These slides briefly describe the relation of dengue virus and an endosymbiont bacteria Wolbachia. We can eliminate Dengue fever by using the strategy to manipulate mosquito biology such that it would be unable to transfer virus to humans.
The document summarizes information about HIV and AIDS, including:
- HIV is a virus that attacks the immune system and can develop into AIDS if not treated. It is transmitted through bodily fluids and can be prevented by using condoms and avoiding risky behaviors.
- Over time, HIV can weaken the immune system to the point where opportunistic infections or cancers can occur. There is no cure for HIV/AIDS yet.
- HIV belongs to a family of retroviruses that use an enzyme to convert their RNA into host DNA, allowing them to infect and replicate within cells.
This document provides an overview of human babesiosis. It begins with an introduction to babesiosis, caused by intraerythrocytic parasites of the genus Babesia. Symptoms can range from asymptomatic to flu-like symptoms to hemolytic anemia. Risk factors include being splenectomized, immunosuppressed, or elderly. Diagnosis involves microscopic identification of the parasite via blood smear staining or PCR/serology tests. Treatment typically involves a combination of antimicrobial medications, with severity determining the specific treatment. Babesiosis poses economic impacts and is an emerging zoonosis worldwide.
Wolbachia based strategies to control insect pests and disease vectorsIGKV, Raipur
Wolbachia is an intracellular bacteria that can manipulate the reproduction of insect hosts. It induces various effects including cytoplasmic incompatibility, feminization, parthenogenesis, and male-killing. These properties allow Wolbachia to spread through insect populations and are being explored for novel biocontrol strategies like incompatible insect technique, population replacement, and life-shortening of disease vectors. While the mechanisms behind various Wolbachia-induced effects are still being studied, some strategies have shown success in suppressing mosquito populations and reducing disease transmission.
Babesiosis, also known as bovine babesiosis, is a tick-borne disease of cattle and buffalo caused by protozoan parasites of the genus Babesia. The parasites infect and lyse red blood cells, causing hemolytic anemia. Clinical signs include fever, anemia, hemoglobinuria, and jaundice. Diagnosis is made by identifying the pear-shaped parasites on blood smears. Treatment involves the use of imidocarb or diminazine aceturate. Control relies on controlling tick vectors with acaricides and vaccination.
Babesiosis is caused by parasites of the genus Babesia that infect red blood cells. It is transmitted through the bites of infected ticks. Symptoms can range from mild to severe illness including fever, chills, sweats, headache, body aches, loss of appetite, nausea, or fatigue. Diagnosis involves examining blood smears for the characteristic ring-shaped parasites or detecting antibodies through serologic tests. Treatment involves antibiotic combinations like atovaquone-azithromycin or clindamycin-quinine. Prevention focuses on avoiding tick bites through proper clothing, repellents, and tick checks.
Bovine babesiosis, also known as cattle fever, is caused by the protozoan parasites Babesia bovis and Babesia bigemina. It is transmitted by ticks of the genus Rhipicephalus, primarily R. microplus and R. annulatus. The disease caused major economic losses to the cattle industry in the southern United States in the late 19th century. While tick eradication programs were successful in eliminating the disease from most of the US, it continues to be a threat where cattle and ticks interact along the US-Mexico border. Effective vaccines and approved anti-babesial drugs for cattle in the US are still lacking.
These slides briefly describe the relation of dengue virus and an endosymbiont bacteria Wolbachia. We can eliminate Dengue fever by using the strategy to manipulate mosquito biology such that it would be unable to transfer virus to humans.
The document summarizes information about HIV and AIDS, including:
- HIV is a virus that attacks the immune system and can develop into AIDS if not treated. It is transmitted through bodily fluids and can be prevented by using condoms and avoiding risky behaviors.
- Over time, HIV can weaken the immune system to the point where opportunistic infections or cancers can occur. There is no cure for HIV/AIDS yet.
- HIV belongs to a family of retroviruses that use an enzyme to convert their RNA into host DNA, allowing them to infect and replicate within cells.
This document provides an overview of human babesiosis. It begins with an introduction to babesiosis, caused by intraerythrocytic parasites of the genus Babesia. Symptoms can range from asymptomatic to flu-like symptoms to hemolytic anemia. Risk factors include being splenectomized, immunosuppressed, or elderly. Diagnosis involves microscopic identification of the parasite via blood smear staining or PCR/serology tests. Treatment typically involves a combination of antimicrobial medications, with severity determining the specific treatment. Babesiosis poses economic impacts and is an emerging zoonosis worldwide.
