This document discusses various ingredients and supplements for hair, skin, and nails. It describes the chemical composition of hair, skin, and nails and how certain nutrients can benefit them. Key ingredients discussed include biotin, pantothenic acid, cysteine, millet extract, hyaluronic acid, collagen peptides, selenium, zinc, vitamins C and E, and omega-3 fatty acids. Specific supplement products are also summarized, including what nutrients they contain and potential benefits. Directions for taking certain supplements are provided.

1. Hair, Skin and Nail products
How and why???

2. • K

4. Hair supplements

5. Chemical Composition of Human Hair
• Hair consists mainly of keratin protein; a biopolymer composed of 25
different amino acids
• and a small amount of lipids
• pigments
• and trace elements.

6. Chemical Composition of Human Hair
• The extreme strength and insolubility of
hair due to its large cystine content, the
filaments of the
• cortex are composed of low sulphur
proteins and
• surrounding matrix is made up of high
sulphur proteins,
• the cuticle cells do not contain any low
sulphur proteins.

7. • The chemistry of hair can be changed by lengthening, aging, and by
environmental insults as pollution, ultraviolet radiation.
• To treat hair loss, pharmaceuticals and cosmetic firms developed new
products claimed to contain effective ingredients to address the
above indirect causes of hair loss; include nutrients, blood flow
promoters, androgenic inhibitors

8. Sebum
composed of :
Triglcerides, free
fatty acids, wax
esters, cholesterol

9. PRIORIN®
• contains the following nutrients:
• Millet extract
• Calcium pantothenate
• L-cystine
• Biotin
• Given as 2 daily capsules of PRIORIN®. Since hair
naturally grows very slowly, the first result may be
seen after around 4 weeks.

10. • Pantothenic acid, also called vitamin B5 (a B vitamin), is a water-
soluble vitamin. Pantothenic acid is an essential nutrient.
• Animals require pantothenic acid in order to synthesize coenzyme-
A (CoA), as well as to synthesize and
metabolize proteins, carbohydrates, and fats.

11. Acetyl Coenzyme A. AcSCoA is a thioester.
N
N
N
NH2
N
O
OH
O
H
N
H
N
O
S
OH
O
O
P
O
O
O
P
O
O
O
P
O
O
O
R

12. Millet ‫الحبوب‬ ‫من‬
‫ن‬ّ‫خ‬ُ‫د‬‫ال‬ ‫نبات‬

13. Millet
• Contains Vitamins and Minerals
• Millet is a good source of B vitamins, which aid in energy metabolism,
enzyme activity, nervous system regulation and red blood cell
production.
• Millet is source of minerals magnesium, potassium, zinc, copper and
manganese from millet. According to the Office of Dietary
Supplements, magnesium is the most abundant mineral in our bodies
and plays a part in over 300 enzyme reactions in our bodies. It's also
essential for proper muscle and nerve function.

14. Millet
• Millet Provides Antioxidants
• Millet help to reduce your risk of developing chronic diseases.
According to a study published in the "Indian Journal of Biochemistry
and Biophysics" in February 2009, millet contains significant amounts
of phenols. These compounds function as antioxidants that help
prevent oxidative stress and damage in your body caused by harmful
free radicals.
• A diet high in antioxidants may help to prevent degenerative diseases
such as heart disease, cancer, osteoporosis and diabetes, according to
a 2005 article in "The American Journal of Clinical Nutrition.

15. Millet ‫مهمة‬ ‫معلومة‬
• Gluten-Free Food
• If you're following a gluten-free diet due to celiac disease, a wheat
allergy or gluten intolerance, millet is a safe grain for you to consume.

