Merck & Co. is one of the largest pharmaceutical companies established in 1891. It manufactures and markets a broad range of healthcare products for human and animal use. Merck has annual revenue of $27.4 billion and employs over 61,500 people worldwide. Some of Merck's major products include vaccines, prescription drugs, consumer health products, and animal health medicines. One of Merck's prescription drugs is lisinopril, an ACE inhibitor used to treat hypertension, heart failure, and diabetic complications. It has annual global sales of over $1 billion.

1. PROJECT REPORT ON MERCK & CO

2. INTRODUCTIONOne of the largest pharmaceutical company in the world both by market capitalization & revenue

3. Established in 1891 as the United States subsidiary of the German company now known as Merck KGaA

4. 1917 as an independent company

5. Manufactures & markets broad range of products to improve human & animal health LOGO

6. BASIC INFORMATIONIndustryFoundedHeadquatersChairman President & CEOPharmaceuticals1891 as a subsidiary of Merck KGaAWhitehouse Station, New Jersey, United StatesRichard T. clarckStanley F. Barshay

7. CONTINUEDRevenueOperating IncomeNet IncomeTotal assetsTotal equityEmployees US$27.4 Billion US$4.83 Billion US$12.9 Billion US$112 BillionUS$59.1 Billion61,500

8. VISION OF MERCK & CO.We make a difference in the lives of people globally through our innovative medicines, vaccines, and consumer health and animal products. We aspire to be the best healthcare company in the world and are dedicated to providing leading innovations and solutions for tomorrow.

9. MISSION OF MERCK & COTo provide innovative, distinctive products and services that save and improve lives and satisfy customer needs, to be recognized as a great place to work, and to provide investors with a superior rate of return.

10. WHAT WE STAND FOR ????Excellence in science and healthcare innovation, with an emphasis on addressing unmet medical needs.Focus on patients and anticipating customers needs

11. CONTINUEDCommitment to expand access to our medicines and vaccines, and to improve global health

12. PRODUCTS WE DEAL IN ….VACCINESPRESCRIPTION PRODUCTSCONSUMER PRODUCTSANIMAL HEALTHPRESCRIBING INFORMATION

13. RESPONSIBILITY OF MERCK & CO.ETHICS & TRANSPARENCYACCESSENVIRONMENTCOMMUNITY

14. OBJECTIVE OF MERCK & COTo develop policy positions that guide our activities and advocacy on a range of issuesTo seek opportunities to adopt industry-leading standards in several areasTo strive to communicate clearly and transparently about our positions

15. CONTINUEDTo work closely with the many groups and individuals who are also trying to address the complex healthcare challenges that confront us

16. PRODUCTS ON THE MARKETAntivenin - for the treatment of Black Widow Spider bitesArcoxia (etoricoxib) - for the symptomatic treatment of osteoarthritisCancidas (caspofungin) - An echinocandins antifungal drug for treatment of Aspergillus and Candida

17. CONTINUEDCosopt (dorzolamide and timolol) - reduces intraocular pressure in people with glaucoma or ocular hypertension.Cozaar/Hyzaar (losartan)- used to treat hypertension, to reduce the risk of strokes and to treat diabetic nephropathy.

18. CONTINUEDCozaar/Hyzaar (losartan)- used to treat hypertension, to reduce the risk of strokes and to treat diabetic nephropathy.Crixivan (indinavir) – a protease inhibitor HIV medication.Emend (aprepitant) – treats vomiting and nausea brought about by chemotherapy.

19. CONTINUEDEmend (aprepitant) – treats vomiting and nausea brought about by chemotherapyEmend Injection (fosaprepitantdimeglumine) - an intravenous drug for nausea and vomiting caused by chemotherapyEmflex (Acemetacin) - a non-steroidal anti-inflammatory drug

20. CONTINUEDFosamax (alendronate) – osteoporosis medication.Fosamax Plus D (alendronate/vitamin D) – osteoporosis medicationIsentress (raltegravir) - HIV integrase inhibitor.

21. COMMON ST. OF MERCK & CO

22. REVENUE GRAPH OF MERCK & CO.

23. COMPETITORS IN UKNAMEOF THE COMPANYTOTAL REVENUE (IN USD BILLIONS)45.8332.81GlaxoSmithKline AstraZeneca

24. COMPETITORS IN USANAME OF THE COMPANYJohnson & JohnsonAbbott LaboratoriesPfizer Eli lillyBristol-Myers SquibbTOTAL REVENUE(IN USD BILLIONS )61.9030.76 50.0 21.8418.81

25. COMPETITORS IN SWITZERLANDNAME OF THE COUNTRYHOFFMAN LA ROCHENOVARTISNYCOMED TOTAL REVENUE (IN USD BILLIONS)47.3544.274.26

26. COMPETITORS IN GERMANYNAME OF THE COUNTRYBAYERBOEHRINGER INGELHEIMMERCK kGaA TOTAL REVENUE (IN USD BILLIONS)22.316.95.17

27. COMPETITORS IN JAPANNAME OF THE COUNTRYTAKEDAPHARMACEUTICALASTELLAS PHARMADAIICHI SANKYO 9 EISAICHUGAI PHARMACEUTICAL .TOTAL REVENUE (IN USD BILLIONS)15.610.795.52.0

28. SELECTIVE PRODUCT :LISINOPRILIt is a drug of the angiotensin converting enzyme (ACE) inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. It has been compared withomapatrilat which is of similar function.

31. SYSTEMATIC IMAGE

32. IDENTIFIERSCAS numberATC codePubChemode8C09AA033915-83-7CID 5362119

33. CHEMICAL DATAFormula Mol. MassSMILESInChISynonymsC21H31N3O5 405.488 g/molEmolecules & Pubchem(2S)-1-[(2S)-6-amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]pyrrolidine-2-carboxylic acid

34. PharmacologyLisinopril is the lysine-analog of enalaprilLisinopril is not a pro drug and is excreted unchanged in the urineIn cases of overdosage, it can be removed from circulation by dialysis

35. CLINICAL USEIts indications, contraindications and side effects are as those for all ACE inhibitorsIts long half-life allows for once a day dosing which aids patient compliancePatients whose creatinine clearance ≥10 mL/min and ≤30 mL/min should be given the standard 5 mg/day dosage, at first

36. CONTINUEDFor patients whose creatinine clearance is less than 10 mL/min, the dosage should start at 2.5 mg/day, adjusted over time according to the patient's blood pressure response

37. ADVERSE EFFECTSChills, infectionDark urine, decreased urination Difficulty swallowing or breathing HoarsenessItching

38. CONTINUEDRapid weight gain, stomach painYellowing of skin or eyes (jaundice)Abdominal pain, bloating, vomitingChest pain or tightness, dizziness, lightheadedness, fainting (syncope)

39. CONTINUEDDry coughFeverJoint painRashDiarrhea, loss of taste, nausea

40. REVENUE OF LISINOPRIL