1) The study evaluated the anticancer potential of the ethanolic extract of Buchanania lanzan leaves against diethylnitrosamine (DEN)-induced hepatocellular carcinoma in rats. 2) Administration of the extract at doses of 200 mg/kg and 400 mg/kg reduced serum markers of liver damage and oxidative stress in DEN-treated rats compared to the DEN alone group. 3) Preliminary phytochemical analysis revealed the presence of flavonoids, alkaloids, gallic acid and glycosides in the extract, which may contribute to its chemo preventive effects against liver cancer.