Colon targeted drug delivery aims to treat diseases of the colon like ulcerative colitis and intestinal cancer. It delivers drugs that would otherwise be degraded in the stomach directly to the colon, minimizing side effects. Various approaches are used, including coating drugs with polymers that dissolve at the pH of the colon, or conjugating drugs to carriers that are cleaved by colonic enzymes. This allows targeted treatment of colon diseases while reducing dosing and systemic side effects compared to traditional oral drug delivery.
RECENT ADVANCES IN COLON TARGETED DRUG DELIVERYVarun Girme
This document summarizes recent advances in colon targeted drug delivery. It discusses the anatomy and physiology of the colon, pharmaceutical approaches for targeting drugs to the colon like prodrug conjugates and coating technologies, evaluation methods for colon delivery systems including in vitro dissolution tests and gamma scintigraphy imaging. It also presents a case study on the formulation of 5-fluorouracil loaded chitosan nanoparticles with Eudragit S100 coating for colon cancer treatment, showing enhanced localized drug release at colonic pH.
Colon Specific Drug Delivery System: Basics and ApproachesNone
Colon drug delivery and approaches can target drugs specifically to the colon through various pH sensitive, time controlled, or microbially triggered mechanisms. Drugs suitable for colon targeting include those for inflammatory bowel disease, colon cancer, protein/peptide delivery, and infectious diseases. Approaches include pH sensitive polymer coatings, time controlled systems, microbially triggered delivery using enzymes, and novel approaches like pressure controlled, osmotic controlled, pulsincap, and port systems. Evaluation involves in vitro dissolution and degradation testing as well as in vivo parameters like drug delivery index and animal studies.
This document discusses pharmaceutical approaches to colon targeted drug delivery systems. It begins with an introduction to colon targeted drug delivery and the advantages of this approach. It then describes the anatomy and physiology of the colon, factors governing colonic drug delivery, and various strategies that can be used for targeting drugs to the colon. These strategies include pH dependent delivery, time dependent delivery, pressure dependent delivery, and bacteria dependent delivery. The document also discusses different approaches for colon targeting, including coating with pH sensitive polymers and formulation of timed release systems. It reviews evaluation methods and some marketed products for colon targeted delivery systems, and concludes with discussing future prospects for this drug delivery approach.
This document presents a project seminar presentation for a Bachelor of Pharmacy degree. It discusses targeted drug delivery systems, with a focus on colon targeted drug delivery. It provides background on the anatomy and physiology of the colon, factors affecting drug absorption in the colon, and various approaches to colon targeted drug delivery including pH dependent, time dependent, bacteria dependent and matrix tablet approaches. It also provides details of the drug sulfasalazine and presents the aim, objectives and plan of work for a research project on the formulation of colon-specific matrix tablets of 5-Amino Salicylic Acid.
This document discusses targeted drug delivery to the colon. It begins with an introduction to colon targeted drug delivery and describes the anatomy and physiology of the colon. Key criteria for drug selection include drugs used to treat gastrointestinal diseases, those poorly absorbed in the upper GI tract, and drugs that degrade in the stomach and small intestine. Approaches for colon targeting include pH sensitive systems, microbially triggered systems using prodrugs and polysaccharides, timed release systems, and osmotically controlled drug delivery systems. The colon offers advantages for drug delivery including treatment of colonic diseases and absorption of proteins and peptides.
The document discusses colon targeted drug delivery. It begins with an introduction describing the desirability of targeted colon delivery. It then discusses the anatomy of the colon, criteria for drug selection, and various approaches for colon targeting including pH sensitive polymers, delayed release systems, microbially triggered delivery, and innovative devices. It also covers evaluation methods and concludes that developing an effective oral colon delivery system remains a challenge that requires consideration of the entire gastrointestinal tract environment.
The document discusses drug delivery to the colon and various approaches for targeted colon drug delivery systems. It provides information on the anatomy and physiology of the colon, factors influencing drug absorption in the colon, and diseases associated with the colon. Various primary and new approaches for colon targeted drug delivery are described, including pH sensitive polymers, time controlled systems, and microbiologically triggered systems. Evaluation methods for these systems include in vitro and in vivo testing.
Colon targeted drug delivery aims to treat diseases of the colon like ulcerative colitis and intestinal cancer. It delivers drugs that would otherwise be degraded in the stomach directly to the colon, minimizing side effects. Various approaches are used, including coating drugs with polymers that dissolve at the pH of the colon, or conjugating drugs to carriers that are cleaved by colonic enzymes. This allows targeted treatment of colon diseases while reducing dosing and systemic side effects compared to traditional oral drug delivery.
RECENT ADVANCES IN COLON TARGETED DRUG DELIVERYVarun Girme
This document summarizes recent advances in colon targeted drug delivery. It discusses the anatomy and physiology of the colon, pharmaceutical approaches for targeting drugs to the colon like prodrug conjugates and coating technologies, evaluation methods for colon delivery systems including in vitro dissolution tests and gamma scintigraphy imaging. It also presents a case study on the formulation of 5-fluorouracil loaded chitosan nanoparticles with Eudragit S100 coating for colon cancer treatment, showing enhanced localized drug release at colonic pH.
Colon Specific Drug Delivery System: Basics and ApproachesNone
Colon drug delivery and approaches can target drugs specifically to the colon through various pH sensitive, time controlled, or microbially triggered mechanisms. Drugs suitable for colon targeting include those for inflammatory bowel disease, colon cancer, protein/peptide delivery, and infectious diseases. Approaches include pH sensitive polymer coatings, time controlled systems, microbially triggered delivery using enzymes, and novel approaches like pressure controlled, osmotic controlled, pulsincap, and port systems. Evaluation involves in vitro dissolution and degradation testing as well as in vivo parameters like drug delivery index and animal studies.
