PACKED CELL VOLUME.pptx
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The hematocrit, also known as the packed cell volume (PCV), measures the percentage of red blood cells in a blood sample. It is determined by centrifuging a blood sample in a glass tube to separate the components. The red blood cells pack tightly at the bottom, while the plasma rises to the top, leaving a thin white blood cell layer between them. After centrifugation, the hematocrit is read as the percentage of the total volume occupied by the packed red blood cells. It provides an accurate estimate of the red blood cell mass and can indicate if a patient is anemic, normal, or has too many red blood cells.
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Pcv
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PCV.pptx
Hematocrit (packed cell volume) is the ratio of the volume of red cells to that of the whole blood.
It indicates relative volume of red cells and plasma (e.g. in anemia red cells are reduced with corresponding reduction in the hematocrit)
Methods
Macromethod using Wintrobe tube
• Micromethod using capillary tube
• Automated analyse
The packed cell volume is a measurement of the proportion of blood that is made up of cells. The value is expressed as a percentage
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This document discusses packed cell volume (PCV), also known as hematocrit. It defines PCV as the volume of erythrocytes (red blood cells) as a percentage of total blood volume. The document describes how PCV is determined through centrifugation and separation of blood components. It notes several clinical implications of PCV levels, such as increases seen in infants and high altitudes and decreases in pregnancy. The key information provided is an overview of PCV/hematocrit testing and its importance in clinical evaluation.
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It indicates relative volume of red cells and plasma (e.g. in anemia red cells are reduced with corresponding reduction in the hematocrit)
Methods
Macromethod using Wintrobe tube
• Micromethod using capillary tube
• Automated analyse
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2. The Hct is calculated by measuring the height of the packed red blood cell column and dividing by the total height of the blood column in a capillary tube, then multiplying by 100.
3. A normal Hct range is 36-46% for females and 40-54% for males. Factors like centrifugation speed and time can affect the Hct results if not done properly. The Hct is used to screen for anemia but hemoglobin is a more significant indicator.
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2) It describes the microhematocrit method used in the experiment, involving drawing blood into a capillary tube, sealing it, centrifuging, and reading the PCV value based on the ratio of red blood cell volume to total blood volume.
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1. Hematocrit (Hct) measures the percentage of red blood cells in blood after centrifugation. Blood is centrifuged to pack the red blood cells below and plasma above using centrifugal force.
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3. A tourniquet is used to locate veins and the site must be cleaned before collection to avoid contamination. Fasting or postprandial timing affects some tests.
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This document discusses the determination of hematocrit (Hct), which is the percentage of red blood cells in blood. Hct is measured by centrifuging a blood sample in a microhematocrit tube to separate the plasma and packed red blood cells. The ratio of the height of the red blood cell layer to the total height provides the Hct percentage. An increased or decreased Hct can indicate various medical conditions like anemia or polycythemia. The normal Hct range is 40-54% for males and 36-47% for females. Proper technique and avoiding sources of error are important for obtaining an accurate Hct measurement.
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1) The document discusses the determination of packed cell volume (PCV), also known as hematocrit (Hct), which is defined as the volume of red blood cells per unit volume of whole blood.
2) It describes the microhematocrit method used in the experiment, involving drawing blood into a capillary tube, sealing it, centrifuging, and reading the PCV value based on the ratio of red blood cell volume to total blood volume.
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Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdf
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
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PACKED CELL VOLUME.pptx
- 2. • Most american references is called Hematocrit • Defined as volume of packed red cells in a given sample of blood. • Expressed as percentage of total volume of blood sample. • Packing of red cells is achieved by centrifugation.
- 3. • Centrifugation of blood in a glass tube. • It is necessary to have i. Optimum speed of centrifuge ii. Optimum speed of centrifuge iii. Optimum duration of centrifuge
- 4. • Packed cell volume is a simple and very accurate method of estimating the red blood cell mass. • It tells the patient is normal, anemic or polycythemic (Inc. red cell mass) • Possible error of only +/- 1% • This makes it far more accurate than the RBC count, unless counted in automated electronic counter
- 5. METHODS OF PCV 1) Wintrobe’s method 2) Micohaematocrit Method
- 7. • Venous blood is used. • Anticoagulant is wintrobe’s mixture or EDTA or Heparin.
- 8. Method Mix the anticoagulated sample thoroughly. 1 – 1.5 ml sample is taken up in to a pasteur pipette with long capillary tip. Insert the tip of pipette all the way to the bottom of tube. Express the blood into tube from bottom, avoid air bubbles, fill tube upto 100 mark
- 9. • Centrifuge the tube in a centrifuge of 15cm radius at 3000rpm for 30minutes. • After centrifugation, 3 definite layers can be easily seen.
- 10. 1. Layer of packed red cells: At the bottom The top of red cell layer often quite clearly noted as a very thin line in which the packed cells are darker, making it easy to read the level against the markings on glass tube
- 11. 2. Thin layer of WBC and platelets Its just above the RBC, greyish in color and called the buffy coat
- 12. 3. The upper most layer of plasma
Editor's Notes
- It is due to consumption of oxygen by these cells during centrifug. Which led to deoxygenation and change towards a dark blue color