This document discusses Pemphigus Vulgaris (PV), a blistering skin disease seen predominantly in elderly patients. The objectives are to discuss the introduction of PV, enumerate its clinical features, and diagnose PV. PV is characterized by the loss of cohesion between epidermal cells, resulting in intraepidermal blisters. Clinical features include flaccid blisters on normal or erythematous skin that rupture easily, leaving denuded areas. Diagnosis involves skin biopsy and IgG testing. PV is distinguished from Pemphigus Foliaceus by PV blisters forming deeper in the epidermis and PV often involving mucous membranes.

1. PEMPHIGUS
Dr. Akshay Shetty
Asst. Professor
SSRAMCH Inchal.

2. Contents
Objectives
Introduction to Pemphigus Vulgaris
Clinical features of Pemphigus Vulgaris
Diagnosis of Pemphigus Vulgaris
Summary
References
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3. Objectives
By the end of the
presentation the students
must be able
•Discuss Introduction of
Pemphigus Vulgaris
•Enumerate clinical features of
Pemphigus Vulgaris
•Diagnose Pemphigus Vulgaris
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4. Introduction of Pemphigus Vulgaris
Pemphigus Vulgaris(PV) is a
blistering skin disease seen
predominantly in elderly patients
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5. Contd…
• Patients with PV has increased incidence of HLA-DR4 and –
DRW6
Serologically defined halo types
• This disorder is characterised by the loss of cohesion between
epidermal cells with resultant formation of intraepidermal
blisters
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6. Clinical features Pemphigus Vulgaris
• Clinical lesions typically consists of flaccid blisters on either normal appearing or
erythematous skin these blisters rupture early , leaving denuded areas that may
crust and enlarge peripherally.
• PV typically present in scalp, face, neck, axilla ,trunk and oral cavity
• In half or more patients lesions begin in the mouth
• Involvement of other mucosal surfaces e.g. Pharyngeal ,laryngeal ,oesophageal ,
conjunctival, vulvar, or rectal
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7. Diagnosis of PV
• Skin biopsy
• IgG test
D/D :Pemphigus foliaceus(PF) is distinguished with
PV by several features
In PF acantholytic blisters are located high within
epidermis usually beneath the stratum corneum,
hence PF is more superficial than PV
Distribution of lesion is much same except that in PF
mucus membrane lesions are rare
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8. Summary
Introduction of
Pemphigus Vulgaris
clinical features of
Pemphigus Vulgaris
Diagnosis of
Pemphigus Vulgaris
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9. References
• Davidson Principles Of Medicine & Practice Of Medicine .20th Ed.
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10. THANK YOU
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