Wolbachia based strategies to control insect pests and disease vectorsIGKV, Raipur
Wolbachia is an intracellular bacteria that can manipulate the reproduction of insect hosts. It induces various effects including cytoplasmic incompatibility, feminization, parthenogenesis, and male-killing. These properties allow Wolbachia to spread through insect populations and are being explored for novel biocontrol strategies like incompatible insect technique, population replacement, and life-shortening of disease vectors. While the mechanisms behind various Wolbachia-induced effects are still being studied, some strategies have shown success in suppressing mosquito populations and reducing disease transmission.
Babesiosis, also known as bovine babesiosis, is a tick-borne disease of cattle and buffalo caused by protozoan parasites of the genus Babesia. The parasites infect and lyse red blood cells, causing hemolytic anemia. Clinical signs include fever, anemia, hemoglobinuria, and jaundice. Diagnosis is made by identifying the pear-shaped parasites on blood smears. Treatment involves the use of imidocarb or diminazine aceturate. Control relies on controlling tick vectors with acaricides and vaccination.
Babesiosis is caused by parasites of the genus Babesia that infect red blood cells. It is transmitted through the bites of infected ticks. Symptoms can range from mild to severe illness including fever, chills, sweats, headache, body aches, loss of appetite, nausea, or fatigue. Diagnosis involves examining blood smears for the characteristic ring-shaped parasites or detecting antibodies through serologic tests. Treatment involves antibiotic combinations like atovaquone-azithromycin or clindamycin-quinine. Prevention focuses on avoiding tick bites through proper clothing, repellents, and tick checks.
Bovine babesiosis, also known as cattle fever, is caused by the protozoan parasites Babesia bovis and Babesia bigemina. It is transmitted by ticks of the genus Rhipicephalus, primarily R. microplus and R. annulatus. The disease caused major economic losses to the cattle industry in the southern United States in the late 19th century. While tick eradication programs were successful in eliminating the disease from most of the US, it continues to be a threat where cattle and ticks interact along the US-Mexico border. Effective vaccines and approved anti-babesial drugs for cattle in the US are still lacking.
vetrinary parasitology
Introduction
Epidemiology: Distribution, Susceptible host/ Reservoirs Transmission
Pathogenesis
Diagnosis and different diagnosis: Clinical Signs and Pathology
Laboratory confirmation
Differential diagnosis
Control / Prevention: Vector Control
Vaccination
Chemoprophylaxis
Control of outbreak
Treatment
Babesia is a protozoan parasite that causes babesiosis, a disease transmitted through the bite of infected Ixodidae ticks. It has a complex life cycle involving ticks and mammalian reservoir hosts. In humans, the most common pathogenic species are B. microti and B. divergens, which are transmitted by the deer tick Ixodidae scapularis. Babesia infects red blood cells and was originally discovered causing illness in cattle and sheep.
This document summarizes the transmission of Babesia parasites between ticks and vertebrate hosts. It describes the Babesia lifecycle, which involves sexual reproduction in the tick gut followed by sporozoite formation. Sporozoites are transmitted to vertebrate hosts during tick feeding and develop through merogony stages in red blood cells. Persistence is enabled by low level chronic infections in vertebrate hosts and transovarial/transstadial transmission between tick life stages. Babesia has evolved mechanisms like antigenic variation and cytoadherence to modulate the host immune response and promote long-term infections.
This document provides an overview of genetically modified mosquitoes for vector control. It discusses the mosquito lifecycle and transmission of vector-borne diseases. Methods for vector control include the use of Wolbachia-infected mosquitoes, which have shown promise in suppressing dengue virus in laboratory and field trials by impairing pathogen development. The document also describes techniques using sterile insects like the sterile insect technique (SIT) and release of insects carrying a dominant lethal gene (RIDL). Field trials on the Cayman Islands demonstrated that Wolbachia-infected mosquitoes can successfully introduce and spread the infection within a native mosquito population. However, more studies are still needed before GM mosquitoes can be effectively used for vector control.
This document summarizes information about bovine babesiosis, a tick-borne disease of cattle caused by Babesia parasites. It discusses the causative agents, vectors, clinical signs, diagnosis, and vaccines. For diagnosis, microscopic examination of blood smears can detect the parasites, while serological tests like ELISA are commonly used to detect antibodies. Live vaccines made from attenuated parasite strains provide lifelong immunity but require strict production controls.
Oncoviruses are viruses that cause cancer. They originated from studies in the 1950s-60s of retroviruses that could transform cells. Now the term refers to any virus with a DNA or RNA genome that causes cancer. Approximately 17.8% of human cancers are caused by viral infections, with 11.9% caused by seven main viruses. These include Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, hepatitis B and C viruses, human papillomavirus, and Merkel cell polyomavirus. Oncoviruses cause cancer through encoding transforming proteins that stimulate tumor formation and cell proliferation.