This document discusses pharmaceutical approaches to colon targeted drug delivery systems. It begins with an introduction to colon targeted drug delivery and the advantages of this approach. It then describes the anatomy and physiology of the colon, factors governing colonic drug delivery, and various strategies that can be used for targeting drugs to the colon. These strategies include pH dependent delivery, time dependent delivery, pressure dependent delivery, and bacteria dependent delivery. The document also discusses different approaches for colon targeting, including coating with pH sensitive polymers and formulation of timed release systems. It reviews evaluation methods and some marketed products for colon targeted delivery systems, and concludes with discussing future prospects for this drug delivery approach.
This document presents a project seminar presentation for a Bachelor of Pharmacy degree. It discusses targeted drug delivery systems, with a focus on colon targeted drug delivery. It provides background on the anatomy and physiology of the colon, factors affecting drug absorption in the colon, and various approaches to colon targeted drug delivery including pH dependent, time dependent, bacteria dependent and matrix tablet approaches. It also provides details of the drug sulfasalazine and presents the aim, objectives and plan of work for a research project on the formulation of colon-specific matrix tablets of 5-Amino Salicylic Acid.
This document discusses targeted drug delivery to the colon. It begins with an introduction to colon targeted drug delivery and describes the anatomy and physiology of the colon. Key criteria for drug selection include drugs used to treat gastrointestinal diseases, those poorly absorbed in the upper GI tract, and drugs that degrade in the stomach and small intestine. Approaches for colon targeting include pH sensitive systems, microbially triggered systems using prodrugs and polysaccharides, timed release systems, and osmotically controlled drug delivery systems. The colon offers advantages for drug delivery including treatment of colonic diseases and absorption of proteins and peptides.
The document discusses colon targeted drug delivery. It begins with an introduction describing the desirability of targeted colon delivery. It then discusses the anatomy of the colon, criteria for drug selection, and various approaches for colon targeting including pH sensitive polymers, delayed release systems, microbially triggered delivery, and innovative devices. It also covers evaluation methods and concludes that developing an effective oral colon delivery system remains a challenge that requires consideration of the entire gastrointestinal tract environment.
The document discusses drug delivery to the colon and various approaches for targeted colon drug delivery systems. It provides information on the anatomy and physiology of the colon, factors influencing drug absorption in the colon, and diseases associated with the colon. Various primary and new approaches for colon targeted drug delivery are described, including pH sensitive polymers, time controlled systems, and microbiologically triggered systems. Evaluation methods for these systems include in vitro and in vivo testing.
This document summarizes a seminar presentation on colon-specific drug delivery. It discusses targeting delivery of drugs to the colon to treat diseases like ulcerative colitis and Crohn's disease. Various pharmaceutical approaches for colon-specific delivery are described, including pH sensitive systems, microbial triggered systems, and time release systems. Platform technologies for colon delivery like PULSINCAP and OROS-CT are also outlined. The document concludes that colonic drug delivery presents many challenges but also opportunities to improve therapy for colonic diseases.
This document provides information on a presentation about pharmaceutical approaches to colon targeted drug delivery systems for treating diseases like Crohn's disease. It discusses the anatomy and physiology of the colon, diseases associated with the colon, drug absorption in the colon, and various approaches for colon targeted drug delivery including pH sensitive polymers, time controlled release systems, microbiologically triggered systems, and new approaches like pressure controlled, pulsatile, and multi particulate systems. The presentation aims to highlight the advantages and limitations of different colon targeted drug delivery approaches.
This presentation related to targeted drug delivery system particularly to colonic region. It includes various approaches for colonic delivery of drug.
Targeted drug delivery systems aim to selectively deliver drugs to a specific site in the body to increase therapeutic effects and reduce side effects. They do this through various carrier systems and approaches. Carriers protect drugs, facilitate transport to target sites, and control drug release. Common carriers include vesicles, microparticles, and polymers. Targeting can be passive by exploiting biodistribution, or active using ligands to bind receptors at target sites. The document discusses the reasons for targeted delivery, ideal properties of systems, types of carriers and approaches, and advantages like reducing dosage and increasing drug concentration at target sites.
This document discusses colon targeted drug delivery systems. The major goals of targeted drug delivery are to selectively deliver drugs to the colon at therapeutic concentrations while limiting access to non-target sites. Approaches to colon targeted delivery include pH sensitive polymers, time dependent systems, and formulations triggered by colonic microflora. Several marketed drugs use these approaches including mesalamine, budesonide, and olsalazine. Challenges to colon delivery include biological barriers in the GI tract, variation in gastric emptying and colonic pH, and impact of colonic microflora on drug activity.
Colon-specific drug delivery systems (CDDS) aim to release drugs in the colon to treat diseases localized in the region. The colon offers advantages for drug absorption and many approaches have been developed. CDDS rely on the colon's distinct pH, transit time, microflora and enzymes to trigger drug release. They include pH-sensitive coatings, prodrugs, polysaccharide matrices and time-delayed systems. In vitro and in vivo tests evaluate release profiles under gastrointestinal conditions while imaging techniques track systems in the colon. CDDS provide localized treatment with fewer side effects compared to traditional therapies.
This document discusses tumor targeting for drug delivery. It begins by defining tumors and the types of cancer. It then discusses the differences between tumor tissue and normal tissue that allow for targeted delivery. The main approaches to tumor targeting discussed are passive targeting, which exploits the enhanced permeability and retention effect, and active targeting using ligands that bind to receptors overexpressed on tumor cells. Examples are given of marketed products that use each approach. Triggered drug delivery is also covered, which releases drugs in response to the unique tumor microenvironment.
The document discusses colon targeted drug delivery systems. It begins by defining colon targeted drug delivery as targeting drugs to the lower parts of the GI tract, mainly the large intestine. This is done for various objectives like reducing dosing frequency or delivering drugs that would otherwise be degraded. Approaches to colon targeting include pH sensitive coatings, microbially triggered systems, and timed release. Evaluation methods include in vitro dissolution tests and studies using animal models. Key advantages are site specific delivery and protecting drugs from degradation, while challenges include multiple manufacturing steps and drug binding in the colon.
