4. Pharyngeal (Branchial) Arches
• They are 6 mesodermal thickenings on both sides of
pharynx.
• They appear in the 4th
and 5th
weeks.
• Arches are covered with ectoderm (externally) and
lined with endoderm (internally).
• Arches are separated from each other by 4 clefts on
outer surface which is covered with ectodermal
cells.
• Arches are separated from each other by 5 pouches
on inner aspect (cavity of pharynx) which are lined
with endodermal cells.
Dr. Sherif Fahmy
12. Structure of each arch
• Each arch is composed of
mesodermal (mesenchymal) cells
that give rise to bones, cartilages
and muscles.
• Each arch has an arterial supply
which is called aortic arch.
• Each arch has a cranial nerve.
Dr. Sherif Fahmy
15. Each arch has a nerve supply:
-Mandibular & Maxillary n. supplies
derivatives of 1st
arch.
-Facial n. supplies derivatives of 2nd
arch.
-Glossopharyngeal n. supplies derivatives
of 3rd
arch.
-Superior laryngeal br. of vagus supplies
derivatives of 4th
arch.
-Recurrent laryngeal n. supplies
derivatives of 6th
arch.
N.B. Pre-trematic nerve crosses from one arch
to other, e.g. chorda tympani n.(branch of
facial n.) supplies anterior 2/3 of tongue.
21. Fate of Pharyngeal Clefts
• Clefts are present on outer surface between
the arches, covered with ectoderm.
• Dorsal part of first cleft forms external
auditory meatus and outer layer of ear drum.
• Downward growth of 2nd
arch will cover the
other clefts with a space inbetween called
cervical sinus.
• Cervical sinus becomes smaller till it is
completely obilterated. Dr. Sherif Fahmy
23. Fate of Pharyngeal Pouches
Arch Ventral partVentral part Dorsal partDorsal part
First pouch Occupied by
developing tongue.
Tubo-tympanic recess
that gives rise to midlle
ear & Eustachian tube
Second pouch Occupied by
developing tongue
Palatine tonsile
Third pouch Thymus gland Inferior parathyroid
gland
Fourth pouch Unknown Superior parathyroid
gland
Fifth pouch Ultimo-branchial
body which form
parafollicular cells
in thyroid
Dr. Sherif Fahmy
24.
25. Congenital Anomalies
• Ectopic thymic present in neck
• Ectopic parathyroid tissue especially inferior
parathyroid gland.
• Branchial cyst: Remenant of cervical sinus.
• Branchial fistula: Remenant of cervical sinus
that communicates with skin through extenal
fistula, while if it communicates with pharynx
it forms internal fistula.
Dr. Sherif Fahmy