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Role of palliative Radiotherapy in bone metastasis in
patients with Cancer in Ganjavian Hospital
Dr. Mohammad Dorchin1F.Bayati2,s.Tavakoli3
1 Oncology dep.Dezfol University of Medical Sciences, Dezfol, Iran
2Neurosurgeon ,Dezfol University of Medical Sciences ,Dezfol, Iran
3General Physician
Statistical Analyses
MATERIALS AND METHODS:
Between 1.6.2012 and 1.6.2013
a total of 48 patients, 33 patients
with all Bone metastatic cancers
esp. Breast and Prostate cancer
was 11 males and 37 females
with an average age of 38 years
(minimum 27 and maximum 79
years).We reviewed the literature
focusing on studies investigating
the efficacy of hypo fractionated
radiotherapy for bone
metastases. We also addressed
the problem of treating multiple
skeletal lesions with irradiation.
Palsy can always be avoided in
these patients. Irradiation can
achieve complete pain relief in
over 20% of patients and
decrease pain markedly in the
remaining cases with only a
single-dose fraction (6-10 Gy),
within 48 hours of irradiation and
with little side-effects. Better
results in terms of pain relief
(80% complete responses) and
duration of palliation come from
fractionated irradiation (up to
17.5 Gy in 7 fractions or 30 Gy in
10 fractions), which however has
a more delayed response (1-2
weeks) and higher toxicity.
Total new cancer cases referred to the
Ganjavian hospital from 2012-2013:
External beam irradiation that
our patients treated in Ahwaz
center and other
radiotherapiotic centers
achieves pain palliation in more
than 75% of patients with bone
metastases, even with EBRT
down to a single-dose
administration. The results of
exclusive radiotherapy in the
cord compression syndrome
depend on a prompt diagnosis,
patient presentation and the
intrinsic radiosensitivity of
tumor cellsin three patients.
Incidence according to the Age
The management of painful
bone metastases requires
multidisciplinary care, with
external beam radiation therapy
(EBRT) providing relief that is
effective and time efficient.
RESULTS:
20-
30,
2
31-40, 9
41-50, 11
51-60, 8
more
than
61, 3
0
100
200
300
400
500
600
2012 2013 Total
New case
my study
Column1
DISCUSSION:
In our study the efficacy of external beam irradiation in the palliation of bone metastasis-related symptoms is confirmed by
this study, even with short treatments and single-dose administrations. This is important for both patient expectations and
the necessity for improved resource allocation with reference to the territorial distribution and waiting lists of radiotherapy
centers. The issue of their efficacy in combination with antiblastic drugs (Bisphosphonates drugs such as Zoledronic acid)
and/or external beam irradiation(EBRT) remains open and will be clarified only with further randomized clinical trials.
INTRODUCTION

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Palliative radiotherapy in bone metastasis

  • 1. Role of palliative Radiotherapy in bone metastasis in patients with Cancer in Ganjavian Hospital Dr. Mohammad Dorchin1F.Bayati2,s.Tavakoli3 1 Oncology dep.Dezfol University of Medical Sciences, Dezfol, Iran 2Neurosurgeon ,Dezfol University of Medical Sciences ,Dezfol, Iran 3General Physician Statistical Analyses MATERIALS AND METHODS: Between 1.6.2012 and 1.6.2013 a total of 48 patients, 33 patients with all Bone metastatic cancers esp. Breast and Prostate cancer was 11 males and 37 females with an average age of 38 years (minimum 27 and maximum 79 years).We reviewed the literature focusing on studies investigating the efficacy of hypo fractionated radiotherapy for bone metastases. We also addressed the problem of treating multiple skeletal lesions with irradiation. Palsy can always be avoided in these patients. Irradiation can achieve complete pain relief in over 20% of patients and decrease pain markedly in the remaining cases with only a single-dose fraction (6-10 Gy), within 48 hours of irradiation and with little side-effects. Better results in terms of pain relief (80% complete responses) and duration of palliation come from fractionated irradiation (up to 17.5 Gy in 7 fractions or 30 Gy in 10 fractions), which however has a more delayed response (1-2 weeks) and higher toxicity. Total new cancer cases referred to the Ganjavian hospital from 2012-2013: External beam irradiation that our patients treated in Ahwaz center and other radiotherapiotic centers achieves pain palliation in more than 75% of patients with bone metastases, even with EBRT down to a single-dose administration. The results of exclusive radiotherapy in the cord compression syndrome depend on a prompt diagnosis, patient presentation and the intrinsic radiosensitivity of tumor cellsin three patients. Incidence according to the Age The management of painful bone metastases requires multidisciplinary care, with external beam radiation therapy (EBRT) providing relief that is effective and time efficient. RESULTS: 20- 30, 2 31-40, 9 41-50, 11 51-60, 8 more than 61, 3 0 100 200 300 400 500 600 2012 2013 Total New case my study Column1 DISCUSSION: In our study the efficacy of external beam irradiation in the palliation of bone metastasis-related symptoms is confirmed by this study, even with short treatments and single-dose administrations. This is important for both patient expectations and the necessity for improved resource allocation with reference to the territorial distribution and waiting lists of radiotherapy centers. The issue of their efficacy in combination with antiblastic drugs (Bisphosphonates drugs such as Zoledronic acid) and/or external beam irradiation(EBRT) remains open and will be clarified only with further randomized clinical trials. INTRODUCTION