Open fractures are unique, complex, and emergently presenting injuries that expose sterile bone to the contaminated environment.
Because a fracture disrupts the intramedullary blood supply, the additionally stripped soft tissue envelope further devitalizes the bone.
The more severe the soft tissue injury or open wound, the more severe the osseous injury.
Historically, open fractures were associated with infection, delayed union, nonunion, amputation, or death.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
management priorities in high energy trauma
Define the terms of fracture, dislocation and Subluxation
Identify the clinical and radiological pictures of fractures
Classify the different types of fractures
general principles of fracture management
Principles of open fracture management
Open fractures are unique, complex, and emergently presenting injuries that expose sterile bone to the contaminated environment.
Because a fracture disrupts the intramedullary blood supply, the additionally stripped soft tissue envelope further devitalizes the bone.
The more severe the soft tissue injury or open wound, the more severe the osseous injury.
Historically, open fractures were associated with infection, delayed union, nonunion, amputation, or death.
Hoffa's Fracture: Diagnosis, management & New Classification System by BAGARI...Vaibhav Bagaria
Hoffa's Fracture - coronal split fracture of distal femur, its diagnosis, management strategy, a new classification and tips and tricks of management. First described Hoffa, a new classification system by Bagaria et al helps plan the surgery for these tricky fracture. The most crucial step is not to miss these fractures in ER.
management priorities in high energy trauma
Define the terms of fracture, dislocation and Subluxation
Identify the clinical and radiological pictures of fractures
Classify the different types of fractures
general principles of fracture management
Principles of open fracture management
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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3. INTRODUCTION
• Definitions
– A fracture is a break or disruption in the
structural continuity of a living bone with
associated injury to the overlying tissue
– An open fracture is one in which the
fracture haematoma communicates with
the external environment
4. INTRODUCTION
• Epidemiology
– Annual incidence for open fracture of long bones: 11.5% (UK)
– About 40% involve the lower limbs
– Tibia is more commonly affected
– Age group: commonly 3rd and 4th decades
– Male > Female
5. AETIOLOGY
• Majority of open fractures (up to 60%) are caused by road traffic crash
• Other aetiological factors
• Fall from height
• Pedestrian/automobile collisions
• Motor to bike collisions
• Gunshot injury
• Bike to bike collisions
• Communal clashes
• Terrorist attacks
• Sports injury
6. CLASSIFICATION OF OPEN FRACTURE
• The most widely used is that of Gustilo and Anderson
• Other classification systems include;
– Tscherne and Oestern
– AO-ASIF
– Orthopaedic Trauma Association
7. GUSTILO AND ANDERSON OPEN FRACTURE
CLASSIFICATION
Open
fracture
Mechanism of
injury
Degree of soft
tissue damage
Fracture
configuration
Level of
contamination
8. GUSTILO AND ANDERSON OPEN FRACTURE
CLASSIFICATION
• Gustilo & Anderson type I
– Wound less than 1cm
– Minimal soft tissue injury
– Minimal contamination
– Fracture usually simple transverse,
short oblique fracture
– Low energy injury
9. GUSTILO AND ANDERSON OPEN FRACTURE
CLASSIFICATION
• Gustilo & Anderson type II
– Wound greater than 1 cm but <10cm
– Moderate soft tissue injury
– Slight or moderate crush
– Moderate contamination
– Simple transverse short oblique fracture with
moderate comminution
– Low-moderate energy
10. GUSTILO AND ANDERSON OPEN FRACTURE
CLASSIFICATION
• Gustilo & Anderson type III
– An open segmental # or a single # with extensive soft-tissue injury
– Highly contaminated
– Usually comminuted
– Severe energy injury
– IIIA, IIIB, IIIC
• Depends on soft tissue injury
11. GUSTILO AND ANDERSON OPEN FRACTURE
CLASSIFICATION
• Gustilo & Anderson type IIIA
– Adequate soft tissue coverage of
the bone
12. GUSTILO AND ANDERSON OPEN FRACTURE
CLASSIFICATION
• Gustilo & Anderson type IIIB
– Extensive periosteal stripping and
bone exposure
– Requires free or local flap for bone
coverage
13. GUSTILO AND ANDERSON OPEN FRACTURE
CLASSIFICATION
• Gustilo & Anderson type IIIC
– Any open fracture that is associated with
an arterial injury that must be repaired
regardless of the degree of soft tissue
injury
15. MANAGEMENT
• Emergency care
– Open fracture is an orthopaedic emergency
– Treatment of open fracture is second only to life threatening and arterial injury
– It is imperative to immediately treat open fracture in order to reduce or prevent
wound sepsis
– Treat the patient, not only the fracture
– ATLS principles
– Take clinical photo
– Neurological status
– Vascular status
16. MANAGEMENT
• Emergency care (cont.)
