Polycystic kidney disease is caused by mutations in genes located on chromosomes 16p13.3 and 4q21. The kidneys become massively enlarged due to the growth of multiple cysts filled with fluid. Patients may be asymptomatic for years until renal insufficiency develops. Symptoms can include pain, bleeding, and high blood pressure as the cysts enlarge and damage the kidney tissue. Complications include liver and heart cysts as well as brain aneurysms. While the condition progresses slowly over decades, it ultimately leads to kidney failure and often death from heart or brain related issues.

1. Polycystic
Kidney disease
Lecture 52
Cystic Diseases
of the Kidney

7. Mutations in genes located on chromosome 16p13.3 (PKD1)
and 4q21 (PKD2),

11. Possible mechanisms of cyst formation in polycystic kidney disease

12. Gross Morphology
The kidneys are usually bilaterally
ENLARGEDand may achieve
enormous sizes; weights as high as 4 kg
for each kidney have been reported.

13. Morphology
• The external surface appears to be composed
solely of a mass of cysts, up to 3 to 4
cm in diameter, with no intervening
parenchyma. However, microscopic
examination reveals functioning nephrons
dispersed between the cysts.

14. Morphology
• The cysts may be filled with
•a clear, serous fluidor,
• more usually, with
turbid, red to
brown,
• sometimes hemorrhagic fluid.

15. A and B, Autosomal-dominant adult polycystic kidney disease viewed
from the external surface and bisected.
The kidney is markedly enlarged and contains numerous dilated cysts.

16. Clinical Features
Many of these patients remain
asymptomatic until renal
insufficiency announces the
presence of the disease.

17. Clinical Features
• Hemorrhage or progressive dilation of cysts
may produce PAIN.
• Excretion of blood clots causes RENAL COLIC.
The enlarged kidneys, usually apparent on
abdominal palpation, may induce a dragging
sensation.

18. Clinical Features
The disease occasionally begins with the
insidious onset of hematuria, followed by
other features of progressive chronic kidney
disease, such as proteinuria (rarely more
than 2 gm/day), polyuria, and hypertension.

19. Clinical features
• Patients with PKD2 mutations
tend to have an older age at
onset and later development
of renal failure.

20. Clinical Features
• Both genetic and environmental factors
influence disease severity.
• Progression is accelerated in blacks
(largely correlated with sickle-cell trait), in
males, and in the presence of
hypertension.

21. Clinical Features
• Intracranial berry aneurysms, presumably
from altered expression of polycystin in
vascular smooth muscle, arise in the circle of
Willis, and subarachnoid hemorrhages from
these account for death in about 4% to 10%
of individuals.

22. Extrarenal Manifestations
• About 40% have one to several cysts in the
liver (polycystic liver disease) that are usually
asymptomatic.
• The cysts are derived from biliary epithelium.
Cysts occur much less frequently in the
spleen, pancreas, and lungs.

23. Extrarenal Manifestations
• Mitral valve prolapse and other cardiac
valvular anomalies occur in 20% to 25% of
patients, but most are asymptomatic.
• The clinical diagnosis is made by radiologic
imaging techniques.

24. Clinical Features
• This form of chronic renal failure is
remarkable in that patients may
survive for many years with
azotemia slowly progressing to
uremia.

29. PROGNOSIS
• Ultimately,
• about 40% of adult patients die of coronary
or hypertensive heart disease,
• 25% of infection,
• 15% of a ruptured berry aneurysm or
hypertensive intracerebral hemorrhage, and
the rest of other causes.