Marburg virus was first identified in 1967 during outbreaks in Germany and Yugoslavia from African green monkeys and fruit bats imported from Uganda. It is transmitted through direct contact with infected humans or animals. Symptoms include fever, headache, stomach issues, rash and red eyes. The Marburg and Ebola viruses are similar in that they cause hemorrhagic fever and are native to Africa. There is no approved vaccine or treatment.
Wolbachia is a group of intracellular bacteria, discovered in the seventies with the invention of electron microscopy. They belong to the order Ricket tsiales and are closely related to the general Ehrlichia, Cowdria and Anaplasma. They are widespread in the arthropods and significant insect pests as well as disease vectors. They are also present in filarial nematodes.
This document provides information about bovine babesiosis, a tick-borne disease caused by the protozoan parasite Babesia. It affects cattle and is transmitted by ticks. The most important species are B. bovis, B. bigemina, and B. divergens. Clinical signs include fever, anemia, jaundice, and red urine. Severe cases can cause death. Diagnosis involves finding the parasites on blood smears. Control relies on tick control, vaccination, and treatment of infected cattle. Babesiosis can also infect humans in some areas.
Human Retroviruses are RNA viruses that contain the enzyme reverse transcriptase, allowing them to convert their RNA genome into DNA. The two major genera that affect humans are Lentiviruses, which include HIV-1 and HIV-2, and HTLV-BLV group, which includes HTLV-1 and HTLV-2. HIV binds host cells via gp120, enters via fusion, reverse transcribes into DNA then integrates into the host genome. It replicates using host cell machinery. Infection can lead to AIDS as CD4+ T cells are depleted. Opportunistic infections are treated with antiretrovirals that target reverse transcriptase and protease.
This document discusses Babesia, a protozoan parasite that causes Babesiosis. It begins with an introduction to Babesia taxonomy and species. It then discusses the life cycle of Babesia, noting it is transmitted through tick bites. Clinical signs of Babesiosis include fever and hemolytic anemia. The document outlines methods used to analyze gene expression changes in ticks infected with Babesia bovis and differences identified. Prevention focuses on avoiding tick habitats while treatment typically involves antibiotics like clindamycin and quinine.
Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...ILRI
Poster prepared John Juma, Vagner Fonseca, Samson Limbaso, Peter van Heusden, Kristina Roesel, Bernard Bett, Rosemary Sang, Alan Christoffels, Tulio de Oliveira and Samuel Oyola for the Kenya One Health Online Conference, 6-8 December 2021
Bovine babesiosis, also known as cattle fever, is caused by the protozoan parasites Babesia bovis and Babesia bigemina. It is transmitted by ticks of the genus Rhipicephalus, primarily R. microplus and R. annulatus. The disease caused major economic losses to the cattle industry in the southern United States in the late 19th century. While eradication programs eliminated the ticks by 1943, threats remain from infected cattle and ticks in Mexico. Clinical signs of bovine babesiosis include hemoglobinuria, fever, anemia and death. Diagnosis involves microscopic examination of blood smears or PCR and serological tests. Control relies on tick eradication, quar
1. Hepatitis A virus (HAV) is a non-enveloped icosahedral virus in the Picornaviridae family that infects liver cells and is transmitted through the fecal-oral route.
2. HAV is resistant to detergents, acids, heat up to 60°C, and can survive for many months in water.
3. The hepatitis A vaccine provides lifelong immune protection against re-infection and is routinely recommended for children and high-risk adults.
The document discusses the virology syllabus and covers various topics including mycology, fungal infections, viruses and specific RNA and DNA viruses. Unit 5 focuses on the DNA virus smallpox, covering its morphology as a brick-shaped virus 300x200x100nm in size with double stranded DNA and an envelope. It also spreads via respiratory droplets and causes pustular lesions before being eradicated in the late 1970s through global vaccination efforts.
This document provides an overview of the Ebola virus. It defines Ebola virus disease as a severe, often fatal disease caused by the Ebola virus. The Ebola virus is an enveloped, negative-strand RNA virus that causes hemorrhagic fever. It is transmitted through contact with infected body fluids and can cause internal and external bleeding. The document outlines the virus's structure, classification, transmission, symptoms, diagnosis, treatment and methods for controlling spread. It emphasizes that there is currently no licensed treatment and extensive research is still needed to develop vaccines and cures.
Infectious bursal disease (IBD) is a highly contagious viral disease affecting young chickens. It is caused by infectious bursal disease virus (IBDV), which destroys lymphocytes in the bursa of Fabricius, impairing the immune system. Clinical signs include diarrhea, lethargy, and immunosuppression. At necropsy, the bursa appears swollen and hemorrhagic. Diagnosis relies on detecting viral antigens or nucleic acids in the bursa. Vaccination is the main control method, with live attenuated and in ovo vaccines available.