Introduction, Anatomy of colon, Advantage of colon drug delivery system, Disadvantage of colon drug delivery system, Factors influencing CDDS, Approaches of CDDS, Evaluation of CDDS
This document discusses colon-specific drug delivery systems. It begins with an introduction to colon targeting and why it is important for treating colonic disorders. It then covers factors to consider in design such as colon anatomy, pH, transit time and microflora. Approaches discussed include pH dependent, time dependent and bacteria dependent systems. It evaluates both in vitro and in vivo methods for testing colon delivery systems.
DRUG DELIVERY SYSTEM (gastro retentive drug delivery system)
Oral route is the most acceptable route for drug administration. Apart from conventional dosage forms several other forms were developed in order to enhance the drug delivery for prolonged time period and for delivering drug to a particular target site. Gastro-retentive drug delivery system (GRDDS) has gainned immense popularity in the field of oral drug delivery recently. it is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. different innovative approaches are being applied to fabricate GRDDS. Gastroretentive drug delivery is an approach to prolong gastric residence time, there by targeting site-specific drugs release in the upper gastrointestinal tract (GIT) for local or systemic effects. It is obtained by retaining dosage form into stomach and by releasing the in controlled manner.
Delivery of drug through buccal mucosa of oral cavity is called BDDS. The buccal mucosa lines the inner cheek
It is placed between the upper gingivae and cheek.
This document provides an overview of targeted drug delivery systems. It discusses the reasons for targeted delivery to increase therapeutic effects and reduce toxicity. The ideal properties of targeted delivery carriers and approaches are described. The document outlines different carrier types including vesicular, particulate, cellular, polymeric, and macromolecular systems. It discusses levels of targeting including passive, active, dual and combination approaches. Active targeting can be achieved through ligand-mediated or physical approaches. The document provides examples to illustrate different targeting strategies and carrier types. In summary, it comprehensively reviews concepts and components of targeted drug delivery systems.
The document discusses colon drug delivery systems. It describes the colon as a site for local and systemic drug delivery to treat diseases like Crohn's disease and ulcerative colitis. Various methods are described for targeting drug delivery to the colon, including the use of prodrugs, pH-sensitive polymers, biodegradable polymers, and timed release systems. Advantages of colon targeting include treatment of local colon diseases, bypassing first-pass metabolism, and reduced side effects. Limitations include multiple manufacturing steps and potential drug binding in the colon. The document then discusses various approaches for colon drug delivery, including the use of pH-sensitive polymers, time-dependent systems, microbially-triggered delivery, bioadhesive systems,
This document discusses gastroretentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs to target drug release in the upper gastrointestinal tract. GRDDS are needed because oral drugs often have short gastric retention times and unpredictable emptying, resulting in incomplete drug release. The document outlines several approaches to achieving gastric retention, including floating, bioadhesive/mucoadhesive, expandable/unfoldable, and magnetic systems. It provides examples of drug candidates that could benefit from GRDDS and evaluates the advantages of these systems.
Nikita Rathi (targeted drug delivery system)NikitaRathi16
This document provides an overview of targeted drug delivery systems. It defines targeted drug delivery as selectively delivering a drug only to its site of action and not to non-target organs. The ideal properties, advantages, and biological processes involved are described. Targeted delivery aims to achieve the desired pharmacological response at selected sites with minimal side effects. It involves cellular uptake, transport across epithelial barriers, extravasation from blood vessels, and lymphatic uptake, which allows drugs to reach systemic circulation. The goal of targeted delivery is to enhance therapeutic effects while reducing toxicity.
Biopharmaceutical system , methods of permeability , generic biologics, gener...Siddhapura Pratik
Biopharmaceutical classification system, methods of permeability, generic biologics ( biosimilar drug product), clinical significance of bioequivalence studies , special concerns in bioavailability and bioequivalence studies , Generic substitution
This document discusses colon targeted drug delivery systems. It begins by stating that colon targeted delivery is used to deliver substances that are degraded in the stomach, such as proteins and peptides. It then discusses various approaches to colon targeted delivery including pH sensitive polymers, delayed release systems, and microbial triggered delivery. The document covers the advantages of colon targeted systems, limitations, factors affecting delivery like gastric emptying and colonic pH, and provides examples of technologies like pulsincap and osmotic systems. It concludes with a discussion of evaluation methods and references.
This document discusses mucoadhesive drug delivery systems. It begins by defining bioadhesion and mucoadhesion, noting that mucoadhesion involves the attachment of a drug carrier to a mucosal surface like epithelial tissue. It then covers the concept of mucoadhesion in more detail and discusses the advantages and disadvantages of mucoadhesive drug delivery. Some key advantages include avoiding first pass metabolism, targeting drug delivery, and allowing delivery of drugs that are unstable in the stomach or intestines. The document also discusses the formulation design of mucoadhesive drug delivery systems.
This document provides an overview of colon specific drug delivery systems. It discusses the advantages of targeting drug delivery to the colon which includes reduced dosing, lower side effects, and improved patient compliance. It also reviews some limitations such as multiple manufacturing steps and potential for drug degradation by colonic microflora. The document then examines the anatomy and physiology of the colon, factors that influence colonic drug delivery such as pH and transit time, and how drugs are absorbed in the colon. It concludes by outlining several approaches to colon specific drug delivery including pH dependent coatings, time release systems, prodrugs activated by colonic bacteria, and the use of carriers degraded by colonic microflora.
This document provides an overview of targeted drug delivery systems. It discusses the need for targeted drug delivery to reduce side effects and dosage while maximizing therapeutic effects. Various carrier systems are described including liposomes, microspheres, nanoparticles, and magnetic microspheres. Methods for preparing microspheres and nanoparticles are also summarized. The document concludes by listing some marketed drugs that utilize nanotechnology and targeted delivery approaches.
