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ORBAS 20, 40 mg
(Olmesartan Medoxomil INN)
Presented by
Mohammed Moshiur Rahaman
Senior Brand Executive
Brand Management Department
Strategic Brand Management Division
The ACME Laboratories Ltd.
ORBAS
(Olmesartan Medoxomil INN 20, 40 mg)
Olmesartan effectively reduces blood
pressure in adult patients along
with 6 years old children
Price & Supply
Price: 20 mg (08 taka)
40 mg (15 taka)
Supply: 3x10 tablets
Product Group : A
Indication
For the treatment of hypertension
Dosage & Administration
 20 mg Once daily OR
may be increased after 2 weeks to 40 mg
 Children (10 mg for weigh <35 kg &
20 mg for weigh >35 kg)
Endothelial Cell:
The endothelium is the thin layer of cells that lines the interior
surface of blood vessels and lymphatic vessels, forming an
interface between circulating blood in the lumen and the rest of the
vessel wall. The cells that form the endothelium are called
endothelial cells.
Major function of Endothelial Cell:
Vasoconstriction and vasodilation, and hence the control of blood
pressure.
Dysfunction of Endothelial Cell:
Endothelial dysfunction can result from and/or contribute to several
disease processes, as occurs in hypertension,
hypercholesterolemia, diabetes.
Product information of Losart, Valtin & Orbas
  Losart Valtin Orbas
Generic Losartan Valsartan Olmesartan
Dosage form Tablet Tablet Tablet
Strength 25, 50, 100 mg 80, 160 mg 20, 40 mg
Indication Hypertension, Congestive Heart
failure
Hypertension, Heart failure, Myocardial
infarction
Hypertension
AT1 affinity 10000 fold 20000 fold 12500 fold
tmax (h), on
set of action
3-4 hrs 2 hrs 1.4-2.8 hrs
IMS market
size
105 crore with 8% positive growth 9.7 crore with 6.21% negative growth 15.56 crore with 65% positive
growth
Positioning Shows better control on blood
pressure
Provides prompt & sustained blood
pressure
More potent ARB Ensures
double digit BP reduction
  Economic ARB Significantly reduces mortality and
morbidity in patients with HF
Shows 24 hrs BP control, even
final 4 hrs
  Also effective in CHF   Shows early onset of action
compared to other ARBs
      Improves endothelial
dependent coronary dilation in
hypertensive patients
Mechanism of
action
Blocks AT1 receptor, as a result Angiotensin II is unable to participate further reaction
Orbas

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Orbas

  • 1. ORBAS 20, 40 mg (Olmesartan Medoxomil INN) Presented by Mohammed Moshiur Rahaman Senior Brand Executive Brand Management Department Strategic Brand Management Division The ACME Laboratories Ltd.
  • 2. ORBAS (Olmesartan Medoxomil INN 20, 40 mg) Olmesartan effectively reduces blood pressure in adult patients along with 6 years old children
  • 3. Price & Supply Price: 20 mg (08 taka) 40 mg (15 taka) Supply: 3x10 tablets Product Group : A
  • 4. Indication For the treatment of hypertension Dosage & Administration  20 mg Once daily OR may be increased after 2 weeks to 40 mg  Children (10 mg for weigh <35 kg & 20 mg for weigh >35 kg)
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  • 9. Endothelial Cell: The endothelium is the thin layer of cells that lines the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. The cells that form the endothelium are called endothelial cells. Major function of Endothelial Cell: Vasoconstriction and vasodilation, and hence the control of blood pressure. Dysfunction of Endothelial Cell: Endothelial dysfunction can result from and/or contribute to several disease processes, as occurs in hypertension, hypercholesterolemia, diabetes.
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  • 15. Product information of Losart, Valtin & Orbas   Losart Valtin Orbas Generic Losartan Valsartan Olmesartan Dosage form Tablet Tablet Tablet Strength 25, 50, 100 mg 80, 160 mg 20, 40 mg Indication Hypertension, Congestive Heart failure Hypertension, Heart failure, Myocardial infarction Hypertension AT1 affinity 10000 fold 20000 fold 12500 fold tmax (h), on set of action 3-4 hrs 2 hrs 1.4-2.8 hrs IMS market size 105 crore with 8% positive growth 9.7 crore with 6.21% negative growth 15.56 crore with 65% positive growth Positioning Shows better control on blood pressure Provides prompt & sustained blood pressure More potent ARB Ensures double digit BP reduction   Economic ARB Significantly reduces mortality and morbidity in patients with HF Shows 24 hrs BP control, even final 4 hrs   Also effective in CHF   Shows early onset of action compared to other ARBs       Improves endothelial dependent coronary dilation in hypertensive patients Mechanism of action Blocks AT1 receptor, as a result Angiotensin II is unable to participate further reaction