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Cytomorphological changes on conventional smears from HIV positive women Dr Genevieve Warner  Learmonth University of Cape Town South Africa Royal Free Hospital London
Aetiology of AIDS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Burkitts lymphoma ,[object Object],[object Object],[object Object]
Along came Acquired Immunodeficiency Disease Syndrome ( AIDS) ,[object Object],[object Object]
Retrovirus ? ,[object Object],[object Object]
If you look carefully Dendritic  Cells are easy to observe  on cervical smears! Cervical Smear, AIDS patient
Dysfunctional Metabolism in HIV/AIDS ,[object Object],[object Object],[object Object],[object Object],[object Object]
The effects of dysfunctional metabolism  are reflected in cytomorphological changes in surface epithelial cells ,[object Object],[object Object],[object Object],[object Object],[object Object]
If you know what you are searching for, keep looking !
Infection and Dendritic Cells
Dendritic cells on cervical smears ,[object Object],[object Object],[object Object],[object Object]
Hyperkeratosis  in HIV “Warty atypia” abnormal keratin production dyskeratosis warthog
Abnormal Keratinization in most cells great and small
Intense orangeophilia: excessive keratinization
Squamous pearls, and  dysplastic cells containing glycogen
HIV and Cytomegaly ,[object Object]
Enlarged cells with normal N/C ratio
Binucleate cells small and large ,[object Object],[object Object]
Huge binucleate macrocytic squamous cells, nuclear cytoplasmic ratio suggests LSIL
Metaplastic and dysplastic  (LSIL)  macrocytic squamous cells
Huge Bizarre Cells
HIV and HPV ,[object Object],[object Object],[object Object]
Bizarre nuclei in large cells, plentiful cytoplasm
The effects of the dysfunction caused by malnutrition, vitamin deficiency  and infection are reflected in epithelial cells ,[object Object],[object Object],[object Object]
Solutions to the AIDS /HIV epidemic ,[object Object],[object Object],[object Object],[object Object],CONDOMS CONDOMS CONDOMS
Remote rural populations, with no infrastructure
Anti Retroviral Drug Therapy (ARVD) ,[object Object],[object Object],[object Object],[object Object]
Availability of ARVD’s ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Women with HIV in Africa ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CONDOMS
Fate of women on ARVD’s ,[object Object],[object Object],[object Object],[object Object]
Result of Freely available ARVD’s  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tuberculosis “ a terrible twin”, which occurs in a large percentage of Patients with HIV/AIDS ,[object Object],[object Object],TB bacilli on sputum smear
Outcome ,[object Object],[object Object],[object Object],[object Object],[object Object]
The only solution  ,[object Object],[object Object],[object Object],[object Object],CONDOMS

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