(1) This study examined how the Makerere University eLearning Environment (MUELE) can be used to improve interaction among distance learners through an activity theory approach. (2) The researchers found that MUELE has the potential to enhance interaction through its affordances like media, navigation, and accessibility features. However, tensions emerged within the activity system including a mismatch between instructors' constructivist approach and MUELE's social constructivist design, heavy workload for online facilitation, and lack of clear online policies. (3) By analyzing contradictions using activity theory, the study provides insights into challenges that must be addressed like staff motivation, user skills development, and adapting institutional culture to better support