16. Pantogar
• Calcium Pantothenate
• Cysteine
• Medicinal yeast

17. Hair multivitamin supplements

18. Pantogar
• The active ingredients of Pantogar® and their importance for hair
growth:
• Cystine, an amino acid, is largely responsible for the structure of hair
keratin and promotes the growth of healthy hair.
• B-group vitamins, such as thiamine (vitamin B1) and calcium
pantothenate (vitamin B5), are indispensable for the high metabolic
activity in the formation of new hair cells.
• Medicinal yeast has a high content of vitamins, essential amino acids,
minerals, trace elements and enzymes and is a rich source of B-group
vitamins. It has beneficial effects on the metabolism of the skin and
hair

19. Saccharomyces cerevisiae
• Brewers yeast contains an abundance of B vitamins, which is vital to the energy of
cells in your body.
• Thiamine (B-1)
• riboflavin (B-2)
• niacin (B-3)
• pantothenic acid (B-5)
• pyridoxine (B-6)
• folic acid (B-9)
• biotin (B-7)
• In addition to B vitamins, brewer's yeast is also a good source of the
minerals selenium, copper, tin, chromium, and zinc; an important part of hair
health.

20. • In addition to 17 vitamins and 14 minerals, brewers yeast also
contains 16 amino acids that are highly 'bioavailable
• Brewers yeast should be accompanied by a wholesome nutritionally
balanced diet, which helps to insure that hair follicles are properly
nourished.

22. Another claims
•Brewers yeast helps create melanin in hair (that gives hair its color)
•so it may help prevent gray hair.>>>>>> There is no evident for this claim
•Brittle hair is caused by many factors including aging, dietary deficiency,
and inadequate blood circulation to the scalp. Brewer's yeast contains many B vitamins,
which improve blood circulation to the scalp to the overall strength of the hair follicle.
•Brewers yeast adds a healthy shine to your hair by providing many essential nutrients.
•Once you start supplementation, you should notice how luxurious your hair feels and looks
and how much your hair shines >>>>>> true
Since brewers yeast is an excellent source of biotin, it may help slow down or prevent hair
loss.
• Insufficient amounts of biotin are said to contribute to baldness.

23. Nutritional
effects on
hair growth
and health

26. Hair, Skin , and Nails

27. Biotin
• Is an important component of enzymes involved in metabolizing fats
and carbohydrates, influencing cell growth, and affecting amino
acids involved in protein synthesis.
• Biotin assists in various metabolic
• Biotin is often recommended as a dietary supplement for
strengthening hair and nails, though scientific data supporting these
outcomes are weak.
• Nevertheless, biotin is found in many cosmetics and health products
for the hair and skin.

28. • Biotin
• plays an important role in metabolic function, in breakdown and
distribution of fatty acids, which result in healthy skin, hair and nails.
This creates a gloss on skin, in which it protects against water loss and
damage from the very harmful sunrays, maintenance and growth of
your hair strands, thickness of nail cuticles thus preventing easy
breakage.
S-CoA
O
+ HCO3
acetyl-CoA
carboxylase
biotin, ATP S-CoA
O
O
O
Malonyl CoA

29. CO2
O
pyruvate
+ CoASH +
OH
O N
HO
P
O
O
O
P
O
O
HO OH
O O O NH2
O
N
N
N
N
H2N
NAD
S-CoA
O
AcSCoA
+
OH
O N
HO
P
O
O
O
P
O
O
HO OH
O O O NH2
O
N
N
N
N
H2N
H
H
NADH
+ CO2 + H+
thiamin diphosphate (vitamin B1)
Lipoic Acid
Flavin adenine diphosphate (VitaminB2)

30. Biotin
• Biotin deficiency is rare.
• The amounts needed are small, a wide range of foods contain biotin,
and intestinal bacteria synthesize biotin, which is then absorbed by
the host animal.
• For that reason, statutory agencies in various countries, for example
the USA and Australia,have not formally established a recommended
daily intake of biotin.