Researchers have genetically modified a bacteria, Pantoes agglomerans, that lives naturally in the gut of mosquitoes. The modified bacteria produces proteins that destroy Plasmodium oocysts, which are early forms of the malaria parasite, reducing malaria infection rates in mosquitoes by 98%. Another approach uses GM mosquitoes with an added gene that kills them as larvae if not given tetracycline, decreasing wild mosquito populations over time. However, long term safety testing of GM mosquitoes interacting with the environment and humans has not been conducted.
This document provides an overview of viruses and their role in periodontal disease. It begins with definitions of viruses and their classification. It then discusses the structure and life cycle of viruses, how the host responds to viral infections, and specific viruses implicated in periodontal disease like herpes viruses and HIV. The document proposes a model where herpes virus activation in the gingiva can enhance the pathogenic potential of bacteria and contribute to periodontal tissue destruction over time, especially in immunosuppressed individuals. It reviews evidence that herpes viral DNA is detected more frequently in gingival tissue and crevicular fluid from periodontally diseased sites compared to healthy sites.
HIV originated from chimpanzees in Central Africa, likely jumping to humans in the late 1800s when humans hunted chimpanzees for meat. It slowly spread across Africa and later worldwide. The earliest known case was detected in 1959 in what is now the Democratic Republic of Congo. By the 1980s, AIDS was recognized as a global epidemic affecting millions of people. There is no cure for HIV/AIDS, but treatment can control the virus.
Burkitt Lymphoma GROUP A BATCH 2 PRESENTATION (1).pptxXavier875943
Burkitt lymphoma is a type of non-Hodgkin's lymphoma first described in 1958 by Denis Burkitt in Uganda. It is caused by a translocation of the MYC gene which leads to uncontrolled B-cell proliferation. The disease is associated with areas that have high rates of malaria and early Epstein-Barr virus infection, which are thought to contribute to B-cell hyperplasia and increase the chances of a MYC translocation occurring. AIDS-associated Burkitt lymphoma has also been reported and its incidence increased with the HIV epidemic.
vetrinary parasitology
Introduction
Epidemiology: Distribution, Susceptible host/ Reservoirs Transmission
Pathogenesis
Diagnosis and different diagnosis: Clinical Signs and Pathology
Laboratory confirmation
Differential diagnosis
Control / Prevention: Vector Control
Vaccination
Chemoprophylaxis
Control of outbreak
Treatment
Babesia is a protozoan parasite that causes babesiosis, a disease transmitted through the bite of infected Ixodidae ticks. It has a complex life cycle involving ticks and mammalian reservoir hosts. In humans, the most common pathogenic species are B. microti and B. divergens, which are transmitted by the deer tick Ixodidae scapularis. Babesia infects red blood cells and was originally discovered causing illness in cattle and sheep.
This document summarizes the transmission of Babesia parasites between ticks and vertebrate hosts. It describes the Babesia lifecycle, which involves sexual reproduction in the tick gut followed by sporozoite formation. Sporozoites are transmitted to vertebrate hosts during tick feeding and develop through merogony stages in red blood cells. Persistence is enabled by low level chronic infections in vertebrate hosts and transovarial/transstadial transmission between tick life stages. Babesia has evolved mechanisms like antigenic variation and cytoadherence to modulate the host immune response and promote long-term infections.
This document provides an overview of genetically modified mosquitoes for vector control. It discusses the mosquito lifecycle and transmission of vector-borne diseases. Methods for vector control include the use of Wolbachia-infected mosquitoes, which have shown promise in suppressing dengue virus in laboratory and field trials by impairing pathogen development. The document also describes techniques using sterile insects like the sterile insect technique (SIT) and release of insects carrying a dominant lethal gene (RIDL). Field trials on the Cayman Islands demonstrated that Wolbachia-infected mosquitoes can successfully introduce and spread the infection within a native mosquito population. However, more studies are still needed before GM mosquitoes can be effectively used for vector control.
This document summarizes information about bovine babesiosis, a tick-borne disease of cattle caused by Babesia parasites. It discusses the causative agents, vectors, clinical signs, diagnosis, and vaccines. For diagnosis, microscopic examination of blood smears can detect the parasites, while serological tests like ELISA are commonly used to detect antibodies. Live vaccines made from attenuated parasite strains provide lifelong immunity but require strict production controls.
Oncoviruses are viruses that cause cancer. They originated from studies in the 1950s-60s of retroviruses that could transform cells. Now the term refers to any virus with a DNA or RNA genome that causes cancer. Approximately 17.8% of human cancers are caused by viral infections, with 11.9% caused by seven main viruses. These include Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, hepatitis B and C viruses, human papillomavirus, and Merkel cell polyomavirus. Oncoviruses cause cancer through encoding transforming proteins that stimulate tumor formation and cell proliferation.