This document summarizes a seminar presentation on colon-specific drug delivery. It discusses targeting delivery of drugs to the colon to treat diseases like ulcerative colitis and Crohn's disease. Various pharmaceutical approaches for colon-specific delivery are described, including pH sensitive systems, microbial triggered systems, and time release systems. Platform technologies for colon delivery like PULSINCAP and OROS-CT are also outlined. The document concludes that colonic drug delivery presents many challenges but also opportunities to improve therapy for colonic diseases.
This document provides information on a presentation about pharmaceutical approaches to colon targeted drug delivery systems for treating diseases like Crohn's disease. It discusses the anatomy and physiology of the colon, diseases associated with the colon, drug absorption in the colon, and various approaches for colon targeted drug delivery including pH sensitive polymers, time controlled release systems, microbiologically triggered systems, and new approaches like pressure controlled, pulsatile, and multi particulate systems. The presentation aims to highlight the advantages and limitations of different colon targeted drug delivery approaches.
This presentation related to targeted drug delivery system particularly to colonic region. It includes various approaches for colonic delivery of drug.
Targeted drug delivery systems aim to selectively deliver drugs to a specific site in the body to increase therapeutic effects and reduce side effects. They do this through various carrier systems and approaches. Carriers protect drugs, facilitate transport to target sites, and control drug release. Common carriers include vesicles, microparticles, and polymers. Targeting can be passive by exploiting biodistribution, or active using ligands to bind receptors at target sites. The document discusses the reasons for targeted delivery, ideal properties of systems, types of carriers and approaches, and advantages like reducing dosage and increasing drug concentration at target sites.
This document discusses colon targeted drug delivery systems. The major goals of targeted drug delivery are to selectively deliver drugs to the colon at therapeutic concentrations while limiting access to non-target sites. Approaches to colon targeted delivery include pH sensitive polymers, time dependent systems, and formulations triggered by colonic microflora. Several marketed drugs use these approaches including mesalamine, budesonide, and olsalazine. Challenges to colon delivery include biological barriers in the GI tract, variation in gastric emptying and colonic pH, and impact of colonic microflora on drug activity.
Colon-specific drug delivery systems (CDDS) aim to release drugs in the colon to treat diseases localized in the region. The colon offers advantages for drug absorption and many approaches have been developed. CDDS rely on the colon's distinct pH, transit time, microflora and enzymes to trigger drug release. They include pH-sensitive coatings, prodrugs, polysaccharide matrices and time-delayed systems. In vitro and in vivo tests evaluate release profiles under gastrointestinal conditions while imaging techniques track systems in the colon. CDDS provide localized treatment with fewer side effects compared to traditional therapies.
This document discusses tumor targeting for drug delivery. It begins by defining tumors and the types of cancer. It then discusses the differences between tumor tissue and normal tissue that allow for targeted delivery. The main approaches to tumor targeting discussed are passive targeting, which exploits the enhanced permeability and retention effect, and active targeting using ligands that bind to receptors overexpressed on tumor cells. Examples are given of marketed products that use each approach. Triggered drug delivery is also covered, which releases drugs in response to the unique tumor microenvironment.
The document discusses colon targeted drug delivery systems. It begins by defining colon targeted drug delivery as targeting drugs to the lower parts of the GI tract, mainly the large intestine. This is done for various objectives like reducing dosing frequency or delivering drugs that would otherwise be degraded. Approaches to colon targeting include pH sensitive coatings, microbially triggered systems, and timed release. Evaluation methods include in vitro dissolution tests and studies using animal models. Key advantages are site specific delivery and protecting drugs from degradation, while challenges include multiple manufacturing steps and drug binding in the colon.
Introduction, Anatomy of colon, Advantage of colon drug delivery system, Disadvantage of colon drug delivery system, Factors influencing CDDS, Approaches of CDDS, Evaluation of CDDS
This document discusses colon-specific drug delivery systems. It begins with an introduction to colon targeting and why it is important for treating colonic disorders. It then covers factors to consider in design such as colon anatomy, pH, transit time and microflora. Approaches discussed include pH dependent, time dependent and bacteria dependent systems. It evaluates both in vitro and in vivo methods for testing colon delivery systems.
DRUG DELIVERY SYSTEM (gastro retentive drug delivery system)
Oral route is the most acceptable route for drug administration. Apart from conventional dosage forms several other forms were developed in order to enhance the drug delivery for prolonged time period and for delivering drug to a particular target site. Gastro-retentive drug delivery system (GRDDS) has gainned immense popularity in the field of oral drug delivery recently. it is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with conventional oral delivery, including poor bioavailability. different innovative approaches are being applied to fabricate GRDDS. Gastroretentive drug delivery is an approach to prolong gastric residence time, there by targeting site-specific drugs release in the upper gastrointestinal tract (GIT) for local or systemic effects. It is obtained by retaining dosage form into stomach and by releasing the in controlled manner.
Delivery of drug through buccal mucosa of oral cavity is called BDDS. The buccal mucosa lines the inner cheek
It is placed between the upper gingivae and cheek.
This document provides an overview of targeted drug delivery systems. It discusses the reasons for targeted delivery to increase therapeutic effects and reduce toxicity. The ideal properties of targeted delivery carriers and approaches are described. The document outlines different carrier types including vesicular, particulate, cellular, polymeric, and macromolecular systems. It discusses levels of targeting including passive, active, dual and combination approaches. Active targeting can be achieved through ligand-mediated or physical approaches. The document provides examples to illustrate different targeting strategies and carrier types. In summary, it comprehensively reviews concepts and components of targeted drug delivery systems.