32. • ‫نم‬

35. How does Perfectil's triple active formula work?
• Perfectil works by delivering nourishment
through the bloodstream, so works 'from
within'.
• Each tablet contains micronutrients
including:
• Riboflavin (vit.B2), Niacin (vit. B3) and
biotin which contribute to the maintenance
of normal skin
• Minerals selenium and zinc which
contribute to the maintenance of
normal hair and nails

37. Nutri-dermal™ capsule
• Each Nutri-dermal™ capsule provides
extra specific nutrients targeted at
skin health.
• Extra biotin†, which contributes to
the maintenance of normal skin
• Essential Omega-3 fatty acids from
fish oil and Omega-6 fatty acids from
Starflower and Blackcurrant Seed oil
• Plus Lutein, Co-enzyme Q10 and
Lycopene extract

38. Omega-3 fatty acids and the skin
• One study in the American Journal of Clinical Nutrition found that adults
who consumed a serving (3.5 ounces cooked) of omega-3-rich fish every
five days, on average, over five years had fewer sun-induced lesions called
actinic keratoses (AKs). These lesions, which can turn into skin cancer, often
develop in older people who have sustained serious sun damage.
• Eating more foods packed with omega-3 fatty acids chia seeds, spinach and
kidney beans, and other inflammation-fighting foods, helps support your
skin’s structure, reducing the appearance of fine lines
• In fact, researchers discovered that women who consumed half a teaspoon
of omega-3-rich flaxseed oil a day increased skin hydration by 39 percent
after 12 weeks. Their skin also felt significantly less rough and was less
sensitive.

39. Perfectil Plus Hair
• This formula is with copper which
contributes to normal hair pigmentation
(colour)
• Biotin, selenium and zinc which all
contribute to the maintenance of
normal hair
• Also includes Amino Acids, Marine
Collagen, Inositol and Grape Seed extract

40. • Extra selenium1 which contributes to
the maintenance of normal nails
• Copper which contributes to the
maintenance of normal connective
tissue
• Horsetail botanical extract
(Equisetum arvense L.), a natural
source of silica
• Methyl Sulphonyl Methane (MSM)
provides sulphur, which is an
important nutrient found in the outer
layer of the skin, hair and nails

41. Rigenforte
• The special prolonged release
capsule contains 4 small tablets. 2 of
them contain mainly sulfur amino
acids and minerals and the other 2
mainly sulfur amino acids and
vitamins.
• The release is delayed and
differential, to give the body the
possibility to use gradually and
wholly the nutrients they contain.

42. • Biotinax
• Folic Acid
• Zinc
• Selenium
• Vitamin E
• Vitamin B5
• Copper

43. • Biotinax
• ESI patented formula made of
Biotin, Methionine and
Cystine. Methionine and
Cystine are sulfur amino acids
that strengthen hair
keratinous structure, giving it
strength and elasticity.

44. • Ingredients
• D, L-methionine (250 mg)
• L-cystine (50 mg)
• Vitamin B5 (9 mg)
• Vitamina E (7,8 mg)
• Zinc oxide (7,5 mg)
• Vitamin B6 (2,1 mg)
• Copper gluconate (1 mg)
• Selenium yeast (55 mcg)
• D-biotin (50 mcg)
• Folic acid (300 mcg)
•

46. Novophane

49. • ‫ىة‬

53. • V

55. Skin supplements

56. • K

57. The dermis – collagen
• The dermis consists of connective tissue , which consists of a fairly dense
network of protein fibers ( such as collagen and elastin , collagen forms the
major constituent of the fibrous protein which give the skin its tensile
strength) embedded in a hydrophilic viscoelastic gel called ground
substance .
• Note : the collagen molecule is large so it cant penetrate the skin . So all
the newer anti-aging and anti wrinkle preparations ex: peptide /
oligopeptide …. etc. are mainly depend on gene signaling mechanism
(indirect process to stimulate the synthesis of natural collagen in the
dermis )---
• (our goal here is to make hydrolysis for collagen in our body to produce
amino acid then our body will respond to these amino acid by the synthesis
of more collagen to decompensate the degraded one

58. The dermis – ground substance
• Ground substance . the dermal ground substance consists of salts,
water and glycosaminoglycans . the latter form complexes with
protein molecules known as proteoglycans . the best-known
examples of glycosaminoglycans are hyaluronic acid and chondroitin
sulfate . hyaluronic acid is known to play a vital role in the hydration
of tissues since it carries with it a large volume of water.