– Remove gross debris, gentle pressure irrigation, sterile dressing
– Reduce fractures or dislocations
– Splint limb
– Analgesia
– Tetanus prophylaxis
– Antibiotics
– Basic investigations
• X-ray of the affected limb
• Trauma x-ray series if indicated
• Haemoglobin or packed cell volume
• Grouping and cross matching
– Pre operative planning
17. MANAGEMENT
• Definitive management
– Diagnosis
• History
– History of trauma
» Pain
» Bruising
» Loss of function
» Deformity
– Limitations and debilitation attributed to the problem
– Good surgical history, especially with regards to orthopaedic surgeries and
prior anesthesia
– Co-morbid conditions
18. MANAGEMENT
• Definitive management
• Physical examination
– General signs
– Local signs
» Look, feel and move principle
» Start with normal structures and move to abnormal
» Look
• Swelling
• bruises
• The posture of the distal extremity and
• The colour of the skin
19. MANAGEMENT
• Definitive management
• Physical examination (cont.)
– Local signs
» Feel
• localized tenderness
• Neurologic exam
• Vascular exam
» Move
• Abnormal movement
• While move when there are x-rays
21. MANAGEMENT
• Definitive treatment
• Goals of treatment
– Preservation of viable soft tissues
– Prevent infection
– Achieve fracture union
– Restore function
22. MANAGEMENT
• Definitive treatment
• Principles of treatment of open fracture
– Antibiotic prophylaxis
– Urgent wound and fracture debridement
– Stabilization of the fracture
– Early definitive wound cover
24. MANAGEMENT
• Definitive treatment
• Debridement
– To render the wound free of foreign materials and devitalized tissues,
leaving a clean surgical field and tissue with good blood supply
– Serial debridement
– Done under anaesthesia
– Principles
» Wound extension and exploration
» Removal of devitalized tissue
» Wound irrigation
» Nerves and tendons
25. MANAGEMENT
• Definitive treatment
• Stabilization of the fracture
– Method depends on
» Degree of contamination
» Duration of injury
» Degree of soft tissue damage
» Nature of fracture
» Other associated injuries and
treatment
» Experience of surgeon and
surgical team
» Implant availability
– No contamination, wound cover
achievable- internal fixation
– Contamination, wound cover not
achievable- external fixation
26. MANAGEMENT
• Definitive treatment
• Definitive wound care
– Criteria for primary closure
» All necrotic material
should be removed
» Circulation should be
normal
» Nerve supply should be
intact
» The patient’s general
condition should be
stable
» Wound should be closed
without tension
» No dead space should be
left after closure
– Otherwise, debridement is
done and fracture stabilized
with external fixator
– Second look surgery may be
needed usually within 48-
72hrs but not later than
5days
27. MANAGEMENT
• Rehabilitation
– Immediate objectives of rehabilitation are to prevent muscle atrophy, prevent joint
stiffness and improve circulation in the extremity
– The ultimate objective is to restore the extremity to the greatest degree of function
– A well-organized rehabilitation program initiated early will help return the patient to
a functional status
– This involves
• Physiotherapy
• Occupational therapy
29. COMPLICATIONS OF FRACTURE
• Late complications
– Delayed union
– Non union
– Malunion
– Avascular necrosis
– Growth disturbance
– Bed sores
– Dysuse atrophy
– Joint stiffness
– osteoarthritis
30. PROGNOSIS
• Type of injury
– High-energy vs low-energy
• Location and extent of injury(s)
– To the soft tissues
– To the bone
• Degree of contamination
• Health status of the patient
• Initial treatment
31. PECULIARITY IN OUR ENVIRONMENT
• TBS patronage and its attendant complications is still a big challenge
32. CONCLUSIONS
• Fractures occur daily and may b associated with other life threatening injuries.
Therefore, management of patients should be given a holistic approach
• Management is directed at getting the patient back to functional capacity as early as
possible
• Advocacy/public education is needed to curb the menace of patronizing the TBS
33. REFERENCES
• Selvadurai Nayagam; Principles of fractures, in Apley’s System of Orthopaedics and
Fractures, 9th ed. 2010; 23: 687-732
• Perminder Singh; Extremity Trauma, in Bailey and Love’s Short Practice of Surgery,
26th ed. 2013; 29: 364-384
• P.V. Giannoudis et al; A Review of the Management of Open Fractures of the Tibia
and Femur, in The Journal of Bone and Joint vol. 88-B, No.3, March 2006: 281-289
• U.E. Anyaehie et al; Pattern of Femoral Fractures and associated Injuries in a
Nigerian Tertiary Trauma Centre, in The Nigerian Journal of Clinical Practice vol. 18,
issue 4, Jul-Aug 2015: 462-466
34. REFERENCES
• John Ebenezer; General principles of fractures and dislocations, in Textbook of
Orthopaedics, 5th ed. 2010; 3:15-29
• John Ebenezer; Complications of fractures, in Textbook of Orthopaedics, 5th ed.
2010; 4:30-49
• I.C. Ikem et al; Open Fractures of the Lower Limbs in Nigeria, in The Journal of
International Orthopaedics (August 2001)25: 386-388
• David J. Dandy and Dennis J. Edwards; Principles of managing trauma, in Essential
orthopaedics and trauma, 5th ed. 2009; 7: 93-122