipulation is suitable forall minimally displaced
fractures,formostfracturesin children and forfracturesthat
arelikely tobestable afterreduction.
(1) The distal part of the limb is pulled
in the line of the bone;
(2) As the fragments disengage, they
are repositioned (by reversing the
original direction of force if this can be
deduced); and
(3) Alignment is adjusted in each plane.
22. Open Vs. Closed
Open reduction
Operative reduction under direct
vision is indicated:
(1) when closed reduction fails
(2) when there is a large articular
fragment that needs accurate
positioning;
(3) for avulsion fractures
(4) when an operation is needed
for associated injuries (e.g. arterial
damage).
26. External splintage
How accurately the fracture needs to be held??
(1)Cast splintage;
(2) Sustained traction;
(3) Functional bracing;
(4) Internal fixation;
(5) External fixation.
27. Cast splintage
POP vs. New types
Advantages
• light in weight, but very strong
• patient may be able to bear weight on
an unprotected cast
• nursing and moving a patient easer
• waterproof
Disadvantages.
• they cannot be readily molded
and are more expensive.
28. Sustained traction
Types Based On Method Of Application
1. Skin traction
The traction force is applied over a large
area of skin
2. Skeletal traction.
Applied directly to the bone either by a pin
or wire through the
bone.
3. Traction by gravity
Applies only to upper limb injuries.
Particularly useful for spiral fractures of long-bone shafts,
which are easily displaced by muscle contraction
29. Types Based On Mechanism
1.Fixed traction,
e.g. Thomas’s splint
2.Balanced traction ,
e.g Braun’s frame for
the tibia
3.Combination of the two.
30. • Allergic reactions to adhesive
• Excortication of skin
• Pressure sores around the malleoli
and over the tendo calcaneus
• Common peroneal nerve palsy
• infection into the bone
• Incorrect placement of the pin or wire may-
o Allow the pin or wire to cut out of the bone causing pain and the
failure of the traction system
o Make control of rotation of the limb difficult
o Make the application of splints difficult
o Result in uneven pull being applied to the ends of the pin or wire
and thus cause the pin or wire to move in the bone
• Distraction at the fracture site
• Ligamentous damage if a large traction force is applied through a joint
for a prolonged period of time
• Damage to epiphyseal growth plates when used in children
• Depressed Scars
Complications of Skeletal Traction
Complications of Skin traction
31. Removal Of Traction
• Elbow fracture with olecranon pin 3weeks
• Tibial fracture with calcaneal pin 3-6 weeks
• Trochanteric fracture of femur 6weeks
• Femoral shaft fracture
o with application of cast brace and 6 weeks
partial weight bearing
o without external support and 12 weeks
partial weight bearing
33. Rehabilitate.
This begins immediately after the primarytreatment. Thelimb is moved and used as muchas the method of fixation
allows
This helps to stimulate union and to prevent joint stiffness. Internal fixation, if secure, has
great advantages in this respect.
Whensplintage is discontinued, a furtherperiod of exercises or physiotherapy is often necessary before full joint
functionis restored