Marburg virus was first identified in 1967 during outbreaks in Germany and Yugoslavia from African green monkeys and fruit bats imported from Uganda. It is transmitted through direct contact with infected humans or animals. Symptoms include fever, headache, stomach issues, rash and red eyes. The Marburg and Ebola viruses are similar in that they cause hemorrhagic fever and are native to Africa. There is no approved vaccine or treatment.
Wolbachia is a group of intracellular bacteria, discovered in the seventies with the invention of electron microscopy. They belong to the order Ricket tsiales and are closely related to the general Ehrlichia, Cowdria and Anaplasma. They are widespread in the arthropods and significant insect pests as well as disease vectors. They are also present in filarial nematodes.
This document provides information about bovine babesiosis, a tick-borne disease caused by the protozoan parasite Babesia. It affects cattle and is transmitted by ticks. The most important species are B. bovis, B. bigemina, and B. divergens. Clinical signs include fever, anemia, jaundice, and red urine. Severe cases can cause death. Diagnosis involves finding the parasites on blood smears. Control relies on tick control, vaccination, and treatment of infected cattle. Babesiosis can also infect humans in some areas.
Human Retroviruses are RNA viruses that contain the enzyme reverse transcriptase, allowing them to convert their RNA genome into DNA. The two major genera that affect humans are Lentiviruses, which include HIV-1 and HIV-2, and HTLV-BLV group, which includes HTLV-1 and HTLV-2. HIV binds host cells via gp120, enters via fusion, reverse transcribes into DNA then integrates into the host genome. It replicates using host cell machinery. Infection can lead to AIDS as CD4+ T cells are depleted. Opportunistic infections are treated with antiretrovirals that target reverse transcriptase and protease.
This document discusses Babesia, a protozoan parasite that causes Babesiosis. It begins with an introduction to Babesia taxonomy and species. It then discusses the life cycle of Babesia, noting it is transmitted through tick bites. Clinical signs of Babesiosis include fever and hemolytic anemia. The document outlines methods used to analyze gene expression changes in ticks infected with Babesia bovis and differences identified. Prevention focuses on avoiding tick habitats while treatment typically involves antibiotics like clindamycin and quinine.
Genomic surveillance of the Rift Valley fever: From sequencing to Lineage ass...ILRI
Poster prepared John Juma, Vagner Fonseca, Samson Limbaso, Peter van Heusden, Kristina Roesel, Bernard Bett, Rosemary Sang, Alan Christoffels, Tulio de Oliveira and Samuel Oyola for the Kenya One Health Online Conference, 6-8 December 2021
Bovine babesiosis, also known as cattle fever, is caused by the protozoan parasites Babesia bovis and Babesia bigemina. It is transmitted by ticks of the genus Rhipicephalus, primarily R. microplus and R. annulatus. The disease caused major economic losses to the cattle industry in the southern United States in the late 19th century. While eradication programs eliminated the ticks by 1943, threats remain from infected cattle and ticks in Mexico. Clinical signs of bovine babesiosis include hemoglobinuria, fever, anemia and death. Diagnosis involves microscopic examination of blood smears or PCR and serological tests. Control relies on tick eradication, quar
1. Hepatitis A virus (HAV) is a non-enveloped icosahedral virus in the Picornaviridae family that infects liver cells and is transmitted through the fecal-oral route.
2. HAV is resistant to detergents, acids, heat up to 60°C, and can survive for many months in water.
3. The hepatitis A vaccine provides lifelong immune protection against re-infection and is routinely recommended for children and high-risk adults.
The document discusses the virology syllabus and covers various topics including mycology, fungal infections, viruses and specific RNA and DNA viruses. Unit 5 focuses on the DNA virus smallpox, covering its morphology as a brick-shaped virus 300x200x100nm in size with double stranded DNA and an envelope. It also spreads via respiratory droplets and causes pustular lesions before being eradicated in the late 1970s through global vaccination efforts.
This document provides an overview of the Ebola virus. It defines Ebola virus disease as a severe, often fatal disease caused by the Ebola virus. The Ebola virus is an enveloped, negative-strand RNA virus that causes hemorrhagic fever. It is transmitted through contact with infected body fluids and can cause internal and external bleeding. The document outlines the virus's structure, classification, transmission, symptoms, diagnosis, treatment and methods for controlling spread. It emphasizes that there is currently no licensed treatment and extensive research is still needed to develop vaccines and cures.
Infectious bursal disease (IBD) is a highly contagious viral disease affecting young chickens. It is caused by infectious bursal disease virus (IBDV), which destroys lymphocytes in the bursa of Fabricius, impairing the immune system. Clinical signs include diarrhea, lethargy, and immunosuppression. At necropsy, the bursa appears swollen and hemorrhagic. Diagnosis relies on detecting viral antigens or nucleic acids in the bursa. Vaccination is the main control method, with live attenuated and in ovo vaccines available.