The document discusses colon drug delivery systems. It describes the colon as a site for local and systemic drug delivery to treat diseases like Crohn's disease and ulcerative colitis. Various methods are described for targeting drug delivery to the colon, including the use of prodrugs, pH-sensitive polymers, biodegradable polymers, and timed release systems. Advantages of colon targeting include treatment of local colon diseases, bypassing first-pass metabolism, and reduced side effects. Limitations include multiple manufacturing steps and potential drug binding in the colon. The document then discusses various approaches for colon drug delivery, including the use of pH-sensitive polymers, time-dependent systems, microbially-triggered delivery, bioadhesive systems,
This document discusses gastroretentive drug delivery systems (GRDDS), which aim to prolong the gastric residence time of drugs to target drug release in the upper gastrointestinal tract. GRDDS are needed because oral drugs often have short gastric retention times and unpredictable emptying, resulting in incomplete drug release. The document outlines several approaches to achieving gastric retention, including floating, bioadhesive/mucoadhesive, expandable/unfoldable, and magnetic systems. It provides examples of drug candidates that could benefit from GRDDS and evaluates the advantages of these systems.
Nikita Rathi (targeted drug delivery system)NikitaRathi16
This document provides an overview of targeted drug delivery systems. It defines targeted drug delivery as selectively delivering a drug only to its site of action and not to non-target organs. The ideal properties, advantages, and biological processes involved are described. Targeted delivery aims to achieve the desired pharmacological response at selected sites with minimal side effects. It involves cellular uptake, transport across epithelial barriers, extravasation from blood vessels, and lymphatic uptake, which allows drugs to reach systemic circulation. The goal of targeted delivery is to enhance therapeutic effects while reducing toxicity.
Biopharmaceutical system , methods of permeability , generic biologics, gener...Siddhapura Pratik
Biopharmaceutical classification system, methods of permeability, generic biologics ( biosimilar drug product), clinical significance of bioequivalence studies , special concerns in bioavailability and bioequivalence studies , Generic substitution
This document discusses colon targeted drug delivery systems. It begins by stating that colon targeted delivery is used to deliver substances that are degraded in the stomach, such as proteins and peptides. It then discusses various approaches to colon targeted delivery including pH sensitive polymers, delayed release systems, and microbial triggered delivery. The document covers the advantages of colon targeted systems, limitations, factors affecting delivery like gastric emptying and colonic pH, and provides examples of technologies like pulsincap and osmotic systems. It concludes with a discussion of evaluation methods and references.
This document discusses mucoadhesive drug delivery systems. It begins by defining bioadhesion and mucoadhesion, noting that mucoadhesion involves the attachment of a drug carrier to a mucosal surface like epithelial tissue. It then covers the concept of mucoadhesion in more detail and discusses the advantages and disadvantages of mucoadhesive drug delivery. Some key advantages include avoiding first pass metabolism, targeting drug delivery, and allowing delivery of drugs that are unstable in the stomach or intestines. The document also discusses the formulation design of mucoadhesive drug delivery systems.
This document provides an overview of colon specific drug delivery systems. It discusses the advantages of targeting drug delivery to the colon which includes reduced dosing, lower side effects, and improved patient compliance. It also reviews some limitations such as multiple manufacturing steps and potential for drug degradation by colonic microflora. The document then examines the anatomy and physiology of the colon, factors that influence colonic drug delivery such as pH and transit time, and how drugs are absorbed in the colon. It concludes by outlining several approaches to colon specific drug delivery including pH dependent coatings, time release systems, prodrugs activated by colonic bacteria, and the use of carriers degraded by colonic microflora.
This document provides an overview of targeted drug delivery systems. It discusses the need for targeted drug delivery to reduce side effects and dosage while maximizing therapeutic effects. Various carrier systems are described including liposomes, microspheres, nanoparticles, and magnetic microspheres. Methods for preparing microspheres and nanoparticles are also summarized. The document concludes by listing some marketed drugs that utilize nanotechnology and targeted delivery approaches.
This document discusses targeted drug delivery systems. It defines targeted drug delivery as selectively delivering medication to its site of action to increase concentration in tissues of interest while reducing it in other tissues, improving efficacy and reducing side effects. The document outlines various strategies for targeted delivery including passive, active, ligand-mediated and physical targeting. It also describes several types of targeted delivery systems including liposomes, dendrimers, nanotubes, nanoshells and others. The goal is to achieve the desired pharmacological response at selected sites with minimal side effects.
Colon specific drug delivery system approaches and applicationTukaram Patil
This document discusses colon specific drug delivery approaches and applications. It begins with an introduction explaining the advantages of targeting drug delivery to the colon and protecting drugs from the upper gastrointestinal tract. It then discusses various factors that affect colonic drug absorption and several primary and new approaches for colon targeted drug delivery systems, including pH sensitive polymers, delayed release systems, and microbial triggered delivery. Examples of different delivery approaches like pulsincap systems, pressure controlled systems, and prodrug approaches are also described. The document concludes that colon targeted delivery offers benefits over traditional systems and novel approaches provide more specific delivery than primary methods.
This document summarizes several novel drug delivery systems targeted for colon delivery. It describes systems such as pressure-controlled drug delivery systems which use capsule thickness and peristalsis to control drug release. It also discusses pH-dependent systems like CODESTM that protect the drug in the stomach and small intestine before bacteria trigger release in the colon. Timed-release systems are explained like OROS-CT which uses osmotic pressure to precisely control release over hours. Other systems presented include pulsincap, hydrophilic capsules, and technologies like Targit, Egalet, and Enterion capsules that aim to topically target drug release in the colon.
Regenerative Medicine: Impact of Convergence on Drug, Device, and Biologics D...MaRS Discovery District
Speaker Dr. Annemarie Moseley, CEO of Aggregate Therapeutics (Palo Alto) explores how drug-device combination products are altering the medical practice from development to regulation to treatment.
Part of the MaRS Emerging Technologies Event Series. More information on the series can be found here:
http://www.marsdd.com/emergingtech/
The document discusses gastro retentive drug delivery systems (GRDDS), which are designed to retain drugs in the stomach for local or systemic drug delivery. It outlines several approaches for prolonging gastric residence time, including high density systems, floating systems, swelling/expanding systems, and mucoadhesive systems. The advantages of GRDDS include enhanced bioavailability and sustained drug delivery. Appropriate candidate drugs are those absorbed in the stomach or having narrow absorption windows. Common limitations are instability in gastric conditions and requirement of sufficient gastric fluid volume.
