This document provides definitions and information about orthotics. It defines orthotics as externally applied devices that modify the structural and functional characteristics of the neuromuscular and skeletal systems to enable better use of the body part. The document then discusses principles, functions, indications, prescription processes, and nomenclature of various orthotic devices for the spine, upper limbs, lower limbs, knees, and hips. Examples and purposes of different orthotic devices are provided for each body region.
it explain about introduction, definition, purpose of applying cast, indcation, type of cast, procedure of application and removal of plaster and management.
what is a sprain and what is the strain, define sprain and grading of sprain, strain and grading of strain, symptoms, causes, treatment, RICE protocol, exercise, prevention, healing of sprain and strain
presentation is about Orthosis and prosthesis. It gives Classification of Orthosis. It describes structure, function, Indication and uses of Orthosis. Also describes different types of Prostheses, their parts and function.
it explain about introduction, definition, purpose of applying cast, indcation, type of cast, procedure of application and removal of plaster and management.
what is a sprain and what is the strain, define sprain and grading of sprain, strain and grading of strain, symptoms, causes, treatment, RICE protocol, exercise, prevention, healing of sprain and strain
presentation is about Orthosis and prosthesis. It gives Classification of Orthosis. It describes structure, function, Indication and uses of Orthosis. Also describes different types of Prostheses, their parts and function.
A complete description of the lower limb orthosis is available in the following presentation with an in depth understanding of the same.It covers the ankle foot orthosis,Knee orthosis the knee ankle foot orthosis and hip orthosis.
upeer limb ortosis is now a day use very fraquently. this ppt provide general guidelines and information on common parts of the orthosis and some recent advances.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Definition
ORTHO ≈ “to straighten” or
“align”
Speciality concerned with
design, manufacture and
application of Orthoses
Externally applied device
used to modify the
structural and functional
characteristics of
neuromuscular and skeletal
system
To enable better use of the
body part
13. Spinal Orthoses
2 groups- Supportive and
Corrective
Mechanical deficiencies are
present eg. Taylor brace, short
spinal brace
Inspite of deficiencies, patients
obtain symptomatic relief-
psycological, abdominal
compression, support of
pendulous abdomen, decrease
in lumbar lordosis,decrease in
movement,activity, support of SI
joint and ilio-lumbar ligaments
18. Immediate Lumbar Orthoses
Cheap and instant
Tubigrip body
bandage used
Rolled from nipples
to upper thighs
POP is rolled over it
19. Rigid Spinal Orthosis
All are constructed on the basis of a metal frame which
takes firm support from pelvis(except anterior
hyperextension orthosis)
Pelvic band/ Moulded pelvic corset
Metallic uprights are present over the base and
connected by crossbars
Abdominal plate
Padded shoulder or clavicular straps
20. Taylor Spinal Brace
1863, by CF Taylor
Used in treatment of TB
Spine
Limits forward flexion,
extension, lateral flexion
and to some extent
rotation of the lumbar
and lower thoracic
regions of spine
Increases movements at
LumboSacral junction
28. Orthoses for Cervical Spine
Head is balanced on Cx Spine by action of neck
muscles
Considerable range of movement in all directions
Inflammatory conditions or mechanical derangements
require immobilisation + support of head to relieve
pressure upn vertebrae, discs, joints and Cranial
nerves
External support must fit the contours
Forehead must also be included in lesions of upper Cx
spine
29. Soft Cervical Collar
Extends from base of
bandible, superior nuchal
line to manubrium and C7
spine inferiorly
Mild soft tissue strain,
sprain, spasm
Kinesthetic reminder
Heat retention
Motion Control
Flexion- 26%
Extension- 20%
Lateral bending- 8%
Rotation- 17%
30. Hard Cervical / Thomas Collar
Hugh Owen Thomas
Originally made from
metal sheet covered with
felt
made from hard
polyethylene
Some more restriction of
movement