59. Special additive / nutrients:
• Vitamins:
• Vitamin C has been used extensively in cosmetic formulations for
their skin lightening activity, free radical scavenger and collagen
synthesis anti-aging properties. Ascorbic acid was found to cause
epithelium thickening, with cells of larger volume in the granular and
spiny layers.
• Vitamin E protect skin from ultraviolet light, reducing the appearance
of fine lines and wrinkles, helps delay ageing and has skin
moisturizing properties due to its antioxidant activity.
• Vitamins B3 (niacin) , B12, Pro Vit. B5 (Panthenole) , K, and F.

60. Claims written on the product:
• increased skin hydration and radiance
• Reduced appearance of fine lines and facial wrinkles
• Increased skin suppleness
• Promote a vital appearance of skin on your entire body – age independent
• Support your beauty from within
• Improve skin elasticity and appearance
• Counteract skin aging
• Maintain hair strands
• Prevents nails breakage
• Reduce eye wrinkle depth

62. Verisol (bioactive collagen peptides )
• They stimulate our skin cells in the Dermis for the regeneration of
skin’s structure from the inside out. As a result the skin intact has less
visible wrinkles, is firmer and smoother and looks more vital
• Reduced appearance of fine lines and facial wrinkles
• -Promote a vital appearance of skin on your entire body – age
independent
• -Reduce eye wrinkle depth
Claim that match the ingredient

63. Hyaluronic acid
• It improves water storage which is an important part of the
connective tissue of the skin.
• It plays an important role in the firmness of the skin, due to its
hygroscopic property, the skin looks clear, plump and radiant.
• Hyaluronic acid keeps collagen synthesis up, as well as retaining skin
moisture, contributing to the anti-aging benefits to the skin

64. Selenium and Zinc
• PROTECTIVE EFFECT OF SELENIUM AND ZINC ON UV-A DAMAGE IN
HUMAN SKIN FIBROBLASTS
• It has been shown that Se supplied in the form of sodium selenite
and Zn supplied as ZnCI, protected cultured fibroblasts from UV-A
radiation and increased their survival rate.
• The mechanisms of action and therapeutic indications for
“antioxidant” molecules remain to be defined. It may become
possible to use antioxidants for the effective prevention of the
harmful effects associated with either phototherapy or exposure to
sunlight

65. selenium , zinc , Vitamin C and E
• Free Radicals and Extrinsic Skin Aging
• A wide variety of antioxidants or other phytochemicals have been
reported to possess substantial skin photoprotective effects, such as
lycopene, coenzyme Q, glutathione, carnosine, selenium, zinc,
bioflavonoids, green tea polyphenols, grape seed proanthocyanidins,
resveratrol, silymarin, genistein, and others on
• Anti oxidants reduce UV-induced skin inflammation, oxidative stress,
and DNA damage.

66. Direction of use:
• Oral daily intake of 25 ml beauty code (bioactive collagen peptides )
• Company name and address:
• Produced by : GELITA HEALTH . D69412 .Germany
• Sale and distribution : legend drug store ‫االسطورة‬ ‫مستودع‬

68. • Ds

69. • ‫ال‬

70. • ‫م‬

72. • Every medication consists of the active drug and one or more
excipients or diluting
• agents to give the drug a suitable form (see Sect.1.4). With remedies
for external use, the action of the medication depends much more on
the vehicle than in the case of orally
• administered drugs.

74. • First, the vehicle may produce a marked effect of its own (cooling, drying, moisturizing,
occluding) that contributes more to the overall effect of the medication than the drug
substance itself.
• Second, the percutaneous absorption of the drug
• substance depends critically on the nature of the vehicle (Fig. 8.1).
• For example, petroleum jelly produces a strong occlusive effect that promotes
absorption by increasing the degree of hydration of the epidermis.
• Other vehicles such as powders or detergents that draw moisture from the stratum
corneum tend to retard penetration.
• Ethanol is a penetration enhancer, explaining why, for example, tincture of arnica has a
much greater allergenicity than arnica cream.
• As noted above, the vehicle can greatly affect the moisture content of the stratum
corneum. Because of these intrinsic physicochemical actions, dermatologic agents