The document discusses pulmonary drug delivery systems including their anatomy, formulations, and devices. It describes the three main regions of the nasal cavity and different types of dosage forms that can be used for nasal drug delivery including drops, sprays, and gels. It also discusses dry powder inhalers, metered dose inhalers, and nebulizers as well as some advantages and disadvantages of pulmonary drug delivery. Key factors that influence nasal drug absorption and strategies to improve nasal drug delivery are also summarized.
Vendor development in pharmaceutical industryshikha singh
This document discusses vendor development and evaluation procedures. It explains that vendor development involves identifying, developing, and evaluating prospective suppliers to ensure materials are procured at the right quality, quantity, price, and time. The key steps include vendor evaluation, rating vendors based on quality, delivery, price, and time performance, maintaining an approved vendor list, and certifying vendors. Periodic re-evaluation and monitoring of current suppliers is important for effective vendor management.
Nanotechnology and nanoparticles show promise in cancer diagnosis and treatment through targeted drug delivery. Nanoparticles are well-suited for these applications due to their small size, high surface area, and ability to control and target drug delivery. This can help reduce side effects while requiring lower dosages than traditional treatments. Many nanodevices like micelles, vesicles, dendritic polymers, and quantum dots are being developed and studied for use in drug delivery systems.
This document summarizes research on gastroretentive drug delivery systems (GRDDS). GRDDS are designed to retain drugs in the stomach for extended periods of time to allow sustained release of drugs. The document discusses various approaches to GRDDS including floating systems, mucoadhesive systems, high density systems, and swollen or expanded systems. It also summarizes several research publications on recent advances in GRDDS technology including development of bioadhesive microspheres and floating microspheres for oral drug delivery.
This document provides an overview of buccal mucosa as a route for drug delivery. It discusses how buccal mucosa absorption was first noted in 1847 and was systematically studied in the 1930s-1970s. The buccal mucosa is an attractive delivery site due to its ease of administration and avoidance of first-pass metabolism. Drugs can permeate through either paracellular or transcellular pathways depending on their properties. In vitro and in vivo methods are used to assess buccal drug permeation and absorption. Several drugs have been delivered via buccal formulations including hormones, analgesics, antifungals, and others. Advantages include direct access to systemic circulation and low enzymatic activity
This document summarizes a seminar on gastroretentive drug delivery systems (GRDDS). GRDDS are designed to retain drugs in the stomach for prolonged periods of time to allow for sustained drug release. The seminar outlines various GRDDS technologies including floating, swelling, mucoadhesive, and high density systems. It also discusses candidate drugs for GRDDS, advantages like improved bioavailability, and evaluation methods like dissolution testing, floating time, and mucoadhesive strength testing. Limitations include instability at gastric pH and requirement of high fluid levels for floating systems.
The document discusses nasal drug delivery systems. It notes that in ancient Ayurvedic medicine, the nasal route was used for drug administration. The nasal route avoids first-pass metabolism, is non-invasive, and absorption is faster compared to other routes. Several factors influence nasal absorption, including molecular size, solution pH, and drug concentration. Drugs suitable for nasal delivery have a molecular weight under 1000 Daltons. Various nasal drug delivery systems are described, including nasal sprays, drops, and powders. In vivo and ex vivo models are used to study nasal absorption.
This document summarizes pulmonary drug delivery systems. It discusses the advantages of pulmonary delivery including rapid drug absorption and avoidance of first-pass metabolism. It also discusses disadvantages like difficulty using inhaler devices and mucociliary clearance reducing drug retention. Factors affecting particle distribution in the lungs like inspiratory flow rate and particle size are also covered. Finally, it describes various pulmonary delivery devices including metered dose inhalers, dry powder inhalers, and nebulizers.
In ancient time Ayurvedic system of medicine used nasal route for administration of drugs and the process is called as “Nasya”.
Nasal route has been used for local effects of decongestants but, in recent time it is being considered as a preferred route of drug delivery for systemic bioavailability.
Various proteins & peptides have shown a good bioavailability through this route.
Pulmonary drug delivery systems aim to directly deliver drugs to the lungs to treat conditions of the airways. This localized delivery reduces the drug dose needed and limits systemic side effects. The document discusses the anatomy and physiology of the lungs, factors influencing drug deposition, and absorption mechanisms. It also outlines current pulmonary drug delivery technologies like nebulizers, metered-dose inhalers, and dry powder inhalers. Advantages include rapid onset of action and avoidance of first-pass metabolism, while limitations involve reproducibility and drug clearance by the mucus layer. In conclusion, pulmonary delivery is effective but technological modifications continue to improve drug release profiles and overcome physiological barriers.
Similar to ''Pharmaceutical Approaches to colon Targeted Drug Delivery system'', Presented By: Raj Kishor [CRC] , Tech Observer iNDIA Pvt. Ltd ...The Global CRO
This document reviews approaches for colon-specific drug delivery (CDDS). It compares earlier approaches like prodrugs, pH-dependent systems, and microbial-triggered systems, which had limitations, to newer approaches like pressure-controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery (ORDS-CT) systems. These novel approaches are unique in achieving in vivo site specificity and feasibility of manufacturing. Factors that must be considered in colon targeted drug delivery system design include anatomy and physiology of the colon, pH levels in different colon regions, colonic microflora and enzymes, transit of materials through the colon, and drug absorption in the colon.
This document summarizes colon targeted drug delivery systems. It discusses pH dependent systems, time dependent systems, and microbially triggered systems as primary approaches. It also discusses newer approaches like pressure controlled colon delivery capsules and complex delivery systems (CODES). Advantages of colon targeted delivery include protection of drugs from degradation in the stomach and small intestine and targeting delivery to the colon for local treatment of diseases like IBD or systemic delivery of proteins and peptides. Novel drug delivery systems discussed include nano systems for targeted delivery to the colon to treat diseases like IBD and colon cancer.
