This document discusses platelet-rich plasma (PRP), which contains a higher concentration of platelets than normal blood. PRP was first used in the 1950s and releases growth factors that can promote tissue regeneration. There are different types of PRP classified by their leukocyte and fibrin contents. PRP is prepared either through plasma-based or buffy coat-based methods. Current clinical applications of PRP include treatment of osteoarthritis, tendonitis, and plantar fasciitis. A study found PRP more effectively reduced pain and improved foot function over 24 weeks compared to corticosteroid injections, which were most effective at 12 weeks.

1. Platelet-rich Plasma (PRP) in
Orthopaedics and Traumatology
By Dr Atanu Kayal, 2nd year PGT(ORTHOPAEDICS)
BURDWAN MEDICAL COLLEGE AND HOSPITAL.

2. WHAT IS PLATELET-RICH PLASMA
 Platelet-rich plasma (PRP)
is VOLUME OF PLASMA THAT HAS
A PLATELET COUNT ABOVE THE
BASELINE OF WHOLE BLOOD
 This works for offering an ''ideal
environment'' for tissue
regeneration and so-called
biological therapy.
 PRP was introduced in the 1950s .
 First used in 1987(open heart
surgery).

3. Platelet
functions
 Main role in Coagulation
Cascade pathway.
 Growth factors released
from platelets includes..
PDGF, TGF-B, VEGF, IGF-1,
EGF, ETGF, FGF-2 etc.
 Proposed function of PRP
 increase ECM deposition
 reduce pro-apoptotic
signals
 minimize joint
inflammation

4. Principles and Methods of Preparation of
Platelet-Rich Plasma
• PRP are four types according to
leukocytes and fibrin contents..
Type 1: leukocytes rich PRP
Type 2: leukocytes reduced
Type 3:fibrin rich PRP
Type 4: leukocytes fibrin rich PRP.
• PRP preparation methods..
PLASMA BASED PRP
OR
BUFFY COAT BASED PRP

5. PRP MECHANISM OF ACTION......

6. Current Clinical Applications of PRP
•OA KNEE grade 1-2
•EPICONDYLITIS
•ROTATOR CUFF TEARS
•PLANTAR FASCITIS
•MENISCUS REPAIR
•TENDONITIS
•LIGAMENTS SURGERY

7. PRP application Technique.........
EPICONDYLITIS.....
ACCELERATE HEALING IN ACHILLES
TENDON RUPTURES

8. HOW TO USE???
 2 injections for every
4-7 days and follow up
after 2-6 weeks to
examine pain/function
 Lignocaine deactivates
alfa granules because
of decrease pH value..
so avoid
 Ultrasound imaging
used to ensure a safe
and precise placement

9. PRP CONTRAINDICATIONS
ABSOLUTE
PLATELET DYSFUNCTION
SYNDROME
CRITICAL THROMBOCYTOPNEA
HEMODYNAMIC INSTABILITY
SEPTICEMIA
LOCAL INFECTION AT PROCEDURE
SITE
RELATIVE
CONSISTENT USE OF NSAIDS
WITHIN 48 HORS OF PROCEDURE
SYSTEMIC CORTICOSTEROIDS
WITHIN 2 WEEKS
TOBACCO USE
LATELET COUNT < 105/ul
Hemoglobin <10
Cancer Patients

10. PLATELET RICH PLASMA VS
CORTICOSTEROIDS INJECTION in the Treatment of
Plantar Fasciitis
VAS score in PRP group,
difference was maximum at 24 weeks and in the steroid
group, it was at 12 weeks.
• visual analog scale (VAS)
FAAM scores shows that maximum
effect of PRP on FAAM score was at 24 weeks whereas in
steroid group, it was at 12 weeks
• foot and ankle ability measure
• (FAAM) scores.

11. THANK YOY