Orbas
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This document discusses Orbas, an olmesartan medication for treating hypertension. It is available in 20 mg and 40 mg tablets, with dosing of 20 mg once daily or up to 40 mg, or for children 10 mg for weight under 35 kg and 20 mg for weight over 35 kg. Olmesartan effectively reduces blood pressure in adults and children aged 6 years and older. The document also discusses endothelial cells, which line blood vessels and control blood pressure, and how endothelial dysfunction can result from and contribute to diseases like hypertension.
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2. Treatment involves stopping warfarin, administering vitamin K1 to restore clotting factors, and plasma or PCC to rapidly reverse coagulopathy based on INR.
3. Superwarfarins require weeks of vitamin K1 due to their long half-lives. Activated charcoal may be given for recent ingestions. Monitoring INR guides further treatment.
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Literature Survey & Market Survey on Amlodipine and its Recent Trends
Literature Survey & Market Survey on Amlodipine and its Recent Trends
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- 4. Indication For the treatment of hypertension Dosage & Administration ï 20 mg Once daily OR may be increased after 2 weeks to 40 mg ï Children (10 mg for weigh <35 kg & 20 mg for weigh >35 kg)
- 9. Endothelial Cell: The endothelium is the thin layer of cells that lines the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. The cells that form the endothelium are called endothelial cells. Major function of Endothelial Cell: Vasoconstriction and vasodilation, and hence the control of blood pressure. Dysfunction of Endothelial Cell: Endothelial dysfunction can result from and/or contribute to several disease processes, as occurs in hypertension, hypercholesterolemia, diabetes.
- 15. Product information of Losart, Valtin & Orbas  Losart Valtin Orbas Generic Losartan Valsartan Olmesartan Dosage form Tablet Tablet Tablet Strength 25, 50, 100 mg 80, 160 mg 20, 40 mg Indication Hypertension, Congestive Heart failure Hypertension, Heart failure, Myocardial infarction Hypertension AT1 affinity 10000 fold 20000 fold 12500 fold tmax (h), on set of action 3-4 hrs 2 hrs 1.4-2.8 hrs IMS market size 105 crore with 8% positive growth 9.7 crore with 6.21% negative growth 15.56 crore with 65% positive growth Positioning Shows better control on blood pressure Provides prompt & sustained blood pressure More potent ARB Ensures double digit BP reduction  Economic ARB Significantly reduces mortality and morbidity in patients with HF Shows 24 hrs BP control, even final 4 hrs  Also effective in CHF  Shows early onset of action compared to other ARBs    Improves endothelial dependent coronary dilation in hypertensive patients Mechanism of action Blocks AT1 receptor, as a result Angiotensin II is unable to participate further reaction