Researchers have genetically modified a bacteria, Pantoes agglomerans, that lives naturally in the gut of mosquitoes. The modified bacteria produces proteins that destroy Plasmodium oocysts, which are early forms of the malaria parasite, reducing malaria infection rates in mosquitoes by 98%. Another approach uses GM mosquitoes with an added gene that kills them as larvae if not given tetracycline, decreasing wild mosquito populations over time. However, long term safety testing of GM mosquitoes interacting with the environment and humans has not been conducted.
This document provides an overview of viruses and their role in periodontal disease. It begins with definitions of viruses and their classification. It then discusses the structure and life cycle of viruses, how the host responds to viral infections, and specific viruses implicated in periodontal disease like herpes viruses and HIV. The document proposes a model where herpes virus activation in the gingiva can enhance the pathogenic potential of bacteria and contribute to periodontal tissue destruction over time, especially in immunosuppressed individuals. It reviews evidence that herpes viral DNA is detected more frequently in gingival tissue and crevicular fluid from periodontally diseased sites compared to healthy sites.
HIV originated from chimpanzees in Central Africa, likely jumping to humans in the late 1800s when humans hunted chimpanzees for meat. It slowly spread across Africa and later worldwide. The earliest known case was detected in 1959 in what is now the Democratic Republic of Congo. By the 1980s, AIDS was recognized as a global epidemic affecting millions of people. There is no cure for HIV/AIDS, but treatment can control the virus.
Burkitt Lymphoma GROUP A BATCH 2 PRESENTATION (1).pptxXavier875943
Burkitt lymphoma is a type of non-Hodgkin's lymphoma first described in 1958 by Denis Burkitt in Uganda. It is caused by a translocation of the MYC gene which leads to uncontrolled B-cell proliferation. The disease is associated with areas that have high rates of malaria and early Epstein-Barr virus infection, which are thought to contribute to B-cell hyperplasia and increase the chances of a MYC translocation occurring. AIDS-associated Burkitt lymphoma has also been reported and its incidence increased with the HIV epidemic.
AIDS stands for: Acquired Immune Deficiency Syndrome
AIDS is a medical condition. A person is diagnosed with AIDS when their immune system is too weak to fight off infections.
Since AIDS was first identified in the early 1980s, an unprecedented number of people have been affected by the global AIDS epidemic. Today, there are an estimated 33.3 million people living with HIV and AIDS worldwide.
http://www.pediatricdentists.blogspot.com
AIDS stands for: Acquired Immunodeficiency Syndrome HIV stands for: Human immunodeficiency virus AIDS is a disease of the human immune system caused by the HIV
The document discusses HIV/AIDS, providing definitions and descriptions. It begins by defining HIV as the human immunodeficiency virus that infects and damages cells of the immune system, specifically CD4+ T cells. It then defines AIDS as acquired immunodeficiency syndrome, which is the final stage of HIV infection where the immune system is severely damaged. The document goes on to provide a brief history of HIV/AIDS, describing its identification and naming over time. It concludes by outlining global statistics on people living with HIV/AIDS and discussing the Bangladesh situation.
2nd term lecture,_,vib,_helico,tb,_spiro,rick[1]عادل الحربي
The document discusses various bacteria including Haemophilus influenzae, which causes diseases like pneumonia but is difficult to diagnose; it also covers Mycobacterium tuberculosis and the symptoms and treatment of tuberculosis; additionally, it summarizes different types of spirochetes, rickettsiae, and how they are transmitted and can cause diseases.
The document discusses fatality rates of various infectious diseases and provides percentages for the chance that an unvaccinated infected person will die from different diseases like rabies (100%), bubonic plague (60%), yellow fever (7.5%), and pertussis in infants (3.7%). It also discusses arranging diseases based on perceived fatality rates and transmissibility rates.
The document provides information about HIV/AIDS, including:
1) It describes what HIV and AIDS are, how HIV causes AIDS by compromising the immune system over time.
2) It provides statistics on HIV infections in the US since 1981, including that 1 in 5 people living with HIV are unaware of their status.
3) It summarizes research showing that HIV likely originated from transmission from chimpanzees to humans in the early 20th century.
4) It lists symptoms that can emerge when HIV progresses to AIDS and compromises the immune system.
