Large volume parenterals are sterile aqueous drug products packaged in single-dose containers holding 100 mL or more. Small volume parenterals are packaged in containers holding 100 mL or less. Both are administered via intravenous, intramuscular, or subcutaneous routes. Key differences include that small volume parenterals may use preservatives and not require isotonicity, while large volume parenterals must be isotonic. Both undergo processes like cleaning, preparation, sterilization, filling, and packaging to ensure sterility. They are tested using methods like sterility testing, particulate testing, and pyrogen testing to ensure quality and safety.