Indications- same as Soft
collar
31. Moulded Cervical Orthoses
Philadelphia Collar
Made of Plastazone/
Polyethylene foam
2 separate pieces
Motion control
Flexion- 70%
Extension-60%
Lateral flexion- 35%
Rotation- 60%
Most effective in injury above
C3
32. SOMI Brace
Sterno- Occipito-
Mandibular- Immobilizer
Indications- stable spinal
fracture dislocations and
moderate to severe soft
tissue damage
Motion control
Flexion- 95%
Extension-40%
Lateral flexion- 35%
Rotation- 70%
33. Four-Poster Cervical Brace
Similar to SOMI brace
Except Posterior post and
extra axillary straps
Motion control
Flexion- 90%
Extension-80%
Lateral flexion- 55%
Rotation- 70%
Modification- chest and
back plates extend further
down
more effective in controlling
flexion and rotation
34. Cervical Halo Orthosis
Rigid Invasive bracing system
Maximum motion control, but
less used due to its invasive
nature
Indication- unstable fracture
dislocation of spine
Motion control
Flexion- 95%
Extension-95%
Lateral flexion- 95%
Rotation- 99%
Ability to provide distracting
forces
35. Cervicothoracic Orthoses
Minerva Jacket
Rigid frame, custom
made, total contact
Covers entire skull except
face, extending upto
inferior costal margin
Indications- Traumatic
and Pott’s spine
Maximum motion control
at lower cervival and
cervicothoracic juntion
36. Cervicothoracolumbosacral Orthosis
Halo Pelvic brace
Rigid, invasive brace
Historical importance only
Four spring loaded
distraction bars
Indication- Immobilisation
in Pott’s spine and deformity
correction of spine
Functions- limits all spinal
movements
46. Sling and Swathe Immobilizer
(Universal Shoulder Immobiliser)
47. Turn-Buckle Splint
Produce gradual
stretching over a
contracted joint. Eg-stiff
elbow, VIC
Corrects contracture
very fast
Decreases rehabilitation
time’
Excellent patient
compliance
48. Lower Limb Orthoses
Foot orthosis
Purpose of shoe modification
Restoration of normal gait
Proper distribution of wt
Balancing while standing
Component of calliper
51. Ankle Foot Orthoses
Support ankle and foot
Maintains ankle stability
Prevent equinus contracture
Heel stop is attached to limit
excessive dorsi/plantar flexion
Weak plantar flexors-
front/calcaneous stop
Weak dorsiflexors-
back/equinous stop
Disadvantage- Axis of movement of
appliance dosnot correspont with
that of ankle, thereby stress is
imposed on heel and shoes
53. Foot Drop Splint
AFO Plantar R- Ankle foot orthosis plantarflexion resist
54. T straps
T-strap is cut from leather.
Vertical limb is attached at the
junction of the upper with the sole
The strap encircles both the ankle
and the side bar
The t-strap may be attached either
inside or outside of the shoe
Weak TA and TP->foot valgus-
>Outside iron and inner T-Strap
Weak Peroneal muscles-> foot varus-
>inside iron and outside T-strap
55. Knee Orthoses
Knee Immobiliser
From mid thigh to mid leg
Maintains knee in extension
Indications
Post-operative knee
Sprains and strains
56. Knee ROM brace
Provides protected and controlled
knee motion
Used in cases of Periarticular
fracture fixation, ligamentous
reconstruction
Valgum Varus brace
Gaining popularity
Corrects deformity around knee
57. Mermaid splint
Nonarticular orthosis
Keeps both knee solidly in
the night
Used when disease is in
active phase and
deformity is mild
Knee Gaiter
Maintains knee in
extension
Used in spastic conditions
like CP
58. Knee joints in lower limb orthoses
Single axis knee
joint
Restriction in
hyperextension
Drop lock
Variant- Posterior
offset type
Stance control
knee joint
No flexion during
weight bearing
59. Polycentric knee
joint
Closer to anatomic
knee joint
Lock-in variable
flexion type knee
joint
Removable hold in
sagital plane which
functions in full
extension and can be
released for flexion
60. Knee Ankle Foot Orthoses
Conventional
Prevent buckling of knee and
facilitate ambulation, eg PPRP
Maintain stability of knee, eg
neuropathic joint
To relieve weight on bone and joint
61. Total contact KAFO
Made up of thermoplastics attached
with the knee joint
Variant- ischial weight bearing type
PTB type
62. Hip Knee Ankle Foot Orthoses
Maintain standing
posture and ensure
mobility
Maintain stability of hip
jouint
Variant- Reciprocating
gain Orthosis
Used in Spina Bifida and
spinal cord injury
Combines flexion of one
hip with extension of
opposite hip