1) Diabetic peripheral neuropathy (DPN) affects around 70% of diabetics and can lead to foot ulcers and amputation. Symptoms include neuropathic pain, numbness, and autonomic dysfunction. 2) DPN results from damage to small and large nerve fibers caused by hyperglycemia. Clinical tests assess sensation of touch, vibration, temperature. 3) Treatment focuses on pain management with pregabalin, duloxetine, or tapentadol, as well as glycemic control and vitamins B1, B6, and B12 to aid nerve regeneration. The goals are symptomatic relief and halting nerve damage progression.