The document discusses various primary immunodeficiency syndromes including T cell deficiencies like DiGeorge syndrome and X-linked hyper IgM syndrome. It also covers combined B- and T-cell immunodeficiencies such as severe combined immunodeficiency disease (SCID) as well as acquired immunodeficiency diseases and diseases of immune dysregulation including hemophagocytic lymphohistiocytosis (HLH), X-linked lymphoproliferative syndrome, and HIV/AIDS. Treatment options discussed include bone marrow transplantation, gene therapy, and highly active antiretroviral therapy. Outcomes for children with immunodeficiencies depend on timely diagnosis, adequate treatment and surveillance, and the underlying disease.
Rene Sabatier noticed unusual symptoms in healthy young homosexual men and realized their bodies were invaded by a new virus. This led to the isolation of HIV in the 1980s. HIV causes AIDS by attacking CD4 cells and weakening the immune system. It is transmitted through sexual contact, blood transfusions, needle sharing, and from mother to child. While there is no cure for AIDS, education programs aim to prevent transmission through promoting safe sex practices and blood safety.
This document discusses Brucellosis, a zoonotic bacterial disease caused by Brucella species. It is one of the most common bacterial zoonoses worldwide, with over 500,000 new cases annually. Brucellosis causes nonspecific flu-like symptoms like intermittent fever and can infect many organs, earning it the nickname the "great imitator". It is typically transmitted through contact with infected animals or consumption of unpasteurized dairy. While treatment with antibiotics can cure the infection, relapses are common if treatment is not prolonged. Brucellosis remains underdiagnosed in many parts of the world.
The document discusses immunity and infection, including:
1) The chain of infection involves a pathogen, reservoir, transmission, entry and establishment in a new host. Breaking the chain prevents spread of disease.
2) The immune system defends against pathogens through physical and chemical barriers, and cells and antibodies that fight infection.
3) Pathogens like bacteria, viruses, fungi and parasites can cause infectious diseases. Emerging diseases are on the rise due to factors like drug resistance, travel and human behavior.
4) Maintaining a healthy immune system involves good nutrition, exercise, rest and controlling stress. Sexually transmitted diseases pose major health risks and can be prevented through education and safe practices.
The document discusses the transmission of HIV/AIDS through various modes:
1) Sexual transmission is the most common mode, occurring through unprotected vaginal, anal and oral sex. Anal intercourse poses the highest risk while oral sex has a lower but present risk.
2) Transmission can also occur through blood, such as transfusions or sharing needles. Procedures involving piercing of skin like tattoos or circumcision can also transmit HIV.
3) Mother-to-child transmission is another mode, where the virus can be passed during pregnancy, delivery or through breastfeeding. The risk of transmission from an HIV-positive mother to her newborn ranges from 12-35%.
The West Nile virus originated in Uganda in 1937 and has since spread throughout Africa, Europe, the Middle East, and Asia, reaching the United States in 1999. It is transmitted primarily between birds via mosquitoes, and can infect humans, causing mild to severe illness. Older adults over 50 are most at risk. While there is no vaccine, individuals can reduce risk of infection by using insect repellent, eliminating standing water where mosquitoes breed, and minimizing outdoor activity during dusk and dawn when mosquitoes are most active.
Similar to Out of africa. cytomorphology of cells on cervical smears from HIV positive women. (20)
Automated identification of Tuberculosis bacilli on sputum smears using digi...Genevieve Warner Learmonth
Tuberculosis is a highly contagious disease which is spreading through communities where the inidence of HIV is high , in many areas in South Africa. A simple device which recognises individual TB bacilli on sputum specimens has been designed. It is inexpensive accurate and 'proof of concept "has been tested. The problem is to get hundreds of thee machines manufacted and installed in to the 480 TB labs, as well as the mobile Tb labs ( called Tutu testers ) in South africa.
The incidence of significant lesions on cervical smears in women under thirty...Genevieve Warner Learmonth
The incidence of HIgh Grade Lesions ( HSIL) on cervical smears from women under 30 years in Cape Town, South Africa is recorded. Women in SA are only offered a free cervical smear at age 30 and then every ten years until age 50.. The clinical, public health, and psycho social implications of this issue are discussed.
A doctor in South Africa encountered a case where Echinococcus Granulosus was found in a fine needle aspirate of a cystic mass in a patient's parotid gland. The parotid gland is a salivary gland located near the ear. Echinococcus Granulosus is a tapeworm that can cause cysts to grow in organs and tissues of the body.
This document describes Genevieve Warner Learmonth's experience working in anatomical pathology laboratories in the UK and South Africa. It provides details on the facilities and physical layout of laboratories in both countries, with UK laboratories described as underground, tiny rooms or windowless, while South African laboratories were initially large and purpose-built but are now state-of-the-art. Case loads between the two countries are also compared, with South Africa seeing more cases of HIV/AIDS, tuberculosis, liver diseases and cancers due to parasites, while the UK saw more breast, cardiac and bone/soft tissue cases. The work culture is described as having staggered starts and fewer meetings in the UK compared to early starts and meetings in South Africa, along
A doctor in South Africa encountered a case where Echinococcus Granulosus was found in a fine needle aspirate of a cystic mass in a patient's parotid gland. The parotid gland is a salivary gland located near the ear. Echinococcus Granulosus is a tapeworm that can cause cysts to grow in organs and tissues of the body.