2.colon specific drug delivery system 2 nd semHanmant Galande
This document summarizes a seminar presentation on colon-specific drug delivery systems. It discusses factors to consider in designing such systems like anatomy, pH, transit time and microflora of the colon. Approaches covered include pH dependent coatings, time dependent controlled release systems and bacterial degradation of polymers or prodrugs. Evaluation methods discussed are in vitro drug release studies under gastric and intestinal conditions and in vivo techniques like animal models, string tests, endoscopy, radiography and scintigraphy. The document provides an overview of colon targeting strategies and assessment of colon delivery systems.
This document discusses colonic specific drug delivery. It begins by introducing the rationale for colon targeted drug delivery of peptides and proteins, which are degraded in the stomach and small intestine. It then covers the anatomy and physiology of the colon, factors affecting colonic drug delivery, and various approaches for colon targeted systems. Key approaches discussed are pH dependent systems, which rely on polymers that dissolve at the higher pH of the colon, and microbially triggered systems, which are activated by enzymes in the colon.
Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiasis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs, NSAIDs, steroids.
The colon is believed to be a suitable absorption site for peptides and protein drugs for the following reasons; (i) less diversity, and intensity of digestive enzymes, (ii) less proteolytic activity of colon mucosa than that of small intestine.
CRITERIA: Drugs used for local effects in colon against GIT diseases.
Drugs poorly absorbed from upper GIT.
Drugs for colon cancer.
Drugs that degrade in stomach and small intestine.
Drugs that undergo extensive first pass metabolism.
Drugs for targeting.
The document discusses various approaches for targeting drug delivery to the colon, including conventional and new approaches. Conventional approaches include pH sensitive polymer coatings, delayed release systems, and use of prodrugs. Newer approaches discussed are osmotic controlled delivery systems, intestinal pressure controlled colon delivery capsules, nanoparticle systems, pulsincap systems, and azo hydrogels. The colon's anatomy, physiology, and factors affecting drug absorption are also summarized.
Colon Targeting by Novel Drug Delivery Drug System: Microsphere a Review ReportBRNSSPublicationHubI
This document discusses microspheres as a drug delivery system for targeted colon delivery. It begins with an introduction to colon targeted drug delivery and reasons for targeting the colon. It then discusses microspheres in more detail, including definitions and types such as bioadhesive, magnetic, floating, and polymeric microspheres. Methods for preparing microspheres and their advantages are summarized. The document concludes with some limitations of microsphere drug delivery systems.
Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, amebiasis ,irritable bowel syndrome, Crohn’s disease, chronic pancreatitis and colon cancer.
Noscapine based oral colon SpecificNanoparticles by Kuldipsinh Thakorkulu2929
This document discusses the design, development and evaluation of oral colon-specific nanoparticles of noscapiene for treating cancer. It begins with an introduction to the drug noscapiene and outlines the need, objectives and plan for the research. It then reviews relevant literature and patents. The materials and methodology, results and discussion are presented. It concludes with a summary and references. The overall aim is to develop a targeted colon-specific drug delivery system using noscapiene-loaded nanoparticles to treat colon cancer and related diseases while avoiding premature drug release in the stomach and small intestine.
This document provides an overview of rectal drug delivery systems. It discusses the anatomy and physiology of the rectum, factors that influence drug absorption through the rectal route, and various rectal dosage forms including suppositories, enemas, and rectal capsules. The advantages of rectal delivery include avoidance of first-pass metabolism and use for patients who cannot swallow oral medications. Selection of drugs for the rectal route depends on their physicochemical properties and therapeutic dose. Evaluation methods for rectal formulations include in vitro tests and animal studies.
colon drug delivery- advantage and disadvantage of colon delivery, anatomy of colon in healthy and diseased state , different approaches (conventional and new) for colon delivery, in vitro and in vivo evaluation
The document discusses modulation of gastrointestinal (GI) transit time and floating drug delivery systems (FDDS). It begins with an introduction to GI transit and factors that affect transit time. It then discusses approaches to extend GI transit time including FDDS, which have a bulk density less than gastric fluids and remain buoyant in the stomach without affecting gastric emptying rate. The document covers classifications of FDDS, formulations, evaluation methods, advantages and applications. It provides examples of marketed floating drug products.
The document discusses modulation of gastrointestinal (GI) transit time and floating drug delivery systems (FDDS). It begins with an introduction to GI transit and factors that affect transit time. It then discusses approaches to extend GI transit time including FDDS, which have a bulk density less than gastric fluids and remain buoyant in the stomach without affecting gastric emptying rate. The document covers classifications of FDDS, formulations, evaluation methods, advantages and applications. It provides examples of marketed floating drug products.
Colon-specific drug delivery (CDDS) aims to target drug release and absorption in the colon for local treatment of colonic diseases or systemic delivery of proteins and peptides. The document discusses the anatomy and physiology of the colon, factors governing colonic drug delivery, and various pharmaceutical approaches for CDDS including pH-sensitive systems, microbially triggered systems, and timed or controlled release platforms. Evaluation methods for CDDS include in vitro drug release tests under simulated gastric and intestinal conditions and in vitro enzymatic degradation assays.
This document provides an overview of gastroretentive drug delivery systems (GRDDS). It begins with an introduction to GRDDS and their advantages such as improving bioavailability and overcoming physiological challenges. It then discusses modulation of gastric transit and the mechanisms of drug permeation. The document outlines the main types of GRDDS including high density, floating, and swelling/expanding systems. It also covers evaluations of GRDDS both in vitro and in vivo. The document concludes that GRDDS offer advantages for drugs that are poorly absorbed in the upper GI tract by maximizing absorption and bioavailability.
