Papillary carcinoma of the thyroid is the most common thyroid cancer, predominantly affecting females and linked to factors like ionizing radiation and familial history. Clinical investigations include thyroid profile, ultrasound, and biopsy, revealing characteristic nuclear features and histopathological changes. The prognosis is generally excellent, although there is potential for local lymph node spread and distant metastasis.

1. PAPILLARY CARCINOMA
THYROID
DR YLS

2. INCIDENCE
MOST COMMON THYROID CANCER
FEMALE PREDOMINANCE
ETIOLOGY
IONISING RADIATION
HASHIMOTOS THYOIDITIS
FAMILIAL ADENOMATOUS HYPERPLASIA
FAMILY HISTORY
MUTATIONS IN BRAF,RAS

3. CLINICAL FEATURES

4. INVESTIGATIONS
 THYROID PROFILE
 ULTRASOUND NECK
 FNAC OF SWELLING
 THYROID SCAN
 VIDEOLARYNGOSCOPY
 CT SCAN NECK
 BIOPSY

5. PATHWAYS OF EPITHELIAL NEOPLASM
OF THYROID

6. GROSS SPECIMEN-
SOLID,WHITE,FIRM,ENCAPSULATED,INFILTRATING MARGINS

7. BIOPSY FINDINGS
 PAPILLARY PATTERN OF ARRANGEMENT WITH FIBROVASCULAR CORE
 NUCLEAR FEATURES ARE TYPICAL
 NULEAR GROOVES
 INTRANUCLEAR PSEUDO INCLUSIONS
 CHROMATIN CLEARING-ORPHAN ANNIE NUCLEI/GROUND GLASS
APPEARANCE
 IRREGULAR NUCLEAR MEMBRANE
 FNAC-NUCLEAR ENLARGEMENT,NUCLEAR CROWDING AND
OVERLAPPING,NUCLEAR GROOVES AND CLEAR CHROMATIN

8. NUCLEAR CHANGES

9. HISTOPATHOLOGY

10. PCT WITH PSAMMOMA BODIES

11. NUCLEAR FEATURES

12. MORPHOLOGICAL VARIENTS

13. IHC MARKERS
 CK AE1/AE3
 CK7
 TTF-1
 PAX -8
 THYROGLOBULIN
 OVERALL EXCELLENT PROGNOSIS
 SPREAD TO LOCAL LYMPHNODES
 CAN METASTASIS TO LUNGS,BONE

14. TREATMENT

15. THANK YOU

21. 7/31/19