This document provides an overview of polycystic kidney disease (PKD), including a history, introduction to the different types (autosomal dominant and recessive), pathophysiology, diagnostic tests and treatments. It discusses the first known case in the 16th century Polish king and subsequent studies defining it as a clinical entity. The two main types are described in more detail, focusing on genetics, characteristics and management. A case study is presented of a 42-year old female diagnosed with autosomal dominant PKD who underwent genetic testing identifying a heterozygous nonsense mutation.