Rectal drug delivery systems can administer medications locally or systemically using the rectal route. This presentation discusses rectal dosage forms like suppositories, enemas, and semisolids. It covers the anatomy and physiology of the rectum, factors affecting drug absorption, and applications. Controlled-release formulations may be advantageous for rectal administration due to the larger acceptable size compared to oral drugs. Mucoadhesive polymers can prolong drug retention for local conditions or systemic delivery.
1) The document outlines the plan and experimental work for developing a buccal mucoadhesive drug delivery system of the drug Simvastatin using polymers like sodium alginate and guar gum.
2) Preformulation studies like drug-polymer compatibility using FTIR and characterization of polymers were carried out. Mucoadhesive tablets were prepared by direct compression method using different drug-polymer ratios.
3) The tablets were evaluated for hardness, weight variation, surface pH, swelling index and ex-vivo bioadhesion. F3 formulation with drug:polymer ratio of 1:5 showed maximum swelling and bioadhesion.
4) The study concluded that sodium alginate and guar gum
This document discusses gastroretentive drug delivery systems (GRDDS). It begins by defining GRDDS as an approach to prolong gastric residence time to target drug release in the upper gastrointestinal tract. It then discusses various approaches to prolong gastric retention time, including floating systems, expandable systems, and bioadhesive systems. The document provides examples of drug candidates suitable for GRDDS and evaluates formulation techniques, in vitro tests for buoyancy and drug release, and methods to test bioadhesion and swelling. It concludes by discussing the advantages and limitations of GRDDS.
Similar to ''Pharmaceutical Approaches to colon Targeted Drug Delivery system'', Presented By: Raj Kishor [CRC] , Tech Observer iNDIA Pvt. Ltd ...The Global CRO (20)
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2. -:CONTENTS:
Introduction
Anatomy and Physiology of colon
Factors governing Colonic drug delivery
Strategies for Targeting drug to colon
Targeting Approaches to colon
Evaluation of C.T.D.D.S
Marketed Preparation
Applications
Future Prospects
Conclusion
References
2
3. INTRODUCTION
Oral route is considered to be most convenient for administration of
drug to patient.
Colon is used as site of Targeted drug delivery.
Colon was considered as a BLACK-BOX , as most of the drug are
absorbed from the upper part of the GI tract.
Prime objective-Beneficial in the treatment of colon diseases.
Increase the pharmacological activity.
Reduce dosing & side effects.
Prevent drug from degradation.
3
4. ADVENTAGES
The site specific delivery of drug to lower part of GIT,
for localized treatment of several colonic diseases.
(ulcerative colitis, Chron's disease, carcinomas and
infections)
Prevent drug from degradation
Ensure direct treatment at disease site.
Suitable absorption site for Protein & Peptide drug.
Used to prolong the drug therapy.
Improved drug utilization.
4
5. Disadvantages
Substantial variation in gastric retention time may
affect drug delivery.
Diseased condition may affect the colonic transit time
and drug release profile.
pH level of colon may vary between individuals due to
disease, state and temperature of food consumed.
5
6. ANATOMY AND PHYSIOLOGY OF COLON
Location-in abdominal cavity
Made up of Serosa – areolar tissue.
Muscularis externa – muscular
coat.
Submucosa – connective tissue.
Mucosa – epithelium.
6
11. FUNCTION OF COLON
Provides suitable environment for the growth of colonic
microorganisms,
Absorption of water and Na+ from the lumen,
concentrating the fecal content, Secretion of K+ ions,
Storage reservoir of faecal contents,
Expulsion of the contents of the colon at an appropriate
time.
11
15. Strategies for targeting Drug to colon
An oral colonic delivery system should retard drug release
in the stomach and small intestine but allow complete
release in the colon.
A variety of strategies has been used and systems have
been developed for the purpose of achieving colonic
targeting .
These strategies are either drug specific ( prodrug ) or
formulation –specific (coated or matrix preparation).
15
16. Continue…
The most commonly used targeting mechanisms
are: pH – dependent delivery
Time - dependent delivery
Pressure- dependent delivery and
Bacteria—dependent delivery
16
17. TARGETING APPROACHES TO COLON
The various targeting Approaches of orally administered
drugs to the colon include:(1)Covalent linkage of a drug with a carrier.
(2)Coating with pH-sensitive polymers.
(3)Formulation of timed released systems.
(4) Exploitation of carriers that are degraded specifically by
colonic bacteria.
(5) bioadhesive systems and osmotic controlled drug
delivery
systems
17
20. 1.Covalent linkage of the drug with a carrier
It involves the formation of a covalent linkage between
drug and carrier in such a manner that upon oral
administration the moiety remains intact in the stomach
and small intestine.
This approach chiefly involves the formation of prodrug,
which is a pharmacologically inactive derivative of a
parent drug molecule that requires spontaneous or
enzymatic transformation in the biological environment to
release the active drug.
20
22. Similarly
1.2. Glycoside conjugates:- Drug is
conjugated with Glycoside.
1.3. Glucuronide conjugates:-Drug is
conjugated with Glucuronide.
1.4.Cyclodextrinconjugates:-Drug is
conjugated with cyclodextrin.
1.5. Dextran conjugates:-Drug is conjugated
with dextrin.
1.6. Amino-acid conjugates:-Drug is
conjugated with amino acid.
22
23. 2 Approaches to deliver the intact molecule to colon
2.1.Coating with polymers .
2.1.1. Coating with pH-sensitive polymers
2.1.2. Coating with biodegradable polymers
2.2 Embedding in matrices
2.2.1. Embedding in biodegradable matrices and
hydro gels
2.2.2. Embedding in pH-sensitive matrices
2.3. Timed release systems
2.4Redox-sensitive polymers
2.5. Bioadhesive systems
2.6. Coating with micro particles
2.7. Osmotic controlled drug delivery
23
29. Osmotically controlled colon targeted drug delivery
Target the drug locally to
the colon
Single or 5-6 push-pull
units
Contains an osmotic push
layer and a drug layer
Surrounded by a semi
permeable membrane
Orifice is drilled through
the membrane next to the
drug layer
29