This document summarizes a research study on using systems-based evaluation (SBE) to assess Zambia's antiretroviral therapy (ART) scale-up strategy. The study used system dynamics modeling to evaluate relationships among ART program elements. Key findings include that the model triggered discussion of system boundaries and interrelationships, but did not lead to transformative action. For SBE to be most effective, stakeholders need opportunities to engage in boundary-setting discussions during both model development and after completion. Determining the system's boundaries is a methodological requirement that can have transformative impact through facilitated discussion.