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PATHOLOGY IN CVI
Dr. B.A.Maithri
Senior Resident
Dept of Ophthalmology
CMC,Vellore
Causes of “insult” to brain
■ Development of CVI depends on:
1. Stage of brain development when the insult happens
2. Severity of the insult
3. Duration of the insult
■ Hypoxic-ischemia
■ Pre-maturity
■ Epilepsy
■ Localised infarction
■ Chromosomal/Metabolic disorders
■ Congenital brain malformations – Holoprosencephaly, Hydrocephalus,
Septo-optic dysplasia
■ Neonatal hypoglycemia
■ Trauma
■ Infections – Meningitis, Encephalitis
■ Vascular supply in an infant: Major cerebral arteries,
■ Watershed areas lie at the interfaces between the major
cerebral arterial distributions.
■ Mild degrees of hypoxic-ischemic injury produce watershed
infarctions in the arterial border zones, injuring both gray and
white matter and resulting in cortical visual loss.
White Matter Disease of Immaturity
■ Ischaemic brain injury
■ Mostly affects pre-term infants
■ White matter gliosis
■ Seen around the ventricles
■ Spastic cerebral palsy with or without epilepsy
DecreasedO2 to brain
Disappearance/degeneration
of brain tissue (grey/white
matter)
Replaced by cystic fluid filled
areas
PVL/Encephalomalacia/WMDI Cerebral atrophy
Intellectual
disability Microcephaly
Spastic
di/tri/quadriplegia
CVI
Normal PVL
Encephalomalacia
PolymicrogyriaNormal
Parietal lobe scarring
Cortical atrophy
Cerebral infarct
Holoprosencephaly
Take Home
■ CVI depends on time, severity and duration of insult to brain
■ Clinical features depend on location of insult
■ Knowing the pathogenesis will help in targeted therapy
THANKYOU

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Pathology in CVI