This document discusses cervical cancer screening in South Africa. It finds that 21% of cervical smear tests in Cape Town from 2010-2011 were from women under 30 years old, and 19% of women referred to colposcopy for suspicious lesions or high-grade abnormalities were under 30. This suggests that starting cervical cancer screening at age 30, as currently recommended in South Africa, may be too late to identify pre-cancerous lesions in many young women. Given risk factors like early sexual debut, HPV infection rates of 21%, and peak HIV rates in women aged 25-29, revising national screening guidelines to start screening earlier is imperative to prevent morbidity and mortality from cervical cancer in South Africa.
The document discusses the Groot Schuur Hospital Breast Clinic located in Cape Town, South Africa. It provides breast cancer screening and diagnosis services. The document also mentions Genevieve Warner Learmonth, Sharon Fenwick, and Yvonne Parfitt who work at the breast clinic and cancer research laboratory affiliated with Groote Schuur Hospital and the University of Cape Town.
This document summarizes cytopathology findings of lytic bone lesions. It describes how lytic lesions can be aspirated using a Jam Shedi needle and discusses common causes including metastatic tumors, infections like tuberculosis and opportunistic infections due to HIV/AIDS, and metabolic diseases. Several case studies are presented including an aneurysmal bone cyst, hydatid disease, siderosis from iron accumulation, and tuberculosis involving the vertebrae. Cytology and histology slides are shown and findings described.
A fine needle aspirate was taken from a cystic mass in a patient's parotid gland. The aspirate was found to contain Echinococcus Granulosus, a type of tapeworm. The cyst was located in the patient's parotid salivary gland near the ear.
The breast clinic at GSH hospital was founded in 1951 and was one of the earliest breast clinics in South Africa. In 1982, they introduced an on-site, real-time cytology service led by three professors/doctors which provided physical exams, imaging, needle biopsies, and immediate cytology results. Over the years the clinic has seen thousands of patients and conducted research on their methods and results, finding high accuracy rates for diagnosing breast cancer. The multidisciplinary team and on-site cytology have improved patient care and reduced anxiety while also serving educational purposes through workshops and international visitors seeking to replicate the clinic's model.
Women under 30years of age are not offered free cervical screen. However some women with symptoms present for a diagnostic cervical smear. These women have a high incidence of High Grade Lesions requiring Colposcopy and treatment.
This document compares and contrasts Genevieve Warner Learmonth's experiences working in anatomical pathology laboratories in the United Kingdom and South Africa. It notes key differences in the facilities and infrastructure between older UK laboratories located underground, in small rooms, and with few microscopes, compared to larger, newer South African laboratories with more equipment. The document also discusses differences in caseloads and diseases encountered between the two countries, as well as differences in work culture and schedules.
In South Africa women under 30years of age are not offered free cervical smear screening. Howeve it has been noted that a significant percentage of women under 30years are found to have High Grade Lesions in the community which we serve.
“I see some cells with
granular cytoplasm”
Review: Eosinophils, Charcot Leyden
Crystals.
Histology: Eosinophilic granuloma
Patient: History of sheep farming.
Heavy worm burden.
Conclusion: Visceral Larva Migrans
Cytological examination of cerebrospinal fluid from a woman who had sudden onset of progressive transverse myelitis revealed a larva like organism, suggestive of toxocariasis, which is occasionally found in peri urban areas near Cape Town. She reccovered very quickly after treatment with Albedazole and small doses of cortison.MRI realed intraspinal lesions a C4 and T8 as well as a "coin" lesion in the parietal lobe of her brain.
Cytopathology of lytic lesions in bone can be helpful to diagnose infectious processes as well as neoplastic lesions. Tuberculosis, hydatid disease of bone are illustrated. Haemosiderosis of bone is also discussed,
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14...Donc Test
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
TEST BANK For Brunner and Suddarth's Textbook of Medical-Surgical Nursing, 14th Edition (Hinkle, 2017) Verified Chapter's 1 - 73 Complete.pdf
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
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Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
Helminthiasis or Worm infestation in Children for Nursing students
Out of africa. cytomorphology of cells on cervical smears from HIV positive women.
1. Cytomorphological changes on conventional smears from HIV positive women Dr Genevieve Warner Learmonth University of Cape Town South Africa Royal Free Hospital London
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6. If you look carefully Dendritic Cells are easy to observe on cervical smears! Cervical Smear, AIDS patient
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